Proteases in invasion: Matrix metalloproteinases

Seminars in Cancer Biology

Volumn 11, Issue 2, 2001, Pages 143-152

  Stetler Stevenson, William G ^a   Yu, Anita E ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Angiogenesis; Cancer; Cellular invasion; Matrix metalloproteinases

Indexed keywords

MATRIX METALLOPROTEINASE;

ANGIOGENESIS; CANCER GROWTH; CANCER INVASION; CELL INVASION; CELL PROLIFERATION; CYTOKINE RELEASE; EXTRACELLULAR MATRIX; NONHUMAN; PROTEIN FAMILY; REVIEW;

EID: 0035000670     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0365     Document Type: Article

References (55)

1. The hallmarks of cancer
2. Matrix metalloproteinases and metastasis
3. Cancer invasion and tissue remodeling - Cooperation of protease systems and cell types
4. Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus waterhouse)
5. Preferential digestion of basement membrane collagen by an enzyme derived form a metastatic murine tumor
6. Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas
7. ECM and cell surface proteolysis: Regulating cellular ecology
8. Cell biology - A cellular striptease act
9. Tumor cell interactions with the extracellular matrix during invasion and metastasis
10. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
11. Matrix metalloproteinases
12. Membrane-type matrix metalloproteinases
13. Proteolysis and cell migration: Creating a path?
14. Matrix metalloproteinases: Biologic activity and clinical implications
15. Matrix metalloproteinases in angiogenesis: A moving target for therapeutic intervention
16. Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells
17. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
18. Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro
19. Tumor cell invasion inhibited by TIMP-2
20. Over-expression of tissue inhibitor of matrix metalloproteinases (timp1 and timp2) suppresses extravasation of pulmonary metastasis of a rat bladder-carcinoma
21. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis
22. The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter
23. Steps in tumor metastasis: New concepts from intravital videomicroscopy
24. Blockade of RAGE-amphoterin signalling suppresses turnout growth and metastases
25. Intertinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
26. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
27. Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases
28. Transgenic TIMP-1 inhibits simian virus 40 T antigen-induced hepatocarcinogenesis by impairment of hepatocellular proliferation and tumor angiogenesis
29. Mechanism-based target identification and drug discovery in cancer research
30. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1
31. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells
32. Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)
33. Tyrosine phosphorylation is crucial for growth signaling by tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2)
34. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
35. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stomelysin, collagenase, plasmin, and heparanases
36. Cell migration: A physically integrated molecular process
37. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
38. Actin-base cell motility and cell locomotion
39. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
40. Selective regulation of integrin - Cytoskeleton interactions by the tyrosine kinase Src Process
41. Cell migration: Regulation of force on extracellular-matrix-integrin complexes
42. Extracellular matrix rigidity causes strengthening of integrin - Cytoskeleton linkages
43. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
44. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
45. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
46. Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules
47. Matrix metalloproteinases generate angiostatin: Effects on neovascularization
48. Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)
49. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma
50. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
51. Clinical studies with matrix metalloproteinase inhibitors
52. Tumor targeting with a selective gelatinase inhibitor
53. Matrilysin-specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model
54. Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system
55. Studies on the contribution of c-fos/AP-1 to arthritic joint destruction