Stem cell factor enhances interleukin-2-mediated expansion of murine natural killer cells in vivo

Blood

Volumn 90, Issue 9, 1997, Pages 3647-3653

  Fehniger, Todd A ^a   Carson, William E ^a   Mrózek, Ewa ^a   Caligiuri, Michael A ^a,b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN;

EID: 0030781918     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.9.3647     Document Type: Article

References (43)

1. Robertson MJ, Ritz J: Biology and clinical relevance of human natural killer cells. Blood 76:2421, 1990
2. Trinchieri G: Biology of natural killer cells. Adv Immunol 47:187, 1989
3. Bancroft GJ: The role of natural killer cells in innate resistance to infection. Curr Opin Immunol 5:503, 1993
4. Biron CA, Gazzinelli RT: Effects of IL-12 on immune responses to microbial infections: A key mediator in regulating disease outcome. Curr Opin Immunol 7:485, 1995
5. + cells. J Immunol 136:3124, 1986
6. Tanaka T, Tsudo M, Karasuyama H, Kitamura F, Kono T, Hatakeyama M, Taniguchi T, Miyasaka M: A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J Immunol 147:2222, 1991
7. Voss SD, Sondel PM, Robb RJ: Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: Association of the p64 1L-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R. J Exp Med 176:531, 1992
8. Caligiuri MA, Zmuidzinas A, Manley TJ, Levine H, Smith KA, Ritz J: Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. J Exp Med 171:1509, 1990
9. Piguet PF, Grau G, Irle C. Vassalli P: Administration of recombinant interleukin 2 to mice enhances production of hemopoietic and natural killer cells. Eur J Immunol 16:1257, 1986
10. Bernstein ZP, Porter MM, Gould M, Lipman B, Bluman EM, Stewart CC, Hewitt RG, Fyfe G, Poiesz B, Caligiuri MA: Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity. Blood 86:3287, 1995
11. Meropol NJ, Porter M, Blumenson LE, Lindemann MJ, P, PR, Vaickus L, Loewen GM, Creaven PJ, Wilkes KA, Giedlin MA, Caligiuri MA: Daily subcutaneous injection of low-dose interleukin 2 expands natural killer cells in vivo without significant toxicity. Clin Cancer Res 2:669, 1996
12. Lotzova E, Savary CA: Human natural killer cell development from bone marrow progenitors: Analysis of phenotype, cytotoxicity and growth. Nat Immunity 12:209, 1993
13. - bone marrow progenitors. J Immunol 150:5263, 1993
14. - primitive progenitors in long-term bone marrow culture. Blood 80:2182, 1992
15. + NK progenitor. Blood 83:2594, 1994
16. Silva MR, Hoffman R, Srour EF, Ascensao JL: Generation of human natural killer cells from immature progenitors does not require marrow stromal cells. Blood 84:841, 1994
17. + hematopoictic progenitor cells. Blood 85:3538, 1995
18. Toksoz D, Zsebo KM, Smith KA, Hu S, Brankow D, Suggs SV, Martin FH, Williams DA: Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc Natl Acad Sci USA 89:7350, 1992
19. + non-MHC-restricted cytotoxic effectors from human hematopoietic precursors: Requirement for c-kit ligand and interleukin 2. Proc Am Soc Clin Oncol 13:294, 1994 (abstr)
20. Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A: Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6:3341, 1987
21. Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A: The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335:88, 1988
22. Geissler EN, Ryan MA, Housman DE: The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55:185, 1988
23. Ashman LK, Cambareri L, Bik To L, Levinsky RJ, Juttner CA: Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. Blood 78:30, 1991
24. Williams DE, Eisenman J, Baird A, Rauch C, Van Ness K, March CJ, Park LS, Martin U, Mochizuki DY, Boswell HS, Burgess GS, Cosman D, Lyman SD: Identification of a ligand for the c-kit proto-oncogene. Cell 63:167, 1990
25. Zsebo KM, Wypych J, McNiece IK, Lu HS, Smith KA, Karkare SB, Sachdev RK, Yuschenkoff VN, Birkett NC, Williams LR, Satyagal VN, Tung W, Bosselman RA, Mediaz EA, Langley KE: Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium. Cell 63:195, 1990
26. Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, Besmer P: The hematopoietic growth factor KL is encoded by the S1 locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63:225, 1990
27. de Vries P, Brasel KA, Eisenman JR. Alpert AR, Williams DE: The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells. J Exp Med 173:1205, 1991
28. McNiece IK, Langley KE, Zsebo KM: Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages. Exp Hematol 19:226, 1991
29. Avraham H, Vannier E, Cowley S, Jiang SX, Chi S, Dinarello CA, Zsebo KM, Groopman JE: Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells. Blood 79:365, 1992
30. + hematopoietic progenitor cells. Blood 87:2632, 1996
31. Andrews RG, Briddell RA, Knitter GH, Opie T, Bronsden M, Myerson D, Appelbaum FR, McNiece IK: In vivo synergy between recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in baboons enhanced circulation of progenitor cells. Blood 84:800, 1994
32. Andrews RG, Briddell RA, Knitter GH, Rowley SD, Appelbaum FR, McNiece IK: Rapid engraftment by peripheral blood progenitor cells mobilized by recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in nonhuman primates. Blood 85:15, 1995
33. Bodine DM, Seidel NE, Orlic D: Bone marrow collected 14 days after in vivo administration of granulocyte colony-stimulating factor and stem cell factor to mice has 10-fold more repopulating ability than untreated bone marrow. Blood 88:89, 1996
34. de Haan G, Donte B, Engel C, Loeffler M, Nijhof W: Prophylactic pretreatment of mice with hematopoietic growth factors induces expansion of primitive cell compartments and results in protection against 5-fluorouracil-induced toxicity. Blood 87:4581, 1996
35. Molineux G, Migdalska A, Szmitkowski M, Zsebo K, Dexter TM: The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor. Blood 78:961, 1991
36. Matos ME, Schnier GS, Beecher MS, Ashman LK, William DE, Caligiuri MA: Expression of a functional c-kit receptor on a subset of natural killer cells. J Exp Med 178:1079, 1993
37. Carson WE, Haldar S, Baiocchi RA, Croce CM, Caligiuri MA: The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2. Proc Natl Acad Sci USA 91:7553, 1994
38. Smith KA: Interleukin-2: Inception, impact, and implications. Science 240:1169, 1988
39. Tripp CS, Wolf SF, Unanue ER: Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 90:3725, 1993
40. Wu H, Klingmuller U, Besmer P, Lodish HF: Interaction of the erythropoietin and stem-cell-factor receptors. Nature 377:242, 1995
41. Mantel C, Luo ZM, Canfield J, Braun S, Deng CX, Broxmeyer HE: Involvement of p21 (cip-1) and p27(kip-1) in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21(cip-1) in the maintenance of stem/progenitor cells in vivo. Blood 88:3710, 1996
42. Puzanov IJ, Bennett M, Kumar V: IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells. J Immunol 157:4282, 1996
43. Aiba Y, Hirayama F, Ogawa M: Clonal proliferation and cytokine requirement of murine progenitors for natural killer (NK) cells. Blood 89:4005, 1997