Phenotypical and functional characterization of the CD8+ T cell repertoire of HLA-A2.1 transgenic, H-2K(bo)D(bo) double knockout mice

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2555-2560

  Ureta Vidal, Abel ^a   Firat, Hüseyin ^a   Pérarnau, Béatrice ^a   Lemonnier, François A ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CHIMERA; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE; VACCINE PRODUCTION; VIRUS INFECTION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CYTOTOXICITY TESTS, IMMUNOLOGIC; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV-1 REVERSE TRANSCRIPTASE; HLA-A2 ANTIGEN; HUMANS; IMMUNOPHENOTYPING; INFLUENZA A VIRUS; LYMPHOCYTE COUNT; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033198143     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Palmiter, R. D., R. L. Brinster, R. E. Hammer, M. E. Trumbauer, M. G. Rosenfeld, N. C. Birnberg, and R. M. Evans. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300:611.
2. Barbosa, J. A., M. E. Kamarck, P. A. Biro, S. M. Weissman, and F. H. Ruddle. 1982. Identification of human genomic clones coding the major histocompatibility antigens HLA-a2 and HLA-B7 by DNA-mediated gene transfer. Proc. Natl. Acad. Sci. USA 79:6327.
3. Lemonnier, F. A., M. Malissen, P. Golstein, P. Le Bouteiller, N. Rebaï, M. Damotte, D. Birnbaum, D. Caillol, J. Trucy, and B. R. Jordan. 1982. Expression of human class I histocompatibility antigens at the surface of DNA-transformed mouse L cells. Immunogenetics 16:355.
4. Pérarnau, B., and F. A. Lemonnier. 1997. Immunologically humanized transgenic mice. In Weir's Handbook of Experimental Immunology. 5th Ed., Vol. 4. L. A. Herzenberg, D. M. Weir, L. A. Herzenberg, and C. Blackwell, eds. Blackwell Science, Inc., Malden, MD, p. 146.
5. Arnold, B., and G. J. Hämmerling. 1991. MHC class-I transgenic mice. Annu. Rev. Immunol. 9:297.
6. Kievits, F., P. Ivanyi, P. Krimpenfort, A. Berns, and H. L. Ploegh. 1987. HLA-restricted recognition of viral antigens in HLA transgenic mice. Nature 329:447.
7. Kievits, F., W. Lokhorst, and P. Ivanyi. 1990a. Abnormal anti-viral immune response in mice is corrected in HLA-B27.2-transgenic mice. Eur J. Immunol. 20:1189.
8. 2m double transgenic mice. J. Immunol. 143:3117.
9. Engelhard, V. H., E. Lacy, and J. P. Ridge. 1991. Influenza A-specific, HLA-A2.1-restricted CTLs from HLA-A2.1 transgenic mice recognize fragments of the M1 protein. J. Immunol. 146:1226.
10. Epstein, H., R. Hardy, J. S. May, M. H. Johnson, and N. Holmes. 1989. Expression and function of HLA-A2.1 in transgenic mice. Eur. J. Immunol. 19:1575.
11. Le, A.-X. T., E. J. Bernhard, M. J. Holterman, S. Strub, E. Lacy, and V. Engelhard. 1989. Cytotoxic T cell responses in HLA-A2.1 transgenic mice: recognition of HLA alloantigens and utilization of HLA-A2.1 as a restriction element. J. Immunol. 142:1366.
12. Connolly, J. M., T. A. Potter, E.-M. Wormstall, and T. H. Hansen. 1988. The Lyt-2 molecule recognizes residues in the class I α3 domain in allogeneic cytotoxic T cell responses. J. Exp. Med 168:325.
13. Vitiello, A., D. Marchesini, J. Furze, L. A. Sherman, and R. W. Chesnut. 1991. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex. J. Exp. Med. 173:1007.
14. Wentworth, P., A. Vitiello, J. Sidney, E. Keogh, R. Chesnut, H. Grey, and A. Sette. 1996. Differences and similarities in the A2.1-restricted cytotoxic T cell repertoire in humans and human leukocyte antigen-transgenic mice. Eur. J. Immunol. 26:97.
15. Shirai, M., T. Arichi, M. Nishioka, T. Nomura, K. Ikeda, K. Kawanishi, V. H. Engelhard, S. M. Feinstone, and J. A. Berzofsky. 1995. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1. J. Immunol. 154:2733.
16. Theobald, M., J. Biggs, J. Hernandez, J. Lustgarten, C. Labadie, and L. A. Sherman. 1997. Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes. J. Exp. Med. 185:833.
17. Barra, C., H. Gournier, Z. Garcia, P. N. Marche, E. Jouvin-Marche, P. Briand, P. Filippi, and F. A. Lemonnier. 1993. Abrogation of H-2-restricted responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice. J. Immunol. 150:3681.
18. + influenza matrix peptide in human class I transgenic mice. J. Immunol. 153:4458.
19. 2m double knockout mice. J. Exp. Med 185:2043.
20. + T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses. Eur. J. Immunol. 29: 1243.
21. Saron, M.-F., P. Truffa-Bachi, and J.-C. Guillon. 1989. Rapid enrichment of mouse natural killer cells by use of wheat germ agglutinin. J. Immunol. Methods 59:151.
22. Johansson, M. H., C. Bieberich, G. Jay, K. Kärre, and P. Höglund. 1997. Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene. J. Exp. Med. 186:353.
23. Wilson, R. K., E. Lai, P. Concannon, R. K. Barth, and L. E. Hood. 1988. Structure, organisation, and polymorphism of murine and human T-cell receptor α and β chain gene families. Immunol. Rev. 101:149.
24. Sun, J., D. J. Leahy, and P. B. Kavathas. 1995. Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the α2and α3 domains of MHC class I. J. Exp. Med. 182: 1275.
25. Gao, G. F., J. Tormo, U. C. Gerth, J. R. Wyer, A. J. McMichael, D. I. Stuart, J. I. Bell, E. Y. Jones, and B. K. Jakobsen. 1997. Crystal structure of the complex between human CD8α(α) and HLA-A2. Nature 387:630.
26. 2-microglobulins on the conformation of HLA-B27 detected by antibody and by CTL. J. Immunol. 153:3543.