Oncogenic targets of β-catenin-mediated transcription in molecular pathogenesis of intestinal polyposis

Lancet

Volumn 357, Issue 9256, 2001, Pages 572-573

  Watson, S A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; CONDUCTIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; DNA BINDING PROTEIN; DOCKING PROTEIN; FATTY ACID; GASTRIN; GLYCINE; GLYCOGEN SYNTHASE KINASE 3BETA; ICOSANOID; LUCIFERASE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROTEIN SERINE THREONINE KINASE; SULINDAC; THYMIDINE KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

BINDING SITE; CANCER GROWTH; CELL ADHESION; CELL CYCLE; CELL PROLIFERATION; CHROMOSOME 5; COLON CARCINOGENESIS; COLON POLYPOSIS; CONSENSUS SEQUENCE; ENZYME ACTIVITY; GENE MUTATION; GENE OVEREXPRESSION; MALIGNANT TRANSFORMATION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NOTE; ONCOGENE C MYC; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 0035941777     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)04074-5     Document Type: Note

References (14)

1. Lessons from hereditary colorectal cancer
2. The adenomatous polyposis coli (APC) tumor suppressor
3. The Yin-Yang of TCF/β-catenin signaling
4. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
5. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
6. Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer
7. Identification of c-MYC as a target of the APC Pathway
8. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
9. PPARd is an APC-regulated target of nonsteroidal anti-inflammatory drugs
10. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis
11. The role of gastrin in the adenomas: Carcinoma sequence in the colon
12. Gastrin and gastrin receptor activation: An early event in the adenoma-carcinoma sequence
13. Gastrin is a target of the b-catentin/TCF-4 growth-signaling pathway in a model of intestinal polyposis
14. Effect of gastrin neutralisation on the progression of the adenoma: Carcinoma sequence in the Min mouse model of familial adenomatous polyposis