Expression and function of transgenic HLA-DQ molecules and lymphocyte development in mice lacking invariant chain

Journal of Immunology

Volumn 169, Issue 4, 2002, Pages 1774-1783

  Rajagopalan, Govindarajan ^a   Smart, Michele K ^a   Krco, Christopher J ^a   David, Chella S ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; HLA DQ ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CYTOKINE PRODUCTION; LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION;

EID: 0037103178     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.4.1774     Document Type: Article

References (58)

1. The gene encoding the Ia antigen-associated invariant chain (Ii) is not linked to the H-2 complex
2. Localization of the HLA class II-associated invariant chain gene to human chromosome band 5q32
3. Intracellular transport of class II MHC molecules directed by invariant chain
4. The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules
5. + T cells
6. Invariant chain structure and MHC class II function
7. MHC class II-restricted antigen processing and presentation
8. Antigen processing in the endocytic compartment
9. The transmembrane segment of invariant chain mediates binding to MHC class II molecules in a CLIP-independent manner
10. A role for the transmembrane domain in the trimerization of the MHC class II-associated invariant chain
11. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
12. Nonclassical MHC class II molecules
13. Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum
14. + T cell selection in mice lacking invariant chain expression
15. Mice lacking the MHC class II-associated invariant chain
16. Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain
17. + T cell function in mice lacking the p41 isoform of invariant chain
18. The influence of invariant chain on the positive selection of single T cell receptor specificities
19. Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAPI double-mutant mice
20. + T cells in mice lacking invariant chain
21. Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes
22. MHC class II expression in double mutant mice lacking invariant chain and DM functions
23. Allelic differences affecting invariant chain dependency of MHC class II subunit assembly
24. Dendritic cell maturation and antigen presentation in the absence of invariant chain
25. MHC class II expression is regulated in dendritic cells independently of invariant chain degradation
26. + T cell development
27. Comparison of thymocyte development in normal and invariant chain-deficient mice provides evidence that maturation-related changes in TCR and co-receptor levels play a critical role in cell fate
28. + T cells in the periphery and secondary proliferative responses elicited upon peptide challenge
29. Requirement for invariant chain in B cell maturation and function
30. Invariant chain induces B cell maturation by activating a TAF(II)105-NF-κB-dependent transcription program
31. Celiac disease and its link to type I diabetes mellitus
32. HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice: Implications in human rheumatoid arthritis
33. Identification of T cell determinants on human type II collagen recognized by HLA-DQ8 and HLA-DQ6 transgenic mice
34. Staphylococcal enterotoxin B-induced activation and concomitant resistance to cell death in CD28 deficient HLA-DQ8 transgenic mice
35. Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma arthritidis superantigen MAM
36. Accessory molecules for MHC class II peptide loading
37. A role of Ia-associated invariant chains in antigen processing and presentation
38. Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells
39. Murine class II (Ia) molecules associate with human invariant chain
40. Invariant chain retains MHC class II molecules in the endocytic pathway
41. Antiviral immune responses of mice lacking MHC class II or its associated invariant chain
42. Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity
43. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis
44. Structural analysis of a human I-A homologue using a monoclonal antibody that recognizes an MB3-like specificity
45. Acquisition of peptides by MHC class II polypeptides in the absence of the invariant chain
46. HLA-DM can partially replace the invariant chain for HLA-DR transport and surface expression in transfected endocrine epithelial cells
47. Immune response to staphylococcal superantigens
48. Role of the T cell receptor α-chain in superantigen recognition
49. Quantitative relationship between MHC class II-superantigen complexes and the balance of T cell activation versus death
50. Diverse repertoire of the MHC class II-peptide complexes is required for presentation of viral superantigens
51. Major histocompatibility complex class II-associated peptides control the presentation of bacterial superantigens to T cells
52. Superantigens and their potential role in human disease
53. Staphylococcal enterotoxin-B-induced lethal shock in mice is T-cell-dependent, but disease susceptibility is defined by the non-T-cell compartment
54. Invariant chain-independent antigen presentation depends primarily upon the pool of newly synthesized MHC class II molecules
55. 7 on the cell surface
56. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type I diabetes
57. Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8
58. HLA class II transgenic mice as models of human diseases