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Volumn 146, Issue 2, 1999, Pages 309-319

Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane

Author keywords

Cytoplasmic cholesteryl ester; Cytotoxic cholesterol; Foam cell; Hydrolysis; Plasma membrane

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; ACETYL LOW DENSITY LIPOPROTEIN; CHLOROQUINE; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; CHOLESTEROL OXIDASE; CP 113818; DNA FRAGMENT; PHOSPHOLIPID; UNCLASSIFIED DRUG;

EID: 0032870291     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00155-0     Document Type: Article
Times cited : (77)

References (49)
  • 1
    • 0019162068 scopus 로고
    • The cholesteryl ester cycle in macrophage foam cells
    • Brown M.S., Ho Y.K., Goldstein J.L. The cholesteryl ester cycle in macrophage foam cells. J Biol Chem. 266:1980;9344-9352.
    • (1980) J Biol Chem , vol.266 , pp. 9344-9352
    • Brown, M.S.1    Ho, Y.K.2    Goldstein, J.L.3
  • 2
    • 0019297268 scopus 로고
    • The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages
    • Brown M.S., Basu S.K., Falck J.R., Ho Y.K., Goldstein J.L. The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages. J Supramol Struct. 13:1980;67-81.
    • (1980) J Supramol Struct , vol.13 , pp. 67-81
    • Brown, M.S.1    Basu, S.K.2    Falck, J.R.3    Ho, Y.K.4    Goldstein, J.L.5
  • 3
    • 0020972414 scopus 로고
    • Lipoprotein metabolism in the macrophage
    • Brown M.S., Goldstein J.L. Lipoprotein metabolism in the macrophage. Annu Rev Biochem. 52:1983;223-261.
    • (1983) Annu Rev Biochem , vol.52 , pp. 223-261
    • Brown, M.S.1    Goldstein, J.L.2
  • 4
    • 0021844647 scopus 로고
    • Early atherogenesis in white Carneau pigeons. II. Ultrastructural and cytochemical observations
    • Jerome W.G., Lewis J.C. Early atherogenesis in white Carneau pigeons. II. Ultrastructural and cytochemical observations. Am J Pathol. 119:1985;210-222.
    • (1985) Am J Pathol , vol.119 , pp. 210-222
    • Jerome, W.G.1    Lewis, J.C.2
  • 5
    • 0018383570 scopus 로고
    • The subcellular biochemistry of human arterial lesions: I. Biochemical constituents and marker enzymes in diseased and unaffected portions of human aortic specimens
    • Berberian P.A., Fowler S. The subcellular biochemistry of human arterial lesions: I. Biochemical constituents and marker enzymes in diseased and unaffected portions of human aortic specimens. Exp Mol Pathol. 30:1979;27-40.
    • (1979) Exp Mol Pathol , vol.30 , pp. 27-40
    • Berberian, P.A.1    Fowler, S.2
  • 6
    • 0018318694 scopus 로고
    • Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester
    • Shio H., Haley N.J., Fowler S. Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester. Lab Invest. 41:1979;160-167.
    • (1979) Lab Invest , vol.41 , pp. 160-167
    • Shio, H.1    Haley, N.J.2    Fowler, S.3
  • 7
    • 0003032398 scopus 로고
    • Intracellular cholesteryl ester hydrolysis and clearance
    • M. Esfahani, & J.B. Swaney. Caldwell, NJ: Telford
    • Glick J.M. Intracellular cholesteryl ester hydrolysis and clearance. Esfahani M., Swaney J.B. Advances in cholesterol research. 1990;171-200 Telford, Caldwell, NJ.
    • (1990) Advances in Cholesterol Research , pp. 171-200
    • Glick, J.M.1
  • 9
    • 0028964742 scopus 로고
    • Cell toxicity induced by inhibition of acyl coenzyme A cholesterol acyltransferase and accumulation of unesterified cholesterol
    • Warner G.J., Stoudt G., Bamberger M., Johnson W.J., Rothblat G.H. Cell toxicity induced by inhibition of acyl coenzyme A cholesterol acyltransferase and accumulation of unesterified cholesterol. J Biol Chem. 270:1995;5772-5778.
    • (1995) J Biol Chem , vol.270 , pp. 5772-5778
    • Warner, G.J.1    Stoudt, G.2    Bamberger, M.3    Johnson, W.J.4    Rothblat, G.H.5
  • 10
    • 0017085980 scopus 로고
    • Cellular cholesterol ester accumulation induced by free cholesterol-rich lipid dispersions
    • Arbogast L.Y., Rothblat G.H., Leslie M.H., Cooper R.A. Cellular cholesterol ester accumulation induced by free cholesterol-rich lipid dispersions. Proc Natl Acad Sci USA. 73:1976;3680-3684.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3680-3684
    • Arbogast, L.Y.1    Rothblat, G.H.2    Leslie, M.H.3    Cooper, R.A.4
  • 11
    • 0014379086 scopus 로고
    • Practical methods for plasma lipoprotein analysis
    • Hatch F.T., Lees R.S. Practical methods for plasma lipoprotein analysis. Adv Lipid Res. 6:1968;1-68.
    • (1968) Adv Lipid Res , vol.6 , pp. 1-68
    • Hatch, F.T.1    Lees, R.S.2
  • 12
    • 0005849853 scopus 로고
    • Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts
    • Basu S.K., Goldstein J.L., Anderson R.G.W., Brown M.S. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci USA. 73:1976;3178-3182.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3178-3182
    • Basu, S.K.1    Goldstein, J.L.2    Anderson, R.G.W.3    Brown, M.S.4
  • 13
    • 0028153446 scopus 로고
    • Pharmacological properties of a novel ACAT inhibitor (CP-113,818) in cholesterol-fed rats, hamsters, rabbits, and monkeys
    • Marzetta C.A., Savoy Y.E., Freeman A.M., Long C.A., Pettini J.L., Hagar R.E. et al. Pharmacological properties of a novel ACAT inhibitor (CP-113,818) in cholesterol-fed rats, hamsters, rabbits, and monkeys. J Lipid Res. 35:1994;1829-1883.
    • (1994) J Lipid Res , vol.35 , pp. 1829-1883
    • Marzetta, C.A.1    Savoy, Y.E.2    Freeman, A.M.3    Long, C.A.4    Pettini, J.L.5    Hagar, R.E.6
  • 14
    • 0024312609 scopus 로고
    • The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-B-[2-(diethylamino)ethoxy]androst-5-en-17-one
    • Liscum L., Faust J.R. The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-B-[2-(diethylamino)ethoxy]androst-5-en-17-one. J Biol Chem. 264:1989;11796-11806.
    • (1989) J Biol Chem , vol.264 , pp. 11796-11806
    • Liscum, L.1    Faust, J.R.2
  • 15
    • 0028288679 scopus 로고
    • Cholesterol transport from plasma membranes to intracellular membranes is inhibited by 3β-[2-(diethylamino)ethoxy]androst-5-en-17-one
    • Harmala A., Porn M.I., Mattjus P., Slotte J.P. Cholesterol transport from plasma membranes to intracellular membranes is inhibited by 3β-[2-(diethylamino)ethoxy]androst-5-en-17-one. Biochim Biophys Acta. 1211:1994;317-325.
    • (1994) Biochim Biophys Acta , vol.1211 , pp. 317-325
    • Harmala, A.1    Porn, M.I.2    Mattjus, P.3    Slotte, J.P.4
  • 16
    • 0029996993 scopus 로고    scopus 로고
    • Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport
    • Underwood K.W., Andemariam B., McWilliams G.L., Liscum L. Quantitative analysis of hydrophobic amine inhibition of intracellular cholesterol transport. J Lipid Res. 37:1996;1556-1568.
    • (1996) J Lipid Res , vol.37 , pp. 1556-1568
    • Underwood, K.W.1    Andemariam, B.2    McWilliams, G.L.3    Liscum, L.4
  • 19
    • 0031573424 scopus 로고    scopus 로고
    • Effects of sphingomyelin and phosphatidylcholine degradation on cyclodextrin-mediated cholesterol efflux in cultured fibroblasts
    • Ohvo H., Olsio C., Slotte J.P. Effects of sphingomyelin and phosphatidylcholine degradation on cyclodextrin-mediated cholesterol efflux in cultured fibroblasts. Biochim Biophys Acta. 1349:1997;131-141.
    • (1997) Biochim Biophys Acta , vol.1349 , pp. 131-141
    • Ohvo, H.1    Olsio, C.2    Slotte, J.P.3
  • 20
    • 0030048396 scopus 로고    scopus 로고
    • Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-γ, tumor necrosis factor-α, and interleukin-1β
    • Geng Y.J., Wu Q., Muszynski M., Hansson G.K., Libby P. Apoptosis of vascular smooth muscle cells induced by in vitro stimulation with interferon-γ, tumor necrosis factor-α, and interleukin-1β Arterioscler Thromb Vasc Biol. 16:1996;19-27.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 19-27
    • Geng, Y.J.1    Wu, Q.2    Muszynski, M.3    Hansson, G.K.4    Libby, P.5
  • 21
    • 0024419722 scopus 로고
    • Effects of sphingomyelin degradation on cell cholesterol oxidizability and steady-state distribution between the cell surface and the cell interior
    • Slotte J.P., Hedstrom G., Rannstrom S., Ekman S. Effects of sphingomyelin degradation on cell cholesterol oxidizability and steady-state distribution between the cell surface and the cell interior. Biochim Biophys Acta. 985:1989;90-96.
    • (1989) Biochim Biophys Acta , vol.985 , pp. 90-96
    • Slotte, J.P.1    Hedstrom, G.2    Rannstrom, S.3    Ekman, S.4
  • 22
    • 0028125208 scopus 로고
    • Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation
    • Smart E.J., Ying Y.-S., Conrad P.A., Anderson R.G.W. Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation. J Cell Biol. 127:1994;1185-1197.
    • (1994) J Cell Biol , vol.127 , pp. 1185-1197
    • Smart, E.J.1    Ying, Y.-S.2    Conrad, P.A.3    Anderson, R.G.W.4
  • 23
    • 0032512758 scopus 로고    scopus 로고
    • Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane
    • Underwood K.W., Jacobs N.L., Howley A., Liscum L. Evidence for a cholesterol transport pathway from lysosomes to endoplasmic reticulum that is independent of the plasma membrane. J Biol Chem. 273:1998;4266-4274.
    • (1998) J Biol Chem , vol.273 , pp. 4266-4274
    • Underwood, K.W.1    Jacobs, N.L.2    Howley, A.3    Liscum, L.4
  • 24
    • 0026596115 scopus 로고
    • Tracking cell cholesterol with cholesterol oxidase
    • Lange Y. Tracking cell cholesterol with cholesterol oxidase. J Lipid Res. 33:1992;315-321.
    • (1992) J Lipid Res , vol.33 , pp. 315-321
    • Lange, Y.1
  • 25
    • 0029034940 scopus 로고
    • Intracellular cholesterol transport and compartmentation
    • Liscum L., Underwood K.W. Intracellular cholesterol transport and compartmentation. J Biol Chem. 270:1995;15443-15446.
    • (1995) J Biol Chem , vol.270 , pp. 15443-15446
    • Liscum, L.1    Underwood, K.W.2
  • 28
    • 0030857552 scopus 로고    scopus 로고
    • Relation of plaque lipid composition and morphology to the stability of human aortic plaques
    • Felton C.V., Cook D., Davies M.J., Oliver M.F. Relation of plaque lipid composition and morphology to the stability of human aortic plaques. Arterioscler Thromb Vasc Biol. 17:1997;1337-1345.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1337-1345
    • Felton, C.V.1    Cook, D.2    Davies, M.J.3    Oliver, M.F.4
  • 29
    • 0023972981 scopus 로고
    • Progression and regression of atherosclerotic lesions
    • Small D.M. Progression and regression of atherosclerotic lesions. Arteriosclerosis. 8:1988;103-129.
    • (1988) Arteriosclerosis , vol.8 , pp. 103-129
    • Small, D.M.1
  • 30
    • 0023224325 scopus 로고
    • Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions
    • Lupu F., Danaricu I., Simionescu N. Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions. Atherosclerosis. 67:1987;127-142.
    • (1987) Atherosclerosis , vol.67 , pp. 127-142
    • Lupu, F.1    Danaricu, I.2    Simionescu, N.3
  • 31
    • 0029787574 scopus 로고    scopus 로고
    • Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis - Proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis
    • Tabas I., Marathe S., Keesler G.A., Beatini N., Shiratori Y. Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis - proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis. J Biol Chem. 271:1996;22773-22781.
    • (1996) J Biol Chem , vol.271 , pp. 22773-22781
    • Tabas, I.1    Marathe, S.2    Keesler, G.A.3    Beatini, N.4    Shiratori, Y.5
  • 32
    • 0025818295 scopus 로고
    • Cholesterol efflux from arterial wall cells
    • Rothblat G.H., Phillips M.C. Cholesterol efflux from arterial wall cells. Curr Opin Lipidol. 20:1991;288-294.
    • (1991) Curr Opin Lipidol , vol.20 , pp. 288-294
    • Rothblat, G.H.1    Phillips, M.C.2
  • 33
    • 0019730393 scopus 로고
    • Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages
    • Fogelman A.M., Haberland M.E., Seager J., Hokom M., Edwards P.A. Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages. J Lipid Res. 22:1981;1131-1141.
    • (1981) J Lipid Res , vol.22 , pp. 1131-1141
    • Fogelman, A.M.1    Haberland, M.E.2    Seager, J.3    Hokom, M.4    Edwards, P.A.5
  • 34
    • 0009627006 scopus 로고
    • Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition
    • Goldstein J.L., Ho Y.K., Basu S.K., Brown M.S. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA. 76:1979;333-337.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 333-337
    • Goldstein, J.L.1    Ho, Y.K.2    Basu, S.K.3    Brown, M.S.4
  • 35
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science. 232:1986;34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 36
    • 0019130571 scopus 로고
    • Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: Stimulation by high density lipoprotein and other agents
    • Ho Y.K., Brown M.S., Goldstein J.L. Hydrolysis and excretion of cytoplasmic cholesteryl esters by macrophages: stimulation by high density lipoprotein and other agents. J Lipid Res. 21:1980;391-398.
    • (1980) J Lipid Res , vol.21 , pp. 391-398
    • Ho, Y.K.1    Brown, M.S.2    Goldstein, J.L.3
  • 37
    • 0021076445 scopus 로고
    • Analysis of the distribution of cholesterol in the intact cell
    • Lange Y., Ramos B.V. Analysis of the distribution of cholesterol in the intact cell. J Biol Chem. 258:1983;15130-15134.
    • (1983) J Biol Chem , vol.258 , pp. 15130-15134
    • Lange, Y.1    Ramos, B.V.2
  • 38
    • 0030970279 scopus 로고    scopus 로고
    • Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers
    • Fielding C.J., Bist A., Fielding P.E. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc Natl Acad Sci USA. 94:1997;3753-3758.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3753-3758
    • Fielding, C.J.1    Bist, A.2    Fielding, P.E.3
  • 39
    • 0028794049 scopus 로고
    • Plasma membrane caveolae mediate the efflux of cellular free cholesterol
    • Fielding P.E., Fielding C.J. Plasma membrane caveolae mediate the efflux of cellular free cholesterol. Biochemistry. 34:1995;14288-14292.
    • (1995) Biochemistry , vol.34 , pp. 14288-14292
    • Fielding, P.E.1    Fielding, C.J.2
  • 40
    • 0031888035 scopus 로고    scopus 로고
    • Regulation of caveolin and caveolae by cholesterol in MDCK cells
    • Hailstones D., Sleer L.S., Parton R.G., Stanley K.K. Regulation of caveolin and caveolae by cholesterol in MDCK cells. J Lipid Res. 39:1998;369-379.
    • (1998) J Lipid Res , vol.39 , pp. 369-379
    • Hailstones, D.1    Sleer, L.S.2    Parton, R.G.3    Stanley, K.K.4
  • 41
    • 0030774479 scopus 로고    scopus 로고
    • On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: Physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes
    • Ahmed S.N., Brown D.A., London E. On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes. Biochemistry. 36:1997;10944-10953.
    • (1997) Biochemistry , vol.36 , pp. 10944-10953
    • Ahmed, S.N.1    Brown, D.A.2    London, E.3
  • 42
    • 0032527642 scopus 로고    scopus 로고
    • Structure and origin of ordered lipid domains in biological membranes
    • Brown D., London E. Structure and origin of ordered lipid domains in biological membranes. J Membr Biol. 164:1998;103-114.
    • (1998) J Membr Biol , vol.164 , pp. 103-114
    • Brown, D.1    London, E.2
  • 43
    • 0026248941 scopus 로고
    • Biological activities of oxygenated sterols: Physiological and pathological implications
    • Hwang P.L. Biological activities of oxygenated sterols: physiological and pathological implications. BioEssays. 13:1991;583-589.
    • (1991) BioEssays , vol.13 , pp. 583-589
    • Hwang, P.L.1
  • 44
    • 0026690582 scopus 로고
    • Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols
    • Hwang P.L.H. Inhibitors of protein and RNA synthesis block the cytotoxic effects of oxygenated sterols. Biochim Biophys Acta. 1136:1992;5-11.
    • (1992) Biochim Biophys Acta , vol.1136 , pp. 5-11
    • Hwang, P.L.H.1
  • 45
    • 0028909854 scopus 로고
    • Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol
    • Kilsdonk E.P.C., Morel D.W., Johnson W.J., Rothblat G.H. Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol. J Lipid Res. 36:1995;505-516.
    • (1995) J Lipid Res , vol.36 , pp. 505-516
    • Kilsdonk, E.P.C.1    Morel, D.W.2    Johnson, W.J.3    Rothblat, G.H.4
  • 47
    • 0028854617 scopus 로고
    • Translocation of both lysosomal LDL-derived cholesterol and plasma membrane cholesterol to the endoplasmic reticulum for esterification may require common cellular factors involved in cholesterol egress from the acidic compartments (lysosomes/endosomes)
    • Spillane D.M., Reagan J.W. Jr, Kennedy N.J., Schneider D.L., Chang T.-Y. Translocation of both lysosomal LDL-derived cholesterol and plasma membrane cholesterol to the endoplasmic reticulum for esterification may require common cellular factors involved in cholesterol egress from the acidic compartments (lysosomes/endosomes). Biochim Biophys Acta. 1254:1995;283-294.
    • (1995) Biochim Biophys Acta , vol.1254 , pp. 283-294
    • Spillane, D.M.1    Reagan J.W., Jr.2    Kennedy, N.J.3    Schneider, D.L.4    Chang, T.-Y.5
  • 48
    • 0030943621 scopus 로고    scopus 로고
    • Acyl-coenzyme A:cholesterol acyltransferase
    • Chang T.-Y., Chang C.C.Y., Cheng D. Acyl-coenzyme A:cholesterol acyltransferase. Annu Rev Biochem. 66:1997;613-638.
    • (1997) Annu Rev Biochem , vol.66 , pp. 613-638
    • Chang, T.-Y.1    Chang, C.C.Y.2    Cheng, D.3
  • 49
    • 0033046871 scopus 로고    scopus 로고
    • Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes
    • Avart S.J., Bernard D.W., Jerome W.G., Glick J.M. Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes. J Lipid Res. 40:1999;405-414.
    • (1999) J Lipid Res , vol.40 , pp. 405-414
    • Avart, S.J.1    Bernard, D.W.2    Jerome, W.G.3    Glick, J.M.4


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