Fluoro-norchloroepibatidine: Preclinical assessment of acute toxicity

Nuclear Medicine and Biology

Volumn 24, Issue 8, 1997, Pages 743-747

  Molina, Patricia E ^a,b   Ding, Yu Shin ^a   Carroll, F Ivy ^c   Liang, F ^c   Volkow, Nora D ^a   Pappas, Naomi ^a   Kuhar, Michael ^d   Abumrad, Naji ^b   Gatley, S John ^a   Fowler, Joanna S ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^c RTI INTERNATIONAL   (United States)

^d EMORY UNIVERSITY   (United States)

Author keywords

Fluoro norchloroepibatidine; Hemodynamics; Nicotinic acetylcholine receptors; Positron emission tomography; Toxicity

Indexed keywords

CATECHOLAMINE; EPIBATIDINE; FLUORINE 18; NICOTINIC RECEPTOR; NORCHLOROEPIBATIDINE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; BABOON; CATECHOLAMINE BLOOD LEVEL; DOSE RESPONSE; DRUG SAFETY; ELECTROCARDIOGRAM; FEMALE; HEMODYNAMIC PARAMETERS; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOOD PRESSURE; CARBON DIOXIDE; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; EPINEPHRINE; FEMALE; FLUORINE RADIOISOTOPES; HEART; HEART RATE; MALE; NOREPINEPHRINE; OXYGEN; PAPIO; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030724888     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(97)00120-0     Document Type: Article

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