메뉴 건너뛰기




Volumn 19, Issue 9, 1999, Pages 2199-2206

Novel effects of the acyl-coenzyme A:cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages

Author keywords

Atherosclerosis; Cholesterol efflux; Foam cells; Human macrophages; Modified lipoproteins

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; ACYL COENZYME A; ADENINE; CELL PROTEIN; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; CHOLESTEROL OLEATE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LACTATE DEHYDROGENASE; STEROL;

EID: 0032868510     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.9.2199     Document Type: Article
Times cited : (39)

References (29)
  • 1
    • 0022591979 scopus 로고
    • The pathogenesis of atherosclerosis: An update
    • Ross R. The pathogenesis of atherosclerosis: an update. N Engl J Med. 1986;314:488-500.
    • (1986) N Engl J Med. , vol.314 , pp. 488-500
    • Ross, R.1
  • 2
    • 0019162068 scopus 로고
    • The cholesteryl ester cycle in macrophage foam cells
    • Brown MS, Ho YK, Goldstein JL. The cholesteryl ester cycle in macrophage foam cells. J Biol Chem. 1980;255:9344-9352.
    • (1980) J Biol Chem. , vol.255 , pp. 9344-9352
    • Brown, M.S.1    Ho, Y.K.2    Goldstein, J.L.3
  • 3
    • 0026077761 scopus 로고
    • Lipoproteins activate acyl-coenzyme A:Cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level
    • Xu X-X, Tabas I. Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level. J Biol Chem. 1991;266: 17040-17048.
    • (1991) J Biol Chem. , vol.266 , pp. 17040-17048
    • Xu, X.-X.1    Tabas, I.2
  • 4
    • 0028326125 scopus 로고
    • ACAT inhibitors as antiatherosclerotic agents: Compounds and mechanisms
    • Matsuda K. ACAT inhibitors as antiatherosclerotic agents: compounds and mechanisms. Med Res Rev. 1994;14:271-305.
    • (1994) Med Res Rev. , vol.14 , pp. 271-305
    • Matsuda, K.1
  • 5
    • 0026347265 scopus 로고
    • Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions
    • Bocan TMA, Mueller SB, Uhlendorf PD, Newton RS, Krause BR. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. Arterioscler Thromb. 1991;11:1830-1843.
    • (1991) Arterioscler Thromb. , vol.11 , pp. 1830-1843
    • Bocan, T.M.A.1    Mueller, S.B.2    Uhlendorf, P.D.3    Newton, R.S.4    Krause, B.R.5
  • 6
    • 0028813538 scopus 로고
    • Effects of HL-004, a novel ACAT inhibitor, on cholesterol accumulation and removal in cultured smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP)
    • Murakami S, Araki H, Otomo S, Nara Y, Yamori Y. Effects of HL-004, a novel ACAT inhibitor, on cholesterol accumulation and removal in cultured smooth muscle cells from stroke-prone spontaneously hypertensive rats (SHRSP). Life Sci. 1995;56:509-520.
    • (1995) Life Sci. , vol.56 , pp. 509-520
    • Murakami, S.1    Araki, H.2    Otomo, S.3    Nara, Y.4    Yamori, Y.5
  • 7
    • 0029044945 scopus 로고
    • Peritoneal macrophages from stroke-prone spontaneously hypertensive rats accumulate more cholesteryl ester than do macrophages from Wistar-Kyoto rats
    • Murakami S, Nara Y, Yamori Y. Peritoneal macrophages from stroke-prone spontaneously hypertensive rats accumulate more cholesteryl ester than do macrophages from Wistar-Kyoto rats. Biochem Biophys Res Commun. 1995;211:547-553.
    • (1995) Biochem Biophys Res Commun. , vol.211 , pp. 547-553
    • Murakami, S.1    Nara, Y.2    Yamori, Y.3
  • 9
    • 0001208808 scopus 로고
    • Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages
    • Fogelman A, Schecter I, Seager J. Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proc Natl Acad Sci U S A. 1980;77:2214-2218.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 2214-2218
    • Fogelman, A.1    Schecter, I.2    Seager, J.3
  • 10
    • 0028071787 scopus 로고
    • Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux
    • Kruth HS, Skarlatos SI, Gaynor PM, Gamble W. Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux. J Biol Chem. 1994;269:24511-24518.
    • (1994) J Biol Chem. , vol.269 , pp. 24511-24518
    • Kruth, H.S.1    Skarlatos, S.I.2    Gaynor, P.M.3    Gamble, W.4
  • 11
    • 0029989388 scopus 로고    scopus 로고
    • Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors
    • Zhang W-Y, Gaynor PM, Kruth HS. Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. J Biol Chem. 1996;271:28641-28645.
    • (1996) J Biol Chem. , vol.271 , pp. 28641-28645
    • Zhang, W.-Y.1    Gaynor, P.M.2    Kruth, H.S.3
  • 12
    • 0029000473 scopus 로고
    • Effect of E5324, a novel inhibitor of acyl-CoA:Cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages
    • Kogushi M, Tanaka H, Kobayashi H, Yamada T, Ohtsuka I, Kimura T, Saito I. Effect of E5324, a novel inhibitor of acyl-CoA:cholesterol acyltransferase, on cholesteryl ester synthesis and accumulation in macrophages. Jpn J Pharmacol. 1995;68:191-199.
    • (1995) Jpn J Pharmacol. , vol.68 , pp. 191-199
    • Kogushi, M.1    Tanaka, H.2    Kobayashi, H.3    Yamada, T.4    Ohtsuka, I.5    Kimura, T.6    Saito, I.7
  • 13
    • 33745026603 scopus 로고
    • Distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
    • Havel RJ, Eder HA, Bragdon JH. Distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345-1353.
    • (1955) J Clin Invest. , vol.34 , pp. 1345-1353
    • Havel, R.J.1    Eder, H.A.2    Bragdon, J.H.3
  • 14
    • 0027997828 scopus 로고
    • Cell density can affect cholesteryl ester accumulation in the human THP-1 macrophage
    • Rodriguez A, Kafonek SD, Georgopoulos A, Bachorik PS. Cell density can affect cholesteryl ester accumulation in the human THP-1 macrophage. J Lipid Res. 1994;35:1909-1917.
    • (1994) J Lipid Res. , vol.35 , pp. 1909-1917
    • Rodriguez, A.1    Kafonek, S.D.2    Georgopoulos, A.3    Bachorik, P.S.4
  • 15
    • 0020790431 scopus 로고
    • Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells
    • Bamberger MJ, Glick JM, Rothblat GH. Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells. J Lipid Res. 1983;24:869-876.
    • (1983) J Lipid Res. , vol.24 , pp. 869-876
    • Bamberger, M.J.1    Glick, J.M.2    Rothblat, G.H.3
  • 16
    • 0042524714 scopus 로고
    • Methods for investigating the essential groups for enzyme activity
    • Frankel-Conrat H. Methods for investigating the essential groups for enzyme activity. Methods Enzymol. 1957;4:247-269.
    • (1957) Methods Enzymol. , vol.4 , pp. 247-269
    • Frankel-Conrat, H.1
  • 17
    • 0025020497 scopus 로고
    • Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells
    • Bernard DW, Rodriguez A, Glick JM, Rothblat GH. Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells. Arteriosclerosis. 1990;10:135-144.
    • (1990) Arteriosclerosis , vol.10 , pp. 135-144
    • Bernard, D.W.1    Rodriguez, A.2    Glick, J.M.3    Rothblat, G.H.4
  • 18
    • 0019162068 scopus 로고
    • The cholesteryl ester cycle in macrophage foam cells
    • Brown MS, Ho YK, Goldstein JL. The cholesteryl ester cycle in macrophage foam cells. J Biol Chem. 1980;255:9344-9352.
    • (1980) J Biol Chem. , vol.255 , pp. 9344-9352
    • Brown, M.S.1    Ho, Y.K.2    Goldstein, J.L.3
  • 19
    • 0016065209 scopus 로고
    • Quantitative analysis of cholesterol in 5 to 20 microliters of plasma
    • Ishikawa TT, MacGee J, Morrison JA, Glueck CJ. Quantitative analysis of cholesterol in 5 to 20 microliters of plasma. J Lipid Res. 1974;15: 286-291.
    • (1974) J Lipid Res. , vol.15 , pp. 286-291
    • Ishikawa, T.T.1    MacGee, J.2    Morrison, J.A.3    Glueck, C.J.4
  • 20
    • 0018178434 scopus 로고
    • A modification of the lowry procedure to simplify protein determination in membrane and lipoprotein samples
    • Markwell MK, Haas SM, Bieber LL, Tolbert NE. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem. 1978;87:206-210.
    • (1978) Anal Biochem. , vol.87 , pp. 206-210
    • Markwell, M.K.1    Haas, S.M.2    Bieber, L.L.3    Tolbert, N.E.4
  • 21
    • 0017682803 scopus 로고
    • Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells
    • Faust JR, Goldstein JL, Brown MS. Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells. J Biol Chem. 1977;252:4861-4871.
    • (1977) J Biol Chem. , vol.252 , pp. 4861-4871
    • Faust, J.R.1    Goldstein, J.L.2    Brown, M.S.3
  • 22
    • 0014867205 scopus 로고
    • Short-term measurement of catabolic rates using iodine-labeled plasma proteins
    • McFarlane AS, Koj A. Short-term measurement of catabolic rates using iodine-labeled plasma proteins. J Clin Invest. 1970;49:1903-1911.
    • (1970) J Clin Invest. , vol.49 , pp. 1903-1911
    • McFarlane, A.S.1    Koj, A.2
  • 23
    • 0020417361 scopus 로고
    • High affinity uptake and degradation of apolipoprotein E-free high density lipoprotein in cultured porcine hepatocytes
    • Bachorik PS, Franklin FA, Virgil DG, Kwiterovich PO. High affinity uptake and degradation of apolipoprotein E-free high density lipoprotein in cultured porcine hepatocytes. Biochemistry. 1982;21:4675-4684.
    • (1982) Biochemistry , vol.21 , pp. 4675-4684
    • Bachorik, P.S.1    Franklin, F.A.2    Virgil, D.G.3    Kwiterovich, P.O.4
  • 24
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem. 1959;37:911-917.
    • (1959) Can J Biochem. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 26
    • 0028964742 scopus 로고
    • Cell toxicity induced by inhibition of acyl coenzyme A:Cholesterol acyltransferase and accumulation of unesterified cholesterol
    • Warner GJ, Stoudt G, Bamberger M, Johnson WJ, Rothblat GH. Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol. J Biol Chem. 1995; 270:5772-5778.
    • (1995) J Biol Chem. , vol.270 , pp. 5772-5778
    • Warner, G.J.1    Stoudt, G.2    Bamberger, M.3    Johnson, W.J.4    Rothblat, G.H.5
  • 27
    • 0028910142 scopus 로고
    • Differential effects of an acyl-coenzyme A:Cholesterol acyltransferase inhibitor on HDL-induced cholesterol efflux from rat macrophage foam cells
    • Hakamata H, Miyazaki A, Sakai M, Sakamoto Y, Matsuo H, Kihara K, Horiuchi S. Differential effects of an acyl-coenzyme A:cholesterol acyltransferase inhibitor on HDL-induced cholesterol efflux from rat macrophage foam cells. FEBS Lett. 1995;363:29-32.
    • (1995) FEBS Lett. , vol.363 , pp. 29-32
    • Hakamata, H.1    Miyazaki, A.2    Sakai, M.3    Sakamoto, Y.4    Matsuo, H.5    Kihara, K.6    Horiuchi, S.7
  • 28
    • 0028101129 scopus 로고
    • The effects of two acylcoenzyme A:Cholesterol acyltransferase (ACAT) inhibitors, cyclandelate and a nonhydrolysable ether analogue, benzy13,3,5-trimethylcyclohexanol on low density lipoprotein metabolism in macrophages and hepatocytes
    • White DA, Heffron F, Knight D, Salter AM. The effects of two acylcoenzyme A:cholesterol acyltransferase (ACAT) inhibitors, cyclandelate and a nonhydrolysable ether analogue, benzy13,3,5-trimethylcyclohexanol on low density lipoprotein metabolism in macrophages and hepatocytes. Biochem Pharmacol. 1994;48:915-922.
    • (1994) Biochem Pharmacol. , vol.48 , pp. 915-922
    • White, D.A.1    Heffron, F.2    Knight, D.3    Salter, A.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.