Glycosylphosphatidylinositol anchors of Plasmodium falciparum: Molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis

Journal of Experimental Medicine

Volumn 192, Issue 11, 2000, Pages 1563-1575

  Naik, Ramachandra S ^a   Branch, OraLee H ^b   Woods, Amina S ^c   Vijaykumar, Matam ^a   Perkins, Douglas J ^b,h   Nahlen, Bernard L ^b,e   Lal, Altaf A ^b   Cotter, Robert J ^c   Costello, Catherine E ^f   Ockenhouse, Christian F ^d   Davidson, Eugene A ^a   Gowda, D Channe ^a,g  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^e KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Department of Biochemistry and Molecular Biology ^*  (United States)

^h DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acquired immunity; Antigenicity; Cytokine response; Malaria parasite; Pathogenesis

Indexed keywords

ANTIBODY; CYTOKINE; GLYCOSYLPHOSPHATIDYLINOSITOL; INOSITOL; INOSITOL PHOSPHATE; MYRISTIC ACID; PALMITIC ACID; PHOSPHOETHANOLAMINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNITY; MALARIA; MASS SPECTROMETRY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ADULT; ANIMALS; ANTIBODIES, PROTOZOAN; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CELL LINE; CHILD; CHILD, PRESCHOOL; ERYTHROCYTES; FEMALE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; IMMUNITY, NATURAL; INFANT; MACROPHAGES; MALARIA, FALCIPARUM; MALE; MICE; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034606283     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.11.1563     Document Type: Article

References (45)

1. Malaria vaccines
2. Multi-gene vaccination against malaria: A multistage, multi-immune response approach
3. Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria
4. Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine
5. Host age as a determinant of naturally acquired immunity to Plasmodium falciparum malaria
6. Clinical case definitions for malaria: Clinical malaria associated with very low parasite densities in African infants
7. Anti-merozoite surface protein-1 19 kDa IgG in mother-infant pairs: Subclass analysis with age, exposure, and protection against Plasmodium falciparum malaria
8. A longitudinal investigation of IgG and IgM antibody response to the merozoite surface protein-1 19 kilodalton domain of Plasmodium falciparum in pregnant women and infants: Association with febrile illness, parasitemia, and anemia
9. The structure biosynthesis, and function of glycosylated phosphatidylinositols in the parasite protozoa and higher eukaryotes
10. The structure and biosynthesis of glycosylphosphatidylinositol protein anchors
11. The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness
12. Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1)
13. Identification of two integral membrane proteins of Plasmodium falciparum
14. A second merozoite surface protein (MSP-4) of Plasmodium falciparum that contains an epidermal growth factor-like domain
15. Glycolipid anchorage of Plasmodium falciparum surface antigens
16. Glycolipid anchorage of Plasmodium falciparum surface antigens
17. Developmental stage-specific biosynthesis of glycosylphosphatidylinositol anchors in intraerythrocytic Plasmodium falciparum and its inhibition in a novel manner by mannosamine
18. Glycosylphosphatidylinositol anchors represent the major carbohydrate modification in proteins of intraerythrocytic stage Plasmodium falciparum
19. Glycosylphosphatidyl-inositols synthesized by asexual erythrocytic stages of the malarial parasite, Plasmodium falciparum. Candidates for plasmodial glycosylphosphatidylinositol membrane anchor precursors and pathogenicity factors
20. Structural analysis of the glycosylphosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum
21. The malaria vaccine: Anti-parasite or anti-disease?
22. Amplification of cytoadherence in cerebral malaria: Towards a more rational explanation of disease
23. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria
24. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria
25. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites
26. Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-α-inducing toxin of Plasmodium falciparum: Prospects for the immunotherapy of severe malaria
27. Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction
28. Signal transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: Activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties
29. Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents
30. Synchronization of Plasmodium falciparum erythrocytic stages in culture
31. Implications of mycoplasma contamination in Plasmodium falciparum cultures and methods for its detection and eradication
32. Concentration from continuous culture of erythrocytes infected with trophozoites and schizonts of Plasmodium falciparum
33. The enhanced folic and folinic acid contents of erythrocytes infected with malaria parasites
34. Labeling of membrane glycoproteins of cultivated Plasmodium falciparum
35. Structural characterization of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase by fast atom bombardment mass spectrometry
36. High-pH anionexchange chromatography of glycoprotein-derived carbohydrates
37. Simplified high-sensitivity sequencing of a major histocompatibility complex class I-associated immunoreactive peptide using matrix-assisted laser desorption/ionization mass spectrometry
38. Antibodies against cell surface carbohydrates: Determination of antigen structure
39. Chemical and enzyme analysis of glycosylphosphatidylinositol anchors
40. Longitudinal data analysis for discrete and continuous outcomes
41. Lipids and the malarial parasite
42. Malaria toxins revisited - Reply
43. Soluble products of inflammatory reactions are not induced in children with asymptomatic Plasmodium falciparum infections
44. A monoclonal antibody that recognizes phosphatidylinositol inhibits induction of tumor necrosis factor alpha by different strains of Plasmodium falciparum