Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1

Diabetologia

Volumn 44, Issue 8, 2001, Pages 992-1004

  Kaburagi, Y ^a   Satoh, S ^a   Yamamoto Honda, R ^a   Ito, T ^a   Ueki, K ^a   Akanuma, Y ^a   Sekihara, H ^a   Kimura, S ^a   Kadowaki, T ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Insulin; Insulin receptor; IRS 1; IRS 3; PH domain; PI 3 kinase; PTB domain

Indexed keywords

CHIMERIC PROTEIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 3; PHENYLALANINE; PHOSPHATIDYLINOSITOL 3 KINASE; PLECKSTRIN; TYROSINE; UNCLASSIFIED DRUG; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MOLECULAR INTERACTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY;

ANDROSTADIENES; ANIMALS; BINDING SITES; BLOOD PROTEINS; COS CELLS; DRUG RESISTANCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GENE EXPRESSION; HUMANS; INSULIN; MICE; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN KINASE INHIBITORS; RABBITS; RECEPTOR, INSULIN; SEQUENCE HOMOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0034883516     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250100587     Document Type: Article

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