Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1588, Issue 2, 2002, Pages 139-148

  Matsuzaki, Yasushi ^a   Bouscarel, Bernard ^b   Ikegami, Tadashi ^a   Honda, Akira ^a,c   Doy, Mikio ^c   Ceryak, Susan ^b   Fukushima, Sugano ^a   Yoshida, Shigemasa ^a   Shoda, Junichi ^a   Tanaka, Naomi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c Ibaraki Prefectural Institute of Public Health   (Japan)

Author keywords

5 Cholestane 3 ,7 ,12 triol 25 hydroxylase (CYP3A); 7 Hydroxy 4 cholesten 3 one 12 hydroxylase (CYP8B1); Bile acid synthesis; Cholestasis; Cholesterol 7 hydroxylase (CYP7A1)

Indexed keywords

5BETA CHOLESTANE 3ALPHA,7ALPHA,12ALPHA TRIOL 25 HYDROXYLASE; 7ALPHA HYDROXYCHOLEST 4 EN 3 ONE 12ALPHA MONOOXYGENASE; BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTANE DERIVATIVE; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; CYTOCHROME P450 3A; ENZYME; MESSENGER RNA; STEROL 27 HYDROXYLASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE ACID SYNTHESIS; BILE DUCT LIGATION; CELL ACTIVITY; CHOLESTASIS; COMMON BILE DUCT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HAMSTER; HUMAN; LIPID BLOOD LEVEL; LIPOGENESIS; LIVER LEVEL; LIVER MICROSOME; MALE; MITOCHONDRION; NONHUMAN; OBSTRUCTIVE JAUNDICE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BILE; CHENODEOXYCHOLIC ACID; CHOLESTASIS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CRICETINAE; CYTOCHROME P-450 CYP27A1; CYTOCHROME P-450 CYP3A; DISEASE MODELS, ANIMAL; DOWN-REGULATION; LIVER; MICROSOMES, LIVER; MODELS, CHEMICAL; OXIDOREDUCTASES, N-DEMETHYLATING; RNA, MESSENGER; STEROID 12-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

CRICETINAE;

EID: 0037145721     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(02)00157-6     Document Type: Article

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