Calpain inhibition protects against virus-induced apoptotic myocardial injury

Journal of Virology

Volumn 75, Issue 1, 2001, Pages 351-361

  DeBiasi, R L ^a   Edelstein, C L ^a   Sherry, B ^a   Tyler, K L ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID DERIVATIVE; CALPAIN; CALPASTATIN; CREATINE KINASE; CX 295; CYSTEINE PROTEINASE; TERT BUTYLOXYCARBONYLLEUCINE AMINOBUTYRIC ACID CARBONYLAMIDE ETHYL 3 MORPHOLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; HEART MUSCLE INJURY; HISTOPATHOLOGY; MORBIDITY; MORTALITY; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; REOVIRUS; STRAIN DIFFERENCE; VIRUS MYOCARDITIS;

EID: 0034749514     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.1.351-361.2001     Document Type: Article

References (79)

1. The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in human cells
2. Serum cardiac troponin T and creatine kinase-MB elevations in murine autoimmune myocarditis
3. Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-KB pathway in limb-girdle muscular dystrophy type 2A
4. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage
5. Cytopathogenic effect in cardiac myocytes but not in cardiac fibroblasts is correlated with reovirus-induced myocarditis
6. Molecular aspects of myocarditis
7. Calpain contributes to silica-induced IKB-degradation and nuclear factor κB activation
8. Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: Modulation by calcium-regulated proteases and protein kinases
9. Enteroviral infection of mice with severe combined immunodeficiency. Evidence for direct viral pathogenesis of myocardial injury
10. Caspases: The executioners of apoptosis
11. Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria
12. Expression of apoptosis-related proteins in experimental coxsackie myocarditis
13. Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors
14. The expression of Fas ligand by macrophages and its upregulation by human immunodeficiency virus infection
15. The rotavirus enterotoxin NSP4 mobilizes calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-triphosphate production
16. Effect of glycine on prelethal and postlethal increases in calpain activity in rat renal proximal tubules
17. Wild isolates of murine cytomegalovirus induce myocarditis and antibodies that cross-react with virus and cardiac myosin
18. Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis
19. Herpes simplex virus 1 blocks caspase-3-independent and caspase-dependent pathways to cell death
20. Roles of the humeral response in coxsackievirus B-induced disease
21. Poliovirus induces apoptosis in the mouse central nervous system
22. Induction of apoptosis in cord blood lymphocytes by HHV-6
23. Does HIV cause depletion of CD4+ T cells in viva by the induction of apoptosis?
24. Increased severity of viral myocarditis in mice lacking lymphocyte maturation
25. From myocarditis to cardiomyopathy: Mechanisms of inflammation and cell death: Learning from the past for the future
26. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
27. Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis
28. Regulation of apoptosis in the immune system
29. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis
30. Viral myocarditis: Balance between viral infection and immune response
31. Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak
32. Protease activation during apoptosis: Death by a thousand cuts?
33. Cytokines in myocarditis and cardiomyopathies
34. Involvement of a p53-dependent pathway in rubella virus-induced apoptosis
35. Calpain and calpastatin
36. Non-erythroid α-spectrin breakdown by calpain and interleukin 1 B-converting-enzyme-like protease(s) in apoptotic cells: Contributory roles of both protease families in neuronal apoptosis
37. Immunolocalization of cytoplamic and myelin mCalpain in transfected Schwann cells. I. Effect of treatment with growth factors
38. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis
39. Apoptosis and the cytopathic effects of reovirus
40. Viruses and apoptosis
41. The role of proteases during apoptosis
42. Apoptosis as a mechanism of peripheral blood mononuclear cell death after measles and varicella-zoster virus infections in children
43. Cleavage of the calpain inhibitor, calpastatin, during apoptosis
44. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2
45. Autoimmunity in myocarditis: Models and mechanisms
46. The pathogenesis of postinfectious myocarditis
47. Implication of calpain in caspase activation during B cell clonal deletion
48. Calpain inhibitor AK295 attenuates motor and cognitive deficits following experimental brain injury in the rat
49. Site-directed activation of calpain is promoted by a membrane-associated natural activator protein
50. Influenza virus neuraminidase activates latent transforming growth factor beta
51. Roles of T cells in coxsackie-B induced disease
52. Expression of cytokine mRNA's in murine hearts with acute myocarditis caused by coxsackievirus b3
53. Expression of costimulatory molecule CD40 in murine heart with acute myocarditis and reduction of inflammation by treatment with anti-CD40L/B7-1 monoclonal antibodies
54. Viruses and apoptosis
55. Pathogenesis of reovirus myocarditis
56. Multiple viral core proteins are determinants of reovirus-induced acute myocarditis
57. Reovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes
58. Derivation and characterization of an efficiently myocarditic reovirus variant
59. Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins
60. Lymphocytes protect against and are not required for reovirus-induced myocarditis
61. Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver
62. Proteases, proteolysis, and apoptosis
63. Structure and physiological function of calpains
64. Calpain and calpastatin regulate neutrophil apoptosis
65. Calpain, an upstream regulator of thymocyte apoptosis
66. Evidence that the epidermal growth factor receptor on host cells confers reovirus infection efficiency
67. Regulation of apoptosis by viral gene products
68. Human papillomavirus (HPV) E6 inter-actions with Bak are conserved amongst E6 proteins from high and low risk HPV types
69. Differences in the capacity of reovirus strains to induce apoptosis are determined by viral attachment protein σ1
70. Measles virus infection induces terminal differentiation of haman thymic epithelial cells
71. Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis
72. Calpain inhibition: An overview of its therapeutic potential
73. Specific cleavage of transcription factors by the thiol protease, m-calpain
74. Developmental and genetic regulation of programmed neuronal death
75. Bax cleavage is mediated by calpain during drug-induced apoptosis
76. Caspase-dependent activation of calpain during drug-induced apoptosis
77. Viral myocarditis: Identification of five differentially expressed genes in coxsackievirus B3-infected mouse heart
78. Life and death in the cardiovascular system
79. Involvement of cellular proteolytic machinery in apoptosis