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Volumn 139, Issue 1, 1998, Pages 21-30

HMG-CoA reductase and ACAT inhibitors act synergistically to lower plasma cholesterol and limit atherosclerotic lesion development in the cholesterol-fed rabbit

Author keywords

ACAT; Atherosclerosis; HMG CoA reductase; Hypercholesterolemia; Rabbit

Indexed keywords

2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; ANTILIPEMIC AGENT; ATORVASTATIN; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA;

EID: 0032126266     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(98)00046-X     Document Type: Article
Times cited : (56)

References (49)
  • 1
    • 0022549920 scopus 로고
    • A receptor mediated pathway for cholesterol homeostasis
    • Brown M.S., Goldstein J.L. A receptor mediated pathway for cholesterol homeostasis. Science. 232:1986;34.
    • (1986) Science , vol.232 , pp. 34
    • Brown, M.S.1    Goldstein, J.L.2
  • 3
    • 0000716338 scopus 로고
    • Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes
    • Bilheimer D.W., Grundy S.M., Brown M.S., Goldstein J.L. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. Proc Natl Acad Sci USA. 80:1983;4124.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 4124
    • Bilheimer, D.W.1    Grundy, S.M.2    Brown, M.S.3    Goldstein, J.L.4
  • 4
    • 0026680805 scopus 로고
    • Effects of lovastatin therapy on very low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins
    • Arad Y., Ramakrishnan R., Ginsberg H.N. Effects of lovastatin therapy on very low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins. Metabolism. 41:1992;487.
    • (1992) Metabolism , vol.41 , pp. 487
    • Arad, Y.1    Ramakrishnan, R.2    Ginsberg, H.N.3
  • 6
    • 0024146936 scopus 로고
    • HMG-CoA reductase inhibitors. Current clinical experience
    • Walker J.F. HMG-CoA reductase inhibitors. Current clinical experience. Drugs. 36:1988;83.
    • (1988) Drugs , vol.36 , pp. 83
    • Walker, J.F.1
  • 7
    • 0025830289 scopus 로고
    • Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolemia
    • McTavish D., Sorkin E.M. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolemia. Drugs. 42:1991;65.
    • (1991) Drugs , vol.42 , pp. 65
    • McTavish, D.1    Sorkin, E.M.2
  • 8
    • 0025077819 scopus 로고
    • Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolemia
    • Todd P.A., Goa K.L. Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolemia. Drugs. 40:1990;583.
    • (1990) Drugs , vol.40 , pp. 583
    • Todd, P.A.1    Goa, K.L.2
  • 9
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Scandinavian Simvastatin Survival Study Group Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet. 344:1994;1383.
    • (1994) Lancet , vol.344 , pp. 1383
    • Scandinavian Simvastatin Survival Study Group1
  • 11
    • 0019781366 scopus 로고
    • Influence of mevinolin on experimental atherosclerosis in rabbits
    • Kritchevsky D., Tepper S.A., Klurfeld D.M. Influence of mevinolin on experimental atherosclerosis in rabbits. Pharmacol Res Commun. 13:1981;921.
    • (1981) Pharmacol Res Commun , vol.13 , pp. 921
    • Kritchevsky, D.1    Tepper, S.A.2    Klurfeld, D.M.3
  • 12
    • 0024597428 scopus 로고
    • Preventive effect of MK-733 (Simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits
    • Kobayaski M., Ishida F., Takahashi T., Kobayashi M., Ishida F., Takahashi T., Taguchi K., Watanabe K., Ohmura I., Kamei T. Preventive effect of MK-733 (Simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits. Jpn J Pharmacol. 49:1989;125.
    • (1989) Jpn J Pharmacol , vol.49 , pp. 125
    • Kobayaski, M.1    Ishida, F.2    Takahashi, T.3    Kobayashi, M.4    Ishida, F.5    Takahashi, T.6    Taguchi, K.7    Watanabe, K.8    Ohmura, I.9    Kamei, T.10
  • 13
    • 0026548516 scopus 로고
    • Effect of lovastatin on suppression and regression of atherosclerosis in lipid-fed rabbits
    • Zhu B.Q., Sievers R.E., Sun Y.P., Isenberg W.M., Parmley W.W. Effect of lovastatin on suppression and regression of atherosclerosis in lipid-fed rabbits. J Cardiovasc Pharmol. 19:1992;246.
    • (1992) J Cardiovasc Pharmol , vol.19 , pp. 246
    • Zhu, B.Q.1    Sievers, R.E.2    Sun, Y.P.3    Isenberg, W.M.4    Parmley, W.W.5
  • 14
    • 0025291781 scopus 로고
    • Suppression of established atherosclerosis and xanthomas in mature WHHL rabbits by keeping their serum cholesterol levels extremely low. Effect of pravastatin sodium in combination with cholestyramine
    • Shiomi M., Ito T., Watanabe Y., Tsujita Y., Kuroda M., Arai M., Fukami M., Fukushige J., Tamura A. Suppression of established atherosclerosis and xanthomas in mature WHHL rabbits by keeping their serum cholesterol levels extremely low. Effect of pravastatin sodium in combination with cholestyramine. Atherosclerosis. 83:1990;69.
    • (1990) Atherosclerosis , vol.83 , pp. 69
    • Shiomi, M.1    Ito, T.2    Watanabe, Y.3    Tsujita, Y.4    Kuroda, M.5    Arai, M.6    Fukami, M.7    Fukushige, J.8    Tamura, A.9
  • 16
    • 0002776685 scopus 로고
    • ACAT inhibitors: Physiologic mechanisms for hypolipidemic and anti-atherosclerotic activities in experimental animals
    • In: Ruffolo RR, Hollinger MA, editors. Boca Raton, FL: CRC Press
    • Krause BR, Bocan TMA. ACAT inhibitors: Physiologic mechanisms for hypolipidemic and anti-atherosclerotic activities in experimental animals. In: Ruffolo RR, Hollinger MA, editors. Inflammation, Mediators, and Pathways. Boca Raton, FL: CRC Press 1995:173.
    • (1995) Inflammation, Mediators, and Pathways , pp. 173
    • Krause, B.R.1    Bocan, T.M.A.2
  • 17
    • 0026347265 scopus 로고
    • Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological and morphometric evaluation
    • Bocan T.M.A., Bak-Mueller S., Uhlendorf P.D., Newton R.S., Krause B.R. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological and morphometric evaluation. Arterioscler Thromb. 11:1991;1830.
    • (1991) Arterioscler Thromb , vol.11 , pp. 1830
    • Bocan, T.M.A.1    Bak-Mueller, S.2    Uhlendorf, P.D.3    Newton, R.S.4    Krause, B.R.5
  • 18
    • 0025976880 scopus 로고
    • Inhibitors of cholesterol biosynthesis. 3. tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus
    • Roth B.D., Blankley C.J., Chucholowski A.W., Ferguson E., Hoefle M.L., Ortwine D.F., Newton R.S., Sekerke C.S., Sliskovic D.R. Inhibitors of cholesterol biosynthesis. 3. tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus. J Med Chem. 34:1991;357.
    • (1991) J Med Chem , vol.34 , pp. 357
    • Roth, B.D.1    Blankley, C.J.2    Chucholowski, A.W.3    Ferguson, E.4    Hoefle, M.L.5    Ortwine, D.F.6    Newton, R.S.7    Sekerke, C.S.8    Sliskovic, D.R.9
  • 19
    • 0026668238 scopus 로고
    • Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents
    • Roth B.D., Blankley C.J., Hoefle M.L., Holmes A., Roark W.H., Trivedi B.K., Essenburg A.D., Kieft K.A., Krause B.R., Stanfield R.L. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem. 35:1992;1609.
    • (1992) J Med Chem , vol.35 , pp. 1609
    • Roth, B.D.1    Blankley, C.J.2    Hoefle, M.L.3    Holmes, A.4    Roark, W.H.5    Trivedi, B.K.6    Essenburg, A.D.7    Kieft, K.A.8    Krause, B.R.9    Stanfield, R.L.10
  • 21
    • 0015847114 scopus 로고
    • Quantitative determination of serum triglycerides by the use of enzymes
    • Bucolo G., David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 19:1973;476.
    • (1973) Clin Chem , vol.19 , pp. 476
    • Bucolo, G.1    David, H.2
  • 22
    • 0025916492 scopus 로고
    • Rapid on-line determination of cholesterol distribution among plasma lipoproteins after high-performance gel filtration chromatography
    • Kieft K.A., Bocan T.M.A., Krause B.R. Rapid on-line determination of cholesterol distribution among plasma lipoproteins after high-performance gel filtration chromatography. J Lipid Res. 32:1991;859.
    • (1991) J Lipid Res , vol.32 , pp. 859
    • Kieft, K.A.1    Bocan, T.M.A.2    Krause, B.R.3
  • 23
    • 0001766690 scopus 로고
    • Cholesterol: enzymatic methods
    • In: Faulkner WR, Meiters S, editors. Washington, DC: American Association of Clinical Chemists
    • Cooper GR. Cholesterol: enzymatic methods. In: Faulkner WR, Meiters S, editors. Selected Methods for the Small Clinical Chemistry Laboratory. Washington, DC: American Association of Clinical Chemists, 1982:165.
    • (1982) Selected Methods for the Small Clinical Chemistry Laboratory , pp. 165
    • Cooper, G.R.1
  • 25
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissue
    • Folch J., Lees M., Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem. 226:1957;497.
    • (1957) J Biol Chem , vol.226 , pp. 497
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 26
    • 0025345669 scopus 로고
    • An improved method for precise quantitation of cellular and tissue apolipoprotein A-I mRNA levels by use of an internal standard
    • Pape M.E., Marotti K.R., Melchior G.W. An improved method for precise quantitation of cellular and tissue apolipoprotein A-I mRNA levels by use of an internal standard. J Lipid Res. 31:1990;727.
    • (1990) J Lipid Res , vol.31 , pp. 727
    • Pape, M.E.1    Marotti, K.R.2    Melchior, G.W.3
  • 27
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156.
    • (1987) Anal Biochem , vol.162 , pp. 156
    • ChoMcZynski, P.1    Sacchi, N.2
  • 28
    • 0027424327 scopus 로고
    • Hepatic expression of genes regulating lipid metabolism in rabbits
    • Rea T.J., DeMattos R.B., Pape M.E. Hepatic expression of genes regulating lipid metabolism in rabbits. J Lipid Res. 34:1993;1901.
    • (1993) J Lipid Res , vol.34 , pp. 1901
    • Rea, T.J.1    Demattos, R.B.2    Pape, M.E.3
  • 29
  • 31
    • 0022965954 scopus 로고
    • Immunocytochemical analysis of cellular components in atherosclerotic lesions. Use of monoclonal antibodies with the Watanabe and fat-fed rabbit
    • Tsukada T., Rosenfeld M., Ross R., Gown A.M. Immunocytochemical analysis of cellular components in atherosclerotic lesions. Use of monoclonal antibodies with the Watanabe and fat-fed rabbit. Arteriosclerosis. 6:1985;601.
    • (1985) Arteriosclerosis , vol.6 , pp. 601
    • Tsukada, T.1    Rosenfeld, M.2    Ross, R.3    Gown, A.M.4
  • 32
    • 0021943984 scopus 로고
    • A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes
    • Gown A.M., Vogel A.M., Gordon D., Lu P.L. A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes. J Cell Biol. 100:1985;807.
    • (1985) J Cell Biol , vol.100 , pp. 807
    • Gown, A.M.1    Vogel, A.M.2    Gordon, D.3    Lu, P.L.4
  • 35
    • 0026567257 scopus 로고
    • Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors
    • Bocan T.M.A., Ferguson E., McNally W., Uhlendorf P.D., Bak Mueller S., Dehart P., Sliskovic D.R., Roth B.D., Krause B.R., Newton R.S. Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: comparison with selected HMG-CoA reductase inhibitors. Biochim Biophys Acta. 1123:1992;133.
    • (1992) Biochim Biophys Acta , vol.1123 , pp. 133
    • Bocan, T.M.A.1    Ferguson, E.2    McNally, W.3    Uhlendorf, P.D.4    Bak Mueller, S.5    Dehart, P.6    Sliskovic, D.R.7    Roth, B.D.8    Krause, B.R.9    Newton, R.S.10
  • 36
    • 0025360699 scopus 로고
    • Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis: Implications for drug discovery
    • Gillies P.J., Robinson C.S., Rathgeb K.A. Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis: implications for drug discovery. Atherosclerosis. 83:1990;177.
    • (1990) Atherosclerosis , vol.83 , pp. 177
    • Gillies, P.J.1    Robinson, C.S.2    Rathgeb, K.A.3
  • 37
    • 0024389833 scopus 로고
    • Inhibition of acyl coenzyme A: Cholesterol acyltransferase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
    • Ishida F., Sata A., Iizuka Y., Kamei T. Inhibition of acyl coenzyme A: cholesterol acyltransferase by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Chem Pharm Bull. 37:1989;1635.
    • (1989) Chem Pharm Bull , vol.37 , pp. 1635
    • Ishida, F.1    Sata, A.2    Iizuka, Y.3    Kamei, T.4
  • 38
    • 0028889942 scopus 로고
    • ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys
    • Carr T.P., Hamilton R.L., Rudel L.L. ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys. J Lipid Res. 36:1995;25.
    • (1995) J Lipid Res , vol.36 , pp. 25
    • Carr, T.P.1    Hamilton, R.L.2    Rudel, L.L.3
  • 39
    • 0027955907 scopus 로고
    • Inhibition of hepatic ACAT decreases Apo B secretion in miniature pigs fed a cholesterol-free diet
    • Huff M.W., Telford D.E., Barrett H.R., Billheimer J.T., Gillies P.J. Inhibition of hepatic ACAT decreases Apo B secretion in miniature pigs fed a cholesterol-free diet. Arterioscl Thromb. 14:1994;1498.
    • (1994) Arterioscl Thromb , vol.14 , pp. 1498
    • Huff, M.W.1    Telford, D.E.2    Barrett, H.R.3    Billheimer, J.T.4    Gillies, P.J.5
  • 40
    • 0027160448 scopus 로고
    • Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes
    • Tanaka M., Jingami H., Otani H., Cho M., Ueda Y., Arai H., Nagano Y., Doi T., Yokode M., Kita T. Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes. J Biol Chem. 268:1993;12713.
    • (1993) J Biol Chem , vol.268 , pp. 12713
    • Tanaka, M.1    Jingami, H.2    Otani, H.3    Cho, M.4    Ueda, Y.5    Arai, H.6    Nagano, Y.7    Doi, T.8    Yokode, M.9    Kita, T.10
  • 42
    • 0027507888 scopus 로고
    • Bile acid synthesis in hamster hepatocytes in primary culture: Sources of cholesterol and comparison with other species
    • Hoang V., Botham K.M., Benson G.M., Eldredge E.E., Jackson B., Pearce N., Suckling K.E. Bile acid synthesis in hamster hepatocytes in primary culture: sources of cholesterol and comparison with other species. Biochim Biophys Acta. 1210:1993;73.
    • (1993) Biochim Biophys Acta , vol.1210 , pp. 73
    • Hoang, V.1    Botham, K.M.2    Benson, G.M.3    Eldredge, E.E.4    Jackson, B.5    Pearce, N.6    Suckling, K.E.7
  • 43
    • 0025942258 scopus 로고
    • Effects of pertubations in hepatic free and esterified cholesterol pools on bile acid synthesis, cholesterol 7α-hydroxylase, HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase
    • Grogan W.M., Bailey M.L., Heuman D.M., Vlahcevic Z.R. Effects of pertubations in hepatic free and esterified cholesterol pools on bile acid synthesis, cholesterol 7α-hydroxylase, HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase. Lipids. 26:1991;907.
    • (1991) Lipids , vol.26 , pp. 907
    • Grogan, W.M.1    Bailey, M.L.2    Heuman, D.M.3    Vlahcevic, Z.R.4
  • 44
    • 0028179080 scopus 로고
    • ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance
    • Krause B.R., Pape M.E., Kieft K., Auerbach B., Bisgaier C.L., Homan R., Newton R.S. ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance. Arterioscl Thromb. 14:1994;598.
    • (1994) Arterioscl Thromb , vol.14 , pp. 598
    • Krause, B.R.1    Pape, M.E.2    Kieft, K.3    Auerbach, B.4    Bisgaier, C.L.5    Homan, R.6    Newton, R.S.7
  • 45
    • 0029817701 scopus 로고    scopus 로고
    • Modulation of intrahepatic cholesterol trafficking: Evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile
    • Puglielli L., Rigotti A., Amigo L., Nunez L., Greco A.V., Santos M.J., Nervi F. Modulation of intrahepatic cholesterol trafficking: evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into rat bile. Biochem J. 317:1996;681.
    • (1996) Biochem J , vol.317 , pp. 681
    • Puglielli, L.1    Rigotti, A.2    Amigo, L.3    Nunez, L.4    Greco, A.V.5    Santos, M.J.6    Nervi, F.7
  • 47
    • 0024380539 scopus 로고
    • Developmental changes in the expression of genes involved in cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers
    • Levin M.S., Pitt A.J.A., Schwartz A.L., Edwards P.A., Gordon J.I. Developmental changes in the expression of genes involved in cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers. Biochim Biophys Acta. 1003:1989;293.
    • (1989) Biochim Biophys Acta , vol.1003 , pp. 293
    • Levin, M.S.1    Pitt, A.J.A.2    Schwartz, A.L.3    Edwards, P.A.4    Gordon, J.I.5
  • 48
    • 0023066504 scopus 로고
    • Cholesterol metabolism and sterol carrier protein-2 (nonspecific lipid transfer protein)
    • Geelan M.J.H., Beynen A.C., Wirtz K.W.A. Cholesterol metabolism and sterol carrier protein-2 (nonspecific lipid transfer protein). J Biochem. 19:1987;619.
    • (1987) J Biochem , vol.19 , pp. 619
    • Geelan, M.J.H.1    Beynen, A.C.2    Wirtz, K.W.A.3
  • 49
    • 0027217640 scopus 로고
    • Regulation of sterol carrier protein-2 gene expression in rat liver and small intestine
    • Baum C.L., Kansal S., Davidson N.O. Regulation of sterol carrier protein-2 gene expression in rat liver and small intestine. J Lipid Res. 34:1993;729.
    • (1993) J Lipid Res , vol.34 , pp. 729
    • Baum, C.L.1    Kansal, S.2    Davidson, N.O.3


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