Salmonella typhimurium mutagenicity tester strains that overexpress oxygen-insensitive nitroreductases nfsA and nfsB

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 501, Issue 1-2, 2002, Pages 79-98

  Carroll, C C ^a,b   Warnakulasuriyarachchi, D ^a   Nokhbeh, M R ^a,c   Lambert, I B ^a  

^a CARLETON UNIVERSITY   (Canada)

^b ROYAL CANADIAN MOUNTED POLICE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Acetyltransferase; Ames assay; MucAB; Nitroreductase; Salmonella typhimurium

Indexed keywords

1 NITROPYRENE; 1,6 DINITROPYRENE; 2 NITROFLUORENE; 2 NITRONAPHTHALENE; 4 NITROQUINOLINE 1 OXIDE; NITROFURAL; NITROPYRENE; NITROREDUCTASE; UNCLASSIFIED DRUG;

AMES TEST; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE OVEREXPRESSION; METABOLIC ACTIVATION; MUTAGEN TESTING; MUTAGENESIS; NFSA GENE; NFSB GENE; NONHUMAN; OAT GENE; PRIORITY JOURNAL; R PLASMID; SALMONELLA TYPHIMURIUM;

BACTERIAL PROTEINS; DRUG RESISTANCE, NEOPLASM; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MUTAGENICITY TESTS; NITRO COMPOUNDS; NITROREDUCTASES; PLASMIDS; SALMONELLA TYPHIMURIUM; SENSITIVITY AND SPECIFICITY;

ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM;

EID: 0037171651     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00018-0     Document Type: Article

References (84)

1. Atmospheric reactions of polycyclic aromatic hydrocarbons: Facile formation of mutagenic nitro derivatives
2. Mutagenicity and genotoxicity of nitroarenes: All nitro-containing chemicals were not created equal 42
3. Mutagenicity and carcinogenicity of nitroarenes and their sources in the environment
4. Mutagenicity of nitrofuran derivatives: A review
5. Mutagenic potency of some conjugated nitoraromatic compounds and its relationship to structure
6. Mutagenicity of nitrofurans in Salmonella typhimurium TA98, TA98NR and TA98/1, 8-DNP6
7. Oxygen-insensitive nitroreductases: Analysis of the roles of nfsA and nfsB in development of resistance to 5-nitrofuran derivatives in Escherichia coli
8. Identification of the DNA adduct formed by metabolism of 1, 8-dinitropyrene in Salmonella typhimurium
9. Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1, 6- and 1, 8-dinitropyrene
10. Dinitropyrene-resistant Salmonella typhimurium are deficient in an acetyl-CoA acetyltransferase
11. N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: Proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes
12. The mutational specificity of furazolidone in the lacI gene of Escherichia coli
13. Reversible interaction of a reactive intermediate derived from furazolidone with glutathione and protein
14. Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity
15. The basis of the insensitivity of Salmonella typhimurium strain TA98/1, 8-DNP-6 to the mutagenic action of nitroarenes
16. A sensitive method for the detection of mutagenic nitroarenes: Construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100
17. Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: New derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels
18. Type I nitroreductases of Escherichia coli
19. Aerobic and anaerobic reduction of nitrated pyrenes in vitro
20. Oxygen-sensitive and oxygen-insensitive nitroreduction by Escherichia coli and rat hepatic microsomes
21. A general genetic approach in Escherichia coli for determining the mechanism(s) of action of tumoricidal agents: Application to DMP 840, a tumoricidal agent
22. Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase
23. Structure and site-directed mutagenesis of a flavoprotein from Escherichia coli that reduces nitrocompounds alteration of pyridine nucleotide binding by a single amino acid substitution
24. Nitroreductase A is regulated as a member of the soxRS regulon of Escherichia coli
25. Gene cloning, purification, and characterization of NfsB, a minor oxygen-insensitive nitroreductase from Escherichia coli, similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri
26. Nucleotide sequence of Salmonella typhimurium nitroreductase gene
27. Purification and characterization of wild-type and mutant classical nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium
28. Evidence for the existence of distinct nitroreductases in Salmonella typhimurium: Roles in mutagenesis
29. A cautionary note the use of nitroreductase-deficient strains of Salmonella typhimurium for the detection of nitroarenes as mutagens in complex mixtures including diesel exhausts
30. Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms
31. Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium
32. Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated polycyclics to mutagens
33. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
34. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test
35. The Ames Salmonella/microsome mutagenicity assay
36. Revised methods for the Salmonella mutagenicity test
37. Recent advances in the construction of bacterial genotoxicity assays
38. Detection of carcinogens as mutagens: Bacterial tester strains with R-factor plasmids
39. Inter-individual differences in the metabolism of environmental toxicants: Cytochrome P-450 1A2 as a prototype
40. Metabolic activation of aromatic amine mutagens by simultaneous expression of human cytochrome P-450 1A2, NADPH-cytochrome P-450 reductase, and N-acetyltransferase in Escherichia coli
41. Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P-450 1A2-catalyzed activation of aromatic amines
42. Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocyclic amines
43. Targeted disruption of the gene encoding the classical nitroreductase enzyme in Salmonella typhimurium Ames test strains TA1535 and TA1538
44. The ΔuvrB mutations in the Ames strains of Salmonella span 15 to 119 genes
45. Identification of plasmid (pKM101)-coded proteins involved in mutagenesis and UV resistance
46. Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA
47. Regulation of chromosomally mediated multiple antibiotic resistance: The mar regulon
48. The Salmonella typhimurium mar locus: Molecular and genetic analyses and assessment of its role in virulence
49. Prevalence of the multiple antibiotic resistance operon (marRAB) in the genus Salmonella
50. Promoter discrimination by the related transcriptional activators MarA and SoxS: Differential regulation by differential binding
51. Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro
52. marA, a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli
53. Mutagenicity of 30 chemicals in Salmonella typhimurium strains possessing different nitroreductase or O-acetyltransferase activities
54. Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution
55. Flavin reductase P: Structure of a dimeric enzyme that reduces flavin
56. Unusual folded conformation of nicotinamide adenine dinucleotide bound to flavin reductase P
57. Metabolism of 1, 8-dinitropyrene by Salmonella typhimurium
58. Roles of the mutagenesis proteins SamAB and MucAB in chemically induced frameshift mutagenesis in Salmonella typhimurium hisD3052
59. Salmonella typhimurium has two homologous but different umuDC operons: Cloning of a new umuDC-like operon (samAB) present in a 60 MDa cryptic plasmid of S. typhimurium
60. UmuD′(2)C is an error-prone DNA polymerase, Escherichia coli polV
61. Plasmid-encoded MucB protein is a DNA polymerase (polRI) specialized for lesion bypass in the presence of MucA′, RecA, and SSB
62. Coping with replication 'train wrecks' in Escherichia coli using PolV, PolII and RecA proteins
63. The Escherichia coli polB locus is identical to dinA, the structural gene for DNA polymerase. Part II. Characterization of PolII purified from a polB mutant
64. A phenotype for enigmatic DNA polymerase. Part II. A pivotal role for polII in replication restart in UV-irradiated Escherichia coli
65. Synthesis and mutagenicity of 1-nitro-6-nitrosopyrene and 1-nitro-8-nitrosopyrene, potential intermediates in the metabolic activation of 1, 6- and 1, 8-dinitropyrene
66. The dinB gene encodes a novel E. coli DNA polymerase, DNA polIV, involved in mutagenesis
67. Escherichia coli DNA polymerase IV mutator activity: Genetic requirements and mutational specificity
68. The beta clamp targets DNA polymerase IV to DNA and strongly increases its processivity
69. All three SOS-inducible DNA polymerases (PolII, PolIV and PolV) are involved in induced mutagenesis
70. The enhanced mutagenic potential of the MucAB proteins correlates with the high efficient processing of the MucA protein
71. Intrinsic polymerase activities of UmuD′(2)C and MucA′(2)B are responsible for their different mutagenic properties during bypass of a T-T cis-syn cyclobutane dimer
72. Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translation DNA synthesis
73. The mutational specificity of 1-nitroso-6-nitropyrene in the lacI gene of Escherichia coli strains deficient in nucleotide excision repair
74. Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli. Part II. Base substitution mutagenesis
75. Mutation spectra of chemical fractions of a complex mixture: Role of nitroarenes in the mutagenic specificity of municipal waste incinerator emissions
76. Target sequences for mutagenesis in Salmonella histidine-requiring mutants
77. Effects of the umuDC, mucAB, and samAB operons on the mutational specificity of chemical mutagenesis in Escherichia coli. Part I. Frameshift mutagenesis
78. Involvement of umuDC ST genes in the nitropyrene-induced-CG frameshift mutagenesis at the CG repetitive sequence of hisD3052 allele of Salmonella typhimurium
79. Methodology for bioassay-directed fractionation studies of air particulate material and other complex environmental matrices
80. Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors
81. SOS factors involved in translation synthesis
82. Construction and characterization of new cloning vehicles. Part II. A multipurpose cloning system