Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6706-6711

  Zweifel, Ben S ^a   Davis, Thomas W ^a   Ornberg, Richard L ^a   Masferrer, Jaime L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; GROWTH INHIBITION; HEAD AND NECK TUMOR; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; HEAD AND NECK NEOPLASMS; HUMANS; ILEUM; INTESTINAL MUCOSA; ISOENZYMES; MALE; MEMBRANE PROTEINS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; SULFONAMIDES; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0037112442     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Koki, A. T., Leahy, K. M., and Masferrer, J. L. Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy. Expert. Opin. Investig. Drugs. 8: 1623-1638, 1999.
2. Seibert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., and Isakson, P. Distribution of COX-1 and COX-2 in normal and inflamed tissues. Adv. Exp. Med. Biol., 400A: 167-170, 1997.
3. Yoshimatsu, K., Golijanin, D., Paty, P. B., Soslow, R. A., Jakobsson, P. J., DeLellis, R. A., Subbaramaiah, K., and Dannenberg, A. J. Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clin. Cancer Res., 7: 3971-3976, 2001.
4. Fu, J. Y., Masferrer, J. L., Seibert, K., Raz, A., and Needleman, P. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem., 265: 16737-16740, 1990.
5. DuBois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., Van De Putte, L. B., and Lipsky, P. E. Cyclooxygenase in biology and disease. FASEB J., 12: 1063-1073, 1998.
6. Thun, M. J. NSAID use and decreased risk of gastrointestinal cancers. Gastroenterol. Clin. N. Am., 25: 333-348, 1996.
7. Funkhouser, E. M., and Sharp, G. B. Aspirin and reduced risk of esophageal carcinoma. Cancer (Phila.), 76: 1116-1119, 1995.
8. Thun, M. J., Namboodiri, M. M., Calle, E. E., Flanders, W. D., and Heath, C. W., Jr. Aspirin use and risk of fatal cancer. Cancer Res., 53: 1322-1327, 1993.
9. Jacoby, R. F., Seibert, K., Cole, C. E., Kelloff, G., and Lubet, R. A. The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. Cancer Res., 60: 5040-5044, 2000.
10. Oshima, M., Dinchuk, J. E., Kargman, S. L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J. M., Evans, J. F., and Taketo, M. M. Suppression of intestinal polyposis in Apc Δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell, 87: 803-809, 1996.
11. Grubbs, C. J., Lubet, R. A., Koki, A. T., Leahy, K. M., Masferrer, J. L., Steele, V. E., Kelloff, G. J., Hill, D. L., and Seibert, K. Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats. Cancer Res., 60: 5599-5602, 2000.
12. Harris, R. E., Alshafie, G. A., Abou-Issa, H., and Seibert, K. Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res., 60: 2101-2103, 2000.
13. Reddy, B. S., Hirose, Y., Lubet, R., Steele, V., Kelloff, G., Paulson, S., Seibert, K., and Rao, C. V. Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. Cancer Res., 293-297, 2000.
14. Liu, C. H., Chang, S. H., Narko, K., Trifan, O. C., Wu, M. T., Smith, E., Haudenschild, C., Lane, T. F., and Hla, T. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J. Biol. Chem., 276: 18563-18569, 2001.
15. Fosslien, E. Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit. Rev. Clin. Lab. Sci., 37: 431-502, 2000.
16. Masferrer, J. L., Leahy, K. M., Koki, A. T., Zweifel, B. S., Settle, S. L., Woerner, B. M., Edwards, D. A., Flickinger, A. G., Moore, R. J., and Seibert, K. Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res., 60: 1306-1311, 2000.
17. 2 production by suppressor monocytes in head and neck cancer patients. Ann. Surg., 196: 645-650, 1982.
18. Bennett, A., Tacca, M. D., Stamford, I. F., and Zebro, T. Prostaglandins from tumours of human large bowel. Br. J. Cancer, 6: 881-884, 1977.
19. Smith, B. J., Wills, M. R., and Savory, J. Prostaglandins and cancer. Ann. Clin. Lab. Sci., 13: 359-365, 1983.
20. Seyberth, H. W., Segre, G. V., Morgan, J. L., Sweetman, B. J., Potts, J. T., Jr., and Oates, J. A. Prostaglandins as mediators of hypercalcemia associated with certain types of cancer. N. Engl. J. Med., 293: 1278-1283, 1975.
21. Taketo, M. M. Cyclooxygenase-2 inhibitors in tumorigenesis (Part II). J. Natl. Cancer Inst. (Bethesda), 90: 1609-1620, 1998.
22. Chan, G., Boyle, J. O., Yang, E. K., Zhang, F., Sacks, P. G., Shah, J. P., Edelstein, D., Soslow, R. A., Koki, A. T., Woerner, B. M., Masferrer, J. L., and Dannenberg, A. J. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res., 59: 991-994, 1999.
23. Jung, T. T., Berlinger, N. T., and Juhn, S. K. Prostaglandins in squamous cell carcinoma of the head and neck: A preliminary study. Laryngoscope, 95: 307-312, 1985.
24. Mestre, J. R., Chan, G., Zhang, F., Yang, E. K., Sacks, P. G., Boyle, J. O., Shah, J. P., Edelstein, D., Subbaramaiah, K., and Dannenberg, A. J. Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer. Ann. N. Y. Acad. Sci., 889: 62-71, 1999.
25. Zimmermann, K. C., Sarbia, M., Weber, A. A., Borchard, F., Gabbert, H. E., and Schror, K. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res., 59: 198-204, 1999.
26. 2 production. J. Oral Pathol. Med., 31: 41-47, 2001.
27. 2 and angiogenesis. Proc. Soc. Exp. Biol. Med., 172: 214-218, 1983.
28. Hanahan, D., and Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86: 353-364, 1996.
29. Leahy, K. M., Ornberg, R. L., Wang, Y., Zweifel, B. S., Koki, A. T., and Masferrer, J. L. Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res., 62: 625-631, 2002.
30. Hsu, A. L., Ching, T. T., Wang, D. S., Song, X., Rangnekar, V. M., and Chen, C. S. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J. Biol. Chem., 275: 11397-11403, 2000.
31. Song, X., Lin, H. P., Johnson, A. J., Tseng, P. H., Yang, Y. T., Kulp, S. K., and Chen, C. S. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. J. Natl. Cancer Inst. (Bethesda), 94: 585-591, 2002.
32. Zhou, X. M., Wong, B. C., Fan, X. M., Zhang, H. B., Lin, M. C., Kung, H. F., Fan, D. M., and Lam, S. K. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis (Lond.), 22: 1393-1397, 2001.
33. Masferrer, J. Approach to angiogenesis inhibition based on cyclooxygenase-2. Cancer J., 7 (Suppl. 3): S144-S150, 2001.
34. Williams, C. S., Tsujii, M., Reese, J., Dey, S. K., and DuBois, R. N. Host cyclooxygenase-2 modulates carcinoma growth. J. Clin. Investig., 105: 1589-1594, 2000.
35. Sacks, P. G., Parnes, S. M., Gallick, G. E., Mansouri, Z., Lichtner, R., Satya-Prakash, K. L., Pathak, S., and Parsons, D. F. Establishment and characterization of two new squamous cell carcinoma cell lines derived from tumors of the head and neck. Cancer Res., 48: 2858-2866, 1988.
36. Ornberg, R. L., Woerner, B. M., and Edwards, D. A. Analysis of stained objects in histological sections by spectral imaging and differential absorption. J. Histochem. Cytochem., 47: 1307-1314, 1999.
37. Ornberg, R. L. Proliferation and apoptosis measurements by color image analysis based on differential absorption. J. Histochem. Cytochem., 49: 1059-1060, 2001.
38. 2. J. Immunol., 155: 4437-4444, 1995.
39. Stolina, M., Sharma, S., Lin, Y., Dohadwala, M., Gardner, B., Luo, J., Zhu, L., Kronenberg, M., Miller, P. W., Portanova, J., Lee, J. C., and Dubinett, S. M. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. J. Immunol., 164: 361-370, 2000.
40. Khan, K. N., Masferrer, J. L., Woerner, B. M., Soslow, R., and Koki, A. T. Enhanced cyclooxygenase-2 expression in sporadic and familial adenomatous polyposis of the human colon. Scand. J. Gastroenterol., 36: 865-869, 2001.
41. Tucker, O. N., Dannenberg, A. J., Yang, E. K., Zhang, F., Teng, L., Daly, J. M., Soslow, R. A., Masferrer, J. L., Woerner, B. M., Koki, A. T., and Fahey, T. J., III. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res., 59: 987-990, 1999.
42. Kulkarni, S., Rader, J. S., Zhang, F., Liapis, H., Koki, A. T., Masferrer, J. L., Subbaramaiah, K., and Dannenberg, A. J. Cyclooxygenase-2 is overexpressed in human cervical cancer. Clin. Cancer Res., 7: 429-434, 2001.
43. Mohammed, S. I., Knapp, D. W., Bostwick, D. G., Foster, R. S., Khan, K. N., Masferrer, J. L., Woerner, B. M., Snyder, P. W., and Koki, A. T. Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. Cancer Res., 59: 5647-5650, 1999.
44. Soslow, R. A., Dannenberg, A. J., Rush, D., Woerner, B. M., Khan, K. N., Masferrer, J., and Koki, A. T. COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer (Phila.), 89: 2637-2645, 2000.
45. Williams, C. S., Sheng, H., Brockman, J. A., Armandla, R., Shao, J., Washington, M. K., Elkahloun, A. G., and DuBois, R. N. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia, 3: 428-436, 2001.
46. Fischer, S. M., Lo, H. H., Gordon, G. B., Seibert, K., Kelloff, G., Lubet, R. A., and Conti, C. J. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol. Carcinog., 25: 231-240, 1999.
47. Pentland, A. P., Schoggins, J. W., Scott, G. A., Khan, K. N., and Han, R. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis (Lond.), 20: 1939-1944, 1999.
48. Sheng, H., Shao, J., Kirkland, S. C., Isakson, P., Coffey, R. J., Morrow, J., Beauchamp, R. D., and DuBois, R. N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J. Clin. Investig., 99: 2254-2259, 1997.
49. Leahy, K. M., Koki, A. T., and Masferrer, J. L. Role of cyclooxygenases in angiogenesis. Curr. Med. Chem., 7: 1163-1170, 2000.
50. Masferrer, J. L., Koki, A., and Seibert, K. COX-2 inhibitors. A new class of antiangiogenic agents. Ann. N. Y. Acad. Sci., 889: 84-86, 1999.
51. Chulada, P. C., Thompson, M. B., Mahler, J. F., Doyle, C. M., Gaul, B. W., Lee, C., Tiano, H. F., Morham, S. G., Smithies, O., and Langenbach, R. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res., 60: 4705-4708, 2000.