Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M2-receptor allosterically

Journal of Medicinal Chemistry

Volumn 43, Issue 11, 2000, Pages 2155-2164

  Botero Cid, Hector M ^a   Tränkle, Christian ^b   Baumann, Knut ^a   Pick, Rainer ^a   Mies Klomfass, Elisabeth ^b   Kostenis, Evi ^b   Mohr, Klaus ^b   Holzgrabe, Ulrike ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 HEXAMETHYLENEBIS[DIMETHYL(3 PHTHALIMIDOPROPYL)AMMONIUM BROMIDE]; AMMONIUM DERIVATIVE; CARBONYL DERIVATIVE; HEXANE; HYDROGEN; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; PHTHALIMIDE DERIVATIVE;

ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; DISSOCIATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SWINE;

ALLOSTERIC REGULATION; ANIMALS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUSCARINIC ANTAGONISTS; MYOCARDIUM; PHTHALIMIDES; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0000025733     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991136e     Document Type: Article

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