The cis-acting RNA trafficking signal from myelin basic protein mRNA and its cognate trans-acting ligand hnRNP A2 enhance cap-dependent translation

Journal of Cell Biology

Volumn 147, Issue 2, 1999, Pages 247-256

  Kwon, Sunjong ^a,b   Barbarese, Elisa ^a   Carson, John H ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Dicistronic RNA; eIF4E; HnRNP A2; RNA trafficking signal; Translation enhancer

Indexed keywords

CIS ACTING ELEMENT; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; LIGAND; MESSENGER RNA; MYELIN BASIC PROTEIN; RNA; RNA BINDING PROTEIN; TRANS ACTING FACTOR;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; RNA CAPPING; RNA TRANSLATION; RNA TRANSPORT; TRANSLATION REGULATION;

ANIMALS; CHO CELLS; CRICETINAE; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; MYELIN BASIC PROTEINS; NUCLEAR PROTEINS; PROTEIN BIOSYNTHESIS; RIBONUCLEOPROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS;

ANIMALIA; MAMMALIA;

EID: 0032753210     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.147.2.247     Document Type: Article

References (41)

1. Ainger, K., D. Avossa, F. Morgan, S.J. Hill, C. Barry, E. Barbarese, and J.H. Carson. 1993. Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes. J. Cell Biol. 123:431-441.
2. Ainger, K., D. Avossa, A.S. Diana, C. Barry, E. Barbarese, and J.H. Carson. 1997. Transport and localization elements in myelin basic protein mRNA. J. Cell Biol. 138:1077-1087.
3. Altmann, M., B. Wittmer, N. Methot, N. Sonenberg, and H. Trachsel. 1995. The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homolog, eIF-4B, have RNA annealing activity. EMBO (Eur. Mol. Biol. Organ.) J. 14:3820-3827.
4. Bunge, M.B., R.P. Bunge, and G.D. Pappas. 1962. Electron microscopic dem-onstrations of connections between glia and myelin sheets in the developing mammalian central nervous system. J. Cell Biol. 12:448-457.
5. Carson, J.H., K. Worboys, K. Ainger, and E. Barbarese. 1997. Translocation of myelin basic protein mRNA in oligodendrocytes requires microtubules and kinesin. Cell Motil. Cytoskel. 38:318-328.
6. Carson, J.H., S. Kwon, and E. Barbarese. 1998. RNA trafficking in myelinating cells. Curr. Opin. Neurobiol 8:607-612.
7. Dahanukar, A., and R.P. Wharton. 1996. The Nanos gradient in Drosophila embryos is generated by translation regulation. Genes Dev. 10:2610-2620.
8. Deshler, J.O., M.I. Highett, and B.J. Schnapp. 1997. Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum. Science. 276: 1128-1131.
9. Dreyfuss, G., M. Hentze, and A.I. Lamond. 1996. From transcript to protein. Cell. 85:963-972.
10. Ephrussi, A.L., and R. Lehmann. 1992. Induction of germ cell formation by oskar. Nature. 358:387-392.
11. Gavis, E.R., L. Lunsford, S.E. Bergsten, and R. Lehmann. 1996a. A conserved 90 nucleotide element mediates translational repression of nanos RNA. Development. 122:2791-2800.
12. Gavis, E.R., D. Curtis, and R. Lehmann. 1996b. Identification of cis-acting sequences that control nanos RNA localization. Dev. Biol. 176:36-50.
13. Gavis, E.R. 1997. Expeditions to the pole: RNA localization in Xenopus and Drosophila. Trends Cell Biol. 7:485-492.
14. Hentze, M.W. 1995. Translational regulation: versatile mechanisms for metabolic and developmental control. Curr. Opin. Cell Biol. 7:393-398.
15. Hiremath, L.S., N.R. Webb, and R.E. Rhoads. 1985. Immunological detection of the messenger RNA cap-binding protein. J. Biol. Chem. 260:7843-7849.
16. Hoek, K.S., G.J. Kidd, J.H. Carson, and R. Smith. 1998. hnRNP A2 selectively binds the cytoplasmic transport sequence of myelin basic protein mRNA. Biochemistry. 37:7021-7029.
17. Jackson, R.J., and M. Wickens. 1997. Translational controls impinging on the 5′-untranslated region and initiation factor proteins. Curr. Opin. Genet. Dev. 7:233-241.
18. Kim-Ha, J., P.J. Webster, J.L. Smith, and P.M. Macdonald. 1993. Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA. Development. 119:169-178.
19. Kozak, M. 1987. An analysis of 5′-noncoding sequences upstream from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125-8148.
20. Kozak, M. 1989. The scanning model for translation: an update. J. Cell Biol. 108:229-241.
21. Kreibich, G. E.E. Marcantonio, and D.D. Sabatini. 1983. Ribophorin I and II-membrane proteins characteristic of rough endoplasmic reticulum. Methods Enzymol. 96:520-530.
22. Kwon, S., and J.H. Carson. 1998. Fluorescence quenching and dequenching analysis of RNA interactions in vitro and in vivo. Anal. Biochem. 264:133-140.
23. McCarthy, J.E.G., and H. Kollmus. 1995. Cytoplasmic mRNA-protein interactions in eukaryotic gene expression. Trends Biochem. Sci. 29:191-197.
24. Macdonald, P.M., and G. Struhl. 1988. Cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos. Nature. 336:595-598.
25. Macdonald, P.M., K. Kerr, J.L. Smith, and A. Leask. 1993. RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization. Development. 118:1233-1243.
26. Marcotrigiano, J., A.C. Gingras, N. Sonenberg, and S.K. Burley. 1997. Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell. 89:951-961.
27. McBratney, S., and P. Sarnow. 1996. Evidence for involvement of trans-acting factors in selection of the AUG start codon during eukaryotic translational initiation. Mol. Cell. Biol. 16:3523-3534.
28. Mikoshiba, K., H. Okano, T.-A. Tamura, and K. Ikenaka. 1991. Structure and function of myelin protein genes. Annu. Rev. Neurosci. 14:201-217.
29. 2+ based on green fluorescent proteins and calmodulin. Nature. 388:882-887.
30. Molineaux, S.M., H. Engh, F. De Ferra, L. Hudson, and R.A. Lazzarini. 1986. Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation. Proc. Natl. Acad. Sci. USA. 83:7542-7546.
31. Mowry, K.L., and D.A. Melton. 1992. Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes. Science. 255: 991-994.
32. Rizzuto, R., M. Brini, F. De Giorgi, R. Rossi, R. Heim, R.Y. Tsien, and T. Pozzan. 1996. Double labeling of subcellular structures with organelle-targeted GFP mutants in vivo. Curr. Biol. 6:183-188.
33. Ross, A.F., Y. Oleynikov, E.H. Kislauskis, K.L. Taneja, and R.H. Singer. 1997. Characterization of a β-actin mRNA zip code-binding protein. Mol. Cell Biol. 17:2158-2165.
34. Sachs, A.B., P. Sarnow, and M.W. Hentze. 1997. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell. 89:831-838.
35. Seydoux, G. 1996. Mechanism of translational control in early development. Curr. Opin. Genes Dev. 6:555-561.
36. Simbert, C.A., J.E. Wilson, K. Kerr. and P.M. Macdonald. 1996. smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo. Genes Dev. 10:2600-2609.
37. Svitkin, Y.V., K. Meerovitch, H.S. Lee, J.N. Dholakia, D.J. Kenan, V.I. Agol, and N. Sonenberg. 1994. Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro. J. Virol. 68:1544-1550.
38. Svitkin, Y.V., L.P. Ovchinnikov, G. Dreyfuss, and N. Sonenberg. 1996. General RNA binding proteins render translation cap dependent. EMBO (Eur. Mol. Biol. Organ.) J. 15:7147-7155.
39. Wilson, J.E., J.E. Connell, and P.M. Macdonald. 1996. Aubergine enhances oskar translation in the Drosophila ovary. Development. 122:1631-1639.
40. Yamamoto, Y.Y., H. Tsuji, and J. Obokata. 1995. 5′-Leader of a photosystem I gene in Nicotiana sylvestris, psaDb, contains a translational enhancer. J. Biol. Chem. 270:12466-12470.
41. Zhou, B., N. Boudreau. C. Coulber, J. Hammarback, and M. Rabinovitch. 1997. Microtubule-associated protein 1 light chain 3 is a fibronectin mRNA-binding protein linked to mRNA translation in lamb vascular smooth muscle cells. J. Clin. Invest. 100:3070-3082.