Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc

British Journal of Cancer

Volumn 87, Issue 6, 2002, Pages 645-653

  Roccato, E ^a   Miranda, C ^a   Ranzi, V ^a   Gishizki, M ^b   Pierotti, M A ^a   Greco, A ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b SUGEN   (United States)

Author keywords

NTRKI; Shc; Signal transduction; Transforming activity; TRK T3

Indexed keywords

ADAPTOR PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; META TYROSINE; NERVE GROWTH FACTOR RECEPTOR; ONCOPROTEIN; PROTEIN SHC; PROTEIN TRK T3; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CELL STRAIN 3T3; CELL TRANSFORMATION; CELL VIABILITY; CHIMERA; CHROMOSOME TRANSLOCATION; GENE FUNCTION; NONHUMAN; ONCOGENE; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0037048328     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600544     Document Type: Article

References (36)

1. Ashcroft M, Stephens RM, Hallberg B, Downward J, Kaplan DR (1999) The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth. Oncogene 18: 4586-4597
2. Boney CM, Gruppuso PA, Faris RA, Frackelton Jr AR (2000) The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadispocytes. Mol Endocrinol 14: 805-813
3. Bongarzone I, Pierotti MA, Monzini N, Mondellini P, Manenti G, Donghi R, Pilotti S, Grieco M, Santoro M, Fusco A, Vecchio G, Della Porta G (1989) High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma. Oncogene 4: 1457-1462
4. Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti MG, Pelicci PG, Pierotti MA (1994) The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Oncogene 9: 1661-1668
5. Canu N, Possenti R, Rinaldi AM, Trani E, Levi A (1997) Molecular cloning and characterization of the human VGF promoter region. J Neurochem 68: 1390-1399
6. Dikic I, Batzer AG, Blaikie P, Obermeier A, Ullrich A, Schlessinger J, Margolis B (1995) Shc binding to Nerve Growth Factor receptor is mediated by the phosphotyrosine interaction domain. J Biol Chem 270: 15125-15129
7. Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP (1999) Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling. Oncogene 18: 507-514
8. Gotoh N, Tojo A, Shibuya M (1996) A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3. EMBO J 15: 6197-6204
9. Gotoh N, Toyoda M, Shibuya M (1997) Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation. Mol Cell Biol 17: 1824-1831
10. Greco A, Fusetti L, Miranda C, Villa R, Zanotti S, Pagliardini S, Pierotti MA (1998) Role of the TFG N-terminus and coiled-coil domain in the transforming activity of the thyroid TRK-T3 oncogene. Oncogene 16: 809-816
11. Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA (1995) The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol 15: 6118-6127
12. Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH, Neel BG (2000) New role for shc activation of the phosphatidynositol 3-kinase/akt pathway. Mol Cell Biol 20: 7109-7120
13. Kaplan DR, Miller FD (1997) Signal transduction by the neurotrophin receptors. Curr Opin Cell Biol 9: 213-221
14. Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J (1997) A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89: 693-702
15. Li K, Shao R, Hung MC (1999) Collagen-homology domain 1 deletion mutant of Shc suppresses transformation mediated by neu through a MAPK-independent pathway. Oncogene 18: 2617-2626
16. MacDonald JIS, Gryz EA, Kubu CJ, Verdi JM, Meakin SO (2000) Direct binding of the signaling adapter protein grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, trkA. J Biol Chem 275: 18225-18235
17. Meakin SO, MacDonald JIS, Gryz EA, Kubu CJ, Verdi JM (1999) The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J Biol Chem 274: 9861-9870
18. Mencinger M, Aman P (1999) Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun 257: 67-73
19. Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P (1997) Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma. Genomics 41: 372-331
20. Mercalli E, Ghizzoni S, Arighi E, Alberti L, Sangregorio R, Radice MT, Gishizky ML, Pierotti MA, Borrello MG (2001) Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein. Oncogene 20: 3475-3485
21. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG (1999) The p66shc adaptor protein controls oxidative stess response and life span in mammals. Nature 402: 309-313
22. Migliaccio E, Mele S, Salcini AE, Pelicci G, Lai KM, Superti-Furga G, Pawson T, Di Fiore PP, Lanfrancone L, Pelicci PG (1997) Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J 16: 706-716
23. Miranda C, Greco A, Miele C, Pierotti MA, Van Obberghen E (2001) IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1. J Cell Physiol 186: 35-46
24. Muragaki Y, Chou TT, Kaplan DR, Trojanowski JQ, Lee VM (1997) Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors. J Neurosci 17: 530-542
25. Obermeier A, Lammers R, Wiesmuller KH, Jung G, Schlessinger J, Ullrich A (1993) Identification of Trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signaling complex. J Biol Chem 268: 22963-22966
26. Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, Lax I (2000) FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol 20: 979-989
27. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Pawson T, Pelicci PG (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93-104
28. Pierotti MA, Bongarzone I, Borrello MC, Greco A, Pilotti S, Sozzi G (1996) Cytogenetics and molecular genetics of the carcinomas arising from the thyroid epithelial follicular cells. Genes Chrom Cancer 16: 1-14
29. Possenti R, Di Rocco G, Nasi S, Levi A (1992) Regulatory elements in the promoter region of vgf, a nerve growth factor-inducible gene. Proc Natl Acad Sci USA 89: 3815-3819
30. Qian X, Riccio A, Zhang Y, Ginty DD (1998) Identification and characterization of novel substrates of Trk receptors in developing neurons. Neuron 21: 1017-1029
31. Rabin SJ, Cleghon V, Kaplan DR (1993) SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell Biol 13: 2203-2213
32. Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA, Kaplan DR (1994) Trk receptors use redundant signal transduction pathways involving SHC and PLC-gammal to mediate NGF responses. Neuron 12: 691-705
33. Stevenson LE, Ravichandran KS, Frackelton AR Jr (1999) Shc dominant negative disrupts cell cycle progression in both G0-G1 and G2-M of ErbB2-positive breast cancer cells. Cell Growth Diff 10: 61-71
34. Thomas D, Bradshaw RA (1997) Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cells. Identification of a new Grb2.Sos1 binding site. J Biol Chem 272: 22293-22299
35. Ulrich E, Duwel A, Kauffmann-Zeh A, Gilbert C, Lyon D, Rudkin B, Evan G, Martin-Zanca D (1998) Specific TrkA survival signals interfere with different apoptotic pathways. Oncogene 16: 825-832
36. Van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D, Shoelson S, Pawson T (1995) A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides. Curr Biol 5: 404-412