Luteinizing hormone-releasing hormone induces nuclear factor κB-activation and inhibits apoptosis in ovarian cancer cells

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 10, 2000, Pages 3815-3820

  Gründker, Carsten ^a   Schulz, Katja ^a   Günthert, Andreas R ^a   Emons, Günter ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; DOXORUBICIN; GONADORELIN AGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRIPTORELIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033756722     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.85.10.6859     Document Type: Article

References (38)

1. Presence of gonadotropin-releasing hormone and its messenger ribonucleic acid in human ovarian epithelial carcinoma
2. Gonadotropin-releasing hormone (GnRH)-binding sites in human breast cancer cell lines and inhibitory effects of GnRH antagonists
3. Expression of luteinizing hormone-releasing hormone and its mRNA in human endometrial cancer cell lines
4. Expression of the messenger RNAs for luteinizing hormone-releasing hormone (LHRH) and its receptor in human ovarian epithelial carcinoma
5. Growth-inhibitory actions of luteinizing hormone releasing hormone on tumor cells
6. The use of luteinizing hormone releasing hormone agonists and antagonists in gynecological cancers
7. High affinity binding and direct antiproliferative effects of luteinizing hormone-releasing hormone analogs in human endometrial cancer cell lines
8. High-affinity binding sites and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines
9. Lupron retards proliferation of ovarian epithelial tumour cells cultured in serum-free medium
10. Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: Evidence for an autocrine-inhibitory LHRH loop
11. Expression and signal transduction pathway of gonadotropin releasing hormone receptors
12. Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines
13. Luteinizing hormone-releasing hormone agonists interfere with mitogenic activity of the insulin-like growth factor system in androgen-independent prostate cancer cells
14. Evidence for tight coupling of gonadotropin-releasing hormone receptor to stimulate Fas ligand expression in reproductive tumors: Possible mechanism for hormonal control of apoptotic cell death
15. Cell lines derived from human ovarian carcinomas: Growth stimulation by gonadotropic and steroid hormones
16. Inhibition of nuclear translocation of transcription factor NF-kB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
17. Rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
18. NF-kappaB induces expression of the BCL-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
19. NFκB to the rescue: RELs, apoptosis and cellular transformation
20. Neuroprotection by aspirin and sodium salicylate through blockade of NFκB activation
21. Selective activation of NFκB by nerve growth factor through the neurotrophin receptor p75
22. Bcl-2 down-regulates the activity of transcription factor NFκB induced upon apoptosis
23. An essential role for NFκB in preventing TNF-α-induced cell death
24. Inhibition of NFκB/Rel induces apoptosis of murine B cells
25. Inhibition of NFκB potentiates amyloid β-mediated neuronal apoptosis
26. Role for nuclear factor κB in the antiapoptotic function of insulin
27. The NFκB transcription factor and cancer: High expression of NFκB- and IκB-related proteins in tumor cell lines
28. Regulation of spontaneons and TNF/IFN-induced IL-6 expression in two human ovarian-carcinoma cell lines
29. Inhibitory effects of cytokines on ovarian and endometrial carcinoma cells in vitro with special reference to induction of specific transcriptional regulators
30. Mitochondria and apoptosis
31. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
32. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
33. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
34. Apaf-1, a human protein homologues to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
35. Dissection of TNF receptor 1 effector function: JNK activation is not linked to apoptosis while NFκB activation prevents cell death
36. Suppression of TNF-α-induced apoptosis by NFκB
37. TNF- and cancer therapy-induced apoptosis potentiation by inhibition NFκB
38. NFκB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation