Immature CD34+CD19- progenitor/stem cells in TEL/AML1-positive acute lymphoblastic leukemia are genetically and functionally normal

Blood

Volumn 100, Issue 2, 2002, Pages 640-646

  Hotfilder, Marc ^a,b   Röttgers, Silja ^a,b   Rosemann, Annegret ^a,b   Jürgens, Heribert ^a,b   Harbott, Jochen ^a,b   Vormoor, Josef ^a,b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD34 ANTIGEN; METHYLCELLULOSE; PROTEIN; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CELL MATURATION; CHILD; CLINICAL ARTICLE; CLONOGENESIS; FLOW CYTOMETRY; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNOTHERAPY; MINIMAL RESIDUAL DISEASE; ONCOGENE; PRIORITY JOURNAL; STEM CELL;

EID: 0037100422     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V100.2.640     Document Type: Article

References (39)

1. Stem cell origins of leukaemia and curability
2. Detection of leukemic cells in the CD34+CD38- bone marrow progenitor population in children with acute lympoblastic leukemia
3. A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia
4. Cytogenetically aberrant cells are present in the CD34+CD33-CD38-CD19- marrow compartment in children with acute lymphoblastic leukemia
5. Clonal diversity of Ig and T-cell receptor gene rearrangements in childhood B-precursor acute lymphoblastic leukemia
6. Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: Results of trial ALL-BFM 90
7. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials
8. The role of prognostic features in the treatment of childhood acute lymphoblastic leukemia
9. TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia
10. Chemosensitivity of TEL-AML1 fusion transcript positive acute lymphoblastic leukemia cells
11. TEL-AML1 fusion transcripts in relapsed childhood acute lymphoblastic leukemia
12. Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: Results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol
13. TEL-AML1 fusion in relapsed childhood acute lymphoblastic leukemia
14. Flow cytometric identification of candidate normal stem cell populations in CD45-negative B-cell precursor acute lymphoblastic leukaemia (ALL)
15. Expression of AC133 and CD117 on candidate normal stem cell populations in childhood B-cell precursor acute lymphoblastic leukaemia
16. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex
17. Flow cytometric analysis of human bone marrow, II: Normal B lymphocyte development
18. Fates of human B-cell precursors
19. An effect human leukaemic cell line: Reh
20. Establishment of a leukemic cell model for studying human pre-B to B cell differentiation
21. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
22. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
23. Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features
24. Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A Pediatric Oncology Group Study
25. Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias
26. The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias
27. Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia
28. Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: Good initial steroid response allows early prediction of a favorable treatment outcome
29. Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia
30. Identification of human juvenile chronic myelogenous leukemia cells capable of initiating the disease in primary and secondary SCID mice
31. Molecular analysis of single colonies reveals a diverse origin of initial clonal proliferation in B-precursor acute lymphoblastic leukemia that can precede the t(12;21) translocation
32. Purified autologous grafting in childhood acute lymphoblastic leukemia in second remission: Evidence for long-term clinical and molecular remissions
33. Autologous bone marrow transplantation for childhood acute lymphoblastic leukemia: A novel combined approach consisting of ex vivo marrow purging, modulation of multi-drug resistance, induction of autograft vs leukemia effect, and post-transplant immuno- and chemotherapy (PTIC)
34. Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia
35. Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood
36. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments
37. A human early B-cell factor-like protein participates in the regulation of the human CD19 promoter
38. Abnormal lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule