Experimental and human ischaemia: Is the penumbra present in human ischaemic stroke?

Folia Neuropathologica

Volumn 40, Issue 4, 2002, Pages 211-217

  Rafałowska, Janina ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Experimental; Human; Ischaemia; Neuroimaging; Penumbra

Indexed keywords

AMINO ACID DERIVATIVE; BIOCHEMICAL MARKER; CALCIUM ION; GLUCOSE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; NEUROPROTECTIVE AGENT; OXYGEN RADICAL; PHOSPHOLIPASE; PROSTAGLANDIN SYNTHASE; PROTEINASE;

BIOENERGY; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN CELL; BRAIN CORTEX; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN NECROSIS; CELL DEATH; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; COMPUTER ASSISTED TOMOGRAPHY; CORRELATION COEFFICIENT; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIFFUSION WEIGHTED IMAGING; DISEASE COURSE; DRUG EFFICACY; EVOKED SOMATOSENSORY RESPONSE; EXPERIMENTAL MODEL; HEART FAILURE; HUMAN; LETHARGY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PERMEABILITY BARRIER; PHYSICIAN; REVIEW;

EID: 0036973002     PISSN: 00283894     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Review

References (60)

1. Albers GA (1999) Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI source. Stroke, 30 (10): 2230-2237.
2. Aronowski J, Cho KH, Strong R, Grotta JC (1999) Neurofilament proteolysis after focal ischemia: When do cells die after experimental stroke? J of Cereb Blood Flow Metabol, 19 (6): 652-660.
3. + at critical levels of brain ischemia. Stroke, 8: 51-57.
4. Astrup J, Siesjo BK, Symon L (1981) Thresholds in cerebral ischemia: The ischemic penumbra. Stroke, 12: 723-725.
5. Back T (1998) Pathophysiology of the ischemic penumbra - Revision of a concept. Cell Mol Neurobiol, 18 (6): 621-638.
6. Barber PA, Davis SM, Darby DG, Desmond PM, Gerraty RP, Yang Q, Jolley D, Donnan GA, Tress BM (1999) Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra. Neurology, 52 (6): 1125-1132.
7. Baron J (1999) Mapping the ischaemic penumbra with PET: Implications for acute stroke treatment. Cerebrovascular Disease, 9 (4): 193-201.
8. Bonavita S, Di Salle F, Tedeschi G (1999) Proton MRS in neurological disorders. Europ J Radiol, 30 (2): 125-131.
9. Carano RA, Li F, Irie K, Helmer KG, Silva MD, Fisher M, Sotak CH (2000) Multispectral analysis of the temporal evolution of cerebral source. J Magnetic Imaging, 12 (6): 842-858.
10. Chen ZL, Strikland S (1997) Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell, 91 (7): 917-925.
11. Chen CJ, Liao SL, Chen WY, Hong JS, Kuo JS (2001) Cerebral ischemia/reperfusion injury in rat brain: Effects of naloxone. NeuroReport, 12 (16): 1245-1249.
12. Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischemic stroke: An integrated view. Trends Neurosci, 22: 391-397.
13. Fujimura M, Gasche Y, Morita-Fujimura Y, Massengale J, Kawase M, Chan PH (1999) Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion. Brain Res, 842 (1): 92-100.
14. Furlan M, Marchal G, Viader F, Derlon JM, Baron JC (1996) Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol, 40 (2): 216-226.
15. Furukawa K, Fu W, Li Y, Witke W, Kwiatkowski DJ, Mattson MP (1997) The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. J Neurosci, 17 (21): 8178-8186.
16. Gashe Y, Fujimura M, Morita-Fujimura Y, Copin JC, Kawase M, Massgale J, Chn PH (1999) Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: A possible role in blood-brain barrier dysfunction. J Cereb Blood Flow Metabol, 19 (9): 1020-1028.
17. Ginsberg MD, Busto R (1998) Combating hyperthermia in acute stroke: A significant clinical concern. Stroke, 29 (2): 529-534
18. Ginsberg MD, Belayev L, Zhao W, Huh PW, Busto R (1999) The acute ischemic penumbra: Topography, life span, and therapeutic response. Acta Neurochir. (suppl.), 73: 45-50.
19. Gursoy-Ozdemir Y, Bolay H, Saribas O, Dalkara T (2000) Role of endothelial nitric oxide generation adn peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke, 31 (8): 1974-1980.
20. Hakim AM (1998) Ischemic penumbra: The therapeutic window. Neurology, 51: (3 Suppl 3) S 44-46.
21. Hata R, Maeda K, Hermann D, Mies G, Hossmann KA (2000) Evolution of brain infarction after transient focal cerebral ischemia in mice. J Cereb. Blood Flow Metabol, 20 (6): 937-946.
22. Hatazawa J, Shimosegawa E, Toyoshima H, Ardekani BA, Suzuki A, Okudera T, Miura Y (1999) Cerebral blood volume in acute brain infarction: A combined study with dynamic susceptibility contrast MRI and 99 mTc-HMPAO-SPECT. Stroke, 30 (4): 800-806.
23. Heiss WD (2000) Ischemic penumbra: Evidence from functional imaging in man. J Cereb Blood Flow Metab, 20 (9): 1276-1293.
24. Heiss WD, Kracht L, Grond M, Rudolf J, Bauer B, Wienhard K, Pawlik G (2000) Early [(11)C] Flumazeni/H(2)O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. Stroke, 31 (2): 366-369.
25. Hillis AE, Barker PB, Beauchamp NJ, Gordon B, Wityk RJ (2000) MR perfusion imaging reveals regions of hypoperfusion associated with aphasia and neglect. Neurology, 55 (6): 782-788.
26. Hossmann KA (1994) Viability thresholds and the penumbra of focal ischemia. Ann Neurol., 36: 557-565.
27. Hossmann KA (1996) Perinfarct depolarizations. Cerebrovascular Brain Metab Rev., 8 (3): 195-208.
28. Ikeda K, Akiyama H, Arai T, Kondo H, Haga C, Tsuchiya K, Yamada S, Murayama S, Hori A (2000) Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: Evidence for the lysosomal degradation of altered tau in human brain? Neurosci Lett, 284 (3): 187-189.
29. Johansson IM, Wester P, Hakova M, Gu WG, Secki JR, Olsson T (2000) Early and delayed induction of immediate early gene expression in a novel focal cerebral ischemia model in the rat. Europ J Neurosci, 12: 3615-3625.
30. Karonen JO, Vanninen RL, Liu Y, Ostergaard L, Kuikka JT, Nuutinen J, Vanninen EJ, Partanen PL, Vainio PA, Korhonen K, Perkio J, Roivainen R, Sivenius J, Aronen HJ (1999) Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke. Ischemic penumbra predicts infarct growth. Stroke, 30 (8): 1583-1590.
31. Kato H, Kogure K (2000) Biochemical and molecular characteristics of the brain with developing cerebral infarction. Cell Mol Neurobiol, 19 (1): 93-108.
32. Katsura K, Kristian T, Smith ML, Siesjo BK (1994) Acidosis induced by hypercapnia exaggerates ischemic brain damage. J Cereb Blood Flow Metab, 14 (2): 243-250.
33. Kaufmann AM, Firlik AD, Fukui MB, Weschsler LR, Jungries CA, Yonas H (1999) Ischemic core and penumbra in human stroke. Stroke, 30 (1): 93-99.
34. Kidwell CS, Alger JR, Di Salle F, Starkman S, Villablanca P, Betson J, Saver JL (1999) Diffusion MRI in patients with transient ischemic attacks. Stroke, 30: 1174-1180.
35. Kidwell CS, Saver JL, Mattiello J, Starkman S, Vinuela F, Duckwiler G, Gobin YP, Jahan R, Vespa P, Kalafut M, Alger JR (2000) Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol, 47 (4): 462-469.
36. Konig M, Banach-Planchamp R, Kraus M, Klotz E, Falk A, Gehlen W, Heuser L (2000) CT perfusion imaging in acute ischemic cerebral infarct: Comparison of cerebral perfusion maps and conventional CT findings. Rofo. Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, 172 (3): 219-226.
37. Kristian T, Katsura K, Gido G, Siesjo BK (1994) The influence of pH on cellular calcium influx during ischemia. Brain Res, 641 (2): 295-302.
38. Kristian T, Gido G, Kuroda S, Schutz A, Siesjo BK (1998) Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion. Exp Brain Res, 120 (4): 503-509.
39. Labelle M, Khiat A, Durocher A, Boulanger Y (2001) Comparison of metabolite levels and water diffusion between cortical and subcortical strokes as monitored by MRI and MRS. Invest Radiol, 36 (3): 155-163.
40. Maeda K, Hata R, Hossmann KA (1999) Regional metabolic disturbances and cerebrovascular anatomy after permanent middle cerebral artery occlusion in C57black/6 and SV129 mice. Neurobiol Dis, 6 (2): 101-108.
41. Marchal G, Beaudouin V, Rioux P, De La Sayette V, Le Doze F, Viader F, Derlon JM, Baron JC (1996) Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: A correlative PET-CT study with voxel-based data analysis. Stroke 27 (4): 599-606.
42. Marsault C, Oppenheim C, Le Bihan D (2000) Does diffusion and perfusion MRI modify the diagnosis and management of cerebral ischemic accidents? Bull. 1 Acad. National. Med., 184 (8): 1687-1699.
43. Martin RL, Lloyd HG, Cowan AL (1994) The early events of oxygen and glucose deprivation: Setting the scene for neuronal death? Trends Neurosci. 17 (6): 251-257.
44. Morley P, Hogan MJ, Hakim AM (1994) Calcium-mediated mechanisms of ischemic injury and protection. Brain Pathol, 4 (1): 37-47.
45. Nagahiro S. Uno M, Sato K, Goto S, Morioko M, Ushio Y (1998) Pathophysiology and treatment of cerebral ischemia. J Med. Invest, 45 (1-4): 57-70.
46. Nowak TS Jr, Jacewicz M (1994) The heat shock/stress response in focal cerebral ischemia. Brain Pathol, 4 (1): 67-76.
47. Planas AM, Sole S, Justicia C (2001) Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. Neurobiol Dis, 8 (5): 834-846.
48. Pulsinelli W (1992) Pathophysiology of acute ischemic stroke. Lancet, 339: 533-536.
49. Read SJ, Hirano T, Abbott DF, Markus R, Sachinidis JL, Tochon-Danguy HJ, Chan JG, Egan GF, Scott AM, Bladin CF, McKay WJ, Donnan GA (2000) The fate of hypoxic tissue on 18F-fluoromisonidazole positron emission tomography after ischemic stroke. Ann Neurol, 48 (2): 228-235.
50. Rohl L, Olstergaard L, Simonsen CZ, Vestergaard-Poulsen P, Andersen G, Sakoh M, Le Bihan D, Gyldensted C (2001) Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient. Stroke, 32 (5): 1140-1146.
51. Rother J (2001) CT and MRI in the diagnosis of acute stroke and their role in thrombolysis . Thromb. Res, 103 (Supp 1): 125-133.
52. Ruscher K, Isaev N, Trendelenburg G, Weih M, Lurato L, Meisel A, Dirnagl U (1998) Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons. Neurosci Lett. 254 (2): 117-120.
53. Schlaug G, Benfield A, Baird AE, Siewert B, Lovblad KO, Parker RA, Edelman RR, Warach S (1999) The ischemic penumbra: Operationally defined by diffusion and perfusion MRI. Neurology 53 (7): 1528-1537.
54. Sharp FR, Lu A, Tang Y, Millhorn DE (2000) Multiple molecular penumbras after focal cerebral ischemia. J Cer Blood Flow Metabol, 20 (7): 1011-1032.
55. Schwab JM, Postler E, Nguyen TD, Mittelbronn M, Meyermann R, Schluesener HJ (2000) Connective tissue growth factor is expressed by a subset of reactive astrocytes in human cerebral infraction. Neuropathol Appl Neurology, 26 (5): 434-440.
56. Siesjo BK, Bengtsson F (1989) Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab, 9 (2): 127-138.
57. Takagi K, Ginsberg MD, Globus MY, Martinez E, Busto R (1994) Effect of hyperthermia on glutamate release in ischemic penumbra after middle cerebral artery occlusion in rats. Am J Phys, 267 (5Pt2): H 1770-1776.
58. Waracho S (2001) New imaging strategies for patient selection for thrombolytic and neuroprotective therapies. Neurology, 57 (5 suppl. 2): S 48-52.
59. Wild JM, Wardlaw JM, Marshall I, Warlow CP (2000) N-acetylaspartate distribution in proton spectroscopic images of ischemic stroke: Relationship to infarct appearance on T2-weighted magnetic resonance imaging. Stroke, 31 (12): 3008-3014.
60. Yepes M, Sandkvist M, Wong MK, Coleman TA, Smith E, Cohan SL, Lawrence DA (2000) Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood, 96 (2): 569-576.