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Volumn 100, Issue 10, 2002, Pages 3681-3689

Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAMMA INTERFERON; HLA A ANTIGEN; HLA ANTIGEN; HYBRID PROTEIN; OLIGODEOXYNUCLEOTIDE; PEPTIDE; PROTEIN; PROTEIN PP65; SINGLE STRANDED DNA; TETANUS TOXOID; TETRAMER; UNCLASSIFIED DRUG; VACCINE;

EID: 0037111674     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-03-0926     Document Type: Article
Times cited : (60)

References (71)
  • 1
    • 0023785193 scopus 로고
    • Cytotoxic T lymphocytes from HLA-A2 transgenic mice specific for HLA-A2 expressed on human cells
    • Bernhard EJ, Le AX, Barbosa JA, Lacy E, Engelhard VH. Cytotoxic T lymphocytes from HLA-A2 transgenic mice specific for HLA-A2 expressed on human cells. J Exp Med. 1988;168:1157-1162.
    • (1988) J Exp Med , vol.168 , pp. 1157-1162
    • Bernhard, E.J.1    Le, A.X.2    Barbosa, J.A.3    Lacy, E.4    Engelhard, V.H.5
  • 2
    • 0030903740 scopus 로고    scopus 로고
    • An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen
    • Rosloniec EF, Brand DD, Myers LK, et al. An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J Exp Med. 1997;185:1113-1122.
    • (1997) J Exp Med , vol.185 , pp. 1113-1122
    • Rosloniec, E.F.1    Brand, D.D.2    Myers, L.K.3
  • 3
    • 0029847916 scopus 로고    scopus 로고
    • The human CTL response to cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T cell receptor usage of pp65-specific CTL
    • Wills MR, Carmichael AJ, Mynard K, et al. The human CTL response to cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T cell receptor usage of pp65-specific CTL. J Virol. 1996;70:7569-7579.
    • (1996) J Virol , vol.70 , pp. 7569-7579
    • Wills, M.R.1    Carmichael, A.J.2    Mynard, K.3
  • 4
    • 0035135665 scopus 로고    scopus 로고
    • Population coverage by HLA class-I restricted cytotoxic T-lymphocyte epitopes
    • Longmate J, York J, La Rosa C, et al. Population coverage by HLA class-I restricted cytotoxic T-lymphocyte epitopes. Immunogenetics. 2001;52:165-173.
    • (2001) Immunogenetics , vol.52 , pp. 165-173
    • Longmate, J.1    York, J.2    La Rosa, C.3
  • 5
    • 0036467791 scopus 로고    scopus 로고
    • High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-sero-negative recipients of stem cell transplants from seropositive donors: Evidence for indirect effects of primary CMV infection
    • Nichols WG, Corey L, Gooley T, Davis C, Boeckh M. High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-sero-negative recipients of stem cell transplants from seropositive donors: Evidence for indirect effects of primary CMV infection. J Infect Dis. 2002;185:273-282.
    • (2002) J Infect Dis , vol.185 , pp. 273-282
    • Nichols, W.G.1    Corey, L.2    Gooley, T.3    Davis, C.4    Boeckh, M.5
  • 6
    • 0036137356 scopus 로고    scopus 로고
    • High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy
    • Limaye AP, Raghu G, Koelle DM, Ferrenberg J, Huang ML, Boeckh M. High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy. J Infect Dis. 2002;185:20-27.
    • (2002) J Infect Dis , vol.185 , pp. 20-27
    • Limaye, A.P.1    Raghu, G.2    Koelle, D.M.3    Ferrenberg, J.4    Huang, M.L.5    Boeckh, M.6
  • 8
    • 0035865528 scopus 로고    scopus 로고
    • Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: Risk factors, correlation with DNA load, and outcomes
    • Nichols WG, Corey L, Gooley T, et al. Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: Risk factors, correlation with DNA load, and outcomes. Blood. 2001;97:867-874.
    • (2001) Blood , vol.97 , pp. 867-874
    • Nichols, W.G.1    Corey, L.2    Gooley, T.3
  • 10
    • 0030993182 scopus 로고    scopus 로고
    • Screening for CMV-specific T cell proliferation to identity patients at risk of developing late onset CMV disease
    • Krause H, Hebart H, Jahn G, Muller CA, Einsele H. Screening for CMV-specific T cell proliferation to identity patients at risk of developing late onset CMV disease. Bone Marrow Transplant. 1997;19:1111-1116.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 1111-1116
    • Krause, H.1    Hebart, H.2    Jahn, G.3    Muller, C.A.4    Einsele, H.5
  • 11
    • 0026490460 scopus 로고
    • The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection
    • Grefte JM, van der Gun BT, Schmolke S, et al. The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infection. J Gen Virol. 1992;73:2923-2932.
    • (1992) J Gen Virol , vol.73 , pp. 2923-2932
    • Grefte, J.M.1    Van der Gun, B.T.2    Schmolke, S.3
  • 12
    • 0025755277 scopus 로고
    • Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression
    • Riddell SR, Rabin M, Geballe AP, Britt WJ, Greenberg PD. Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression. J Immunol. 1991;146:2795-2804.
    • (1991) J Immunol , vol.146 , pp. 2795-2804
    • Riddell, S.R.1    Rabin, M.2    Geballe, A.P.3    Britt, W.J.4    Greenberg, P.D.5
  • 13
    • 0030928128 scopus 로고    scopus 로고
    • Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection
    • Diamond DJ, York J, Sun J, Wright CL, Forman SJ. Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection. Blood. 1997;90:1751-1767.
    • (1997) Blood , vol.90 , pp. 1751-1767
    • Diamond, D.J.1    York, J.2    Sun, J.3    Wright, C.L.4    Forman, S.J.5
  • 14
    • 0036241804 scopus 로고    scopus 로고
    • Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses
    • BenMohamed L, Krishnan R, Auge C, Primus J, Diamond DJ. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology. 2002;106:113-121.
    • (2002) Immunology , vol.106 , pp. 113-121
    • BenMohamed, L.1    Krishnan, R.2    Auge, C.3    Primus, J.4    Diamond, D.J.5
  • 16
    • 0029898025 scopus 로고    scopus 로고
    • Comparison of adjuvant formulations for cytotoxic T cell induction using synthetic peptides
    • Hioe CE, Qiu H, Chend PD, et al. Comparison of adjuvant formulations for cytotoxic T cell induction using synthetic peptides. Vaccine. 1996;14:412-418.
    • (1996) Vaccine , vol.14 , pp. 412-418
    • Hioe, C.E.1    Qiu, H.2    Chend, P.D.3
  • 17
    • 0032193773 scopus 로고    scopus 로고
    • Controlled lipidation and encapsulation of peptides as a useful approach to mucosal immunizations
    • Mora AL, Tam JP. Controlled lipidation and encapsulation of peptides as a useful approach to mucosal immunizations. J Immunol. 1998;161:3616-3623.
    • (1998) J Immunol , vol.161 , pp. 3616-3623
    • Mora, A.L.1    Tam, J.P.2
  • 18
    • 0030782958 scopus 로고    scopus 로고
    • CTL responses induced by a single immunization with peptide encapsulated in biodegradable microparticles
    • Partidos CD, Vohra P, Jones D, Farrar G, Steward MW. CTL responses induced by a single immunization with peptide encapsulated in biodegradable microparticles. J Immunol Methods. 1997;206:143-151.
    • (1997) J Immunol Methods , vol.206 , pp. 143-151
    • Partidos, C.D.1    Vohra, P.2    Jones, D.3    Farrar, G.4    Steward, M.W.5
  • 19
    • 0026093754 scopus 로고
    • Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides
    • Hart MK, Weinhold KJ, Scearce RM, et al. Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides. Proc Natl Acad Sci U S A. 1991;88:9448-9452.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 9448-9452
    • Hart, M.K.1    Weinhold, K.J.2    Scearce, R.M.3
  • 20
    • 0028203840 scopus 로고
    • Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs
    • Shirai M, Pendleton CD, Ahlers J, Takeshita T, Newman M, Berzofsky JA. Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs. J Immunol. 1994;152:549-556.
    • (1994) J Immunol , vol.152 , pp. 549-556
    • Shirai, M.1    Pendleton, C.D.2    Ahlers, J.3    Takeshita, T.4    Newman, M.5    Berzofsky, J.A.6
  • 21
    • 0031204408 scopus 로고    scopus 로고
    • The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection
    • Livingston B, Crimi C, Grey H, et al. The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection. J Immunol. 1997;159:1383-1392.
    • (1997) J Immunol , vol.159 , pp. 1383-1392
    • Livingston, B.1    Crimi, C.2    Grey, H.3
  • 22
    • 0026471201 scopus 로고
    • Immunization of mice with lipopeptides bypasses the prerequisite for adjuvant: Immune response of BALB/c mice to human immunodeficiency virus envelope glycoprotein
    • Martinon F, Gras-Masse H, Boutillon C, et al. Immunization of mice with lipopeptides bypasses the prerequisite for adjuvant: Immune response of BALB/c mice to human immunodeficiency virus envelope glycoprotein. J Immunol. 1992;149:3416-3422.
    • (1992) J Immunol , vol.149 , pp. 3416-3422
    • Martinon, F.1    Gras-Masse, H.2    Boutillon, C.3
  • 23
    • 0032769963 scopus 로고    scopus 로고
    • A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus
    • Heathcote J, McHutchison J, Lee S, et al. A pilot study of the CY-1899 T-cell vaccine in subjects chronically infected with hepatitis B virus. Hepatology. 1999;30:531-536.
    • (1999) Hepatology , vol.30 , pp. 531-536
    • Heathcote, J.1    McHutchison, J.2    Lee, S.3
  • 24
    • 0342647378 scopus 로고    scopus 로고
    • Multiepitopic B- and T-cell responses in humans by a HIV type 1 lipopeptide vaccine
    • Gahery-Segard H, Pialoux G, Charmeteau B, et al. Multiepitopic B- and T-cell responses in humans by a HIV type 1 lipopeptide vaccine. J Virol. 2000;74;1694-1703.
    • (2000) J Virol , vol.74 , pp. 1694-1703
    • Gahery-Segard, H.1    Pialoux, G.2    Charmeteau, B.3
  • 25
    • 0034052914 scopus 로고    scopus 로고
    • Evaluation of a lipopeptide immunogen as a therapeutic in HIV type 1-seropositive individuals
    • Seth A, Yasutomi Y, Jacoby H, et al. Evaluation of a lipopeptide immunogen as a therapeutic in HIV type 1-seropositive individuals. AIDS Res Hum Retroviruses. 2000;16:337-343.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 337-343
    • Seth, A.1    Yasutomi, Y.2    Jacoby, H.3
  • 26
    • 0035417932 scopus 로고    scopus 로고
    • Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine
    • Banchereau J, Palucka AK, Dhodapkar M, et al. Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. Cancer Res. 2001;61:6451-6458.
    • (2001) Cancer Res , vol.61 , pp. 6451-6458
    • Banchereau, J.1    Palucka, A.K.2    Dhodapkar, M.3
  • 29
    • 0031171898 scopus 로고    scopus 로고
    • Induction of cross-reactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponin adjuvant (QS-21) supplemented subunit vaccine formulations
    • Newman MJ, Wu JY, Gardner BH, et al Induction of cross-reactive cytotoxic T-lymphocyte responses specific for HIV-1 gp120 using saponin adjuvant (QS-21) supplemented subunit vaccine formulations. Vaccine. 1997;15:1001-1007.
    • (1997) Vaccine , vol.15 , pp. 1001-1007
    • Newman, M.J.1    Wu, J.Y.2    Gardner, B.H.3
  • 30
    • 0025785898 scopus 로고
    • Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates
    • Wiedemann F, Link R, Pumpe K, et al. Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates. J Pathol. 1991;164:265-271.
    • (1991) J Pathol , vol.164 , pp. 265-271
    • Wiedemann, F.1    Link, R.2    Pumpe, K.3
  • 31
    • 0035661880 scopus 로고    scopus 로고
    • Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques
    • Belyakov IM, Hel Z, Kelsall B, et al. Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques. Nat Med. 2001;7:1320-1326.
    • (2001) Nat Med , vol.7 , pp. 1320-1326
    • Belyakov, I.M.1    Hel, Z.2    Kelsall, B.3
  • 32
    • 0032514616 scopus 로고    scopus 로고
    • Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
    • Krieg AM, Wu T, Weeratna R, et al. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci U S A. 1998;95:12631-12636.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 12631-12636
    • Krieg, A.M.1    Wu, T.2    Weeratna, R.3
  • 33
    • 0034087642 scopus 로고    scopus 로고
    • Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines
    • Boyer JD, Cohen AD, Vogt S, et al. Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines. J Infect Dis. 2000;181:476-483.
    • (2000) J Infect Dis , vol.181 , pp. 476-483
    • Boyer, J.D.1    Cohen, A.D.2    Vogt, S.3
  • 34
    • 0035171689 scopus 로고    scopus 로고
    • Nonmyeloablative immunosuppressive regimen prolongs in vivo persistence of gene-modified autologous T cells in a nonhuman primate model
    • Berger C, Huang ML, Gough M, Greenberg PD, Riddell SR, Kiem HP. Nonmyeloablative immunosuppressive regimen prolongs in vivo persistence of gene-modified autologous T cells in a nonhuman primate model. J Virol. 2001;75:799-808.
    • (2001) J Virol , vol.75 , pp. 799-808
    • Berger, C.1    Huang, M.L.2    Gough, M.3    Greenberg, P.D.4    Riddell, S.R.5    Kiem, H.P.6
  • 35
    • 0031964257 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    • Davis HL, Weeratna R, Waldschmidt TJ, et al. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol. 1998;160:870-876.
    • (1998) J Immunol , vol.160 , pp. 870-876
    • Davis, H.L.1    Weeratna, R.2    Waldschmidt, T.J.3
  • 36
    • 0035423454 scopus 로고    scopus 로고
    • Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites
    • Horner AA, Datta SK, Takabayashi K, et al. Immunostimulatory DNA-based vaccines elicit multifaceted immune responses against HIV at systemic and mucosal sites. J Immunol. 2001;167:1584-1591.
    • (2001) J Immunol , vol.167 , pp. 1584-1591
    • Horner, A.A.1    Datta, S.K.2    Takabayashi, K.3
  • 37
    • 0004582004 scopus 로고    scopus 로고
    • CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
    • Brazolot Millan CL, Weeratna R, Krieg AM, Siegrist CA, Davis HL. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc Natl Acad Sci U S A. 1998;95:15553-15558.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15553-15558
    • Brazolot Millan, C.L.1    Weeratna, R.2    Krieg, A.M.3    Siegrist, C.A.4    Davis, H.L.5
  • 38
    • 0028675323 scopus 로고
    • Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides
    • Alexander J, Sidney J, Southwood S, et al. Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity. 1994;1:751-761.
    • (1994) Immunity , vol.1 , pp. 751-761
    • Alexander, J.1    Sidney, J.2    Southwood, S.3
  • 39
    • 0035869405 scopus 로고    scopus 로고
    • Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries
    • La Rosa C, Krishnan R, Markel S, et al. Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries. Blood. 2001;97:1776-1786.
    • (2001) Blood , vol.97 , pp. 1776-1786
    • La Rosa, C.1    Krishnan, R.2    Markel, S.3
  • 40
    • 0030850462 scopus 로고    scopus 로고
    • CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
    • Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants. Eur J Immunol. 1997;27:2340-2344.
    • (1997) Eur J Immunol , vol.27 , pp. 2340-2344
    • Lipford, G.B.1    Bauer, M.2    Blank, C.3    Reiter, R.4    Wagner, H.5    Heeg, K.6
  • 41
    • 0028931102 scopus 로고
    • CpG motifs in bacterial DNA trigger direct B-cell activation
    • Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 1995;374:546-549.
    • (1995) Nature , vol.374 , pp. 546-549
    • Krieg, A.M.1    Yi, A.K.2    Matson, S.3
  • 42
    • 0030977234 scopus 로고    scopus 로고
    • Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization
    • Tobery TW, Siliciano RF. Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J Exp Med. 1997;185:909-920.
    • (1997) J Exp Med , vol.185 , pp. 909-920
    • Tobery, T.W.1    Siliciano, R.F.2
  • 43
    • 0035825604 scopus 로고    scopus 로고
    • Site-directed mutation in a conserved kinase domain of human cytomegalovirus-pp65 with preservation of cytotoxic T lymphocyte targeting
    • Yao ZQ, Gallez-Hawkins G, Lomeli NA, et al. Site-directed mutation in a conserved kinase domain of human cytomegalovirus-pp65 with preservation of cytotoxic T lymphocyte targeting. Vaccine. 2001;19:1628-1635.
    • (2001) Vaccine , vol.19 , pp. 1628-1635
    • Yao, Z.Q.1    Gallez-Hawkins, G.2    Lomeli, N.A.3
  • 44
    • 0022402441 scopus 로고
    • Vaccinia virus expression vector: Coexpression of beta-galactosidase provides visual screening of recombinant virus plaques
    • Chakrabarti S, Brechling K, Moss B. Vaccinia virus expression vector: Coexpression of beta-galactosidase provides visual screening of recombinant virus plaques. Mol Cell Biol. 1985;5:3403-3409.
    • (1985) Mol Cell Biol , vol.5 , pp. 3403-3409
    • Chakrabarti, S.1    Brechling, K.2    Moss, B.3
  • 45
    • 0031039485 scopus 로고    scopus 로고
    • Comparison of cytotoxic T lymphocyte responses induced by peptide or DNA immunization: Implications on immunogenicity and immunodominance
    • Vitiello A, Sette A, Yuan L, et al. Comparison of cytotoxic T lymphocyte responses induced by peptide or DNA immunization: Implications on immunogenicity and immunodominance. Eur J Immunol. 1997;27:671-678.
    • (1997) Eur J Immunol , vol.27 , pp. 671-678
    • Vitiello, A.1    Sette, A.2    Yuan, L.3
  • 46
    • 0026576422 scopus 로고
    • HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
    • Wei ML, Cresswell P. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature. 1992;356:443-446.
    • (1992) Nature , vol.356 , pp. 443-446
    • Wei, M.L.1    Cresswell, P.2
  • 47
    • 0035425575 scopus 로고    scopus 로고
    • Human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy maintain activated CD8+ T cell subsets as a strong adaptive immune response to cytomegalovirus
    • Villacres MC, Lacey SF, La Rosa C, et al. Human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy maintain activated CD8+ T cell subsets as a strong adaptive immune response to cytomegalovirus. J Infect Dis. 2001;184:256-267.
    • (2001) J Infect Dis , vol.184 , pp. 256-267
    • Villacres, M.C.1    Lacey, S.F.2    La Rosa, C.3
  • 48
    • 0028972123 scopus 로고
    • Long-lasting anti-viral cytotoxic T lymphocytes induced in vivo with chimeric-multirestricted lipopeptides
    • Sauzet JP, Deprez B, Martinon F, Guillet JG, Gras-Masse H, Gomard E. Long-lasting anti-viral cytotoxic T lymphocytes induced in vivo with chimeric-multirestricted lipopeptides. Vaccine. 1995;13:1339-1345.
    • (1995) Vaccine , vol.13 , pp. 1339-1345
    • Sauzet, J.P.1    Deprez, B.2    Martinon, F.3    Guillet, J.G.4    Gras-Masse, H.5    Gomard, E.6
  • 49
    • 0026091287 scopus 로고
    • Efficiency of peptides and lipopeptides for in vivo priming of virus-specific cytotoxic T cells
    • Schild H, Deres K, Wiesmuller KH, Jung G, Rammensee HG. Efficiency of peptides and lipopeptides for in vivo priming of virus-specific cytotoxic T cells. Eur J Immunol. 1991;21:2649-2654.
    • (1991) Eur J Immunol , vol.21 , pp. 2649-2654
    • Schild, H.1    Deres, K.2    Wiesmuller, K.H.3    Jung, G.4    Rammensee, H.G.5
  • 50
    • 0020475449 scopus 로고
    • A simple method for displaying the hydropathic character of a protein
    • Kyte J, Doolittle RF. A simple method for displaying the hydropathic character of a protein. J Mol Biol. 1982;157:105-132.
    • (1982) J Mol Biol , vol.157 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2
  • 51
    • 0021112868 scopus 로고
    • Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure
    • Sweet RM, Eisenberg D. Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure. J Mol Biol. 1983;171:479-488.
    • (1983) J Mol Biol , vol.171 , pp. 479-488
    • Sweet, R.M.1    Eisenberg, D.2
  • 52
    • 0033605091 scopus 로고    scopus 로고
    • Lipopeptide particles as the immunologically active component of CTL inducing vaccines
    • Tsunoda I, Sette A, Fujinami R, et al. Lipopeptide particles as the immunologically active component of CTL inducing vaccines. Vaccine. 1999;17:675-685.
    • (1999) Vaccine , vol.17 , pp. 675-685
    • Tsunoda, I.1    Sette, A.2    Fujinami, R.3
  • 54
    • 0033923205 scopus 로고    scopus 로고
    • Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity
    • Tighe H, Takabayashi K, Schwartz D, et al. Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity. Eur J Immunol. 2000;30:1939-1947.
    • (2000) Eur J Immunol , vol.30 , pp. 1939-1947
    • Tighe, H.1    Takabayashi, K.2    Schwartz, D.3
  • 55
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med. 1997;186:1623-1631.
    • (1997) J Exp Med , vol.186 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 56
    • 0029743737 scopus 로고    scopus 로고
    • Phenotypic analysis of antigen-specific T lymphocytes
    • Altman JD, Moss PAH, Goulder PJR, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996;274:94-96.
    • (1996) Science , vol.274 , pp. 94-96
    • Altman, J.D.1    Moss, P.A.H.2    Goulder, P.J.R.3
  • 57
    • 0034600786 scopus 로고    scopus 로고
    • HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
    • Appay V, Nixon DF, Donahoe SM, et al. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med. 2000;192:63-75.
    • (2000) J Exp Med , vol.192 , pp. 63-75
    • Appay, V.1    Nixon, D.F.2    Donahoe, S.M.3
  • 58
    • 0343938862 scopus 로고    scopus 로고
    • The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire
    • Hernandez J, Lee PP, Davis MM, Sherman LA. The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire. J Immunol. 2000;164:596-602.
    • (2000) J Immunol , vol.164 , pp. 596-602
    • Hernandez, J.1    Lee, P.P.2    Davis, M.M.3    Sherman, L.A.4
  • 59
    • 0033997662 scopus 로고    scopus 로고
    • Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G)
    • Morris CB, Cheng E, Thanawastien A, Cardenas-Freytag L, Clements JD. Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G). Vaccine. 2000;18:1944-1951.
    • (2000) Vaccine , vol.18 , pp. 1944-1951
    • Morris, C.B.1    Cheng, E.2    Thanawastien, A.3    Cardenas-Freytag, L.4    Clements, J.D.5
  • 60
    • 0035859288 scopus 로고    scopus 로고
    • Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants
    • McCluskie MJ, Weeratna RD, Clements JD, Davis HL. Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants. Vaccine. 2001;19:3759-3768.
    • (2001) Vaccine , vol.19 , pp. 3759-3768
    • McCluskie, M.J.1    Weeratna, R.D.2    Clements, J.D.3    Davis, H.L.4
  • 61
    • 0033198143 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of the CD8+ T cell repertoire of HLA-A2.1 transgenic, H-2KbnullDbnull double knockout mice
    • Ureta-Vidal A, Firat H, Perarnau B, Lemonnier FA. Phenotypical and functional characterization of the CD8+ T cell repertoire of HLA-A2.1 transgenic, H-2KbnullDbnull double knockout mice. J Immunol. 1999;163:2555-2560.
    • (1999) J Immunol , vol.163 , pp. 2555-2560
    • Ureta-Vidal, A.1    Firat, H.2    Perarnau, B.3    Lemonnier, F.A.4
  • 62
    • 0029861143 scopus 로고    scopus 로고
    • The N-end rule: Functions, mysteries, uses
    • Varshavsky A. The N-end rule: Functions, mysteries, uses. Proc Natl Acad Sci U S A. 1996;93:12142-12149.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 12142-12149
    • Varshavsky, A.1
  • 63
    • 0032971227 scopus 로고    scopus 로고
    • Degradation of cell proteins and the generation of MHC class I-presented peptides
    • Rock KL, Goldberg AL. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu Rev Immunol. 1999;17:739-79:739-779.
    • (1999) Annu Rev Immunol , vol.17 , pp. 739-779
    • Rock, K.L.1    Goldberg, A.L.2
  • 64
    • 0031573132 scopus 로고    scopus 로고
    • Derivation of HLA-A11/Kb transgenic mice: Functional CTL repertoire and recognition of human A11-restricted CTL epitopes
    • Alexander J, Oseroff C, Sidney J, et al. Derivation of HLA-A11/Kb transgenic mice: Functional CTL repertoire and recognition of human A11-restricted CTL epitopes. J Immunol. 1997;159:4753-4761.
    • (1997) J Immunol , vol.159 , pp. 4753-4761
    • Alexander, J.1    Oseroff, C.2    Sidney, J.3
  • 65
    • 0035469815 scopus 로고    scopus 로고
    • Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection
    • Gratama JW, van Esser JW, Lamers CH, et al. Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection. Blood. 2001;98:1358-1364.
    • (2001) Blood , vol.98 , pp. 1358-1364
    • Gratama, J.W.1    Van Esser, J.W.2    Lamers, C.H.3
  • 66
    • 0035282725 scopus 로고    scopus 로고
    • Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation
    • Cwynarski K, Ainsworth J, Cobbold M, et al. Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation. Blood. 2001;97:1232-1240.
    • (2001) Blood , vol.97 , pp. 1232-1240
    • Cwynarski, K.1    Ainsworth, J.2    Cobbold, M.3
  • 67
    • 0028820386 scopus 로고
    • Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor
    • Walter EA, Greenberg PD, Gilbert MJ, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med. 1995;333:1038-1044.
    • (1995) N Engl J Med , vol.333 , pp. 1038-1044
    • Walter, E.A.1    Greenberg, P.D.2    Gilbert, M.J.3
  • 68
    • 0036624737 scopus 로고    scopus 로고
    • Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy
    • Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002;99:3916-3922.
    • (2002) Blood , vol.99 , pp. 3916-3922
    • Einsele, H.1    Roosnek, E.2    Rufer, N.3
  • 69
    • 18744436552 scopus 로고    scopus 로고
    • Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression
    • Pepperl S, Munster J, Mach M, Harris JR, Plachter B. Dense bodies of human cytomegalovirus induce both humoral and cellular immune responses in the absence of viral gene expression. J Virol. 2000;74:6132-6146.
    • (2000) J Virol , vol.74 , pp. 6132-6146
    • Pepperl, S.1    Munster, J.2    Mach, M.3    Harris, J.R.4    Plachter, B.5
  • 70
    • 0028353829 scopus 로고
    • Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: Correlation with CMV disease and effect of ganciclovir prophylaxis
    • Li CR, Greenberg PD, Gilbert MJ, Goodrich JM, Riddell SR. Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: Correlation with CMV disease and effect of ganciclovir prophylaxis. Blood. 1994;83:1971-1979.
    • (1994) Blood , vol.83 , pp. 1971-1979
    • Li, C.R.1    Greenberg, P.D.2    Gilbert, M.J.3    Goodrich, J.M.4    Riddell, S.R.5
  • 71
    • 0027440690 scopus 로고
    • Mapping the major human T helper epitopes of tetanus toxin: The emerging picture
    • Reece JC, Geysen HM, Rodda SJ. Mapping the major human T helper epitopes of tetanus toxin: The emerging picture. J Immunol. 1993;151:6175-6184.
    • (1993) J Immunol , vol.151 , pp. 6175-6184
    • Reece, J.C.1    Geysen, H.M.2    Rodda, S.J.3


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