A V(H)11V(κ)9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4586-4593

  Chumley, Michael J ^a,b   Dal Porto, Joseph M ^a   Kawaguchi, Susumu ^c   Cambier, John C ^a,b   Nemazee, David ^d   Hardy, Richard R ^e  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c SHIMANE UNIVERSITY   (Japan)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; B LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; CD5 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CALCIUM MOBILIZATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CALCIUM SIGNALING; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; IMMUNOPHENOTYPING; INTRACELLULAR FLUID; LYMPHOCYTE ACTIVATION; METABOLISM; PERITONEUM; PHYSIOLOGY; RNA EDITING; SPLEEN; STEM CELL; STEM CELL TRANSPLANTATION; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD5; B-LYMPHOCYTE SUBSETS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL SURVIVAL; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; INTRACELLULAR FLUID; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PERITONEUM; RECEPTORS, ANTIGEN, B-CELL; RNA EDITING; SPLEEN; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 0034178253     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4586     Document Type: Article

References (91)

1. Best, C. G., J. D. Kemp, and T. J. Waldschmidt. 1995. Murine B-cell subsets defined by CD23. Methods Companion Methods Enzymol. 8:3.
2. Carsetti, R., G. Köhler, and M. C. Lamers. 1995. Transitional B cells are the target of negative selection in the B cell compartment. J. Exp. Med. 181:2129.
3. Oyster, J. G., J. I. Healy, K. Kishihara, T. M. Mak, M. L. Thomas, and C. C. Goodnow. 1996. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Science 381:325.
4. Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
5. + B-cell subset. Semin. Immunol. 8:37.
6. Hertz, M., V. Kouskoff, T. Nakamura, and D. Nemazee. 1998. V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen receptor signaling. Nature 394:292.
7. + IgD bone marrow B cells in vitro. Immunity 6:429.
8. Klinman, N. R. 1996. The "clonal selection hypothesis" and current concepts of b cell tolerance. Immunity 5:189.
9. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751.
10. Kroese, F. G., R. de Waard, and N. A. Bos 1996. B-1 cells and their reactivity with the murine intestinal microflora. Semin. Immunol. 8:11.
11. Hayakawa, K., R. R. Hardy, and L. A. Herzenberg. 1986. Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased A light chain expression. Eur. J. Immunol. 16:450.
12. Hayakawa, K., R. R. Hardy, D. R. Parks, and L. A. Herzenberg. 1983. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J. Exp. Med. 157:202.
13. Bikah, G., J. Carey, J. R. Ciallella, A. Tarakhovsky, and S. Bondada. 1996. CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science 274:1906.
14. Morris, D. L., and T. L. Rothstein. 1993. Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes. J. Exp. Med. 177:857.
15. Morris, D. L., and T. L. Rothstein. 1994. Decreased surface IgM receptor-mediated activation of phospholipase Cγ2 in B-1 lymphocytes. Int. Immunol. 6:1011.
16. Rothstein, T. L., D. L. Kolber, T. P. Murphy, and D. P. Cohen. 1991. Induction of phorbol ester responsiveness in conventional B cells after activation via surface Ig. J. Immunol. 147:3728.
17. Herzenberg, L. A., A. M. Stall, P. A. Lalor, C. Sidman, W. A. Moore, D. R. Parks, and L. A. Herzenberg. 1986. The Ly-1 B cell lineage. Immunol. Rev. 93:81.
18. Kroese, F. G., E. C. Butcher, A. M. Stall, P. A. Lalor, S. Adams, and L. A. Herzenberg. 1989. Many of the IgA producing plasma cells in murine gut arc derived from self-replenishing precursors in the peritoneal cavity. Int. Immunol. 1:75.
19. Stall, A. M., S. M. Wells, and K.-P. Lam. 1996. B-1 cells: unique origins and functions. Semin. Immunol. 8:45.
20. + B cells. Science 236:81.
21. H genes, fine specificities, and the role of Thy-1 glycoprotein. J. Exp. Med. 172:869.
22. Hayakawa, K., R. R. Hardy, M. Honda, L. A. Herzenberg, A. D. Steinberg, and L. A. Herzenberg. 1984. Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc. Natl. Acad. Sci. USA 81:2494.
23. + antibodies) are produced by peritoneal CD5 B lymphocytes. Int. Immunol. 2:515.
24. + (CD5) B cells that recognize phosphatidylcholine: relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes. J. Exp. Med. 168:687.
25. Murakami, M., T. Tsubata, M. Okamoto, A. Shimizu, S. Kumagai, H. Imura, and T. Honjo. 1992. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature 357:77.
26. + B cells in viable moth-eaten and normal mice. Science 232:1423.
27. H11 in the Ly-1 B cell lineage. J. Exp. Med. 172:371.
28. Chen, X., and J. K. Kearney. 1996. Generation and function of natural self-reactive B lymphocytes. Semin. Immunol. 8:19.
29. + B cell precursor in B-1 cell differentiation. J. Exp. Med. 187:1325.
30. H11 family. J. Immunol. 142:3643.
31. Pennell, C. A., T. J. Mercolino, T. A. Grdina, L. W. Arnold, G. Haughton, and S. H. Clarke. 1989. Biased immunoglobulin variable region gene expression by Ly-1 B cells due to clonal selection. Eur. J. Immunol. 19:1289.
32. H12-expressmg B cells are excluded from the peripheral repertoire in adults. Eur. J. Immunol. 25:2511.
33. Kawaguchi, S. 1998. Induction of tolerance in B-1 cells for bromelain-treated mouse red blood cells by a transient presence of anti-idiotypic antibodies in neonatal and adult mice. J. Immunol. 160:4796.
34. Nisitani, S., T. Tsubata, M. Murakami, and T. Honjo. 1993. The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J. Exp. Med. 178:1247.
35. Okamoto, M., M. Murakami, A. Shimizu, S. Ozaki, T. Tsubata, S. Kumagai, and T. Honjo. 1992. A transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 175:71.
36. Hartley, S. B., and C. C. Goodnow. 1994. Censoring of self-reactive B cells with a range of receptor affinities in transgenic mice expressing heavy chains for a lysozyme-specific antibody. Int. Immunol. 6:1417.
37. Lang, J., M. Jackson, L. Teyton, A. Brunmark, K. Kane, and D. Nemazee. 1996. B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigens. J. Exp. Med 184:1685.
38. Riley, R. L., and N. R. Klinman. 1986. The affinity threshold for antigenic triggering differs for tolerance susceptible immature precursors vs mature primary B cells. J. Immunol. 136:3147.
39. +) B cells that recognize phosphatidylcholine. J. Exp. Med. 169:1869.
40. + B cell lymphomas. J. Immunol. 141:2788.
41. + (CD5) B cells. Eur. J. Immunol. 19:2115.
42. h gene family encodes anti-bromelinized mouse red blood cell autoantibodies. Eur. J. Immunol. 18:1521.
43. Hardy, R. R., and K. Hayakawa. 1991. A developmental switch in B lymphopoiesis. Proc. Natl. Acad. Sci. USA 88:11550.
44. Hardy, R. R., and K. Hayakawa. 1992. Generation of Ly-1 B cells from developmentally distinct precursors: enrichment by stomal cell culture or cell sorting. In CD5 B Cells in Development and Disease, Vol. 651. L. A. Herzenberg, K. Rajewsky, and G. Haughton, ed. New York Academy of Science, New York, pp. 84-98.
45. Hayakawa, K., R. R. Hardy, L. A. Herzenberg, and L. A. Herzenberg. 1985. Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J. Exp. Med. 161:1554.
46. Hayakawa, K., D. Tarlinton, and R. R. Hardy. 1994. Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice. J. Immunol. 152:4801.
47. Kantor, A. B., A. M. Stall, S. Adams, L. A. Herzenberg, and L. A. Herzenberg. 1992. Differential development of progenitor activity for three B-cell lineages. Proc. Natl. Acad. Sci. USA 89:3320.
48. Lam, K. P., and A. M. Stall. 1994. Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny. J. Exp. Med. 180:507.
49. Li, Y. S., K. Hayakawa, and R. R. Hardy. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
50. Solvason, N., A. Lehuen, and J. F. Kearney. 1991. An embryonic source of Ly1 but not conventional B cells. Int. Immunol. 3:543.
51. Stall, A. M., F. G. Kroese, F. T. Gadus, D. G. Sieckmann, L. A. Herzenberg, and L. A. Herzenberg. 1988. Rearrangement and expression of endogenous immunoglobulin genes occur in many murine B cells expressing transgenic membrane IgM. Proc. Natl. Acad. Sci. USA 85:3546.
52. Bandyopadhyay, R. S., M. R. Teutsch, and H. H. Wortis. 1995. Activation of B-cells by sIgM cross-linking induces accumulation of CD5 mRNA. Curr. Top. Microbiol. Immunol. 194:219.
53. - B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int. Immunol. 3:467.
54. Rabin, E., C. Ying-Ze, and H. H. Wortis. 1992. Loss of CD23 is a consequence of B-cell activation: implication for the analysis of B cell lineages. In CD5 B Cells in Development and Disease, Vol. 651. L. A. Herzenberg, K. Rajewsky, and G. Haughton, eds. New York Academy of Science, New York, pp. 130-142.
55. Teutsh, M., M. Higer, D. Wang, and H. H. Wortis. 1995. Induction of CD5 on B and T cells is suppressed by cyclosporin A. FK-520, and rapamycin. Int. Immunol. 7:381.
56. Wortis, H. H., M. Teutsch, M. Higer, J. Zheng, and D. C. Parker. 1995. B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. Proc. Natl. Acad. Sci. USA 92:3348.
57. Ahearn, J. M., M. B. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, R. G. Howard, T. L. Rothstein, and M. C. Carroll. 1996. Disruption of the Cr2 locus results in a reduction it B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4:251.
58. Engel, P., L.-J. Zhou, D. C. Ord, S. Sato, B. Koller, and T. F. Tedder. 1995. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 3:39.
59. Rickert, R. C., K. Rajewsky, and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376:352.
60. Haughton, G., L. W. Arnold, A. C. Whitmore, and S. H. Clarke. 1993. B-1 cells are made, not born. Immunol. Today 14:84.
61. Kantor, A. B., and L. A. Herzenberg. 1993. Origin of murine B cell lineages. Annu. Rev. Immunol. 11:501.
62. Hayakawa, K., M. Asano, S. A. Shinton, M. Gui, D. S. Allman, C. L. Stewart, J. Silver, and R. R. Hardy. 1999. Positive selection of natural autoreactive B cells. Science 285:113.
63. Wasserman, R., Y.-S. Li, S. A. Shinton, C. E. Carmack, T. Manser, D. L. Wiest, K. Hayakawa, and R. R. Hardy. 1998. A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly. J. Exp. Med. 187:259.
64. Feeney, A. J. 1990. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences. J. Exp. Med. 172:1377.
65. H junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies. J. Immunol. 149:222.
66. H joining: implications for the joining mechanism and the ontogenetic liming of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9:2133.
67. Chen, C., M. Z. Radic, J. Erikson, S. A. Camper, S. Litwin,R. R. Hardy, and M. Weigert. 1994. Deletion and editing of B cells that express antibodies to DNA. J. Immunol. 152:1970.
68. Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353:765.
69. Arnold, L. W., C. A. Pennell, S. K. McCray, and S. H. Clarke. 1994. Development of B-1 cells: segregation of phosphatidylcholine-specific B cells to the B-1 population occurs after immunoglobulin gene expression. J. Exp. Med. 179:1585.
70. Nemazee, D. A., and K. Burki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562.
71. Ozato, K., N. Mayer, and D. H. Sachs. 1980. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J. Immunol. 124:533.
72. Melamed, D., J. A. Kench, K. Grabstein, A. Rolink, and D. Nemazee. 1997. A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors. J. Immunol. 159:1233.
73. Melamed, D., and D. Nemazee. 1997. Self-antigen does not accelerate immature B-cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest. Proc. Natl. Acad. Sci. USA 94:9267.
74. Hodgkin, P. D., J.-H. Lee, and A. B. Lyons. 1996. B cell differentiation and isotype switching is related to division and cycle number. J. Exp. Med. 184:277.
75. Tiegs, S. L., D. M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009.
76. Russell, D. M., Z. Dembic, G. Morahan, J, F. Miller, K. Burki, and D. Nemazee. 1991. Peripheral deletion of self-reactive B cells. Nature 354:308.
77. + B cells; the Ly-1 B lineage? Annu. Rev. Immunol. 6:197.
78. Chen, C., E. L. Prak, and M. Weigert. 1997. Editing disease-associated autoantibodies. Immunity 6:97.
79. Fang, W., B. C. Weintraub, B. Dunlap, P. Garside, K. A. Pape, M. K. Jenkins, C. C. Goodnow, D. L. Mueller, and T. W. Behrens. 1998. Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity 9:35.
80. Prak, E. L., M. Trounstine, D. Huszar, and M. Weigert. 1994. Light chain editing in κ-deficient animals: a potential mechanism of B cell tolerance. J. Exp. Med. 180:1805.
81. Benedict, C. L., and J. F. Kearney. 1999. Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice. Immunity 10:607.
82. Watanabe, N., S. Nisitani, K. Ikuta, M. Suzuki, T. Chiba, and T. Honjo. 1999. Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment. J. Exp. Med. 190:461.
83. Cyster, J. G., S. B. Hartley, and C. G. Goodnow. 1994. Competition for follicular niches excludes self-reactive cells from the re-circulating B-cell repertoire. Nature 371:389.
84. Hartley, S. B., M. P. Cooke, D. A. Fulcher, A. W. Harris, S. Cory, A. Basten, and C. C. Goodnow. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72:325.
85. Mandik-Nayak, L., S. J. Seo, C. Sokol, K. M. Potts, A. Bui, and J. Erikson. 1999. MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded CNA B cells. J. Exp. Med. 189:1799.
86. Dingjan, G. M., A. Maas, M. C. Nawijn, L. Smit, J. S. Voerman, F. Grosveld, and R. W. Hendriks. 1998. Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase. EMBO J. 17:5309.
87. Kishihara, K., J. Penninger, V. A. Wallace, T. M. Kundig, K. Kawai, A. Wakeham, E. Timms, K. Pfeffer, P. S. Ohashi, M. L. Thomas, et al. 1993. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell 74:143.
88. Turner, M., A. Gulbranson-Judge, M. E. Quinn, A. E. Walters, I. C. MacLennan, and V. L. Tybulewicz. 1997. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool. J. Exp. Med. 186:2013.
89. Turner, M., P. J. Mee, P. S. Costello, O. Williams, A. A. Price, L. P. Duddy, M. T. Furlong, R. L. Geahlen, and V. L. Tybulewicz. 1995. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378:298.
90. Lam, K.-P., R. Kühn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073.
91. H12-expressing B cells in the neonate. Eur. J. Immunol. 23:3327.