Structure - Activity relationships in a series of 2(1H)-Quinolones bearing different acidic function in the 3-Position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties

Journal of Medicinal Chemistry

Volumn 39, Issue 1, 1996, Pages 197-206

  Desos, Patrice ^a   Lepagnol, Jean M ^a   Morain, Philippe ^a   Lestage, Pierre ^a   Cordi, Alex A ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; 6,7 DICHLORO 2(1H) OXO 3 QUINOLINEPHOSPHONIC ACID; 6,7 DINITRO 3 TRIFLUOROMETHANESULFONAMIDO 2(1H) QUINOLINONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; AMPA RECEPTOR; GLYCINE RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; QUINOLONE DERIVATIVE; S 16678; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDIOGENIC SEIZURE; BRAIN ISCHEMIA; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; GERBIL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEUROPROTECTION; NONHUMAN; OOCYTE; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BRAIN; BRAIN ISCHEMIA; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GERBILLINAE; KAINIC ACID; MICE; MOLECULAR STRUCTURE; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; PHOSPHONIC ACIDS; QUINOLONES; QUINOXALINES; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0030026595     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950323j     Document Type: Article

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