Cell adhesion and Rho small GTPases

Journal of Cell Science

Volumn 112, Issue 24, 1999, Pages 4491-4500

  Fukata, Masaki ^a,b   Nakagawa, Masato ^a   Kuroda, Shinya ^a,c   Kaibuchi, Kozo ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; BETA CATENIN; CADHERIN; GUANOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR;

CELL ADHESION; NOTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CADHERINS; CELL ADHESION; DIMERIZATION; GTP PHOSPHOHYDROLASES; PHOSPHORYLATION; TYROSINE;

EID: 0033373784     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (104)

1. Adams, C. L. and Nelson, W. J. (1998). Cytomechanics of cadherin-mediated cell-cell adhesion. Curr. Opin. Cell Biol. 10, 572-577.
2. Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y. and Kaibuchi, K. (1996). Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271, 20246-20249.
3. Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y. and Kaibuchi, K. (1997). Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science 275, 1308-1311.
4. Amano, M., Chihara, K., Nakamura, N., Fukata, Y., Yano, T., Shibata, M, Ikebe, M. and Kaibuchi, K. (1998). Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells 3, 177-188.
5. Amano, M., Chihara, K., Nakamura, N., Kaneko, T., Matsuura, Y. and Kaibuchi, K. (1999). The COOH-terminal of Rho-kinase negatively regulates Rho-kinase activity. J. Biol. Chem. 274, 32418-32424.
6. Aono, S., Nakagawa, S., Reynolds, A. B. and Takeichi, M. (1999). p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J. Cell Biol. 145, 551-562.
7. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., Mareel, M. M. and Birchmeier, W. (1993). Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phophosrylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-Src gene. J. Cell Biol. 120, 757-766.
8. Bourne, H. R., Sanders, D. A. and McCormick, F. (1991). The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127.
9. Braga, V., Machesky, L. M., Hall, A. and Hotchin, N. A. (1997). The small GTPases rho and rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137, 1421-1431.
10. Braga, V. M. M., Del Maschio, A., Machesky, L. and Dejana, E. (1999). Regulation of cadherin function by rho and rac: modulation by junction maturation and cellular context. Mol. Biol. Cell 10, 9-22.
11. Bresnick, A. R., Wolff-Long, V. L., Baumann, O. and Pollard, T. D. (1995). Phosphorylation on threonine-18 of the regulatory light chain dissociates the ATPase and motor properties of smooth muscle myosin II. Biochemistry 34, 12576-12583.
12. Chew, T. L., Masaracchia, R. A., Goeckeler, Z. M. and Wysolmerski, R. B. (1998). Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK). J. Mus. Res. Cell Motil. 19, 839-854.
13. Clark, E. A. and Brugge, J. S. (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.
14. Crespo, P., Schuebel, K. E., Ostrom, A. A., Gutkind, J. S. and Bustelo, X. R. (1997). Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385, 169-172.
15. Dessauer, C. W., Tesmer, J. J., Sprang, S. R. and Gilman, A. G. (1998). Identification of a Giα binding site on type V adenylyl cyclase. J. Biol. Chem. 273, 25831-25839.
16. Fleming, T. P. and Johnson, M. H. (1988). From egg to epithelium. Annu. Rev. Cell Biol. 4, 459-485.
17. Fukata, M., Kuroda, S., Nakagawa, M., Kawajiri, A., Itoh, N., Shoji, I., Matsuura, Y., Yonehara, S., Fujisawa, H., Kikuchi, A. and Kaibuchi, K. (1999). Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin. J. Biol. Chem. 274, 26044-26050.
18. Fukata, Y., Oshiro, N., Kinoshita, N., Kawano, Y., Matsuoka, Y., Bennett, V., Matsuura, Y. and Kaibuchi, K. (1999). Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J. Cell Biol. 145, 347-361.
19. 2+ sensitization of smooth muscle. Proc. Natl. Acad. Sci. USA 93, 1340-1345.
20. Guasch, R. M., Scambler, P., Jones, G. E. and Ridley, A. J. (1998). RhoE regulates actin cytoskeleton organization and cell migration. Mol. Cell Biol 18, 4761-4771.
21. Gumbiner, B. M. (1996). Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84, 345-357.
22. Hall, A. (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
23. Han, J., Das, B., Wei, W., Van Aelst, L., Mosteller, R. D., Khosravi-Far, R., Westwick, J. K., Der, C. J. and Broek, D. (1997). Lck regulates Vav activation of members of the Rho family of GTPases. Mol. Cell. Biol. 17, 1346-1353.
24. Hart, M. J., Callow, M. G., Souza, B. and Polakis, P. (1996). IQGAP1, a calmodulin-binding protein with a rasGAP-relaled domain, is a potential effector for cdc42Hs. EMBO J. 15, 2997-3005.
25. Hartmann, G., Weidner, K. M., Schwarz, H. and Birchmeier, W. (1994). The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras. J. Biol. Chem. 269, 21936-21939.
26. Hawkins, P. T., Eguinoa, A., Qiu, R. G., Stokoe, D., Cooke, F. T., Walters, R., Wennstrom, S., Claesson-Welsh, L., Evans, T., Symons, M. and Stephens, L. (1995). PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5, 393-403.
27. Hirata, K., Kikuchi, A., Sasaki, T., Kuroda, S., Kaibuchi, K., Matsuura, Y., Seki, H., Saida, K. and Takai, Y. (1992). Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J. Biol. Chem. 267, 8719-8722.
28. Hirose, M., Ishizaki, T., Watanabe, N., Uehata, M., Kranenburg, O., Moolenaar, W. H., Matsumura, F., Maekawa, M., Bito, H. and Narumiya, S. (1998). Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. J. Cell Biol. 141, 1625-1636.
29. Hordijk, P. L., ten Klooster, J. P., van der Kammen, R. A., Michiels, F., Oomen, L. C. and Collard, J. G. (1997). Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278, 1464-1466.
30. Hughes, P. E. and Pfaff, M. (1998). Integrin affinity modulation. Trends Cell Biol. 8, 359-364.
31. Huttenlocher, A., Sandborg, R. R. and Horwitz, A. (1995). Adhesion in cell migration. Curr. Opin. Cell Biol. 7, 697-706.
32. Ishizaki, T., Naito, M., Fujisawa, K., Maekawa, M., Watanabe, N., Saito, Y. and Narumiya, S. (1997). p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions. FEBS Lett. 404, 118-124.
33. Jalink, K., van Corven, E. J., Hengeveld, T., Morii, N., Narumiya, S. and Moolenaar, W. H. (1994). Inhibition of lysophosphatidate-and thrombin-induced neurite retraction and neuronal cell founding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol. 126, 801-810.
34. Kaibuchi, K., Kuroda, S. and Amano, M. (1999). Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu. Rev. Biochem. 68, 459-486.
35. Kamisoyama, H., Araki, Y. and Ikebe, M. (1994). Mutagenesis of the phosphorylation site (serine 19) of smooth muscle myosin regulatory light chain and its effects on the properties of myosin. Biochemistry 33, 840-847.
36. Kamm, K. E. and Stull, J. T. (1985). The function of myosin and myosin light chain kinase phosphorylation in smooth muscle. Annu. Rev. Pharmacol. Toxicol. 25, 593-603.
37. Kawakami, A., Kitsukawa, T., Takagi, S. and Fujisawa, H. (1996). Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system. J. Neurobiol. 29, 1-17.
38. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K. (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248.
39. Kishi, K., Sasaki, T., Kuroda, S., Itoh, T. and Takai, Y. (1993). Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI). J. Cell Biol. 120, 1187-1195.
40. Kodama, A., Takaishi, K., Nakano, K., Nishioka, H. and Takai, Y. (1999). Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells. Oncogene 18, 3996-4006.
41. Kotani, K., Yonezawa, K., Hara, K., Ueda, H., Kitamura, Y., Sakaue, H. ando, A., Chavanieu, A., Calas, B., Grigorescu, F., Nishiyama, M., Waterfield, M. and Kasuya, M. (1994). Involvement of phosphoinositide 3-kinase in insulin-or IGF-1-induced membrane ruffling. EMBO J. 13, 2313-2321.
42. Kotani, K., Hara, K., Kotani, K., Yonezawa, K. and Kasuga, M. (1995). Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling. Biochem. Biophys. Res. Commun. 208, 985-990.
43. Kozma, R., Ahmed, S., Best, A. and Lim, L. (1995). The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15, 1942-1952.
44. Kozma, R., Sarner, S., Ahmed, S. and Lim, L. (1997). Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1 and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol. Cell. Biol. 17, 1201-1211.
45. Kuroda, S., Fukata, M., Kohayashi, K., Nakafuku, M., Nomura, N., Iwamatsu, A. and Kaibuchi, K. (1996). Identification of IQCAP as a putative target for the small GTPases, Cdc42 and Rac 1. J. Biol. Chem. 271, 23363-23367.
46. Kuroda, S., Fukata, M., Fujii, K., Nakamura, T., Izawa, I. and Kaibuchi, K. (1997). Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases. Biochem. Biophys. Res. Commun. 240, 430-435.
47. Kuroda, S., Fukata M., Nakagawa M., Fujii K., Nakamura T., Ookubo T., Izawa I., Nagase T., Nomura N., Tani H., Shoji I., Matsuura Y., Yonehara S. and Kaibuchi K. (1998). Role of IQCAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science 281, 832-835.
48. Kuroda, S., Fukata M., Nakagawa M. and Kaibuchi K. (1999). Cdc42. Rac1 and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion. Biochem. Biophys. Res. Commun. 262, 1-6.
49. Laudanna, C., Campbell, J. J. and Butcher, F., C. (1996). Role of Rho in chemoattractant-activated leukocyte adhesion through integrins. Science 271, 981-983.
50. Leeuwen, F. N., Kain, H. E., Kammen, R. A., Michiels, F., Kranenburg, O. W. and Collard, J. G. (1997). The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. J. Cell Biol. 139, 797-807.
51. Leung, T., Chen, X. Q., Manser, E. and Lim, L. (1996). The p160 RhoA-binding kinase ROKα is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell Biol. 16, 5313-5327.
52. Leung, T., Chen, X. Q., Tan, I., Manser, E. and Lim, L. (1998). Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganisation. Mol. Cell. Biol 18, 130-140.
53. Lu, Q., Paredes, M., Medina, M., Zhou, J., Cavallo, R., Reifer, M., Orecchio, L. and Kosik, K. S. (1999). Delta-catenin, an adhesive junction-associated protein, which promotes cell scattering. J. Cell Biol. 144, 519-532.
54. Mabuchi, I., Hamaguchi, Y., Fujimoto, H., Morii, N., Mishima, M. and Narumiya, S. (1993). A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygote 1, 325-331.
55. Maeno, Y., Moroi, S., Nagashima, H., Noda, T., Shiozaki, H., Monden, M., Tsukita, S. and Nagafuchi, A. (1999). Alpha-catenin-deficient F9 cells differentiate into signet ring cells. Am. J. Pathol 154, 1323-1328.
56. Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q., Dong, J.-M., Leung, T. and Lim, L. (1997). Expression of constitutively active α-PAK reveals effects of the kinase on actin and local complexes. Mol. Cell. Biol. 17, 1129-1143.
57. Manser, E., Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T and Lim L. (1998). PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1, 183-192.
58. Matsuyoshi, N., Hamaguchi, M., Taniguchi, S., Nagafuchi, A., Tsukita, S. and Takeichi, M. (1992). Cadherin-mediated cell-cell adhesion is perturbed by v-Src tyrosine phosphorylation in metastatic fibroblast. J. Cell Biol. 118, 703-714.
59. Miller, J. R. and McClay, D. R. (1997a). Changes in the pattern of adherens junction-associated β-catenin accompany morphogenesis in the sea urchin embryo. Dev. Biol. 192, 310-322.
60. Miller, J. R. and McClay, D. R. (1997b). Characterization of the role of cadherin in regulating cell adhesion during sea urchin development. Dev. Biol. 192, 323-339.
61. Nagafuchi, A., Ishihara, S. and Tsukita, S. (1994). The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-α-catenin fusion molecules. J. Cell Biol 127, 235-245.
62. Nishiki, T., Narumiya, S., Morii, N., Yamamoto, M., Fujiwara, M., Kamata, Y., Sakaguchi, G. and Kozaki, S. (1990). ADP-ribosylation of the rho/rac proteins induces growth inhibition, neurite outgrowth and acetylcholine esterase in cultured PC-12 cells. Biochem. Biophys. Res. Commun. 167, 265-272.
63. Nishiyama, T., Sasaki, T., Takaishi, K., Kato, M., Yaku, H., Araki, K., Matsuura, Y. and Takai, Y. (1994). rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor-and 12-O-tetradecanoylphorhol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol. Cell. Biol. 14, 2447-2456.
64. Nobes, C. D. and Hall, A. (1995). Rho, rac and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81, 53-62.
65. Nobes, C. D., Lauritzen, I., Mattei, M. G., Paris, S., Hall, A. and Chardin, P. (1998). A new member of the Rho family, Rnd1. promotes disassembly of actin filament structures and loss of cell adhesion. J. Cell Biol. 141, 187-197.
66. Obermeier, A., Ahmed, S., Manser, E., Yen, S. C., Hall, C. and Lim, L. (1998). PAK promotes morphological changes by acting upstream of Rac. EMBO J 17, 4328-4339.
67. Ochiai, A., Akimoto, S., Shimoyama, Y., Nagafuchi, A., Tsukita, S. and Hirohashi, S. (1994). Frequent loss of alpha catenin expression in scirrhous carcinomas with scattered cell growth. Jpn J. Cancer Res. 85, 266-273.
68. Ohkubo T and Ozawa M. (1999). p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity. J. Biol. Chem. 274, 21409-21415.
69. Overduin, M., Harvey, T. S., Bagby, S., Tong, K. I., Yau, P., Takeichi, M. and Ikura, M. (1995). Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. Science 267, 386-389.
70. Ozawa, M., Baribault, H. and Kemler, R. (1989). The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 8, 1711-1717.
71. Ozawa, M. and Kemler, R. (1998a). Altered cell adhesion activity by pervanadate due to the dissociation of alpha-catenin from the E-cadherin-catenin complex. J. Biol. Chem. 273, 6166-6170.
72. Ozawa, M. and Kemler, R. (1998b). The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol. 142, 1605-1613.
73. Paterson, H. F., Self, A. J., Garrett, M. D., Just, I., Aktories, K. and Hall, A. (1990). Microinjection of recombinant p21rho induces rapid changes in cell morphology. J. Cell Biol. 111, 1001-1007.
74. Pece, S., Chiariello, M., Murga, C. and Gutkind, J. S. (1999). Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. J. Biol. Chem. 274, 19347-19351.
75. Price, L. S., Leng, J., Schwartz, M. A. and Bokoch, G. M. (1998). Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol. Biol. Cell 9, 1863-1871.
76. Reif, K., Nobes, C. D., Thomas, G., Hall, A. and Cantrell, D. A. (1996) Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6, 1445-1455.
77. Ren, X. D., Kiosses, W. B. and Schwartz, M. A. (1999). Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578-585.
78. Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
79. Ridlej, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
80. Ridley, A. J., Comoglio, P. M. and Hall, A. (1995). Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac and Rho in MDCK cells. Mol. Cell. Biol. 15, 1110-1122.
81. Rottner, K., Hall, A. and Small, J. V. (1999). Interplay between rac and rho in the control of substrate contact dynamics. Curr. Biol. 9, 640-648.
82. Sako, Y., Nagafuchi, A., Tsukita, S., Takeichi, M. and Kusumi, A. (1998). Cytoplasmic regulation of the movement of E-cadherin on the free cell surface as studied by optical tweezers and single particle tracking: corralling and tethering by the membrane skeleton. J. Cell Biol. 140, 1227-1240.
83. Sanders, L. C., Matsumura, F., Bokoch, G. M. and de Lanerolle, P. (1999) Inhibition of myosin light chain kinase by p21-activated kinase. Science 283, 2083-2085.
84. Sells, M. A., Knaus, U. G., Bagrodia, S., Ambrose, D. M., Bokoch, G. M. and Chernoff, J. (1997). Human p21-activated kinase (PAK) regulates actin reorganization in mammalian cells. Curr. Biol. 7, 202-210.
85. Sells, M. A., Boyd, J. T. and Chernoff, J. (1999). p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. J. Cell Biol. 145, 837-849.
86. Shapiro, L., Fannon, A. M., Kwong, P. D., Thompson, A., Lehmann, M. S., Grubel, G., Legrand, J. F., Als-Nielsen, J., Colman, D. R. and Hendrickson, W. A. (1995). Structural basis of cell-cell adhesion by cadherins. Nature 374, 327-337.
87. Shibamoto, S., Hayakawa, K., Takeuchi, K., Hori, T., Oku, N., Miyazawa, K., Kitamura, N., Takeichi, M. and Ho, F. (1994). Tyrosine phosphorylation of β-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes. Commun. 1, 295-305.
88. Sweeney, H. L., Yang, Z., Zhi, G., Stull, J. T. and Trybus, K. M. (1994). Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation. Proc. Natl. Acad. Sci. USA 91, 1490-1494.
89. Takai, Y., Sasaki, T., Tanaka, K. and Nakanishi, H. (1995). Rho as a regulator of the cytoskeleton. Trends Biochem. Sci. 20, 227-231.
90. Takaishi, K., Sasaki, T., Kato, M., Yamochi, W., Kuroda, S., Nakamura, T., Takeichi, M. and Takai, Y. (1994). Involvement of Rho P21 small GTP-binding protein and its regulator in the HGF-induced cell motility. Oncogene 9, 273-279.
91. Takaishi, K., Sasaki, T., Kameyama, T., Tsukita, S., Tsukita, S. and Takai, Y. (1995). Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene 11, 39-48.
92. Takaishi, K., Sasaki, T., Kotani, H., Nishioka, H. and Takai, Y. (1997). Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J. Cell Biol. 139, 1047-1059.
93. Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J., Birchmeier, W. and Tsukita, S. (1995). V-Src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and β-catenin is not required for the shift. J. Cell Biol. 131, 1839-1847.
94. Takeichi, M. (1995). Morphogenetic roles of classic cadherins. Curr. Opin. Cell Biol. 7, 619-627.
95. Taussig, R., Tang, W. J., Hepler, J. R. and Gilman, A. G. (1994). Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J. Biol. Chem. 269, 6093-6100.
96. Tsukita, Sh., Tsukita, Sa., Nagafuchi, A. and Yonemura, S. (1992). Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Curr. Opin. Cell Biol. 4, 834-839.
97. Van Aelst, L. and D'Souza-Schorey, C. (1997). Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322.
98. 2+-independent contraction of smooth muscle. J. Biol. Chem. 273, 23433-23439.
99. Watabe, M., Nagafuchi, A., Tsukita, S. and Takeichi, M. (1994). Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J. Cell Biol. 127, 247-256.
100. Watanabe, N., Kato, T., Fujita, A., Ishizaki, T. and Narumiya, S. (1999). Cooperation between mDial and ROCK in Rho-induced actin reorganization. Nature Cell Biol. 1, 136-143.
101. Wittpoth, C., Scholich, K., Yigzaw, Y., Stringfield, T. M. and Patel, T. B. (1999). Regions on adenylyl cyclase that are necessary for inhibition of activity by βγ and Giα subunits of heterotrimeric G proteins. Proc. Natl. Acad. Sci. USA 96, 9551-9556.
102. ctn. J. Cell Biol. 141, 779-789.
103. Yron, I., Deckert, M., Reff, M. E., Munshi, A., Schwartz, M. A. and Altman, A. (1999). Integrin-dependent tyrosine phosphorylation and growth regulation by Vav. Cell Adhes. Commun. 7, 1-11.
104. Zhao, Z. S., Manser, E., Chen, X. Q., Chong, C., Leung, T. and Lim, L. (1998). A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol. Cell. Biol. 18, 2153-2163.