Pathophysiology and treatment of cerebral ischemia

Journal of Medical Investigation

Volumn 45, Issue 1-2, 1998, Pages 57-70

  Nagahiro, Shinji ^a   Uno, Masaaki ^a   Sato, Koichi ^a   Goto, Satoshi ^b   Morioka, Motohiro ^b   Ushio, Yukitaka ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Cerebral ischemia; Excitotoxicity; Penumbra; Reperfusion; Selective neuronal death

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; CALCINEURIN; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE II; FIBRINOLYTIC AGENT; HEAT SHOCK PROTEIN; NERVE PROTEIN; NEUROPROTECTIVE AGENT; NEUROTOXIN; PROTEIN KINASE (CALCIUM,CALMODULIN);

ADAPTATION; ANIMAL; BRAIN ISCHEMIA; CALCIUM SIGNALING; CELL DEATH; CORPUS STRIATUM; CRYOANESTHESIA; ENZYMOLOGY; FIBRINOLYTIC THERAPY; GENE EXPRESSION REGULATION; GENETICS; GERBIL; HIPPOCAMPUS; HUMAN; METABOLISM; MOUSE; NERVE CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; RAT; REPERFUSION INJURY; REVIEW; VASCULARIZATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BRAIN ISCHEMIA; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCINEURIN; CALCIUM SIGNALING; CELL DEATH; CORPUS STRIATUM; EXCITATORY AMINO ACID ANTAGONISTS; FIBRINOLYTIC AGENTS; GENE EXPRESSION REGULATION; GERBILLINAE; HEAT-SHOCK PROTEINS; HIPPOCAMPUS; HUMANS; HYPOTHERMIA, INDUCED; MAGNETIC RESONANCE IMAGING; MICE; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; RATS; REPERFUSION INJURY; THROMBOLYTIC THERAPY;

EID: 0032130321     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. 2+/calmodulin-dependent protein kinase II and calcineurin in the hippocampus of rat brain after transient forebrain ischemia. J Neurochem, 58 : 1798-1809, 1992
2. Goto S, Nagahiro S, Korematsu K, Ushio Y : Striatonigral involvement following transient focal cerebral ischemia in the rats : an immunohistochemical study on a reversible ischemia model. Acta Neuropathol. 85 : 515-520, 1993
3. Korematsu K, Goto S, Nagahiro S, Ushio Y : Changes of immunoreactivity for synaptophysin ('protein p38') following a transient cerebral ischemia in the rat striatum. Brain Res, 616 : 320-324, 1993
4. Goto S, Korematsu K, Inoue N, Yamada K, Oyama T, Nagahiro S, Ushio Y : N-methyl-D-asparate receptor antagonist MK-801 induced circling behavior in rats with unilateral striatal ischemic lesions of nigral 6-hydroxydopamine lesions. Acta Neuropathol, 86 : 480-483, 1993
5. Nagahiro S, Goto S, Korematsu K, Sumi M, Takahashi M, Ushio Y : Disruption of the blood-cerebrospinal fluid barrier by transient cerebral ischemia. Brain Res, 633 : 305-311, 1994
6. Goto S, Nagahiro S, Korematsu K, Kogo K, Ushio Y : Subdivisional ischemic injury of the striatum causes apomorphine-induced rotational behavior in rats. Acta Neuropathol, 87 : 211-216, 1994
7. Korematsu K, Goto S, Nagahiro S, Ushio Y : Microglial response to transient focal cerebral ischemia : an immunocytochemical study on the rat cerebral cortex using anti-phosphotyrosine antibody. J Cereb Blood Flow Metab, 14 : 825-830, 1994
8. Yamada K, Goto S, Inoue N, Nagahiro S, Ushio Y : Elevated immunoreactivity for glutamic acid decarboxylase in the rat cerebral cortex following transient middle cerebral artery occlusion. Acta Neuropathol, 88 : 55-59, 1994
9. Goto S, Yamada K, Inoue N, Nagahiro S, Ushio Y : Increased expression of growth-associated protein GAP-43/B-50 following cerebral hemitransection and striatal ischemic injury in the substantia nigra of adult rats. Brain Res, 647 : 333-339, 1994
10. Nagahiro S, Goto S, Kogo K, Sumi M, Takahashi M, Ushio Y : Sequential changes in ischemic edema following transient focal cerebral ischemia in rats : magnetic resonance imaging study. Neurol Med Chir (Tokyo), 34 : 412-417, 1994
11. 2+/calmodulin-regulated protein phosphatase, calcineurin. Neuroscience 62 : 698-705, 1994
12. Yamada K, Goto S, Oyama T, Inoue N, Nagahiro S, Ushio Y : In vivo induction of the growth associated protein GAP43/B-50 in rat astrocytes following transient middle cerebral artery occlusion. Acta Neuropathol, 88 : 553-557, 1994
13. Korematsu K, Goto S, Nagahiro S, Inoue N, Oyama T, Yamada K, Ushio Y : Changes of phosphotyrosine immunoreativity on microglia in the rat substantia nigra following striatal ischemic injury. Glia, 13 : 147-153, 1995
14. 2+-binding protein calretinin (protein10) in ischemia-induced neuronal injury. Acta Neuropathol, 89 : 172-177, 1995
15. 2+/calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons. J Neurochem, 64 : 2132-2139, 1995
16. Nagahiro S, Ushio Y, Sumi M, Takahashi M : Gadolinium-DTPA-enhanced MRI in transient cerebral ischemia : experimental study. Takahashi M, Korogi Y, Moseley I, eds. Proceedings of the XV symposium Neuroradiologicum. Springer, 1995, pp 100-101
17. Inoue N, Yamamoto YL, Nagao T, Goto S, Nagahiro S, Ushio Y : Alterations of local cerebral blood flow, phorbol 12,13-dibutylate binding activity, and histological damage during acute focal ischemia in rat brain, A pathophysiology of acute focal ischemia : part 1. Acta Neurochir (Wien), 138 : 1118-1125, 1996
18. Inoue N, Goto S, Korematsu K, Oyama T, Yamada K, Nagahiro S, Ushio Y : Cytochrome oxidase activity during focal ischemia in rat brain. A pathophysiology of acute focal ischemia : part 2. Acta Neurochir (Wien), 138 : 1126-1131, 1996
19. Korematsu K, Goto S, Nagahiro S, Yamada K, Yoshikawa M, Okamura A Ushio Y : Time-sequential changes in apomorphine-induced rotational behavior following transient middle cerebral occlusion in rats. Biomedical Research 17 : 395-398, 1996
20. Inoue N, Yamamoto YL, Korematsu K, Goto S, Nagahiro S, Oyama T, Yamada K : Ushio Y, Effectiveness of retrograde perfusion of the cerebral vein for attenuating neuronal injury after transient ischemia following reperfusion in the rat brain. Neurol Med Chir (Tokyo) 37: 243-249, 1997
21. + at critical levels of brain ischemia. Stroke 8 : 51-57, 1977
22. Astrup J : Energy-requiring cell functions in the ischemic brain. Their critical supply and possible inhibition in protective therapy. J Neurosurg 56 : 482-497, 1982
23. Branston NM, Hope DT, Symon L: Barbiturates in focal ischemia of primate cortex : effects on blood flow distribution, evoked potential and extracellular potassium. Stroke 10 : 647-653, 1979
24. Jones TH, Morawetz RB, Crowell RM : Thresholds of focal ischemia in awake monkeys. J Neurosurg 54 : 773-782, 1981
25. Garcia JH, Liu KF, Ye Z, Gutierrez JA : Incom-plete infarcts and delayed death after transient middle cerebral artery occlusion in rats. Stroke 28 : 2303-2310, 1997
26. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G : experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. No Socchu 8 : 1-7, 1986 (in Japanese)
27. Longa EZ, Weinstein PR, Carlson S, Cummins R : Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 : 84-91, 1989
28. Nakano S, Kogure K, Fujikura H : Ischemic-induced slowly progressive neuronal damage in the rat brain. Neuroscience 8: 115-124, 1990
29. Yamada K, Goto S, Ushio Y : Occurrence of heat shock response in deafferented neurons in the substantia nigra of rats. Neuroscience 62 : 793-801, 1994
30. Ito U, Ohno K, Nakamura R, Suganuma F, Inaba Y : Brain edema during ischemia and after restoration of blood flow, measurement of water, sodium, potassium content and plasma protein permeability. Stroke 10 : 542-547, 1979
31. Mamezawa H, Smith M, Siesjo BK : Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23 : 552-559, 1992
32. Tamura A, Kirino T, Sano K, Takagi K, Oka H : Atrophy of the ipsilateral substantia nigra following middle cerebral artery occlusion in the rat. Brain Res 510 : 154-157, 1990
33. Saji M, Reis DJ : Delayed transneuronal death of substantia nigra neurons prevented by r-aminobutyric acid agonist. Science 235 : 66-69, 1987
34. Yamada K, Goto S, Yoshikawa M, Ushio Y : GABAergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons : an in vivo study using a reversible ischemia model of rats. Neuroscience 73 : 783-789, 1996
35. Kirino T : Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239 : 57-69, 1982
36. Pulsinelli WA, Brieley JB, Plum F : Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491-498, 1982
37. Choi DW : Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634, 1988
38. Cheung JY, Bonventre JV, Malis CD, Leaf A : Calcium and ischemic injury. N Engl J Med 314 : 1670-1676, 1986
39. Siesjo BK, Bengtsson F : Calcium influxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression : a unifying hypothesis. J Cereb Blood Flow Metab 9 : 127-140, 1989
40. Choi DW, Rothman SM : The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 13 :171-182, 1990
41. Schlaepher WW, Zimmerman U : Mechanisms underlying the neuronal response to ischemic injury : Calcium activated proteolysis of neurofilaments. Prog Brain Res 63 : 185-196, 1985
42. Goto S, Yamamoto H, Fukunaga K, Iwasa T, Matsukado Y, Miyamoto E : Dephosphorylation of microtubule-associated protein 2, t factor, and tublin by calcineurin. J Neurochem 45 : 276-283, 1985
43. Halpain S, Greengard P : Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2. Neuron 5:237-246, 1990
44. Melenka R, Kauer JA, Perkel DJ, Mauk MD, Kelly PT, Nicoll RA, Waxham MN : An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 340 : 554-557, 1989
45. Kitagawa K, Matsumoto M, Tagaya M, Hata R, Ueda H, Niinobe M, Handa N, Fukunaga R, Kimura K, Mikoshiba K, Kamada T: 'Ischemic tolerance' phenomenon found in the brain. Brain Res 528 : 21-24, 1990
46. Kirino T, Tsujita Y, Tamura A : Induced tolerance to ischemia in gerbil hippocampal neurons. J Cereb Blood Flow Metab 11 : 299-307, 1991
47. Nowak TSJr : Localization of 70 kDa stress protein mRNA induction in gerbil after ischemia. J Cereb Blood Flow Metab 11: 432-439, 1991
48. Vass K, Welch WJ, Nowak TS Jr. : Localization of 70 kDa stress protein induction in gerbil after ischemia. Acta Neuropathol(Berl) 77 : 128-135, 1988
49. Neumann-Haefelin T, Wiessner C, Vogel P, Back T, Hossmann KA : Differential expression of the immediate early genes c-fos, c-jun, jun B, and NGF1-B in the rat brain following transient forebrain ischemia. J Cereb Blood Flow Metab 14 : 206-216, 1994
50. Akins PT, Liu PK, Hsu CY : Immediate early gene expression in response to cerebral ischemia. Friend or Foe? Stroke 27 : 1682-1687, 1996
51. Thompson CB : Apoptosis in the pathogenesis and treatment of disease. Science 267 : 1456-1462, 1995
52. Li Y, Chopp M, Zhang ZG, Zaloga C, Niewenhuis L, Gautam S : p53-immunoreactive protein and p53 expression after transient middle cerebral artery occlusion in rats. Stroke 25 : 849-856, 1994
53. Reed JC : Cellular mechanisms of disease series. Bcl-2 and the regulation of programmed cell death. J Cell Biol 124 : 1-6, 1994
54. Martinou JC, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C, Huarte J : Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13 : 1017-1030, 1994
55. Okamoto M, Matsumoto M, Ohtsuki T, Taguchi A, Mikoshiba K, Yanagihara T, Kamada T: Internucleosomal DNA cleavage involved in ischemia-induced neuronal death. Biochem Biophys Res Commun 196 : 1356-1362, 1993
56. Nitatori T, Sato N, Waguri S, Karasawa Y, Araki H, Shibanai K, Kominami E, Uchiyma Y : Delayed neuronal death in the CA1pyramidal cell layers of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15 : 1001-1011, 1995
57. Hacke W, Kaste M, Fieschi C, Toni D, Lasaffre E, Kummer R, Boysen G, Bluhmski E, Hoxter G, Mahagne MH, Hennerici M : Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. JAMA 274 : 1017-1025, 1995
58. The National Institute of Neurological Disorder and Stroke rt-PA Stroke Study Group : Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333 : 1581-1587, 1995
59. Sato K : The efficacy of topical thrombolytic therapy in cases of acute major cerebral artery occlusion. Shikoku Acta Medica, 50 : 105-118, 1994
60. Welsh FA, Sims RE, Harris VA : Mild hypothermia prevents ischemic injury in gerbil hippocampus. J Cereb Blood Flow Metab 10 : 557-563, 1990
61. Ridenour TR, Warner DS, Todd MM, McAllister AC : Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. Stroke 23 : 733-738, 1992
62. Chopp M, Knight R, Tidwell CD, Helpern JA, Brown E, Welch KMA : The metabolic effects of mild hypothermia on global cerebral ischemia and recirculation in the cat : Comparison to normothermia and hyperthermia. J Cereb Blood Flow Metab 9 : 141-148, 1989
63. Busto R, Globus MY-T, Dietrich WD, Martinez E, Valdes I, Ginsberg MD : Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20 : 904-910, 1989
64. Kill HO, Zhang J, Piantadosi CA : Brain temperature alters hydroxy radical production during cerebral ischemia/reperfusion in rats. J Cereb Blood Flow Metab 16 : 100-106, 1996
65. Dietrich WD, Halley M, Valdes I, Busto R : Interrelationships between increased vascular permeability and acute neuronal damage following temperature-controlled brain ischemia in rats. Acta Neuropathol 81 : 615-625, 1991
66. Naritomi H, Shimizu T, Oe H, Kinugawa H, Sawada T, Hirata T : Mild hypothermia therapy in acute embolic stroke : a pilot study. J. Stroke Cerebrovasc Dis 1 (suppl 1) : 193-196, 1996
67. Siesjo BK : Pathophysiology and treatment of focal cerebral ischemia. Part II : mechanisms of damage and treatment. J Neurosurg 77 : 337-354, 1992
68. Sharkey J, Butcher SP : Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischemia. Nature 371: 336-339, 1994
69. Ueda T, Yamamoto YL, Diksic M : Transvenous perfusion of the brain with verapamil during focal cerebral ischemia in rats. Stroke 20 : 501-506, 1989
70. Inoue N, Yamamoto YL, Ito Y, Clemens JA, Panetta JK, Diksic M : The efficacy of retrograde infusion with LY 231617 in a rat middle cerebral artery occlusion in model. Can J Neurol Sci 23 : 175-183, 1996
71. Warach S, Dashe JF, Edelman RR : Clinical outcome in ischemic stroke predicted by early diffusion-weighted and perfusion magnetic resonance imaging : a preliminary analysis. J Cereb Blood Flow Metab 16 : 53-59,1996
72. Minematsu K, Li L, Sotak H, Davis MA, Fisher M : Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats. Stroke 23 :1304-1311, 1992