-
1
-
-
0035675427
-
Hyper IgM syndrome: The other side of the coin
-
Fuleihan RL. Hyper IgM syndrome: the other side of the coin. Curr Opin Pediatr 2001; 13:528-532.
-
(2001)
Curr Opin Pediatr
, vol.13
, pp. 528-532
-
-
Fuleihan, R.L.1
-
2
-
-
0034685914
-
Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling
-
Hostager BS, Catlett IM, Bishop GA. Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling. J Biol Chem 2000; 275:15392-15398.
-
(2000)
J Biol Chem
, vol.275
, pp. 15392-15398
-
-
Hostager, B.S.1
Catlett, I.M.2
Bishop, G.A.3
-
3
-
-
0034601071
-
CD40 signaling in human dendritic cells is initiated within membrane rafts
-
Vidalain PO, Azocar O, Servet-Delprat C, et al. CD40 signaling in human dendritic cells is initiated within membrane rafts. EMBO J 2000; 19:3304-3313.
-
(2000)
EMBO J
, vol.19
, pp. 3304-3313
-
-
Vidalain, P.O.1
Azocar, O.2
Servet-Delprat, C.3
-
4
-
-
0037119484
-
Clustering of CD40 ligand is required to form a functional contact with CD40
-
Grassme H, Bock J, Kun J, Gulbins E. Clustering of CD40 ligand is required to form a functional contact with CD40. J Biol Chem 2002; 277:30289-30299. This paper outlines the novel concept that clustering of CD40 receptor depends on reciprocal clustering of CD40 ligand.
-
(2002)
J Biol Chem
, vol.277
, pp. 30289-30299
-
-
Grassme, H.1
Bock, J.2
Kun, J.3
Gulbins, E.4
-
5
-
-
0036134864
-
Ceramide-rich membrane rafts mediate CD40 clustering
-
Grassme H, Jendrossek V, Bock J, et al. Ceramide-rich membrane rafts mediate CD40 clustering. J Immunol 2002; 168:298-307. The authors show that acid sphingomyelinase is essential for the clustering of CD40 and evidence is provided for the mechanism that mediates the aggregation.
-
(2002)
J Immunol
, vol.168
, pp. 298-307
-
-
Grassme, H.1
Jendrossek, V.2
Bock, J.3
-
6
-
-
0034733682
-
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
-
Chan FK, Chun HJ, Zheng L, et al. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 2000; 288:2351-2354.
-
(2000)
Science
, vol.288
, pp. 2351-2354
-
-
Chan, F.K.1
Chun, H.J.2
Zheng, L.3
-
7
-
-
0035900703
-
Molecular characterization of CD40 signaling intermediates
-
Werneburg BG, Zoog SJ, Dang TT, et al. Molecular characterization of CD40 signaling intermediates. J Biol Chem 2001; 276:43334-43342. This paper presents a system for studying endogenous CD40 signaling and shows that expression of soluble trimeric CD40 cytoplasmic tail is sufficient to activate signaling pathway.
-
(2001)
J Biol Chem
, vol.276
, pp. 43334-43342
-
-
Werneburg, B.G.1
Zoog, S.J.2
Dang, T.T.3
-
8
-
-
0033553392
-
CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs): Binding site specificity and activation of downstream pathways by distinct TRAFs
-
Pullen SS, Dang TT, Crute JJ, Kehry MR. CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs): binding site specificity and activation of downstream pathways by distinct TRAFs. J Biol Chem 1999; 274:14246-14254.
-
(1999)
J Biol Chem
, vol.274
, pp. 14246-14254
-
-
Pullen, S.S.1
Dang, T.T.2
Crute, J.J.3
Kehry, M.R.4
-
9
-
-
0033574060
-
Specificities of CD40 signaling: Involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation
-
Lee HH, Dempsey PW, Parks TP, et al. Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation. Proc Natl Acad Sci U S A 1999; 96:1421-1426.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 1421-1426
-
-
Lee, H.H.1
Dempsey, P.W.2
Parks, T.P.3
-
10
-
-
0036146317
-
Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent
-
Manning E, Pullen SS, Souza DJ, et al. Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent. Eur J Immunol 2002; 32:39-49. This paper provides evidence that complete abrogation of CD40-mediated signaling requires the disruption of more than two known TRAF binding sites, suggesting the existence of TRAF-independent CD40 signals.
-
(2002)
Eur J Immunol
, vol.32
, pp. 39-49
-
-
Manning, E.1
Pullen, S.S.2
Souza, D.J.3
-
11
-
-
0033574051
-
Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40
-
Tsukamoto N, Kobayashi N, Azuma S, et al. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proc Natl Acad Sci U S A 1999; 96:1234-1239.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 1234-1239
-
-
Tsukamoto, N.1
Kobayashi, N.2
Azuma, S.3
-
12
-
-
0034650867
-
Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions
-
Jalukar SV, Hostager BS, Bishop GA. Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions. J Immunol 2000; 164:623-630.
-
(2000)
J Immunol
, vol.164
, pp. 623-630
-
-
Jalukar, S.V.1
Hostager, B.S.2
Bishop, G.A.3
-
13
-
-
0033561039
-
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
-
Lomaga MA, Yeh WC, Sarosi I, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 1999; 13:1015-1024.
-
(1999)
Genes Dev
, vol.13
, pp. 1015-1024
-
-
Lomaga, M.A.1
Yeh, W.C.2
Sarosi, I.3
-
14
-
-
0031463025
-
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
-
Yeh WC, Shahinian A, Speiser D, et al. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 1997; 7:715-725.
-
(1997)
Immunity
, vol.7
, pp. 715-725
-
-
Yeh, W.C.1
Shahinian, A.2
Speiser, D.3
-
15
-
-
0036098501
-
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells
-
Ahonen C, Manning E, Erickson LD, et al. The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat Immunol 2002; 3:451-456. This work helps to dissect the role of specific CD40-TRAF associations in well defined aspects of humoral immunity. The authors produced transgenic mice that expressed mutant CD40 in which specific TRAF binding sites were disrupted, and they tested the mutant molecules for their ability to mediate humoral immune responses in vivo.
-
(2002)
Nat Immunol
, vol.3
, pp. 451-456
-
-
Ahonen, C.1
Manning, E.2
Erickson, L.D.3
-
16
-
-
0036195954
-
Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals
-
Yasui T, Muraoka M, Takaoka-Shichijo Y, et al. Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Int Immunol 2002; 14:319-329. To dissect CD40-mediated signaling through TRAFs, the authors produced transgenic mice that expressed mutant human CD40 molecules in a mouse CD40-deficient background, obtaining a B cell-specific expression of hCD40 mutated in TRAF binding sites.
-
(2002)
Int Immunol
, vol.14
, pp. 319-329
-
-
Yasui, T.1
Muraoka, M.2
Takaoka-Shichijo, Y.3
-
17
-
-
0030917141
-
Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
-
Hanissian SH, Geha RS. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 1997; 6:379-387.
-
(1997)
Immunity
, vol.6
, pp. 379-387
-
-
Hanissian, S.H.1
Geha, R.S.2
-
18
-
-
0035896734
-
Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)
-
Brown KD, Hostager BS, Bishop GA. Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1). J Exp Med 2001; 193:943-954. Using a model system designed to directly compare signals mediated by CD40 and latent membrane protein 1 cytoplasmic tails, the authors demonstrated that TRAF2 and 3 are degraded after CD40, but not latent membrane protein 1-induced signaling.
-
(2001)
J Exp Med
, vol.193
, pp. 943-954
-
-
Brown, K.D.1
Hostager, B.S.2
Bishop, G.A.3
-
19
-
-
0037205442
-
Regulation of TRAF2 signaling by self-induced degradation
-
Brown KD, Hostager BS, Bishop GA. Regulation of TRAF2 signaling by self-induced degradation. J Biol Chem 2002; 277:19433-19438. This study provides evidence that the mechanism of CD40-mediated TRAF2 degradation involves TRAF2 ubiquitination and proteasomal activity.
-
(2002)
J Biol Chem
, vol.277
, pp. 19433-19438
-
-
Brown, K.D.1
Hostager, B.S.2
Bishop, G.A.3
-
20
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
-
Revy P, Muto T, Levy Y, et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 2000; 102:565-575.
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
Muto, T.2
Levy, Y.3
-
21
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu M, Kinoshita K, Fagarasan S, et al. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000; 102:553-563.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
-
22
-
-
0037149473
-
The AID enzyme induces class switch recombination in fibroblasts
-
Okazaki IM, Kinoshita K, Muramatsu M, et al. The AID enzyme induces class switch recombination in fibroblasts. Nature 2002; 416:340-345. This paper provides evidence that expression of AID is sufficient to induce CSR in murine fibroblast cells.
-
(2002)
Nature
, vol.416
, pp. 340-345
-
-
Okazaki, I.M.1
Kinoshita, K.2
Muramatsu, M.3
-
23
-
-
0037076967
-
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts
-
Yoshikawa K, Okazaki IM, Eto T, et al. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science 2002; 296:2033-2036. This paper provides evidence that ectopic expression of AID induces somatic hypermutation in an artificial GFP substrate in murine fibroblast cells.
-
(2002)
Science
, vol.296
, pp. 2033-2036
-
-
Yoshikawa, K.1
Okazaki, I.M.2
Eto, T.3
-
24
-
-
0037019315
-
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
-
Petersen-Mahrt SK, Harris RS, Neuberger MS. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002; 418:99-103. In this study the authors documented the observation that ectopic expression of AID in E. coli is able to induce hypermutations, suggesting a direct role of AID protein on DNA.
-
(2002)
Nature
, vol.418
, pp. 99-103
-
-
Petersen-Mahrt, S.K.1
Harris, R.S.2
Neuberger, M.S.3
-
25
-
-
0035818990
-
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
-
Petersen S, Casellas R, Reina-San-Martin B, et al. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 2001; 414:660-665. This paper shows that localization of Nbs-1 and gamma-H2AX, two proteins involved in DNA double-strand break repair, to immunoglobulin H locus during CSR is dependent on AID.
-
(2001)
Nature
, vol.414
, pp. 660-665
-
-
Petersen, S.1
Casellas, R.2
Reina-San-Martin, B.3
-
26
-
-
0036234459
-
Missing pieces in the NF-kappaB puzzle
-
Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109 (Suppl):S81-S96.
-
(2002)
Cell
, vol.109
, Issue.SUPPL.
-
-
Ghosh, S.1
Karin, M.2
-
27
-
-
0035286726
-
Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia
-
Jain A, Ma CA, Liu S, et al. Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia. Nat Immunol 2001; 2:223-228. This paper demonstrates that missense mutations in the coding region of IKK-γ cause HIM-ED and are associated with CD40-mediated CSR.
-
(2001)
Nat Immunol
, vol.2
, pp. 223-228
-
-
Jain, A.1
Ma, C.A.2
Liu, S.3
-
28
-
-
0028033310
-
Activation of human dendritic cells through CD40 cross-linking
-
Caux C, Massacrier C, Vanbervliet B, et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994; 180:1263-1272.
-
(1994)
J Exp Med
, vol.180
, pp. 1263-1272
-
-
Caux, C.1
Massacrier, C.2
Vanbervliet, B.3
-
29
-
-
0028858649
-
Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes
-
Kiener PA, Moran-Davis P, Rankin BM, et al. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J Immunol 1995; 155:4917-4925.
-
(1995)
J Immunol
, vol.155
, pp. 4917-4925
-
-
Kiener, P.A.1
Moran-Davis, P.2
Rankin, B.M.3
-
30
-
-
0029925517
-
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection
-
Soong L, Xu JC, Grewal IS, et al. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 1996; 4:263-273.
-
(1996)
Immunity
, vol.4
, pp. 263-273
-
-
Soong, L.1
Xu, J.C.2
Grewal, I.S.3
-
31
-
-
0029933509
-
Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
-
Kamanaka M, Yu P, Yasui T, et al. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 1996; 4:275-281.
-
(1996)
Immunity
, vol.4
, pp. 275-281
-
-
Kamanaka, M.1
Yu, P.2
Yasui, T.3
-
32
-
-
0029965957
-
CD40 ligand is required for protective cell-mediated immunity to Leishmania major
-
Campbell KA, Ovendale PJ, Kennedy MK, et al. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 1996; 4:283-289.
-
(1996)
Immunity
, vol.4
, pp. 283-289
-
-
Campbell, K.A.1
Ovendale, P.J.2
Kennedy, M.K.3
-
33
-
-
0032979758
-
Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii
-
Seguin R, Kasper LH. Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii. J Infect Dis 1999; 179:467-474.
-
(1999)
J Infect Dis
, vol.179
, pp. 467-474
-
-
Seguin, R.1
Kasper, L.H.2
-
34
-
-
0034254583
-
Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: Dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-gamma
-
Subauste CS, Wessendarp M. Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-gamma. J Immunol 2000; 165:1498-1505.
-
(2000)
J Immunol
, vol.165
, pp. 1498-1505
-
-
Subauste, C.S.1
Wessendarp, M.2
-
35
-
-
0037083150
-
CD154 and type-1 cytokine response: From hyper IgM syndrome to human immunodeficiency virus infection
-
Subauste CS. CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection. J Infect Dis 2002; 185 (Suppl 1):S83-S89.
-
(2002)
J Infect Dis
, vol.185
, Issue.SUPPL. 1
-
-
Subauste, C.S.1
-
36
-
-
0033083971
-
Specific activated T cells regulate IL-12 production by human monocytes stimulated with Cryptococcus neoformans
-
Retini C, Casadevall A, Pietrella D, et al. Specific activated T cells regulate IL-12 production by human monocytes stimulated with Cryptococcus neoformans. J Immunol 1999; 162:1618-1623.
-
(1999)
J Immunol
, vol.162
, pp. 1618-1623
-
-
Retini, C.1
Casadevall, A.2
Pietrella, D.3
-
37
-
-
0035143596
-
Influence of costimulatory molecules on immune response to Leishmania major by human cells in vitro
-
Brodsky CI, DeKrey GK, Titus RG. Influence of costimulatory molecules on immune response to Leishmania major by human cells in vitro. Infect Immun 2001; 69:665-672.
-
(2001)
Infect Immun
, vol.69
, pp. 665-672
-
-
Brodsky, C.I.1
DeKrey, G.K.2
Titus, R.G.3
-
38
-
-
0031906464
-
Requirement of CD40-CD40 ligand interaction for elimination of Cryptosporidium parvum from mice
-
Cosyns M, Tsirkin S, Jones M, et al. Requirement of CD40-CD40 ligand interaction for elimination of Cryptosporidium parvum from mice. Infect Immun 1998; 66:603-607.
-
(1998)
Infect Immun
, vol.66
, pp. 603-607
-
-
Cosyns, M.1
Tsirkin, S.2
Jones, M.3
-
39
-
-
0033006404
-
Role of CD40 ligand in Mycobacterium avium infection
-
Hayashi T, Rao SP, Meylan PR, et al. Role of CD40 ligand in Mycobacterium avium infection. Infect Immun 1999; 67:3558-3565.
-
(1999)
Infect Immun
, vol.67
, pp. 3558-3565
-
-
Hayashi, T.1
Rao, S.P.2
Meylan, P.R.3
-
40
-
-
0032851210
-
CD40-CD40 ligand interactions augment survival of normal mice, but not CD40 ligand knockout mice, challenged orally with Salmonella dublin
-
Marriott I, Thomas EK, Bost KL. CD40-CD40 ligand interactions augment survival of normal mice, but not CD40 ligand knockout mice, challenged orally with Salmonella dublin. Infect Immun 1999; 67:5253-5257.
-
(1999)
Infect Immun
, vol.67
, pp. 5253-5257
-
-
Marriott, I.1
Thomas, E.K.2
Bost, K.L.3
-
41
-
-
0029083389
-
CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice
-
Wiley JA, Harmsen AG. CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice. J Immunol 1995; 155:3525-3529.
-
(1995)
J Immunol
, vol.155
, pp. 3525-3529
-
-
Wiley, J.A.1
Harmsen, A.G.2
-
42
-
-
0036107635
-
CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: The role of macrophage-derived nitric oxide
-
Netea MG, Meer JW, Verschueren I, Kullberg BJ. CD40/CD40 ligand interactions in the host defense against disseminated Candida albicans infection: the role of macrophage-derived nitric oxide. Eur J Immunol 2002; 32:1455-1463.
-
(2002)
Eur J Immunol
, vol.32
, pp. 1455-1463
-
-
Netea, M.G.1
Meer, J.W.2
Verschueren, I.3
Kullberg, B.J.4
-
43
-
-
0035940417
-
Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM
-
Ferrari S, Giliani S, Insalaco A, et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A 2001; 98:12614-12619. This paper demonstrated for the first time that mutations in CD40 gene cause a form of autosomal recessive hyper-IgM syndrome (HIGM3).
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12614-12619
-
-
Ferrari, S.1
Giliani, S.2
Insalaco, A.3
-
44
-
-
12244287804
-
Disseminated Cryptosporidium infection in an infant with hyper-IgM syndrome due to CD40 deficiency
-
in press
-
Kutukculter N, Moratto D, Aydinok Y, et al. Disseminated Cryptosporidium infection in an infant with hyper-IgM syndrome due to CD40 deficiency. J Pediatr (in press).
-
J Pediatr
-
-
Kutukculter, N.1
Moratto, D.2
Aydinok, Y.3
-
45
-
-
0035852646
-
Regulation of CD40 function by its isoforms generated through alternative splicing
-
Tone M, Tone Y, Fairchild PJ, et al. Regulation of CD40 function by its isoforms generated through alternative splicing. Proc Natl Acad Sci U S A 2001; 98:1751-1756.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1751-1756
-
-
Tone, M.1
Tone, Y.2
Fairchild, P.J.3
-
46
-
-
0033669973
-
Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome
-
Minegishi Y, Lavoie A, Cunningham-Rundles C, et al. Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome. Clin Immunol 2000; 97:203-210.
-
(2000)
Clin Immunol
, vol.97
, pp. 203-210
-
-
Minegishi, Y.1
Lavoie, A.2
Cunningham-Rundles, C.3
-
47
-
-
0033658369
-
A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO)
-
Zonana J, Elder ME, Schneider LC, et al. A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO). Am J Hum Genet 2000; 67:1555-1562.
-
(2000)
Am J Hum Genet
, vol.67
, pp. 1555-1562
-
-
Zonana, J.1
Elder, M.E.2
Schneider, L.C.3
-
48
-
-
0034713270
-
Genomic rearrangement in NEMO impairs NF-κB activation and is a cause of incontinentia pigmenti
-
The International Incontinentia Pigmenti (IP) Consortium
-
Smahi A, Courtois G, Vabres P, et al. Genomic rearrangement in NEMO impairs NF-κB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature 2000; 405:466-472.
-
(2000)
Nature
, vol.405
, pp. 466-472
-
-
Smahi, A.1
Courtois, G.2
Vabres, P.3
-
49
-
-
0035093630
-
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling
-
Doffinger R, Smahi A, Bessia C, et al: X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet 2001; 27:277-285. This paper demonstrates that mutations of IKK-γ have been found in patients with OL-ED-ID.
-
(2001)
Nat Genet
, vol.27
, pp. 277-285
-
-
Doffinger, R.1
Smahi, A.2
Bessia, C.3
-
50
-
-
0030710169
-
Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome
-
Ameratunga R, Lederman HM, Sullivan KE, et al. Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome. J Pediatr 1997; 131:147-150.
-
(1997)
J Pediatr
, vol.131
, pp. 147-150
-
-
Ameratunga, R.1
Lederman, H.M.2
Sullivan, K.E.3
-
51
-
-
0033152563
-
CD40-CD40 ligand interaction is central to cell-mediated immunity against Toxoplasma gondii: Patients with hyper IgM syndrome have a defective type 1 immune response that can be restored by soluble CD40 ligand trimer
-
Subauste CS, Wessendarp M, Sorensen RU, Leiva LE. CD40-CD40 ligand interaction is central to cell-mediated immunity against Toxoplasma gondii: patients with hyper IgM syndrome have a defective type 1 immune response that can be restored by soluble CD40 ligand trimer. J Immunol 1999; 162:6690-6700.
-
(1999)
J Immunol
, vol.162
, pp. 6690-6700
-
-
Subauste, C.S.1
Wessendarp, M.2
Sorensen, R.U.3
Leiva, L.E.4
-
52
-
-
18244397199
-
CD40 is expressed and functional on neuronal cells
-
Tan J, Town T, Mori T, et al. CD40 is expressed and functional on neuronal cells. EMBO J 2002; 21:643-652. In this study the authors demonstrate that CD40 protein is expressed on neuronal cells and has a role in neuronal development.
-
(2002)
EMBO J
, vol.21
, pp. 643-652
-
-
Tan, J.1
Town, T.2
Mori, T.3
-
53
-
-
0030702854
-
Clinical spectrum of X-linked hyper-Igm syndrome
-
Levy J, Espanol-Boren T, Thomas C, et al. Clinical spectrum of X-linked hyper-Igm syndrome. J Pediatr 1997; 131:47-54.
-
(1997)
J Pediatr
, vol.131
, pp. 47-54
-
-
Levy, J.1
Espanol-Boren, T.2
Thomas, C.3
-
54
-
-
0034080364
-
X-linked immunodeficiency with hyper-IgM (XHIM)
-
Notarangelo LD, Hayward AR. X-linked immunodeficiency with hyper-IgM (XHIM). Clin Exp Immunol 2000; 120:399-405.
-
(2000)
Clin Exp Immunol
, vol.120
, pp. 399-405
-
-
Notarangelo, L.D.1
Hayward, A.R.2
-
55
-
-
0029094825
-
Brief report: Correction of X-linked hyper-Igm syndrome by allogeneic bone marrow transplantation
-
Thomas C, de Saint Basile G, Le Deist F, et al. Brief report: correction of X-linked hyper-Igm syndrome by allogeneic bone marrow transplantation. N Engl J Med 1995; 333:426-429.
-
(1995)
N Engl J Med
, vol.333
, pp. 426-429
-
-
Thomas, C.1
De Saint Basile, G.2
Le Deist, F.3
-
56
-
-
0031787859
-
Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice
-
Brown MP, Topham DJ, Sangster MY, et al. Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice. Nat Med 1998; 4:1253-1260.
-
(1998)
Nat Med
, vol.4
, pp. 1253-1260
-
-
Brown, M.P.1
Topham, D.J.2
Sangster, M.Y.3
|