Identification of the tissue inhibitor of metalloproteinases-2 (TIMP-2) binding site on the hemopexin carboxyl domain of human gelatinase A by site- directed mutagenesis: The hierarchical role in binding TIMP-2 of the unique cationic clusters of hemopexin modules III and IV

Journal of Biological Chemistry

Volumn 274, Issue 7, 1999, Pages 4421-4429

  Overall, Christopher M ^a   King, Angela E ^a   Sam, Douglas K ^a   Ong, Aldrich D ^a   Lau, Tim T Y ^a   Wallon, U Margaretha ^a   DeClerck, Yves A ^b   Atherstone, Juliet ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CATION; GELATINASE A; HEMOPEXIN; LYSINE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

AFFINITY CHROMATOGRAPHY; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; GELATINASES; HEMOPEXIN; HUMANS; MATRIX METALLOPROTEINASE 2; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

ANIMALIA;

EID: 0033548069     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.7.4421     Document Type: Article

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