Extragastric effects of gastrin gene knock-out mice

Pharmacology and Toxicology

Volumn 91, Issue 6, 2002, Pages 368-374

  Koh, Theodore J ^a  

^a UMASS MEMORIAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN; GLYCINE; PROGASTRIN;

ACID SECRETION; AMIDATION; ANIMAL EXPERIMENT; ANIMAL MODEL; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; GASTROINTESTINAL TRACT; HORMONAL REGULATION; KIDNEY FUNCTION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PANCREAS FUNCTION; PRIORITY JOURNAL; STOMACH MUCOSA; STOMACH PARIETAL CELL;

ANIMALS; BRAIN; COLONIC NEOPLASMS; GASTRINS; KIDNEY; MICE; MICE, KNOCKOUT; PANCREAS; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ;

ANIMALIA;

EID: 0036968061     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2002.910615.x     Document Type: Conference Paper

References (96)

1. Bakke, I., G. Qvigstad, E. Brenna, A. K. Sandvik & H. L. Waldum: Gastrin has a specific proliferative effect on the rat enterochromaffin- like cell, but not on the parietal cell: a study by elutriation centrifugation. Acta physiol. scand. 2000, 169, 29-37.
2. Baldum et al. 1996.
3. Bardram, L., L. Hilsted & J. F. Rehfeld: Cholecystokinin, gastrin and their precursors in pheochromocytomas. Acta endocrin. (Copenh.) 1989, 120, 479-484.
4. Bardram, L., L. Hilsted & J. F. Rehfeld: Progastrin expression in mammalian pancreas. Proc. Natl. Acad. Sci. U S A 1990, 87, 298-302.
5. Botella, A., M. Delvaux, P. Berry, J. Frexinos & L. Bueno: Cholecystokinin and gastrin induce cell contraction in pig ileum by interacting with different receptor subtypes. Gastroenterology 1992, 102, 779-786.
6. Brand, S. J. & T. C. Wang: Gastrin gene expression and regulation in rat islet cell lines. J. Biol. Chem. 1988, 263, 16597-16603.
7. Caplin, M., K. Khan, S. Grimes, D. Michaeli, K. Savage, R. Pounder & A. Dhillon: Effect of gastrin and anti-gastrin anti-bodies on proliferation of hepatocyte cell lines. Dig. Dis. Sci. 2001, 46, 1356-1366.
8. Chen, D., M. Destree, R. Håkanson & G. Willems: Endogenous hypergastrinaemia does not promote growth of colonic mucosa or of a transplanted colon adenocarcinoma in rats. Eur. J. Gastroenterol. Hepatol. 1998, 10, 293-299.
9. Chen, D., X. Q. Ding, J. F. Rehfeld & R. Håkanson: Endogenous gastrin and cholecystokinin do not promote growth of rat liver. Scand. J. Gastroenterol. 1994, 29, 688-692.
10. Chen, D., A. G. Nylander, P. Norlen & R. Håkanson: Gastrin does not stimulate growth of the rat pancreas. Scand. J. Gastroenterol. 1996, 31, 404-410.
11. Chu, M., E. Kullman, J. F. Rehfeld & K. Borch: Effect of chronic endogenous hypergastrinaemia on pancreatic growth and carcinogenesis in the hamster. Gut 1997, 40, 536-540.
12. Ciccotosto, G. D., A. McLeish, K. J. Hardty & A. Shulkes: Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 1995, 109, 1142-1153.
13. Clerc, P., S. Leung-Theung-Long, T. C. Wang, G. J. Dockray, M. Bouisson, M. B. Delisle, N. Vaysse, L. Pradayrol, D. Fourmy & M. Dufresne: Expression of CCK2 receptors in the murine pancreas: proliferation, transdifferentiation of acinar cells, and neoplasia. Gastroenterology 2002, 122, 428-437.
14. Conteas, C. N. & A. P. Majumdar: The effects of gastrin, epidermal growth factor, and somatostatin on DNA synthesis in a small intestinal crypt cell line (IEC-6). Proc. Soc. Exp. Biol. Med. 1987, 184, 307-311.
15. Crean, G. P., M. W. Marshall & R. D. Rumsey: Parietal cell hyperplasia induced by the administration of pentagastrin (ICI 50, 123) to rats. Gastroenterology 1969, 57, 147-155.
16. de Weerth, A., L. Jonas, R. Schade, T. Schoneberg, G. Wolf, A. Pace, F. Kirchhoff, M. Schulz, T. Heinig, H. Greten & T. von Schrenck: Gastrin/cholecystokinin type B receptors in the kidney: molecular, pharmacological, functional characterization, and localization. Eur. J. Clin. Invest. 1998, 28, 592-601.
17. Ekundayo, A. A., C. Y. Lee & R. A. Goodlad: Gastrin and the growth of the gastrointestinal tract. Gut 1995, 36, 203-208.
18. Frankland, P. W., S. A. Josselyn, J. Bradwejn, F. J. Vaccarino & J. S. Yeomans: Intracerebroventricular infusion of the CCKB receptor agonist pentagastrin potentiates acoustic startle. Brain Res. 1996, 733, 129-132.
19. Friis-Hansen, L., I. J. Rourke, J. R. Bundgaard, J. F. Rehfeld & L. C. Samuelson: Molecular structure and genetic mapping of the mouse gastrin gene. FEBS Lett. 1996, 386, 128-132.
20. Friis-Hansen, L., F. Sundler, Y. Li, P. J. Gillespie, T. L. Saunders, J. K. Greenson, C. Owyang, J. F. Rehfeld & L. C. Samuelson: Impaired gastric acid secretion in gastrin-deficient mice. Amer. J. Physiol. 1998, 274, G561-G568.
21. Furuse, M., R. Ao, T. Bungo, R. Ando, M. Shimojo, Y. Masuda & N. Saito: Central gastrin inhibits feeding behavior and food passage in neonatal chicks. Life Sci. 1999, 65, 305-311.
22. Goetze, J. P., F. C. Nielsen, F. Burcharth & J. F. Rehfeld: Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer 2000, 88, 2487-2494.
23. Grider, J. R. & G. M. Makhlouf: Distinct receptors for cholecystokinin and gastrin on muscle cells of stomach and gallbladder. Amer. J. Physiol. 1990, 259, G184-G190.
24. Hellmich, M. R., X. L. Rui, H. L. Hellmich, R. Y. Fleming, B. M. Evers & C. M. Townsend, Jr.: Human colorectal cancers express a constitutively active cholecystokinin-B/Gastrin receptor that stimulates cell growth. J. Biol. Chem. 2000, 275, 32122-32128.
25. Hollande, F., A. Imdahl, T. Mantamadiotis, G. D. Ciccotosto, A. Shulkes & G. S. Baldwin: Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line. Gastroenterology 1997, 113, 1576-1588.
26. Ito, M., T. Matsui, T. Taniguchi, T. Tsukamoto, T. Murayama, N. Arima, H. Nakata, T Chiba & K. Chihara: Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin. J. Biol. Chem. 1993, 268, 18300-18305.
27. Ji, B., Y. Bi, D. Simeone, R. M. Mortensen & C. D. Logsdon: Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology 2001, 121, 1380-1390.
28. Johnson, L. R.: New aspects of the trophic action of the gastrointestinal tract. Gastroenterology 1977, 72, 788-792.
29. Kermorgant, S. & T. Lehy: Glycine-extended gastrin promotes the invasiveness of human colon cancer cells. Biochem. Biophys. Res. Commun. 2001, 285, 136-141.
30. Kikendall, J. W., A. R. Glass, L. H. Sobin & P. E. Bowen: Serum gastrin is not higher in subjects with colonic neoplasia. Amer. J. Gastroenterol. 1992, 87, 1394-1397.
31. Kinzler, K. W. & B. Vogelstein: Lessons from hereditary colorectal cancer. Cell 1996, 87, 159-170.
32. Kochman, M. L., J. DelValle, C. J. Dickinson & C. R. Boland: Post-translational processing of gastrin in neoplastic human colonic tissues. Biochem. Biophys. Res. Commun. 1992, 189, 1165-1169.
33. Koh, T. J., C. J. Bulitta, J. V. Fleming, G. J. Dockray, A. Varro & T. C. Wang: Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis. J. Clin. Invest. 2000, 106, 533-539.
34. Koh, T. J., G. J. Dockray, A. Varro, R. J. Cahill, C. A. Dangler, J. G. Fox & T. C. Wang: Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J. Clin. Invest. 1999, 103, 1119-1126.
35. Koh, T. J., J. R. Goldenring, S. Ito, H. Mashimo, A. S. Kopin, A. Varro, G. J. Dockray & T. C. Wang: Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology 1997, 113, 1015-1025.
36. Kopin, A. S., Y. M. Lee, E. W. McBride, L. J. Miller, M. Lu, H. Y. Lin, L. F. Kolakowski, Jr. & M. Beinborn: Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc. Natl. Acad. Sci. U S A 1992, 89, 3605-3609.
37. Kusyk, C. J., N. O. McNiel & L. R. Johnson: Stimulation of growth of a colon cancer cell line by gastrin. Am. J. Physiol. 1986, 251, G597-G601.
38. Lacourse, K. A., L. J. Swanberg, P. J. Gillespie, J. F. Rehfeld, T. L. Saunders & L. C. Samuelson: Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am. J. Physiol. 1999, 276, G1302-G1309.
39. Langhans, N., G. Rindi, M. Chiu, J. F. Rehfeld, B. Ardman, M. Beinborn & A. S. Kopin: Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice. Gastroenterology 1997, 112, 280-286.
40. Lay, J. M., C. Jenkins, L. Friis-Hansen & L. C. Samuelson: Structure and developmental expression of the mouse CCK-B receptor gene. Biochem. Biophys. Res. Commun. 2000, 272, 837-842.
41. Lee, Y. M., M. Beinborn, E. W. McBride, M. Lu, L. F. Kolakowski, Jr. & A. S. Kopin: The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. J. Biol. Chem. 1993, 268, 8164-8169.
42. Lichtenberger, L., L. R. Miller, D. N. Erwin & L. R. Johnson: Effect of pentagastrin on adult rat duodenal cells in culture. Gastroenterology 1973, 65, 242-251.
43. Lloyd et al. 1993.
44. Lüttichau, H. R., W. W. Van Solinge, F. C. Nielsen & J. F. Rehfeld: Developmental expression of the gastrin and cholecystokinin genes in rat colon. Gastroenterology 1993, 104, 1092-1098.
45. Malecka-Panas, E., S. E. Fligiel, R. Jaszewski & A. P. Majumdar: Differential responsiveness of proximal and distal colonic mucosa to gastrin. Peptides 1997, 18, 559-565.
46. Mantyh, C. R., T. N. Pappas & S. R. Vigna: Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. Gastroenterology 1994, 107, 1019-1030.
47. Matsushima, Y., Y. Kinoshita, H. Nakata, Y. Inomoto-Naribayashi, M. Asahara, C. Kawanami, A. Nakamura, M. Ito, T. Matsui, T. Fujiwara et al.: Gastrin receptor gene expression in several human carcinomas. Jap. J. Cancer Res. 1994, 85, 819-824.
48. Mayston, P. D., J. A. Barrowman & R. H. Dowling: Effect of pentagastrin on small bowel structure and function in the rat. Digestion 1975, 12, 78-84.
49. McGregor, D. B., L. L. Morriss, P. B. Manalo, R. A. Bomberger & R. S. Pardini: Pentagastrin stimulation of human colon carcinoma. Arch. Surg. 1989, 124, 470-472.
50. McWilliams, D. F., S. A. Watson, D. M. Crosbee, D. Michaeli & R. Seth: Coexpression of gastrin and gastrin receptors (CCK-B and delta CCK-B) in gastrointestinal tumour cell lines. Gut 1998, 42, 795-798.
51. Miyake, A: A truncated isoform of the human CCK-B/Gastrin receptor generated by alternative usage of a novel exon. Biochem. Biophys. Res. Commun. 1995, 208, 230-237.
52. Nakata, H., S. L. Wang, D. C. Chung, J. K. Westwick & L. G. Tillotson: Oncogenic ras induces gastrin gene expression in colon cancer. Gastroenterology 1998, 115, 1144-1153.
53. Niv, Y., N. Heizelracht, S. A. Lamprecht, A. D. Sperber, G. M. Fraser & B. Schwartz: Gastrin levels in colorectal cancer. Isr. J. Med. Sci. 1997, 33, 186-189.
54. Ohtake, M. & T. Sakaguchi: Gastrin-17 injected into the hypothalamic paraventricular nucleus can induce gastric acid secretion in rats. Brain Res. 1990, 508, 325-328.
55. Rasmussen, T. N., P. E. Jørgensen, T. Almdal, S. S. Poulsen & P. S. Olsen: Effect of gastrin on liver regeneration after partial hepatectomy in rats. Gut 1990, 31, 92-95.
56. Rehfeld, J. F.: Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog. J. Biol. Chem. 1978a, 253, 4022-4030.
57. Rehfeld, J. F.: Localisation of gastrins to neuro- and adenohypophysis. Nature 1978b, 271, 771-773.
58. Rehfeld, J. F.: Accumulation of nonamidated preprogastrin and preprocholecystokinin products in porcine pituitary corticotrophs. Evidence of post-translational control of cell differentiation. J. Biol. Chem. 1986, 261, 5841-5847.
59. Rehfeld, J. F.: Progastrin and its products in the cerebellum. Neuropeptides 1991, 20, 239-245.
60. Rehfeld, J. F., L. Bardram & L. Hilsted: Gastrin in human bronchogenic carcinomas: constant expression but variable processing of progastrin. Cancer Res. 1989, 49, 2840-2843.
61. Rooman, I., J. Lardon & L. Bouwens: Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 2002, 51, 686-690.
62. Saillan-Barreau, C., M. Dufresne, P. Clerc, D. Sanchez, H. Corominola, C. Moriscot, O. Guy-Crotte, C. Escrieut, N. Vaysse, R. Gomis, N. Tarasova & D. Fourmy: Evidence for a functional role of the cholecystokinin-B/gastrin receptor in the human fetal and adult pancreas. Diabetes 1999, 48, 2015-2021.
63. Schmitz, F., J. M. Otte, H. U. Stechele, B. Reimann, T. Banasiewicz, U. R. Folsch, W. E. Schmidt & K. H. Herzig: CCK-B/gastrin receptors in human colorectal cancer. Eur. J. Clin. Invest. 2001, 31, 812-820.
64. Seitz, J. F., M. Giovannini, J. Gouvernet & A. P. Gauthier: Elevated serum gastrin levels in patients with colorectal neoplasia. J. Clin. Gastroenterol. 1991, 13, 541-545.
65. Seva, C., C. J. Dickinson & T. Yamada: Growth-promoting effects of glycine-extended progastrin. Science 1994, 265, 410-412.
66. Singh, P., A. Owlia, A. Varro, B. Dai, S. Rajaraman & T. Wood: Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res. 1996, 56, 4111-4115.
67. Singh, P., M. Velasco, R. Given, A. Varro & T. C. Wang: Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology 2000a, 119, 162-171.
68. Singh, P., M. Velasco, R. Given, M. Wargovich, A. Varro & T. C. Wang: Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM. Amer. J. Physiol. Gastrointest. Liver Physiol. 2000b, 278, G390-G399.
69. Singh, P., Z. Xu, B. Dai, S. Rajaraman, N. Rubin & B. Dhruva: Incomplete processing of progastrin expressed by human colon cancer cells: role of noncarboxyamidated gastrins. Amer. J. Physiol. 1994, 266, G459-G468.
70. Smith, J. P., A. Shih, Y. Wu, P. J. McLaughlin & I. S. Zagon: Gastrin regulates growth of human pancreatic cancer in a tonic and autocrine fashion. Amer. J. Physiol. 1996, 270, R1078-R1084.
71. Smith, J. P. & T. E. Solomon: Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology 1988, 95, 1541-1548.
72. Smith, J. P., M. F. Verderame & I. S. Zagon: Antisense oligonucleotides to gastrin inhibit growth of human pancreatic cancer. Cancer Lett. 1999, 135, 107-112.
73. Smith, J. P., J. G. Wood & T. E. Solomon: Elevated gastrin levels in patients with colon cancer or adenomatous polyps. Dig. Dis. Sci. 1989, 34, 171-174.
74. Solomon, T. E., J. Morisset, J. G. Wood & L. J. Bussjaeger: Additive interaction of pentagastrin and secretin on pancreatic growth in rats. Gastroenterology 1987, 92, 429-435.
75. Sparks, A. B., P. J. Morin, B. Vogelstein & K. W. Kinzler: Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res. 1998, 58, 1130-1134.
76. Stepan, V. M., D. F. Krametter, M. Matsushima, A. Todisco, J. Delvalle & C. J. Dickinson: Glycine-extended gastrin regulates HEK cell growth. Amer. J. Physiol. 1999a, 277, R572-R581.
77. Stepan, V. M., M. Sawada, A. Todisco & C. J. Dickinson: Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells. Mol. Med. 1999b, 5, 147-159.
78. Straathof, J. W., C. B. Lamers & A. A. Masclee: Effect of gastrin-17 on lower esophageal sphincter characteristics in man. Dig. Dis. Sci. 1997, 42, 2547-2551.
79. Suzuki, H., K. Matsumoto & H. Terashima: Serum levels of gastrin in patients with colorectal neoplasia. Dis. Colon Rectum 1988, 31, 716-717.
80. Thorburn, C. M., G. D. Friedman, C. J. Dickinson, J. H. Vogelman, N. Orentreich & J. Parsonnet: Gastrin and colorectal cancer: a prospective study. Gastroenterology 1998, 115, 275-280.
81. Upp, J. R., Jr., P. Singh, C. M. Townsend, Jr. & J. C. Thompson: Clinical significance of gastrin receptors in human colon cancers. Cancer Res. 1989, 49, 488-492.
82. van Nieuwenhove, Y., T. De Backer, D. Chen, R. Håkanson & G. Willems: Gastrin stimulates epithelial cell proliferation in the oesophagus of rats. Virchows Arch. 1998, 432, 371-375.
83. van Solinge, W. W., F. C. Nielsen, L. Friis-Hansen, U. G. Falkmer & J. F. Rehfeld: Expression but incomplete maturation of progastrin in colorectal carcinomas. Gastroenterology 1993, 104, 1099-1107.
84. van Solinge, W. W., L. Odum & J. F. Rehfeld: Ovarian cancers express and process progastrin. Cancer Res. 1993, 53, 1823-1828.
85. von Schrenck, T., M. Ahrens, A. de Weerth, C. Bobrowski, G. Wolf, L. Jonas, T. Jocks, M. Schulz, M. Blaker, M. Neumaier & R. A. Stahl: CCKB/gastrin receptors mediate changes in sodium and potassium absorption in the isolated perfused rat kidney. Kidney Int. 2000, 58, 995-1003.
86. Wang, R. N., J. F. Rehfeld, F. C. Nielsen & G. Kloppel: Expression of gastrin and transforming growth factor-alpha during duct to islet cell differentiation in the pancreas of duct-ligated adult rats. Diabetologia 1997, 40, 887-893.
87. Wang, T. C., T. J. Koh, A. Varro, R. J. Cahill, C. A. Dangler, J. G. Fox & G. J. Dockray: Processing and proliferative effects of human progastrin in transgenic mice. J. Clin. Invest. 1996, 98, 1918-1929.
88. Watson, S. A.: Oncogenic targets of beta-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis. Lancet 2001, 357, 572-573.
89. Watson, S. A. & A. D. Gilliam: G17DT - a new weapon in the therapeutic armoury for gastrointestinal malignancy. Expert Opin. Biol. Ther. 2001, 1, 309-317.
90. Watson, S. A., D. Michaeli, S. Grimes, T. M. Morris, G. Robinson, A. Varro, T. A. Justin & J. D. Hardcastle: Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res. 1996, 56, 880-885.
91. Watson, S. A. & A. M. Smith: Hypergastrinemia promotes adenoma progression in the APC(Min-/+) mouse model of familial adenomatous polyposis. Cancer Res. 2001, 61, 625-631.
92. Winsett, O. E., C. M. Townsend, Jr., E. J. Glass & J. C. Thompson: Gastrin stimulates growth of colon cancer. Surgery 1986, 99, 302-307.
93. Xu, G., S. Sumi, M. Koike, K. Tanigawa, Y. Nio & K. Tamura: Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy. Dig. Dis. Sci. 1996, 41, 2433-2439.
94. Yao, C. Z., R. J. Bold, J. Ishizuka, C. M. Townsend, Jr. & J. C. Thompson: Growth of mouse hepatocytes is stimulated by gastrin. J. Cell. Physiol. 1995, 163, 532-537.
95. Yen, T. W, E. P. Sandgren, H. D. Liggitt, R. D. Palmiter, W. Zhou, T. R. Hinds, P. J. Grippo, J. M. McDonald, L. M. Robinson & R. H. Bell, Jr.: The gastrin receptor promotes pancreatic growth in transgenic mice. Pancreas 2002, 24, 121-129.
96. Zavros, Y., G. Rieder, A. Ferguson, L. C. Samuelson & J. L. Merchant: Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology 2002, 122, 119-133.