Peptidyl α-keto amide inhibitor of calpain blocks excitotoxic damage without affecting signal transduction events

Journal of Neuroscience Research

Volumn 67, Issue 6, 2002, Pages 787-794

  Caba, Ebru ^b   Brown, Queenie B ^b   Kawasaki, Brian ^b   Bahr, Ben A ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b Cortex Pharmaceuticals Inc ^*  (United States)

Author keywords

Calpain inhibition; Hippocampal slice culture; MAPK; NF B; Spectrin breakdown

Indexed keywords

2 OXOACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; CALPAIN; CALPASTATIN; CX 270; CX 295; CX 349; CYSTEINE PROTEINASE INHIBITOR; DIZOCILPINE; GLUTAMATE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID; NEUROPROTECTIVE AGENT; PEPTIDYL ALPHA KETO AMIDE; RECEPTOR SUBUNIT; SPECTRIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; BRAIN SLICE; CONTROLLED STUDY; CYTOSKELETON; GENETIC TRANSCRIPTION; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CALPAIN; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; HIPPOCAMPUS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROTOXINS; NF-KAPPA B; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SPECTRIN;

EID: 0037085940     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10163     Document Type: Article

References (58)

1. Calpain inhibitors improve the recovery, of synaptic transmission from hypoxia in hippocampal slices
2. Disruption of the murine calpain small subunit gene, Capn4: Calpain is essential for embryonic development but not for cell growth and division
3. Disruption of the mouse mu-calpain gene reveals an essential role in platelet function
4. Long-term hippocarupal slices: A model system for investigating synaptic mechanisms and pathologic processes
5. Integrin-type signaling has a distinct influence on NMDA-induced cytoskeletal disassembly
6. Induction of β-amyloid containing polypeptides in hippocampus: Evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin
7. Stable maintenance of glutamate receptors and other synaptic components in long-term hippocampal slices
8. Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices
9. R antigen (GR53) in brain tissue
10. Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein
11. Structural chemistries underlying synaptic signaling and regulation
12. Survival signaling and selective neuroprotection through glutamatergic transmission
13. Post-ischemic adruinistradon of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage
14. Calpain inhibitor AK295 protects neurons from focal brain ischemia
15. Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices
16. Regional distribution and time-course of calpain activation following kainate-induced seizure activity in adult rat brain
17. Calpain-mediated proteolysis of GluR1 subunits in organotypic hippocampal cultures following kainic acid treatment
18. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
19. Delayed antagonism of calpain reduces excitotoxicity in cultured neurons
20. Involvement of the secretory, pathway for AMPA receptors in NMDA-induced potentiation in hippocampus
21. Caspase and calpain substrates: Roles in synaptic plasticity and cell death
22. Impairment of NF-κB activation and modulation of gene expression by calpastatin
23. Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain
24. Calpain inhibition protects against virus-induced apoptotic myocardial injury
25. Stimulation of NMDA receptors activates calpain in cultured hippocampal slices
26. Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin glycoprotein IIbIIIa
27. NMDA receptor-mediated regulation of AMPA receptor properties in organotypic hippocampal slice cultures
28. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway
29. Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia
30. Regulation of cell migration by the calcium-dependent protease calpain
31. Examination of DNA-binding activity, of neuronal transcription factors by electrophoretical mobility shift assay
32. Variants of the receptor/channel clustering molecule gephyrin in brain: Distinct distribution patterns, developmental profiles, and proteolytic cleavage by calpain
33. Neurturin, a relative of glial-cell-line-derived neurotrophic factor
34. Inhibition of proteolysis protects hippocampal neurons from ischemia
35. Peptide α-keto ester, α-keto amide, and α-keto acid inhibitors of calpains and other cysteine proteases
36. Novel peptidyl α-keto amide inhibitors of calpains and other cysteine proteases
37. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
38. Roles of nuclear factor κB in neuronal survival and plasticity
39. Calpain inhibitor I reduces the activation of nuclear factor-kappaB an organ injury/dysfunction in hemorrhagic shock
40. Calpain activity in the rat brain after transient forebrain ischemia
41. A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat
42. Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo
43. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
44. Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events
45. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat
46. Spatial resolution of fodrin proteolysis in postischemic brain
47. Calpain: New perspectives in molecular diversity, and physiological-pathological involvement
48. Calcium, protease action, and the regulation of cell cycle
49. Crucial role of the amino-terminal tyrosine residue 42 and the carboxyl terminal PEST domain of IκBα in NF-κB activation by an oxidative stress
50. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells
51. Activation of the extracellular signal-regulated protein kinase cascade in the hippocampal CA1 region in a rat model of global cerebral ischemic preconditioning
52. The PEST domain of IκBα is necessary and sufficient for in vitro degradation by μ-calpain
53. Modulation of the ERK pathway of signal transduction by cysteine protease inhibitors
54. Life and death decisions: Regulation of apoptosis by proteolysis of signaling molecules
55. The pathogenic activation of calpain: A marker and mediator of cellular toxicity and disease states
56. Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis
57. Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage
58. The calpain small subunit gene is essential: Its inactivation results in embryonic lethality