Dynamics of stromelysin/inhibitor interactions studied by 15N NMR relaxation measurements: Comparison of ligand binding to the S1-S3 and S'1-S'3 subsites

Journal of Biomolecular NMR

Volumn 15, Issue 1, 1999, Pages 55-64

  Yuan, Peng ^a,c   Marshall, Vincent P ^b   Petzold, Gary L ^b   Poorman, Roger A ^b   Stockman, Brian J ^a  

^a Structural   (United States)

^b Protein Science   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Hydroxamic acid; Ligand; Matrix metalloproteinase; Protein dynamics; Stromelysin; Thiadiazole

Indexed keywords

HYDROXAMIC ACID; N METHYL 3 PHENYL 2 [3 (2 THIOXO 1,3,4 THIADIAZOL 5 YL)UREIDO]PROPIONAMIDE; PNU 142372; PNU 99533; STROMELYSIN; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME INHIBITOR COMPLEX; ENZYME INHIBITOR INTERACTION; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION;

BINDING SITES; ENZYME INHIBITORS; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASE 3; MODELS, MOLECULAR; NITROGEN ISOTOPES; PROTEIN CONFORMATION; THIADIAZOLES; UREA;

EID: 0032830040     PISSN: 09252738     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008398807718     Document Type: Article

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