Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells

Genes Chromosomes and Cancer

Volumn 16, Issue 1, 1996, Pages 1-14

  Pierotti, Marco A ^a   Bongarzone, Italia ^a   Borrello, Maria Grazia ^a   Greco, Angela ^a   Pilotti, Silvana ^a   Sozzi, Gabriella ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DIFFERENTIATION; CHROMOSOME 1; CHROMOSOME 10; DIFFERENTIAL DIAGNOSIS; EPITHELIUM CELL; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR GENETICS; PRIORITY JOURNAL; REVIEW; THYROID TUMOR;

CARCINOMA, PAPILLARY; CHROMOSOME ABERRATIONS; DROSOPHILA PROTEINS; HUMANS; KARYOTYPING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; THYROID NEOPLASMS;

EID: 0029939832     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199605)16:1<1::AID-GCC1>3.0.CO;2-4     Document Type: Review

References (105)

1. Asai N, Iwashita T, Matsuyama M, Takahashi M (1995) Mechanism of activation of the Ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 15:1613-1619.
2. Avantaggiato V, Dathan NA, Grieco M, Fabien N, Lazzaro D, Fusco A, Simeone A, Santoro M (1994) Developmental expression of the RET protooncogene. Cell Growth Differ 5:305-311.
3. Barbacid M (1993) Nerve growth factor: A tale of two receptors. Oncogene 8:2033-2042.
4. Barbacid M, Lamballe F, Pulido D, Klein R (1991) The trk family of tyrosine protein kinase receptors. Biochim Biophys Acta 1072: 115-127.
5. Bondesan L, Bengtsson A, Bondesan A-G, Dalhenfors R, Grimelius L, Wedell B, Mark J (1989) Chromosome studies in thyroid neoplasia. Cancer 64:680-685.
6. Bongarzone I, Pierotti MA, Monzini N, Mondellini P, Manenti G, Donghi R, Pilotti S, Grieco M, Santoro M, Fusco A, Vecchio G, Della Porta G (1989) High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma. Oncogene 4:1457-1462.
7. Bongarzone I, Monzini N, Borrello MG, Carcano C, Ferraresi G, Arighi E, Mondellini P, Della Porta G, Pierotti MA (1993) Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RIa of cyclic AMP-dependent protein kinase A. Mol Cell Biol 13:358-366.
8. Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA (1994) Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Res 54:2979-2985.
9. Borrello MG, Bongarzone I, Pierotti MA, Luksch R, Gasparini M, Collini P, Pilotti S, Rizzetti MG, Mondellini P, De Bernardi B, Di Martino D, Garaventa A, Brisigotti M, Tonini GP (1993) trk and ret proto-oncogene expression in human neuroblastoma specimens: High frequency of trk expression in non-advanced stages, Int J Cancer 54:540-545.
10. Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti MG, Pelicci PG, Pierotti MA (1994) The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Oncogene 9:1661-1668.
11. Borrello MG, Smith DP, Pasini B, Bongarzone I, Greco A, Lorenzo MJ, Arighi E, Miranda C, Eng C, Alberti L, Bocciardi R, Mondellini P, Scopsi L, Romeo G, Ponder BAJ, Pierotti MA (1995) RET activation by germline MEN2A and MEN2B mutations. Oncogene 11:2419-2427.
12. Bottaro DP, Rubin SJ, Faletto DL, Chan AM-L, Kmiecik TE, Vande Woude GF, Aaronson SA (1991) Identification of the hepatocyte growth factor receptors as the c-met proto-oncogene product. Science 251:802.
13. Bunone G, Borrello MG, Picetti R, Bongarzone I, Peverali FA, de Franciscis V, Della Valle G, Pierotti MA (1995) Induction of RET proto-oncogene expression in neuroblastoma cells precedes neuronal differentiation and is not mediated by protein synthesis. Exp Cell Res 217:92-99.
14. Butti MG, Bongarzone I, Ferraresi G, Mondellini P, Borrello MG, Pierotti MA (1995) A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. Genomics 28:15-24.
15. Carlson KM, Dou S, Chi D, Scavarda NJ, Toshima K, Jackson CE, Wells SAJ, Goodfellow P, Donis-Keller H (1994) Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. Proc Natl Acad Sci USA 91:1579-1583.
16. Di Renzo M, Olivero M, Ferro S, Prat M, Bongarzone I, Pilotti S, Belfiore A, Costantino A, Vigneri R, Pierotti MA, Comoglio PM (1992) Overexpression of the c-met/HGF receptor gene in human thyroid carcinomas. Oncogene 7:2549-2553.
17. Donghi R, Sozzi G, Pierotti MA, Biunno I, Miozzo M, Fusco A, Grieco M, Santoro M, Vecchio G, Spurr NK, Della Porta G (1989) The oncogene associated with human papillary thyroid carcinoma (PTC) is assigned to chromosome 10q11-q12 in the same region as multiple endocrine neoplasia type 2A (MEN2A). Oncogene 4:521-523.
18. Donghi R, Longoni A, Pilotti S, Michieli P, Della Porta G, Pierotti MA (1993) Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland. J Clin Invest 91:1753-1760.
19. Donis-Keller H, Dou S, Chi D, Carlson KM, Toshima K, Lairmore TC, Howe JR, Moley JF, Goodfellow P, Wells SAJ (1993) Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Genet 2:851-856.
20. Durick K, Yao VJ, Borrello MG, Bongarzone I, Pierotti MA, Taylor SS (1995) Mitogenic activity of RET/ptc2 is due to dimerization via the type 1 regulatory subunit of protein kinase A. J Biol Chem 270:24642-24645.
21. Edery P, Lyonnet S, Mulligan LM, Pelet A, Dow E, Abel L, Holder S, Nihoul-Feketé C, Ponder BAJ, Munnich A (1994) Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature 367:378-380.
22. Eng C, Smith DP, Mulligan LM, Nagai MA, Healey CS, Ponder MA, Gardner E, Scheumann GFW, Jackson CE, Tunnacliffe A, Ponder BAJ (1994) Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours. Hum Mol Genet 3:237-241.
23. Fabien N, Paulin C, Santoro M, Berger N, Grieco M, Galvain D, Barbier Y, Dubois PM, Fusco A (1992) Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation. Br J Cancer 66:1094-1098.
24. Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang SH, Koeffier HP (1993) High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest 91:179-184.
25. Fugazzola L, Pilotti S, Pinchera A, Vorontsova TV, Mondellini P, Bongarzone I, Greco A, Astakhova L, Butti MG, Demidchik EP, Pacini F, Pierotti MA (1995) Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to Chernobyl nuclear accident. Cancer Res 55: 5617-5620.
26. Fusco A, Grieco M, Santoro M, Berlingieri MT, Pilotti S, Pierotti MA, Della Porta G, Vecchio G (1987) A new oncogene in human papillary thyroid carcinomas and their lymph-nodal metastases. Nature 328:170-172.
27. Greco A, Pierotti MA, Bongarzone I, Pagliardini S, Lanzi C, Della Porta G (1992) TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene 7:237-242.
28. Greco A, Mariani C, Miranda C, Pagliardini S, Pierotti MA (1993) Characterization of the NTRK1 genomic region involved in chromosomal rearrangements generating TRK oncogenes. Genomics 18:397-400.
29. Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA (1995) The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Mol Cell Biol 15: 6118-6127.
30. Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878.
31. Grieco M, Santoro M, Berlingieri MT, Melillo RM, Donghi R, Bongarzone I, Pierotti MA, Della Porta G, Fusco A, Vecchio G (1990) PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60:557-563.
32. Grieco M, Cerrato A, Santoro M, Fusco A, Melillo RM, Vecchio G (1994) Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo. Oncogene 9:2531-2535.
33. Harris CC, Hollstein M (1993) Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 329:1318-1327.
34. Hedinger C, Williams ED, Sobin LH (1988) Histological Typing of Thyroid Tumours. WHO 2nd Ed. Berlin: Springer-Verlag.
35. Herrmann MA, Hay ID, Bartelt DH, Ritland SR, Dhal RJ, Grant CS, Jenkins RB (1991) Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers. J Clin Invest 88:1596-1604.
36. Hockenbery D, Nuñez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336.
37. Hofstra RM, Landsvater RM, Ceccherini I, Stulp RP, Stelwagen T, Luo Y, Pasini B, Hoppener JWM, Ploos van Hemstel HK, Romeo G, Lips CJM, Buys CHCM (1994) A mutation in the RET protooncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 367:375-376.
38. Hollstein M, Sidransky H, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49-53.
39. Ishizaka Y, Itoh F, Tahira T, Ikeda I, Sugimura T, Tucker J, Fertitta A, Carrano AV, Nagao M (1989) Human ret proto-oncogene mapped to chromosome 10q11.2. Oncogene 4:1519-1521.
40. Ito T, Seyama T, Mizuno T, Tsuyama N, Hayashi T, Hayashi Y, Dohi K, Nakamura N, Akiyama M (1992) Unique association of p53 mutations with undifferentiated but not with differentiated thyroid carcinomas of thyroid gland. Cancer Res 53:1369-1371.
41. Ito T, Seyama T, Iwamoto KS, Hayashi T, Mizuno T, Tsuyama N, Dohi K, Nakamura N, Akiyama M (1993) In vitro irradiation is able to cause RET oncogene rearrangement. Cancer Res 53: 2940-2943.
42. Ito T, Seyama T, Iwamoto KS, Mizuno T, Tronko ND, Komissarenko IV, Cherstovoy ED, Satow Y, Takeichi N, Dohi K, Akiyama M (1994) Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident. Lancet 344:259.
43. Iwamoto T, Takahashi M, Ito M, Hamaguchi M, Isobe K-I, Misawa N, Asai J-P, Yoshida T, Nakashima I (1990) Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice. Oncogene 5:535-542.
44. Iwamoto T, Takashashi M, Ito M, Hamatani K, Ohbayashi M, Wajjwalku Isobe K, Nakashima I (1991) Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J 10:3167-3175.
45. Jenkins RB, Hay ID, Berath JF, Schultz CG, Spurbeck JL, Grant CS, Goellner JR, Dewald GW (1990) Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma. Cancer 66:1213-1220.
46. Jhiang SM, Mazzaferri EL (1994) The ret/PTC oncogene in papillary thyroid carcinoma. J Lab Clin Med 123:331-337.
47. Karga H, Lee J, Vickery AL, Thor A, Gaz RD, Jameson L (1991) Ras oncogene mutations in benign and malignant thyroid neoplasms. J Clin Endocr Metab 73:832-836.
48. Lemoine NR, Mayall SE, Wyllie FS, Farr CJ, Hughes D, Padua AR, Thurston V, Williams ED, Wynford-Thomas D (1988) Activated ras oncogenes in human thyroid cancers. Cancer Res 48: 4459-4463.
49. Lemoine NR, Mayall ES, Wyllie FS, Williams ED, Goyns M, Stringer B, Wynford-Thomas D (1989) High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis. Oncogene 4:159-164.
50. Lyons J, Landis CA, Harsh G, Vallar L, Grunewald K, Feichtinger H (1990) Two G protein oncogenes in human endocrine tumors. Science 249:655-659.
51. Manenti G, Pilotti S, Re FC, Della Porta G, Pierotti MA (1994) Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas. Eur J Cancer 30A:987-993.
52. Martin-Zanca D, Hughes SH, Barbacid M (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319:743-748.
53. Martin-Zanca D, Barbacid M, Parada LF (1990) Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev 4:683-694.
54. Minoletti F, Butti MG, Coronelli S, Miozzo M, Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I (1994) The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2. Genes Chromosom Cancer 11:51-57.
55. Miozzo M, Pierotti MA, Sozzi G, Radice P, Bongarzone I, Spurr NK, Della Porta G (1990) Human TRK proto-oncogene maps to chromosome 1q32-q41. Oncogene 5:1411-1414.
56. Miranda C, Minoletti F, Greco A, Sozzi G, Pierotti MA (1994) Refined localization of the human TPR gene to chromosome 1q25 by in situ hybridization. Genomics 23:714-715.
57. Morris CM, Hao QL, Heisterkamp N, Fitzgerald PH, Groffen J (1991) Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24. Oncogene 6:1093-1095.
58. Mulligan LM, Kwok JBJ, Healey CS, Elsdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papl L, Ponder MA, Telenlus H, Tunnacliffe A, Ponder BAJ (1993) Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363:458-460.
59. Nagakawara A, Arima M, Azar CG, Scavarda NJ, Brodeur GM (1992) Inverse relationship between trk expression and N-myc amplification in human neuroblastomas. Cancer Res 52:1364-1368.
60. Nakamura T, Yana I, Kobayashi T, Shin E, Karakawa K, Fujita S, Miya A, Mori T, Nishisho I, Takai S (1992) p53 gene mutations associated with anaplastic transformation of human thyroid carcinomas. Jpn J Cancer Res 83:1293-1298.
61. Nakamura T, Ishizaka Y, Nagao M, Hara M, Ishikawa T (1994) Expression of the RET proto-oncogene product in human normal and neoplastic tissues of neural crest origin. J Pathol 172:255-260.
62. Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, Comoglio PM (1991) Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-met. Oncogene 6:501-504.
63. Namba H, Rubin S, Fagin JA (1990) Point mutations of ras oncogenes are an early event in thyroid tumorigenesis. Mol Endocrinol 4:1474-1479.
64. Pachnis V, Mankoo B, Costantini F (1993) Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119: 1005-1017.
65. Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude GF (1987) Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci USA 84:6379-6383.
66. Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, et al. (1993) Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365:654.
67. Pasini B, Borrello MG, Greco A, Bongarzone I, Luo Y, Mondellini P, Alberti L, Miranda C, Arighi E, Bocciardi R, Seri M, Barone V, Romeo G, Pierotti MA (1995) Loss of function effect of RET mutations causing Hirschsprung disease. Nat Genet 10:35-40.
68. Pierotti MA, Santoro M, Jenkins RB, Sozzi G, Bongarzone I, Grieco M, Monzini N, Miozzo M, Herrmann MA, Fusco A, Hay ID, Della Porta G, Vecchio G (1992) Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and ret and creating the oncogenic sequence ret/ptc. Proc Natl Acad Sci USA 89:1616-1620.
69. Pierotti MA, Arighi E, Bongarzone I, Borrello MG, Butti MG, Greco A, Mariani C, Miozzo M, Miranda C, Sozzi G (1993) RET/ptc and TRK oncogenes in papillary thyroid carcinoma. In Heilmeyer LMG (ed): Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling. New York: NATO ASI Series, pp 87-98.
70. Pilotti S, Collini P, Del Bo R, Cattoretti G, Pierotti MA, Rilke F (1994a) A novel panel of antibodies segregates immunocytochemically poorly differentiated carcinoma from undifferentiated carcinoma of the thyroid gland. Am J Surg Pathol 18:1054-1064.
71. Pilotti S, Collini P, Rilke F, Cattoretti G, Del Bo R, Pierotti MA (1994b) bcl-2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland. J Pathol 172:337-342.
72. Pilotti S, Manenti G, De Gregorio L, Rilke F, Chiarle R, Pierotti MA (1995) Identification of the same HRAS1 in a primary minimally invasive follicular carcinoma on the thyroid gland and its bone metastasis developed 15 years later (letter to the editor). Diagn Mol Pathol 4:73-74.
73. Porcellini A, Ciullo I, Laviola L, Amabile G, Fenzi G, Avvedimento VE (1994) Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. J Clin Endocr Metab 79:657-661.
74. Rabbitts TH (1994) Chromosomal translocations in human cancer. Nature 372:143-149.
75. Radice P, Sozzi G, Miozzo M, De Benedetti V, Cariani T, Bongarzone I, Spurr NK, Pierotti MA, Della Porta G (1991) The human tropomyosin gene involved in the generation of the trk oncogene maps to chromosome 1q31. Oncogene 6:2145-2148.
76. Romeo G, Ronchetto P, Luo Y, Barone V, Seri M, Ceccherini I, Pasini B, Bocciardi R, Lerone M, Kaariainen H, Martucciello G (1994) Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature 367:377-378.
77. Roque L, Catedo S, Gomes P, Soares P, Clode A, Soares J (1993) Cytogenetic findings in 18 follicular thyroid adenomas. Cancer Genet Cytogenet 67:1-6.
78. Santoro M, Rosati R, Grieco M, Berlinieri MT, Colucci-D'Amato GL, de Franciscis V, Fusco A (1990) The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas. Oncogene 5:1595-1598.
79. Santoro M, Carlomagno F, Hay ID, Herrmann MA, Grieco M, Melillo R, Pierotti MA, Bongarzone I, Della Porta G, Berger N, Peix JL, Paulin C, Fabien N, Vecchio G, Jenkins RB, Fusco A (1992) Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. J Clin Invest 89:1517-1522.
80. Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (1994) Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene 9:509-516.
81. Santoro M, Carlomagno F, Romano A, Bottaro DP, Dathan NA, Grieco M, Fusco A, Vecchio G, Matoskova B, Kraus MH, Di Fiore PP (1995) Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B. Science 267:381-383.
82. Shi Y, Zou M, Schmidt H, Juhasz F, Stensky V, Robb D, Farid NR (1991) High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area. Cancer Res 51:2690-2693.
83. Smanik PA, Furminger TL, Mazzaferri EL, Jhiang SM (1995) Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma. Hum Mol Genet 4:2313-2318.
84. Smith ML, Chen IT, Zhan Q, O'Connor PM, Fornace AJ (1995) Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. Oncogene 10:1053-1059.
85. Songyang Z, Carraway KL III, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C, Lorenzo MJ, Ponder BAJ, Mayer BJ, Cantley LC (1995) Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature 373:536-539.
86. Sozzi G, Pierotti MA, Miozzo M, Donghi R, Radice P, De Benedetti V, Grieco M, Santoro M, Fusco A, Vecchio G, Mathew CGP, Ponder BAJ, Spurr NK, Della Porta G (1991) Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC. Oncogene 6:339-342.
87. Sozzi G, Bongarzone I, Miozzo M, Cariani CT, Mondellini P, Calderone C, Pilotti S, Pierotti MA, Della Porta G (1992a) Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas. Genes Chromosom Cancer 5:212-218.
88. Sozzi G, Miozzo M, Cariani CT, Bongarzone I, Pilotti S, Pierotti MA, Della Porta G (1992b) A t(2;3)(q12-13;p24-25) in follicular thyroid adenomas. Cancer Genet Cytogenet 63:38-41.
89. Sozzi G, Bongarzone I, Miozzo M, Borrello MG, Butti MG, Pilotti S, Della Porta G, Pierotti MA (1994) A t(10;17) translocation creates the RET/ptc2 chimeric transforming sequence in papillary thyroid carcinoma. Genes Chromosom Cancer 9:244-250.
90. Suarez HG, du Villard JA, Severino M, Caillou B, Schlumberger M, Tubiana M, Parmentier C, Monier R (1990) Presence of mutations in all three ras genes in human thyroid tumors. Oncogene 5:565-570.
91. Suarez HG, du Villard JA, Caillou B, Schlumberger M, Parmentier C, Monier R (1991) gsp mutations in human thyroid tumours. Oncogene 6:677-679.
92. Szeberenyl J, Cai H, Cooper GM (1990) Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol Cell Biol 10:5324-5332.
93. Tahira T, Ishizaka Y, Itoh F, Sugimura T, Nagao M (1990) Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. Oncogene 5:97-102.
94. Tahira T, Ishizaka Y, Itoh F, Sugimura T, Nagao M (1991) Expression of the ret proto-oncogene in human neuroblastoma cell lines and its increase during neuronal differentiation induced by retinoic acid. Oncogenes 6:2333-2338.
95. Takahashi M, Cooper GM (1987) Ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Mol Cell Biol 7:1378-1385.
96. Takahashi M, Ritz J, Cooper GM (1985) Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 42: 581-588.
97. Takahashi M, Buma Y, Hiai H (1989) Isolation of Ret proto-oncogene cDNA with an amino-terminal signal sequence. Oncogene 4:805-806.
98. Teyssier J-R, Liautaud-Roger F, Ferre D, Patey M, Dufer J (1990) Chromosomal changes in thyroid tumors. Relation with DNA content, karyotypic features, and clinical data. Cancer Genet Cytogenet 50:249-263.
99. van den Berg E, van Doormaal JJ, Oosterhuis JW, Jong B, Wiersema J, Vos AM, Dam A, Vermeij B (1991) Chromosomal aberrations in follicular thyroid carcinoma. Case report of a primary tumor and its metastasis. Cancer Genet Cytogenet 54:215-222.
100. Wajjwalku W, Nakamura S, Hasegawa Y, Miyazaki K, Satoh Y, Funahashi H, Matsuyama M, Takahashi M (1992) Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas. Jpn J Cancer Res 83:671-675
101. Wang XW, Yeh H, Schaeffer L, Roy R, Moncollin V, Egly J-M, Wang Z, Friedberg EC, Evans MK, Taffe BG, Bohr VA, Weeda G, Hoeijmakers JHJ, Forrester K, Harris CC (1995) p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet 10:188-195.
102. Williams ED (1979) The aetiology of thyroid tumours. Clin Endocrinol Metab 8:193-207.
103. Williams ED (1993) Radiation-induced thyroid cancer. Histopathology 23:387-389.
104. Williams ED, Doniach I, Bjarnason O, et al. (1977) Thyroid cancer in an iodine rich area. Cancer 39:215-222.
105. Zou M, Shi Y, Farid NR (1994) Low rate of ret proto-oncogene activation (PTC/ret TPC) in papillary thyroid carcinomas from Saudi Arabia. Cancer 73:176-180.