Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C domain

Journal of Biological Chemistry

Volumn 277, Issue 50, 2002, Pages 48696-48707

  Kai, Heidi S T ^a   Butler, Georgina S ^a   Morrison, Charlotte J ^a   King, Angela E ^a   Pelman, Gayle R ^a   Overall, Christopher M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; ENZYMES; MUTAGENESIS; SPECTROSCOPIC ANALYSIS; SUBSTITUTION REACTIONS; TISSUE;

BINDING STABILITY;

BIOCHEMISTRY;

AMINO ACID; ASPARTIC ACID; CONCANAVALIN A; GLUTAMIC ACID; HEMOPEXIN; HYBRID PROTEIN; MYOGLOBIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

ACIDITY; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELLS, CULTURED; CLONING, MOLECULAR; DNA PRIMERS; ENZYME ACTIVATION; HEMOPEXIN; HUMANS; MATRIX METALLOPROTEINASE 2; MOLECULAR SEQUENCE DATA; MYOGLOBIN; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 0037073703     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209177200     Document Type: Article

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