Is there a toxicological advantage for non-hyperbolic kinetics in cytochrome P450 catalysis?. Functional allostery from "distributive catalysis"

Journal of Biological Chemistry

Volumn 277, Issue 36, 2002, Pages 33258-33266

  Atkins, William M ^a   Lu, Weiya Doug ^a   Cook, Daniel L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPUTER SIMULATION; ENZYMES; METABOLISM; PROBABILITY; SUBSTRATES;

ENZYMATIC DETOXIFICATION;

DETOXIFICATION;

CYTOCHROME P450; LIGAND; TOXIN;

ALLOSTERISM; ARTICLE; DETOXIFICATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MICHAELIS CONSTANT; MOLECULAR RECOGNITION; PRIORITY JOURNAL;

ALLOSTERIC SITE; AREA UNDER CURVE; CATALYSIS; CATALYTIC DOMAIN; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN ISOFORMS; TIME FACTORS;

EID: 0037031876     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M204425200     Document Type: Article

References (27)