메뉴 건너뛰기




Volumn 41, Issue 3, 2000, Pages 442-451

Regulation of 25- and 27-hydroxylation side chain cleavage pathways for cholic acid biosynthesis in humans, rabbits, and mice: Assay of enzyme activities by high-resolution gas chromatography-mass spectrometry

Author keywords

5 cholestane 3 , 7 , 12 , 25 tetrol 27 hydroxylase; 5 cholestane 3 , 7 , 12 triol 25 hydroxylase; 5 cholestane 3 , 7 , 12 , 25 tetrol 23R hydroxylase; 5 cholestane 3 , 7 , 12 , 25 tetrol 24R hydroxylase; 5 cholestane 3 , 7 , 12 , 25 tetrol 24S hydroxylase; 5 cholestane 3 , 7 , 12 triol 27 hydroxylase; Bile acids

Indexed keywords

CHOLESTANOL; CHOLIC ACID;

EID: 0034034044     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (9)

References (38)
  • 1
    • 0027050068 scopus 로고
    • Function and regulation of hydroxylases involved in the bile acid biosynthesis pathway
    • Vlaheevic, Z. R., W. M. Pandak, D. M. Heuman, and P. B. Hylemon. 1992. Function and regulation of hydroxylases involved in the bile acid biosynthesis pathway. Semin. Liver Dis. 12: 403-419.
    • (1992) Semin. Liver Dis. , vol.12 , pp. 403-419
    • Vlaheevic, Z.R.1    Pandak, W.M.2    Heuman, D.M.3    Hylemon, P.B.4
  • 2
    • 0015712539 scopus 로고
    • Enzymatic characteristics of CO-sensitive 26-hydroxylase system for 5ß-cholestane-3a, 7α, 12α-triol in rat-liver mitochondria and its intramitochondrial localization
    • Taniguchi, S., N. Hoshita, and K. Okuda. 1973. Enzymatic characteristics of CO-sensitive 26-hydroxylase system for 5ß-cholestane-3a, 7α, 12α-triol in rat-liver mitochondria and its intramitochondrial localization. Eur. J. Biochem. 40: 607-617.
    • (1973) Eur. J. Biochem. , vol.40 , pp. 607-617
    • Taniguchi, S.1    Hoshita, N.2    Okuda, K.3
  • 3
    • 0024267223 scopus 로고
    • Purification and characterization of 5ß-cholestane-3α, 7α, 12α-triol 27-hydroxylase from female rat liver mitochondria
    • Okuda, K., O. Masumoto, and Y. Ohyama. 1988. Purification and characterization of 5ß-cholestane-3α, 7α, 12α-triol 27-hydroxylase from female rat liver mitochondria. J. Biol. Chem. 263: 18138-18142.
    • (1988) J. Biol. Chem. , vol.263 , pp. 18138-18142
    • Okuda, K.1    Masumoto, O.2    Ohyama, Y.3
  • 4
    • 0017159179 scopus 로고
    • Side chain hydroxylations in biosynthesis of cholic acid
    • Björkhem, I., H. Danielsson, and K. Wikvall. 1976. Side chain hydroxylations in biosynthesis of cholic acid. J. Biol. Chem. 251: 3495-3499.
    • (1976) J. Biol. Chem. , vol.251 , pp. 3495-3499
    • Björkhem, I.1    Danielsson, H.2    Wikvall, K.3
  • 5
    • 0020644535 scopus 로고
    • 3 by a constitutive cytochrome P-450 from rat liver microsomes
    • 3 by a constitutive cytochrome P-450 from rat liver microsomes. J. Biol. Chem. 258: 6777-6781.
    • (1983) J. Biol. Chem. , vol.258 , pp. 6777-6781
    • Andersson, S.1    Holmberg, I.2    Wikvall, K.3
  • 6
    • 0025868097 scopus 로고
    • Characterization of human sterol 27-hydroxylase
    • Cali, J. J., and D. W. Russell. 1991. Characterization of human sterol 27-hydroxylase. J. Biol. Chem. 266: 7774-7778.
    • (1991) J. Biol. Chem. , vol.266 , pp. 7774-7778
    • Cali, J.J.1    Russell, D.W.2
  • 7
    • 0014408157 scopus 로고
    • Separation of 5ß-cholestane-3α,7α,12α,26-tetrol oxidoreductase, ethanol-NAD oxidoreductase, 5ß-cholestane-3α,7α, 12α-triol-26-al oxidoreductase, and acetaldehyde-NAD oxidoreductase from the soluble fraction of rat liver by gel filtration
    • Okuda, K., and N. Takigawa. 1968. Separation of 5ß-cholestane-3α,7α,12α,26-tetrol oxidoreductase, ethanol-NAD oxidoreductase, 5ß-cholestane-3α,7α, 12α-triol-26-al oxidoreductase, and acetaldehyde-NAD oxidoreductase from the soluble fraction of rat liver by gel filtration. Biochem. Biophys. Res. Commun. 33: 788-793.
    • (1968) Biochem. Biophys. Res. Commun. , vol.33 , pp. 788-793
    • Okuda, K.1    Takigawa, N.2
  • 8
    • 0020570422 scopus 로고
    • Physiological function and kinetic mechanism of human liver alcohol dehydrogenase as 5ß-cholestane-3α,7α,12α,26-tetrol dehydrogenase
    • Okuda, A., and K. Okuda. 1983. Physiological function and kinetic mechanism of human liver alcohol dehydrogenase as 5ß-cholestane-3α,7α,12α,26-tetrol dehydrogenase. J. Biol. Chem. 258: 2899-2905.
    • (1983) J. Biol. Chem. , vol.258 , pp. 2899-2905
    • Okuda, A.1    Okuda, K.2
  • 10
    • 0017365020 scopus 로고
    • Cholic acid biosynthesis: Conversion of 5ß-cholestane-3α, 7α. 12α, 25-tetrol into 5ß-cholestane-3α, 7α, 12α, 24ß, 25-pentol by human and rat liver microsomes
    • Cheng, F. W., S. Shefer, B. Dayal, G. S. Tint, T. Setoguchi, G. Salen, and E. H. Mosbach. 1977. Cholic acid biosynthesis: conversion of 5ß-cholestane-3α, 7α. 12α, 25-tetrol into 5ß-cholestane-3α, 7α, 12α, 24ß, 25-pentol by human and rat liver microsomes. J. Lipid Res. 18:6-13.
    • (1977) J. Lipid Res. , vol.18 , pp. 6-13
    • Cheng, F.W.1    Shefer, S.2    Dayal, B.3    Tint, G.S.4    Setoguchi, T.5    Salen, G.6    Mosbach, E.H.7
  • 13
    • 0023801335 scopus 로고
    • Quantitative importance of the 25-hydroxylation pathway for bile acid biosynthesis in the rat
    • Duane, W. C., I. Björkhem, J. N. Hamilton, and S. M. Mueller. 1988. Quantitative importance of the 25-hydroxylation pathway for bile acid biosynthesis in the rat. Hepatology. 8: 613-618.
    • (1988) Hepatology , vol.8 , pp. 613-618
    • Duane, W.C.1    Björkhem, I.2    Hamilton, J.N.3    Mueller, S.M.4
  • 14
    • 0025914556 scopus 로고
    • Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis
    • Cali, J. J., C-L. Hsieh, U. Francke, and D. W. Russell. 1991. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J. Biol. Chem. 266: 7779-7783.
    • (1991) J. Biol. Chem. , vol.266 , pp. 7779-7783
    • Cali, J.J.1    Hsieh, C.-L.2    Francke, U.3    Russell, D.W.4
  • 16
    • 0019198483 scopus 로고
    • Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis
    • Hoshita, T., M. Yasuhara, M. Une, A. Kibe, E. Itoga, S. Kito, and T. Kuramoto. 1980. Occurrence of bile alcohol glucuronides in bile of patients with cerebrotendinous xanthomatosis. J. Lipid Res. 21: 1015-1021.
    • (1980) J. Lipid Res. , vol.21 , pp. 1015-1021
    • Hoshita, T.1    Yasuhara, M.2    Une, M.3    Kibe, A.4    Itoga, E.5    Kito, S.6    Kuramoto, T.7
  • 17
    • 0021784183 scopus 로고
    • Effect of chenodeoxycholic acid on biliary and urinary bile acids and bile alcohols in cerebrotendinous xanthomatosis; monitoring by high performance liquid chtomatography
    • Batta, A. K., S. Shefer, M. Batta, and G. Salen. 1985. Effect of chenodeoxycholic acid on biliary and urinary bile acids and bile alcohols in cerebrotendinous xanthomatosis; monitoring by high performance liquid chtomatography. J. Lipid Res. 26: 690-698.
    • (1985) J. Lipid Res. , vol.26 , pp. 690-698
    • Batta, A.K.1    Shefer, S.2    Batta, M.3    Salen, G.4
  • 18
    • 0032511035 scopus 로고    scopus 로고
    • Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene
    • Rosen, H., A. Reshef, N. Maeda, A. Lippoldt, S. Shpizen, L. Triger, G. Eggertsen, I. Björkhem, and E. Leitersdorf. 1998. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. J. Biol. Chem. 273: 14805-14812.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14805-14812
    • Rosen, H.1    Reshef, A.2    Maeda, N.3    Lippoldt, A.4    Shpizen, S.5    Triger, L.6    Eggertsen, G.7    Björkhem, I.8    Leitersdorf, E.9
  • 19
    • 0001730548 scopus 로고
    • Preparation of some hydroxy coprostanes, 3a,7α- and 3a, 12α-dihydroxy coprostane
    • Bergström. S., and L. Krabisch. 1957. Preparation of some hydroxy coprostanes, 3a,7α- and 3a, 12α-dihydroxy coprostane. Acta Chem. Scand. 11: 1067.
    • (1957) Acta Chem. Scand. , vol.11 , pp. 1067
    • Bergström, S.1    Krabisch, L.2
  • 20
    • 0016882337 scopus 로고
    • Synthesis of 5ß-cholestane-3α, 7α, 12α, 25-tetrol and 5ß-Cholestane-3α, 7α, 12α, 24ξ, 25-pentol
    • Dayal, B., S. Shefer, G. S. Tint, G. Salen, and E. H. Mosbach. 1976. Synthesis of 5ß-cholestane-3α, 7α, 12α, 25-tetrol and 5ß-Cholestane-3α, 7α, 12α, 24ξ, 25-pentol. J. Lipid Res. 17: 74-77.
    • (1976) J. Lipid Res. , vol.17 , pp. 74-77
    • Dayal, B.1    Shefer, S.2    Tint, G.S.3    Salen, G.4    Mosbach, E.H.5
  • 21
    • 0016524415 scopus 로고
    • Identification of pentahydroxy bile alcohols in cerebrotendinous xanthomatosis: Characterization of 5ß-cholestane-3α, 7α, 12α, 24ξ, 25-pentol and 5ß-cholestane-3α, 7α. 12α, 23ξ, 25-pentol
    • Shefer, S., B. Dayal, G. S. Tint, G. Salen, and E. H. Mosbach. 1975. Identification of pentahydroxy bile alcohols in cerebrotendinous xanthomatosis: characterization of 5ß-cholestane-3α, 7α, 12α, 24ξ, 25-pentol and 5ß-cholestane-3α, 7α. 12α, 23ξ, 25-pentol. J. Lipid Res. 16: 280-286.
    • (1975) J. Lipid Res. , vol.16 , pp. 280-286
    • Shefer, S.1    Dayal, B.2    Tint, G.S.3    Salen, G.4    Mosbach, E.H.5
  • 22
    • 0000664331 scopus 로고
    • Stero-bile acids and bile sterols. XLVII. Syntheses of 3α, 7α, 12α, 25ξ, 26- And 3α, 7α, 12α, 24ξ, 25-pentahydroxycoprostanes
    • Hoshita, T. 1962. Stero-bile acids and bile sterols. XLVII. Syntheses of 3α, 7α, 12α, 25ξ, 26- and 3α, 7α, 12α, 24ξ, 25-pentahydroxycoprostanes. J. Biochem. 52: 176-179.
    • (1962) J. Biochem. , vol.52 , pp. 176-179
    • Hoshita, T.1
  • 24
    • 0018087609 scopus 로고
    • Gas-liquid chromalography - Mass spectrometry of trimethylsilyl ethers of bile alcohols
    • Tint, G. S., B. Dayal, A. K. Batta, S. Shefer, F. W. Cheng, G. Salen, and E. H. Mosbach. 1978. Gas-liquid chromalography - mass spectrometry of trimethylsilyl ethers of bile alcohols. J. Lipid Res. 19: 956-966.
    • (1978) J. Lipid Res. , vol.19 , pp. 956-966
    • Tint, G.S.1    Dayal, B.2    Batta, A.K.3    Shefer, S.4    Cheng, F.W.5    Salen, G.6    Mosbach, E.H.7
  • 25
    • 0018391890 scopus 로고
    • Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones
    • S.
    • Ahlberg, J., B. Angelin, I. Björkhem, S., K. Einarsson, and B. Leijd. 1979. Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones. J. Lipid. Res. 20: 107-115.
    • (1979) J. Lipid. Res. , vol.20 , pp. 107-115
    • Ahlberg, J.1    Angelin, B.2    Björkhem, I.3    Einarsson, K.4    Leijd, B.5
  • 27
    • 0023718731 scopus 로고
    • Drug solubilizers to aid pharmacologists: Amorphous cyclodextrin derivatives
    • Pitha, J., T. Irie, P. B. Sklar, and J. S. Nye. 1988. Drug solubilizers to aid pharmacologists: amorphous cyclodextrin derivatives. Life Sci. 43: 493-502.
    • (1988) Life Sci. , vol.43 , pp. 493-502
    • Pitha, J.1    Irie, T.2    Sklar, P.B.3    Nye, J.S.4
  • 28
    • 0025967184 scopus 로고
    • The utility of 2-hydroxypropyl-ß-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs
    • Yaksh, T. L., J. Jang, Y. Nishiuchi, K. P. Braun, S. Ro, and M. Goodman. 1991. The utility of 2-hydroxypropyl-ß-cyclodextrin as a vehicle for the intracerebral and intrathecal administration of drugs. Life Sci. 48:623-633.
    • (1991) Life Sci. , vol.48 , pp. 623-633
    • Yaksh, T.L.1    Jang, J.2    Nishiuchi, Y.3    Braun, K.P.4    Ro, S.5    Goodman, M.6
  • 29
    • 0027456308 scopus 로고
    • Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol
    • Petrack, B., and B. J. Latario. 1993. Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. J. Lipid Res. 34: 643-649.
    • (1993) J. Lipid Res. , vol.34 , pp. 643-649
    • Petrack, B.1    Latario, B.J.2
  • 30
    • 0028865414 scopus 로고
    • Different effects on the expression of CYP7 and CYP27 in rabbit liver by cholic acid and cholestyramine
    • Araya, Z., H. Sjoberg, and K. Wikvall. 1995. Different effects on the expression of CYP7 and CYP27 in rabbit liver by cholic acid and cholestyramine. Biochem. Biophys. Res. Commun. 216: 868-873.
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 868-873
    • Araya, Z.1    Sjoberg, H.2    Wikvall, K.3
  • 32
    • 15444346370 scopus 로고    scopus 로고
    • Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: Effects of cholesterol feeding and bile acid depletion
    • Xu, G., G. Salen, S. Shefer, G. S. Tint, L. B. Nguyen, T. T. Parker, T. S. Chen, J. Roberts, X. Kong, and D. Greenblatt. 1998. Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion. J. Lipid Res. 39: 1608-1615.
    • (1998) J. Lipid Res. , vol.39 , pp. 1608-1615
    • Xu, G.1    Salen, G.2    Shefer, S.3    Tint, G.S.4    Nguyen, L.B.5    Parker, T.T.6    Chen, T.S.7    Roberts, J.8    Kong, X.9    Greenblatt, D.10
  • 34
    • 0028963087 scopus 로고
    • Unexpected inhibition of cholesterol 7α-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits
    • Xu, G., G. Salen, S. Shefer, G. C. Ness, L. B. Nguyen, T. S. Parker, T. S. Chen, Z. Zhao, T. M. Donnelly, and G. S. Tint. 1995. Unexpected inhibition of cholesterol 7α-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits. J. Clin. Invest. 95: 1497-1504.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1497-1504
    • Xu, G.1    Salen, G.2    Shefer, S.3    Ness, G.C.4    Nguyen, L.B.5    Parker, T.S.6    Chen, T.S.7    Zhao, Z.8    Donnelly, T.M.9    Tint, G.S.10
  • 35
    • 0032545281 scopus 로고    scopus 로고
    • CDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
    • Lund, E. G., T. A. Kerr, J. Sakai, W. P. Li, and D. W. Russell. 1998. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. J. Biol. Chem. 273: 34316-34327.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34316-34327
    • Lund, E.G.1    Kerr, T.A.2    Sakai, J.3    Li, W.P.4    Russell, D.W.5
  • 36
    • 0033613935 scopus 로고    scopus 로고
    • Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5ß-cholestane-3α,7α,12α-triol in human liver microsomes
    • Furster, C., and K. Wikvall. 1999. Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5ß-cholestane-3α,7α,12α-triol in human liver microsomes. Biochim. Biophys. Acta. 1437: 46-52.
    • (1999) Biochim. Biophys. Acta. , vol.1437 , pp. 46-52
    • Furster, C.1    Wikvall, K.2
  • 37
    • 0014910222 scopus 로고
    • Effect of cholestyramine and diet on hydroxylations in the biosynthesis and metabolism of bile acids
    • Johansson, G. 1970. Effect of cholestyramine and diet on hydroxylations in the biosynthesis and metabolism of bile acids. Eur. J. Biochem. 17: 292-295.
    • (1970) Eur. J. Biochem. , vol.17 , pp. 292-295
    • Johansson, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.