Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 1, 2000, Pages 418-423

  Harth, Günter ^a   Zamecnik, Paul C ^b   Tang, Jin Yan ^c   Tabatadze, David ^c   Horwitz, Marcus A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HYBRIDON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; ETHAMBUTOL; GLUTAMATE AMMONIA LIGASE; GLUTAMINE; ISONIAZID; MESSENGER RNA; PHOSPHOROTHIOIC ACID; POLYGLUTAMIC ACID; POLYMYXIN B NONAPEPTIDE;

ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; CELL DIVISION; CELL WALL; DNA, ANTISENSE; ENZYME INHIBITORS; ETHAMBUTOL; GLUTAMATE-AMMONIA LIGASE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; PEPTIDES; PEPTIDOGLYCAN; POLYGLUTAMIC ACID; RNA, MESSENGER;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0034602726     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.1.418     Document Type: Article

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