Impaired NK cell development in an IFN-γ transgenic mouse: Aberrantly expressed IFN-γ enhances hematopoietic stem cell apoptosis and affects NK cell differentiation

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1746-1752

  Shimozato, Osamu ^a   Ortaldo, John R ^a   Komschlies, Kristin L ^a   Young, Howard A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOPOIETIC GROWTH FACTOR; PROTEIN TYROSINE KINASE; STEM CELL FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; IMMUNE SYSTEM; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0037083590     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1746     Document Type: Article

References (45)

1. Natural killer cell differentiation insights from knockout and transgenic mouse models and in vitro systems
2. Lineage commitment and differentiation of T and natural killer lymphocytes in the fetal mouse
3. Development and tolerance of natural killer cells
4. Transplantable NK cell progenitors in murine bone marrow
5. neg population of mouse bone marrow
6. Stem cell factor enhances interleukin-2-mediated expansion of murine natural killer cells in vivo
7. - cells from multipotent murine bone marrow progenitors in a stroma-free culture: Definition of cytokine requirements and developmental intermediates
8. + multipotent marrow progenitor cells
9. + human natural killer cell progenitor that responds to interleukin-15
10. Capacity of human large granular lymphocytes to produce multiple cytokines: IL-2, 1FN, and colony-stimulating factor
11. 1L-2-mediated immune IFN-γ production by human T cells and T cell subsets
12. Functional identity between murine interferon and macrophage activating factor
13. Antiproliferative effect of 1FN-γ in immune regulation. I. 1FN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
14. Recombinant 1FN-γ increases HLA-DR synthesis and expression
15. IFN-γ stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide
16. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b, and IgG3 antibody subclasses in vivo
17. Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon γ in the epidermis
18. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ
19. Chronic active hepatitis in transgenic mice expressing interferon-γ in the liver
20. γ interferon expression disrupts lens and retinal differentiation in transgenic mouse
21. Bone marrow and thymus expression of interferon-γ results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies
22. IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response
23. Regulation of local host-mediated antitumor mechanisms by cytokines
24. + cells in murine bone marrow does not express CD19 and contains natural killer cell progenitor
25. Lymphokine-activated killer (LAK) cells. IV. Characterization of murine LAK effector subpopulations
26. Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium
27. The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus
28. Stem cell factor enhances interleukin-2-mediated expansion of murine natural killer cells in vivo
29. d anemia mice
30. The receptor tyrosine kinase c-kit provides a critical signal for expansion and maturation of mouse natural killer cells
31. Glucocorticoid-induced thymoeyte apoptosis is associated with endogenous endonuclease activity
32. Relative contribution of CD2 and LFA-1 to murine T and NK cell functions
33. CD27-mediated activation of murine NK cells
34. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ
35. Interferon-γ overcomes glucocorticoid suppression of cachectin/tumor necrosis factor biosynthesis by murine macrophage
36. + natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production
37. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and NK cells
38. Target disruption of flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
39. Flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors
40. Combined signaling through interleukin-7 receptors and flt3 but not c-kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells
41. Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7
42. Expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement
43. Interferon-γ arrests prolifer and causes apoptosis in stromal cell/interleukin-7-dependent normal murine pre-B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin-positive B cells
44. Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressor of cytokine signaling-1 transgenic mice
45. Socs1 binds to multiple signaling proteins and suppresses steel factor-dependent proliferation