Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta

Science

Volumn 272, Issue 5267, 1996, Pages 1502-1504

  Fried, Michal ^a   Duffy, Patrick E ^a  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN 4 SULFATE; SCLEROPROTEIN;

ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNITY; MALARIA; MATERNAL DISEASE; NONHUMAN; PLACENTA; PLASMODIUM FALCIPARUM; PREGNANCY COMPLICATION; PRIORITY JOURNAL;

EID: 0029992826     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5267.1502     Document Type: Article

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19. Women aged 18 and above who were admitted to deliver at the New Nyanza Provincial Hospital, Kisumu, Kenya, were asked to participate in the study. All volunteers signed an informed consent form translated into their native language after receiving a study explanation form and an oral explanation from a nurse in their native language.
20. Uninfected placenta tissue was incubated with 0.1 U of chondroitinase AC for 30 min at 37°C, after which the tissue was rinsed several times with phosphate-buffered saline (PBS), and a binding assay was performed as described in Fig. 2, A and B.
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29. We thank the Kenya Medical Research Institute and D. Gordon for their support, R. Muga and H. Odollo for organizing sample collection, L. Miller and G. Ward for reviewing the manuscript, and R. Rothlein for ICAM-1. Supported in part by the Defense Women's Health Research Program. M.F. is a National Research Council fellow. The views expressed in this report do not necessarily reflect those of the U.S. Department of Defense.