Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: Search for the minimum essential distances between the pharmacophoric elements

Journal of Medicinal Chemistry

Volumn 42, Issue 5, 1999, Pages 849-858

  Nassif Makki, Tamer ^a   Tränkle, Christian ^a   Zlotos, Darius ^a   Bejeuhr, Gesine ^a   Cambareri, Antonella ^a   Pfletschinger, Claudia ^a   Kostenis, Evi ^a   Mohr, Klaus ^a   Holzgrabe, Ulrike ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,6 HEXAMETHYLENEBIS[DIMETHYL(3 PHTHALIMIDOPROPYL)AMMONIUM BROMIDE]; ALCURONIUM; CURARE DERIVATIVE; GALLAMINE; LIGAND; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; OXIME;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL BOND; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; ANIMALS; HYDROLYSIS; KINETICS; LIGANDS; MODELS, MOLECULAR; MYOCARDIUM; PHTHALIMIDES; PYRIDINES; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0344507513     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981023f     Document Type: Article

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