A 250-nucleotide UA-rich element in the 3′ untranslated region of Xenopus laevis Vg1 mRNA represses translation both in vivo and in vitro

RNA

Volumn 7, Issue 12, 2001, Pages 1753-1767

  Otero, L J ^a   Devaux, A ^a   Standart, N ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

3 UTR; Cap; Oogenesis; Poly(A); Translational control

Indexed keywords

ADENINE; CELL PROTEIN; CIS ACTING ELEMENT; GENE PRODUCT; LUCIFERASE; MESSENGER RNA; POLYADENYLIC ACID; PROTEIN P42; PROTEIN P45; PROTEIN P60; PROTEIN VG1; PROTEIN VTE; UNCLASSIFIED DRUG; URIDINE;

3' UNTRANSLATED REGION; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BINDING SITE; CELL MATURATION; CODON USAGE; CONTROLLED STUDY; GENE DELETION; NONHUMAN; OOCYTE DEVELOPMENT; PESTIVIRUS; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN LOCALIZATION; RACE PAT METHOD; REPRESSOR GENE; RNA TRANSLATION; TRANSLATION REGULATION; XENOPUS LAEVIS;

3' UNTRANSLATED REGIONS; ADENINE; ANIMALS; BASE SEQUENCE; GENE EXPRESSION REGULATION; GENES, REPORTER; GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; OOGENESIS; PROTEIN BIOSYNTHESIS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEINS; TRANSFORMING GROWTH FACTOR BETA; URIDINE; XENOPUS LAEVIS; XENOPUS PROTEINS;

AMPHIBIA; ANIMALIA; CLASSICAL SWINE FEVER VIRUS; PESTIVIRUS; REPTILIA; SUS SCROFA; XENOPUS LAEVIS;

EID: 0035678561     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos
2. Translational control of cyclin B1 mRNA during meiotic maturation: Coordinated repression and cytoplasmic polyadenylation
3. RNA localization in development
4. Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system
5. Role for mRNA localization in translational activation but not spatial restriction of nanos mRNA
6. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
7. Control of oskar mRNA translation by Bruno in a novel cell-free system from Drosophila ovaries
8. Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism
9. A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization
10. Overlapping but distinct RNA elements control repression and activation of nanos translation
11. Translational regulation in development
12. Smaug, a novel RNA-binding protein that operates a translational switch in Drosophila
13. The Nanos gradient in Drosophila embryos is generated by translational regulation
14. Developmental expression of the protein product of Vg1, a localized maternal mRNA in the frog Xenopus laevis
15. Cytoplasmic polyadenylation elements mediate masking and unmasking of cyclin B1 mRNA
16. A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates
17. Oskar organizes the germ plasm and directs localization of the posterior determinant nanos
18. Two copies of a subelement from Vg1 RNA localization sequence are sufficient to direct vegetal localization in Xenopus oocytes
19. Localization of nanos RNA controls embryonic polarity
20. Translational regulation of nanos by RNA localization
21. A conserved 90 nucleotide element mediates translational repression of nanos RNA
22. Translational control of dosage compensation in Drosophila by Sex-lethal: Cooperative silencing via the 5′ and 3′ UTRs of msl-2 mRNA is independent of the poly(A) tail
23. Control of translation initiation in animals
24. CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: Implications for local translational control of cell division
25. CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation
26. RNA binding protein conserved in both microtubule and microfilament-based RNA localization
27. The left-right coordinator: The role of Vg1 in organizing left-right axis formation
28. Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae
29. Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential
30. oskar mRNA is localized to the posterior pole of the Drosophila oocyte
31. Polarizing genetic information in the egg: RNA localization in the frog oocyte
32. On the synthesis and destruction of A- and B-type cyclin during oogenesis and meiotic maturation in Xenopus laevis
33. Translational blockade imposed by cytokine-derived UA-rich sequences
34. Mapping of a minimal AU-rich sequence required for lipopolysaccharide-induced binding of a 55-kDa protein on tumor necrosis factor-alpha mRNA
35. Translational regulation of oskar mRNA occurs independent of the cap and poly(A) tail in Drosophila ovarian extracts
36. Translational regulation of maternal mRNAs
37. The Drosophila pumilio gene: An unusually long transcription unit and an unusual protein
38. Fertilization of Xenopus eggs imposes a complete translational arrest of mRNAs containing 3′UUAUUUAU elements
39. A highly efficient, cell-free translation/translocation system prepared from Xenopus eggs
40. Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes
41. Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex
42. Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element
43. Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes
44. Binding of Pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos
45. Cell cycle extracts
46. Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identities a family of RNA-binding proteins
47. Biochemical identification of Xenopus Pumilio as a sequence-specific cyclin B1 mRNA-binding protein that physically interacts with a Nanos homolog (Xcat-2) and a cytoplasmic polyadenylation element-binding protein (CPEB)
48. Analysis of translational activity of extracts derived from oocytes and eggs of Xenopus laevis
49. Identification and cloning of localized maternal RNAs from Xenopus eggs
50. Dynamics of poly(A) addition and removal during development
51. Rapid and sensitive analysis of mRNA polyadenylation states by PCR
52. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
53. The 3′-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation
54. Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro
55. Smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo
56. Recruitment of Nanos to hunchback mRNA by Pumilio
57. The intracellular localization of messenger RNAs
58. Maskin is a CPEB-associated factor that transiently interacts with elF-4E
59. CPEB controls the cytoplasmic polyadenylation of cyclin, Cdk2 and c-mos mRNAs and is necessary for oocyte maturation in Xenopus
60. Localized synthesis of the Vg1 protein during early Xenopus development
61. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
62. The clam 3′UTR masking element-binding protein p82 is a member of the CPEB family
63. Nanos is the localized posterior determinant in Drosophila
64. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-β
65. The Pumilio RNA-binding domain is also a translational repressor
66. Translational control of developmental decisions
67. Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes
68. Preparation of synthetic mRNAs and analyses of translational efficiency in microinjected Xenopus oocytes
69. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay
70. The maternal mRNA Vg1 is correctly localized following injection into Xenopus oocytes