메뉴 건너뛰기




Volumn 451, Issue 1, 2002, Pages 11-17

Avasimibe and atorvastatin synergistically reduce cholesteryl ester content in THP-1 macrophages

Author keywords

Acyl CoA cholesterol acyltransferase; Atorvastatin; Avasimibe; Cholesteryl ester; Hydroxymethyl glutaryl CoA reductase; Macrophage

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; ATORVASTATIN; AVASIMIBE; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; GERANYLGERANIOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID;

EID: 0037031614     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02152-0     Document Type: Article
Times cited : (21)

References (42)
  • 1
    • 0032562494 scopus 로고    scopus 로고
    • Effect of hypolipidemic drugs on key enzyme activities related to lipid metabolism in normolipidemic rabbits
    • Alegret M., Verd J.C., Diaz C., Hernandez G., Adzet T., Sanchez R.M., Laguna J.C. Effect of hypolipidemic drugs on key enzyme activities related to lipid metabolism in normolipidemic rabbits. Eur. J. Pharmacol. 347:1998;283-291.
    • (1998) Eur. J. Pharmacol. , vol.347 , pp. 283-291
    • Alegret, M.1    Verd, J.C.2    Diaz, C.3    Hernandez, G.4    Adzet, T.5    Sanchez, R.M.6    Laguna, J.C.7
  • 2
    • 0025963002 scopus 로고
    • The human leukemia cell line, THP-1: A multifaceted model for the study of monocyte-macrophage differentiation
    • Auwerx J. The human leukemia cell line, THP-1: a multifaceted model for the study of monocyte-macrophage differentiation. Experientia. 47:1991;22-31.
    • (1991) Experientia , vol.47 , pp. 22-31
    • Auwerx, J.1
  • 3
    • 0033066137 scopus 로고    scopus 로고
    • Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages
    • Azuma Y., Kawasaki T., Ikemoto K., Ohno K., Yamada T., Yamasaki M., Nobuhara Y. Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. Jpn. J. Pharmacol. 79:1999;159-167.
    • (1999) Jpn. J. Pharmacol. , vol.79 , pp. 159-167
    • Azuma, Y.1    Kawasaki, T.2    Ikemoto, K.3    Ohno, K.4    Yamada, T.5    Yamasaki, M.6    Nobuhara, Y.7
  • 4
    • 0005849853 scopus 로고
    • Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts
    • Basu S.K., Goldstein J.L., Anderson G.W., Brown M.S. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 73:1976;3178-3182.
    • (1976) Proc. Natl. Acad. Sci. U. S. A. , vol.73 , pp. 3178-3182
    • Basu, S.K.1    Goldstein, J.L.2    Anderson, G.W.3    Brown, M.S.4
  • 5
    • 0027738796 scopus 로고
    • Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages
    • Bernini F., Didoni G., Bonfadini G., Bellosta S., Fumagalli R. Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. Atherosclerosis. 104:1993;19-26.
    • (1993) Atherosclerosis , vol.104 , pp. 19-26
    • Bernini, F.1    Didoni, G.2    Bonfadini, G.3    Bellosta, S.4    Fumagalli, R.5
  • 6
    • 0029116986 scopus 로고
    • HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages
    • Bernini F., Scurati N., Bonfadini G., Fumagalli R. HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages. Arterioscler. Thromb. Vasc. Biol. 15:1995;1352-1358.
    • (1995) Arterioscler. Thromb. Vasc. Biol. , vol.15 , pp. 1352-1358
    • Bernini, F.1    Scurati, N.2    Bonfadini, G.3    Fumagalli, R.4
  • 7
    • 0026347265 scopus 로고
    • Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation
    • Bocan T.M., Mueller S.B., Uhlendorf P.D., Newton R.S., Krause B.R. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation. Arterioscler. Thromb. 11:1991;1830-1843.
    • (1991) Arterioscler. Thromb. , vol.11 , pp. 1830-1843
    • Bocan, T.M.1    Mueller, S.B.2    Uhlendorf, P.D.3    Newton, R.S.4    Krause, B.R.5
  • 8
    • 0027223535 scopus 로고
    • Inhibition of acyl-CoA cholesterol O-acyltransferase reduces the cholesteryl ester enrichment of atherosclerotic lesions in the Yucatan micropig
    • Bocan T.M., Mueller S.B., Uhlendorf P.D., Brown E.Q., Mazur M.J., Black A.E. Inhibition of acyl-CoA cholesterol O-acyltransferase reduces the cholesteryl ester enrichment of atherosclerotic lesions in the Yucatan micropig. Atherosclerosis. 99:1993;175-186.
    • (1993) Atherosclerosis , vol.99 , pp. 175-186
    • Bocan, T.M.1    Mueller, S.B.2    Uhlendorf, P.D.3    Brown, E.Q.4    Mazur, M.J.5    Black, A.E.6
  • 9
    • 0032126266 scopus 로고    scopus 로고
    • HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit
    • Bocan T.M., Mueller S.B., Brown E.Q., Lee P., Bocan M.J., Rea T., Pape M.E. HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit. Atherosclerosis. 139:1998;21-30.
    • (1998) Atherosclerosis , vol.139 , pp. 21-30
    • Bocan, T.M.1    Mueller, S.B.2    Brown, E.Q.3    Lee, P.4    Bocan, M.J.5    Rea, T.6    Pape, M.E.7
  • 11
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 12
  • 13
  • 14
    • 0031815798 scopus 로고    scopus 로고
    • Differential effects of lovastatin on the trafficking of endogenous and lipoprotein-derived cholesterol in human monocyte-derived macrophages
    • Cignarella A., Brennhausen B., von Eckardstein A., Assmann G., Cullen P. Differential effects of lovastatin on the trafficking of endogenous and lipoprotein-derived cholesterol in human monocyte-derived macrophages. Arterioscler. Thromb. Vasc. Biol. 18:1998;1322-1329.
    • (1998) Arterioscler. Thromb. Vasc. Biol. , vol.18 , pp. 1322-1329
    • Cignarella, A.1    Brennhausen, B.2    Von Eckardstein, A.3    Assmann, G.4    Cullen, P.5
  • 15
    • 0031025656 scopus 로고    scopus 로고
    • Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis
    • Colli S., Eligini S., Lalli M., Camera M., Paoletti R., Tremoli E. Vastatins inhibit tissue factor in cultured human macrophages. A novel mechanism of protection against atherothrombosis. Arterioscler. Thromb. Vasc. Biol. 17:1997;265-272.
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , pp. 265-272
    • Colli, S.1    Eligini, S.2    Lalli, M.3    Camera, M.4    Paoletti, R.5    Tremoli, E.6
  • 17
    • 0033393022 scopus 로고    scopus 로고
    • Low-density lipoprotein-independent effects of statins
    • Davignon J., Laaksonen R. Low-density lipoprotein-independent effects of statins. Curr. Opin. Lipidol. 10:1999;543-559.
    • (1999) Curr. Opin. Lipidol. , vol.10 , pp. 543-559
    • Davignon, J.1    Laaksonen, R.2
  • 18
    • 0034752442 scopus 로고    scopus 로고
    • Update on the role of acyl-CoA:cholesterol acyltransferase inhibitors in atherosclerosis
    • Doshi R., Wu J., Fishelevich R., Rodriguez A. Update on the role of acyl-CoA:cholesterol acyltransferase inhibitors in atherosclerosis. Expert Opin. Ther. Pat. 11:2001;1655-1662.
    • (2001) Expert Opin. Ther. Pat. , vol.11 , pp. 1655-1662
    • Doshi, R.1    Wu, J.2    Fishelevich, R.3    Rodriguez, A.4
  • 20
    • 0028910142 scopus 로고
    • Differential effects of an acyl-coenzyme A:cholesterol acyltransferase inhibitor on HDL-induced cholesterol efflux from rat macrophage foam cells
    • Hakamata H., Miyazaki A., Sakai M., Sakamoto Y.I., Matsuda H., Kihara K., Horiuchi S. Differential effects of an acyl-coenzyme A:cholesterol acyltransferase inhibitor on HDL-induced cholesterol efflux from rat macrophage foam cells. FEBS Lett. 363:1995;29-32.
    • (1995) FEBS Lett. , vol.363 , pp. 29-32
    • Hakamata, H.1    Miyazaki, A.2    Sakai, M.3    Sakamoto, Y.I.4    Matsuda, H.5    Kihara, K.6    Horiuchi, S.7
  • 23
    • 0035116435 scopus 로고    scopus 로고
    • F 12511, a novel ACAT inhibitor, and atorvastatin regulate endogenous hypercholesterolemia in a synergistic manner in New Zealand rabbits fed a casein-enriched diet
    • Junquero D., Bruniquel F., N'Guyen X., Autin J.M., Patoiseau J.F., Degryse A.D., Colpaert F.C., Delhon A. F 12511, a novel ACAT inhibitor, and atorvastatin regulate endogenous hypercholesterolemia in a synergistic manner in New Zealand rabbits fed a casein-enriched diet. Atherosclerosis. 155:2001;131-142.
    • (2001) Atherosclerosis , vol.155 , pp. 131-142
    • Junquero, D.1    Bruniquel, F.2    N'Guyen, X.3    Autin, J.M.4    Patoiseau, J.F.5    Degryse, A.D.6    Colpaert, F.C.7    Delhon, A.8
  • 25
    • 0032870291 scopus 로고    scopus 로고
    • Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmatic cholesteryl ester and transported to the plasma membrane
    • Kellner-Weibel G., Geng Y.J., Rothblat G.H. Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmatic cholesteryl ester and transported to the plasma membrane. Atherosclerosis. 146:1999;309-319.
    • (1999) Atherosclerosis , vol.146 , pp. 309-319
    • Kellner-Weibel, G.1    Geng, Y.J.2    Rothblat, G.H.3
  • 27
    • 0035967492 scopus 로고    scopus 로고
    • Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice
    • Kusunoki J., Hansoty D.K., Aragane K., Fallon J.T., Badimon J.J., Fisher E.A. Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 103:2001;2604-2609.
    • (2001) Circulation , vol.103 , pp. 2604-2609
    • Kusunoki, J.1    Hansoty, D.K.2    Aragane, K.3    Fallon, J.T.4    Badimon, J.J.5    Fisher, E.A.6
  • 28
    • 0030472785 scopus 로고    scopus 로고
    • Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: An acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets
    • Lee H.T., Sliskovic D.R., Picard J.A., Roth B.D., Wierenga W., Hicks J.L., Bousley R.F., Hamelehle K.L., Homan R., Speyer C., Stanfield R.L., Krause B.R. Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J. Med. Chem. 39:1996;5031-5034.
    • (1996) J. Med. Chem. , vol.39 , pp. 5031-5034
    • Lee, H.T.1    Sliskovic, D.R.2    Picard, J.A.3    Roth, B.D.4    Wierenga, W.5    Hicks, J.L.6    Bousley, R.F.7    Hamelehle, K.L.8    Homan, R.9    Speyer, C.10    Stanfield, R.L.11    Krause, B.R.12
  • 29
  • 30
    • 0033534118 scopus 로고    scopus 로고
    • Estrogen and progesterone reduce lipid accumulation in human monocyte-derived macrophages: A sex-specific effect
    • McCrohon J.A., Nakhla S., Jessup W., Stanley K.K., Celermajer D.S. Estrogen and progesterone reduce lipid accumulation in human monocyte-derived macrophages: a sex-specific effect. Circulation. 100:1999;2319-2325.
    • (1999) Circulation , vol.100 , pp. 2319-2325
    • McCrohon, J.A.1    Nakhla, S.2    Jessup, W.3    Stanley, K.K.4    Celermajer, D.S.5
  • 31
    • 0004782175 scopus 로고
    • The isolation and purification of plasma lipoproteins
    • G.L. Mills, P.A. Lane, & P.K. Weech. Amsterdam: Elsevier
    • Mills G.L., Lane P.A., Weech P.K. The isolation and purification of plasma lipoproteins. Mills G.L., Lane P.A., Weech P.K. A Guidebook to Lipoprotein Technique. 1984;25-50 Elsevier, Amsterdam.
    • (1984) A Guidebook to Lipoprotein Technique , pp. 25-50
    • Mills, G.L.1    Lane, P.A.2    Weech, P.K.3
  • 33
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cell growth and survival: Application to proliferation and cytotoxicity assays
    • Mossman T. Rapid colorimetric assay for cell growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mossman, T.1
  • 36
    • 0033523101 scopus 로고    scopus 로고
    • Glycated phosphatidylethanolamine promotes macrophage uptake of low density lipoprotein and accumulation of cholesteryl esters and triacylglycerols
    • Ravandi A., Kuksis A., Shaikh N.A. Glycated phosphatidylethanolamine promotes macrophage uptake of low density lipoprotein and accumulation of cholesteryl esters and triacylglycerols. J. Biol. Chem. 274:1999;16494-16500.
    • (1999) J. Biol. Chem. , vol.274 , pp. 16494-16500
    • Ravandi, A.1    Kuksis, A.2    Shaikh, N.A.3
  • 37
    • 0032868510 scopus 로고    scopus 로고
    • Novel effects of the acyl-coenzyme A:cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages
    • Rodriguez A., Bachorik P.S., Wee S.B. Novel effects of the acyl-coenzyme A:cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages. Arterioscler. Thromb. Vasc. Biol. 19:1999;2199-2206.
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 2199-2206
    • Rodriguez, A.1    Bachorik, P.S.2    Wee, S.B.3
  • 38
    • 0022591979 scopus 로고
    • The pathogenesis of atherosclerosis: An update
    • Ross R. The pathogenesis of atherosclerosis: an update. New Engl. J. Med. 314:1986;488-500.
    • (1986) New Engl. J. Med. , vol.314 , pp. 488-500
    • Ross, R.1
  • 39
    • 0031911857 scopus 로고    scopus 로고
    • ACAT-inhibitors: Evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents
    • Roth B.D. ACAT-inhibitors: evolution from cholesterol-absorption inhibitors to antiatherosclerotic agents. Drug Discov. Today. 3:1998;19-25.
    • (1998) Drug Discov. Today , vol.3 , pp. 19-25
    • Roth, B.D.1
  • 40
    • 0025756150 scopus 로고
    • Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents
    • Sliskovic D.R., White A.D. Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. Trends Pharmacol. Sci. 12:1991;194-199.
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 194-199
    • Sliskovic, D.R.1    White, A.D.2
  • 41
    • 0032796939 scopus 로고    scopus 로고
    • Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits
    • Verd J.C., Peris C., Alegret M., Diaz C., Hernandez G., Vazquez M., Adzet T., Laguna J.C., Sanchez R.M. Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits. Br. J. Pharmacol. 127:1999;1479-1485.
    • (1999) Br. J. Pharmacol. , vol.127 , pp. 1479-1485
    • Verd, J.C.1    Peris, C.2    Alegret, M.3    Diaz, C.4    Hernandez, G.5    Vazquez, M.6    Adzet, T.7    Laguna, J.C.8    Sanchez, R.M.9
  • 42
    • 0028964742 scopus 로고
    • Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol
    • Warner G.J., Stoudt G., Bamberger M., Johnson W.J., Rothblat G.H. Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol. J. Biol. Chem. 270:1995;5772-5778.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5772-5778
    • Warner, G.J.1    Stoudt, G.2    Bamberger, M.3    Johnson, W.J.4    Rothblat, G.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.