DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 4, 1996, Pages 199-206

  Sekiguchi, Mutsuo ^a   Nakabeppu, Yusaku ^a   Sakumi, Kunihiko ^a   Tuzuki, Teruhisa ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Alkylation; Cancer; DNA repair; Methyltransferase; Mutation; O6 methylguanine

Indexed keywords

6 O METHYLGUANINE; METHYLTRANSFERASE;

ANIMAL MODEL; CARCINOGENESIS; CONTROLLED STUDY; DNA REPAIR; MOUSE; MUTATION; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; CRICETINAE; DNA REPAIR; DNA, COMPLEMENTARY; HUMANS; METHYLTRANSFERASES; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NEOPLASMS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RABBITS; RATS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0029991162     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01209646     Document Type: Review

References (64)

1. Ayi TC, Loh KC, Ali RB, Li BFL (1992) Intracellular localization of human DNA repair enzyme methylguanine-DNA methyltransferase by antibodies and its importance. Cancer Res 52:6423-6430
2. Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, Elliott EA, Yu J, Ashley T, Arnheim N, Flavell RA, Liskay RM (1995) Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 82:309-319
3. Branch P, Aquilina G, Bignami M, Karren P (1993) Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature 362:652-654
4. 6-methylguanine-DNA methyltransferase. Oncol Res 5:83-86
5. 6-methylguanine-DNA methyltransferase activity: analyses of three residues at or near the methyl acceptor site. Carcinogenesis 13:837-843
6. Coulondre C, Miller JH (1977) Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli. J Mol Biol 117:577-606
7. Day RS III, Ziolkowski CHJ, Scudiero DA, Meyer SA, Mattern MR (1980) Human tumor cell strains defective in the repair of alkylation damage. Carcinogenesis 1:21-32
8. 6-methylguanine-DNA methyltransferase. J Biol Chem 257: 13776-13780
9. Demple B, Sedgwick B, Robins P, Totty N, Waterfield MD, Lindahl T (1985) Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis. Proc Natl Acad Sci USA 82:2688-2692
10. 6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene. Cancer Res 51:3391-3398
11. 6-alkylguanine-DNA alkyltransferase. Science 259:219-222
12. 6-alkylguanine-DNA-alkyltransferase cDNA in human cells and transgenic mice. Nucleic Acids Res 18:5723-5727
13. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis 7:745-749
14. 6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc Natl Acad Sci USA 71:639-643
15. 6-methylguanine-DNA methyltransferase. J Bacteriol 173:3663-3672
16. 6-methylguanine-DNA methyltransferase gene. Nucleic Acids Res 19:6163-6167
17. 6-methylguanine in DNA. J Mol Biol 213:739-747
18. 6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening. Mol Gen Genet 243:379-389
19. Ishibashi T, Nakabeppu Y, Kawate H, Sakumi K, Hayakawa H, Sekiguchi M (1994a) Intracellular localization and function of DNA repair methyltransferase in human cells. Mutat Res 315:199-212
20. Ishibashi T, Nakabeppu Y, Sekiguchi M (1994b) Artificial control of nuclear translocation of DNA repair methyltransferase. J Biol Chem 269:7645-7650
21. Ito T, Nakamura T, Maki H, Sekiguchi M (1994) Roles of transcription and repair in alkylation mutagenesis. Mutat Res 314:273-285
22. Iyama A, Sakumi K, Nakabeppu Y, Sekiguchi M. (1994) A unique structural feature of rabbit DNA repair methyltransferase as revealed by cDNA cloning. Carcinogenesis 15:627-633
23. Jones M, Wagner R (1981) N-Methyl-Ń-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair. Mol Gen Genet 184:562-563
24. 6-methylguanine, DNA strand breaks and cytotoxicity. Carcinogenesis 9:1749-1753
25. 6-methylguanine residues in E. coli DNA. Nature 296:868-869
26. Kat A, Thilly WG, Fang W-H, Logley MJ, Li G-M, Modrich P (1993) An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci USA 90: 6424-6428
27. 4-methylthymine in DNA. Carcinogenesis 16:1595-1602
28. 6-methylguanine from DNA. J Natl Cancer Inst 53:1839-1841
29. - cells. Mutat Res 218:153-163
30. 6-methylguanine-DNA methyltransferase. J Biol Chem 265: 14754-14762
31. 6-alkylguanine-DNA alkyltransferase in human liver and melanoma. Br J Cancer 66:355-360
32. LeMotte PK, Walker GC (1985) Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents. J Bacteriol 161: 888-895
33. 6-alkylguanine-DNA alkyltransferase (ada) gene in transgenic mice. Cancer Res 50:1701-1708
34. Lindahl T, Sedgwick B, Sekiguchi M, Nakabeppu Y (1988) Regulation and expression of the adaptive response to alkylating agents. Annu Rev Biochem 57:133-157
35. Loveless A (1969) Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides. Nature 223:206-207
36. 6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay. Nucleic Acids Res 13:1939-1952
37. 6-methylguanine-DNA methyltransferase activity in transgenic mice containing an integrated E. coli ada repair gene. Mutat Res 218:197-206
38. 6-methylguanine-DNA alkyltransferase. Nucleic Acids Res 17:6531-6543
39. Morohoshi F, Hayashi K, Munakata N (1990) Bacillus subtilis ada operon encodes two DNA alkyltransferases. Nucleic Acids Res 18:5473-5480
40. 6-methylguanine-DNA methyltransferase. J Biol Chem 260:7281-7288
41. 6-methylguanine-DNA methyltransferase. Mutat Res 293: 119-132
42. 6-methylguanine-DNA methyltransferase in transgenic mice introduced with the E. coli ada gene. Mutat Res 254:225-230
43. 6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc Natl Acad Sci USA 90:6468-6472
44. Olsson M, Lindahl T (1980) Repair of alkylated DNA in Escherichia coli. J Biol Chem 255:10569-10571
45. 6-alkylguanine-DNA-alkyltransferase gene of E. coli. Nucleic Acids Res 15:9177-9193
46. 6-alkylguanine-DNA alkyltransferase gene, molecular analysis of expression in rat liver. Carcinogenesis 12: 727-733
47. 6-alkylguanine-DNA alkyltransferase cDNA. Nucleic Acids Res 20:1891-1895
48. 6-methylguanine-DNA methyltransferase. Biochem Biophys Res Commun 177:597-602
49. 6-methylguanine DNA repair methyltransferase. J Bacteriol 173:2068-2076
50. 6-methylguanine-DNA methyltransferase: cDNA expression in Escherichia coli and gene expression in human cells. J Biol Chem 265: 9563-569
51. 6-methylguanine-DNA methyltransferase. Nucleic Acids Res 19:5597-5601
52. Sekiguchi M, Nakabeppu Y (1987) Adaptive response: induced synthesis of DNA repair enzymes by alkylating agents. Trends Genet 3:51-54
53. 6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli. Biochemistry 31:1897-1903
54. 6-methylguanine-DNA methyltransferase. Carcinogenesis 13:289-296
55. 6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. Nature 289:417-420
56. Strauss B, Scudiero D, Henderson E (1975) The nature of the alkylation lesion in mammalian cells. In: Hanawalt PC, Setlow RB (eds) Molecular mechanisms for repair of DNA, Part A, Plenum, New York, pp 13-24
57. Sukumar S, Natario V, Martin-Zanca D, Barbacid M (1983) Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras 1 locus by single point mutations. Nature 306:658-661
58. 6-methylguanine-DNA methyltransferases in DNA repair. Mutat Res 254:37-44
59. 6-alkylguanine. Proc Natl Acad Sci USA 87:686-690
60. 4-methylthymine in dodecadeoxyribonucleotides. Nucleic Acids Res 17:8475-8484
61. Wind N de, Dakker M, Berns A, Radman M, te Riele H (1995) Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82:321-330
62. 4-methylthymine DNA repair methyltransferase gene. EMBO J 10:2179-2186
63. 6-methylguanine in DNA by demethylation is lacking in Mer human tumor cell lines. Carcinogenesis 4:199-205
64. 6-methylguanine-DNA methyltransferases. J Biol Chem 269:730-733