Strategy to design peptide inhibitors: Structure of a complex of proteinase K with a designed octapeptide inhibitor N-Ac-Pro-Ala-Pro-Phe-DAla-Ala-Ala-Ala-NH2 at 2.5 Å resolution

Protein Science

Volumn 5, Issue 12, 1996, Pages 2453-2458

  Saxena, Ajay K ^a   Singh, Tej P ^a   Peters, Klaus ^b   Fittkau, Siegfried ^b   Betzel, Christian ^c  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c DESY   (Germany)

Author keywords

Conformation; Inhibition rate; Octapeptide inhibitor; Proteinase K; X ray structure

Indexed keywords

OCTAPEPTIDE; PROTEINASE K;

ARTICLE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMIDES; ANIMALS; DRUG DESIGN; ENDOPEPTIDASE K; HUMANS; PEPTIDES; PROTEIN CONFORMATION;

EID: 0030448626     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560051207     Document Type: Article

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