Substituted pentacyclic carbazolones as novel muscarinic allosteric agents: Synthesis and structure - Affinity and cooperativity relationships

Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2002, Pages 1259-1274

  Gharagozloo, Parviz ^a   Lazareno, Sebastian ^a   Miyauchi, Masao ^a,b   Popham, Angela ^a   Birdsall, Nigel J M ^c  

^a Centre for Therapeutics Discovery   (United Kingdom)

^b DAIICHI SANKYO CO   (Japan)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 7,8,10,11,12,13 HEXAHYDRO 6H DIPYRIDO[3,4 C:1',2',3' LM]CARBAZOL 6 ONE; 1 METHOXY 7,8,10,11,12,13 HEXAHYDRO 6H DIPYRIDO[3,4 C:1',2',3' LM]CARBAZOL 6 ONE; 8,8 DIMETHYL 2,3 DIMETHOXY 7,8,10,11,12,13 HEXAHYDRO 6H DIPYRIDO[4,3 C:1',2',3' LM]CARBAZOL 6 ONE; 9 ACETOXYMETHYL 2,3 DIMETHOXY 7,8,10,11,12,13 HEXAHYDRO 6H DIPYRIDO[3,4 C:1',2',3' LM]CARBAZOL 6 ONE; ACETYLCHOLINE; CARBAZOLE DERIVATIVE; LIGAND; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; NITROGEN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL REACTION; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG SYNTHESIS; MOLECULAR INTERACTION; MOLECULAR WEIGHT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; ALLOSTERIC REGULATION; ANIMALS; BINDING, COMPETITIVE; CARBAZOLES; CHO CELLS; CRICETINAE; HUMANS; KETONES; LEAST-SQUARES ANALYSIS; MUSCARINIC ANTAGONISTS; N-METHYLSCOPOLAMINE; NONLINEAR DYNAMICS; POLYCYCLIC COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037075830     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010946z     Document Type: Article

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