The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea

Blood

Volumn 98, Issue 12, 2001, Pages 3489-3491

  Patel, Sheral S ^a,b,c   Mehlotra, Rajeev K ^a,b   Kastens, William ^a,b   Mgone, Charles S ^a,b   Kazura, James W ^a,b   Zimmerman, Peter A ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^c Alzheimer Research Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLYCOPHORIN C;

ARTICLE; BLOOD SMEAR; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ELLIPTOCYTOSIS; ENDEMIC DISEASE; ERYTHROCYTE; ERYTHROCYTE STRUCTURE; EXON; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALARIA; NUCLEOTIDE SEQUENCE; PAPUA NEW GUINEA; PARASITEMIA; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROLOGY;

EID: 0035761478     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.12.3489     Document Type: Article

References (12)

1. Miller LH, Good MF, Milon G. Malaria pathogenesis. Science. 1994;264:1878-1883.
2. Mgone CS, Koki G, Paniu MM, et al. Occurrence of the erythrocyte band 3 (AE1) gene deletion in relation to malaria endemicity in Papua New Guinea. Trans R Soc Trop Med Hyg. 1996;90:228-231.
3. Allen SJ, O'Donnell A, Alexander NDE, et al. Prevention of cerebral malaria in children in Papua New Guinea by Southeast Asian Ovalocytosis band 3. Am J Trop Med Hyg. 1999;60:1056-1060.
4. Booth PB, McLoughlin K. The Gerbich blood group system, especially in Melanesians. Vox Sang. 1972;22:73-84.
5. Colin Y, Le Van Kim C, Tsapis A, et al. Human erythrocyte glycophorin C gene structure and rearrangements in genetic variants. J Biol Chem. 1989;264:3773-3780.
6. High S, Tanner MJA, MacDonald EB, Anstee DJ. Rearrangements of the red-cell membrane glycophorin C (sialoglycoprotein beta) gene. Biochem J. 1989;262:47-54.
7. Serjeantson SW, White BS, Bhatia K, Trent RJ. A 3.5 kb deletion in the glycophorin C gene accounts for the Gerbich-negative blood group in Melanesians. Immunol Cell Biol. 1994;72:23-27.
8. Genton B, Al-Yaman F, Beck HP, et al. The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials, I: malariometric indices and immunity. Ann Trop Med Parasitol. 1995;89:359-376.
9. Sapak P, Sleigh A, Williams G, Peter W, Glnny M, Waranduo M. Measurement of ovalocyte frequency in peripheral blood smears in defining ovalocytosis in Papua New Guinea. Trop Med Int Health 1998;10:809-817.
10. Jarolim P, Palek J, Amato D, et al. Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis. Proc Natl Acad Sci U S A. 1991;88:11022-11026.
11. Serjeantson SW. A selective advantage for the Gerbich-negative phenotype in malarious areas of Papua New Guinea. P N G Med J. 1989;32:5-9.
12. Zimmerman PA, Woolley I, Masinde GL, et al. Emergence of the FY*(null) in a Plasmodium vivax-endemic region of Papua New Guinea. Proc Natl Acad Sci U S A. 1999;96:13973-13977.