Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system

Oncogene

Volumn 21, Issue 52, 2002, Pages 7991-8000

  Kirch, Hans Christoph ^a   Ruschen, Sabine ^a   Brockmann, Dieter ^a   Esche, Helmut ^a   Horikawa, Izumi ^b   Barrett, J Carl ^b   Opalka, Bertram ^a   Hengge, Ulrich R ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

E1A; Histone deacetylase; hTERT promoter; Tumor suppressor; Tumor specific expression

Indexed keywords

HISTONE DEACETYLASE; HOMOSERINE ACETYLTRANSFERASE; MUTANT PROTEIN; PROTEIN P300; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; E BOX ELEMENT; ENZYME ACTIVITY; ENZYME REPRESSION; FIBROBLAST; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION SYSTEM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; ONCOGENE; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TUMOR CELL;

ADENOVIRUS E1A PROTEINS; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HISTONE DEACETYLASES; HUMANS; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); SEQUENCE DELETION; TELOMERASE; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE;

EID: 0037079227     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205965     Document Type: Article

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