Sensitized lymphocytes and CD40 ligation augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii

Journal of Infectious Diseases

Volumn 179, Issue 2, 1999, Pages 467-474

  Séguin, Rosanne ^a   Kasper, Lloyd H ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; INTERLEUKIN 12; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 4;

ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD40; CD40 LIGAND; DENDRITIC CELLS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; LYMPHOCYTES; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; TOXOPLASMA;

EID: 0032979758     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314601     Document Type: Article

References (40)

1. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991;9:271-96.
2. Hart DNJ. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997;90:3245-87.
3. Bhardwaj N, Friedman SM, Cole BC, Nisanian AJ. Dendritic cells are potent antigen-presenting cells for microbial superantigens. J Exp Med 1992;175:267-73.
4. Inaba K, Inaba M, Naito M, Steinman RM. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guérin organisms and sensitize mice to mycobacterial antigen in vivo. J Exp Med 1993;178:479-88.
5. Pancholi P, Steinman RM, Bhardwaj N. Dendritic cells efficiently immunoselect mycobacterial-reactive T cells in human blood, including clonable antigen-reactive precursors. Immunology 1992;76:217-24.
6. Roth R. Spiegelberg HL. Activation of cloned human CD4′ TH-1 and TH-2 cells by blood dendritic cells. Scand J Immunol 1996;43:646-51.
7. Bhardwaj N, Seder RA, Reddy A, Feldman MV. IL-12 in conjunction with dendritic cells enhances antiviral CD8′ CTL responses in vitro. J Clin Invest 1996;98:715-22.
8. Will A, Blank C, Rollinghof M, Moll H. Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis. Eur J Immunol 1992;22:1341-7.
9. Koch F, Stanzl U, Jennewein P, et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med 1996;184:741-6.
10. Heufier C, Koch F, Stanzl U, et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-τ production by T helper 1 cells. Eur J Immunol 1996;26:659-68.
11. Celia M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cells′ stimulatory capacity: T-T help via APC activation. J Exp Med 1996;184:747-52.
12. Kasper LH. Toxoplasma infection. In: Fauci AS, Braunwald E, Isselbaucher KJ, et al, eds. Harrison's principles of internal medicine. New York: McGraw-Hill, 1998;1197-202.
13. Kasper LH, Buzoni-Gatel D. Some opportunistic parasitic infections in AIDS: candidiasis, pneumocystosis, cryptosporidiosis, toxoplasmosis. Parasitol Today 1998;14:150-6.
14. Suzuki Y, Conley FK, Remington JS. Importance of endogenous IFN-τ for prevention of toxoplasmic encephalitis in mice. J Immunol 1990;143:2045-50.
15. Hunter CA, Sabauste CS, Van Cleave VH, Remington JS. Production of gamma-interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infect Immun 1994;62:2818-24.
16. Suzuki S, Remington JS. Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2τ and Lyt-2τ, L3T4τ T cells in mice. J Immunol 1988;140:3943-6.
17. Gazzinelli RT, Hakim FT, Hieny S, Shearer GM, Sher A. Synergistic role of CD4τ and CD8τ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 1991;146:286-92.
18. Montoya JG, Lowe KE, Clayberger C, et al. Human CD4τ and CD8τ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells. Infect Immun 1996;64:176-81.
19. Purner MB, Berens RL, Nash PB, et al. CD4-mediated and CD8- mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans. Infect Immun 1996;64:4330-8.
20. Khan IA, Smith KA, Kasper LH. Induction of antigen-specific human cytotoxic T cells by Toxoplasma gondii. J Clin Invest 1990;85:1879-86.
21. Khan I, Matsurra T, Kasper LH. Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect Immun 1994;62:1639-42.
22. Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon-τ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci USA 1993;90:6115-9.
23. Gazzinelli R, Wysocka M, Hayashi S, et al. Parasite-induced IL-12 stimulates early IFN-τ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 1994;153:2533-44.
24. Reis e Sousa C, Hieny S, Scharton-Kersten T, et al. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin-12 by dendritic cells and their redistribution to T cell areas. I J Exp Med 1997;186:1819-29.
25. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumour necrosis factor. J Exp Med 1994;179:1109-18.
26. Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994;180:83-93.
27. Khan IA, Kasper LH. IL-15 augments CD8′ T cell-mediated immunity against Toxoplasma gondii infection in mice. J Immunol 1996;157:2103-8.
28. Flechner ER, Freudenthal PS, Kaplan G, Steinman RM. Antigen specific T lymphocytes efficiently cluster with dendritic cells in the human primary mixed leukocyte reaction. Cell Immunol 1995;111:183-95.
29. Inaba K, Romani N, Steinman RM. An antigen-independent contact mechanism as an early step in T cell proliferative responses to dendritic cells. J Exp Med 1989;170:527-42.
30. Bender A, Bui LK, Feldman MA, Larsson M, Bhardwaj N. Inactivated influenza virus, when presented on dendritic cells, elicits human CD8′ cytolytic T cell responses. J Exp Med 1995;182:1663-71.
31. Young JW, Steinman RM. Dendritic cells stimulate primary human cytolytic lymphocytes in the absence of CD4′ helper T cells. J Exp Med 1990;171:1315-32.
32. DeKruyff RH, Gieni RS, Umetsu DT. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J Immunol 1997;158:359-66.
33. Nijman HW, Kleijmeer MJ, Ossevoort MA, et al. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells. J Exp Med 1995;182:163-74.
34. Witmer-Pack MD, Olivier W, Valinsky J, Schuler G, Steinman RM. Granulocyte/macropbage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med 1987;166:1484-8.
35. Romani N, Koide S, Crowly M, et al. Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med 1989;169:1169-78.
36. McLellan AD, Sorg RV, Williams LA, Hart DN. Human dendritic cells activate T lymphocytes via a CD40:CD40 ligand-dependent pathway. Eur J Immunol 1996;26:1204-10.
37. Starling GC, Egner W, McLellan AD, Fawcett J, Simmons DL, Hart DN. Intercellular adhesion molecule-3 is a costimulatory ligand for LFA-l expressed on human blood dendritic cells. Eur J Immunol 1995;25:2528-32.
38. Ridge JP, Di Rosa F, Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4′ T-helper and a T-killer cell. Nature 1998;393:474-8.
39. Bennett SRM, Carbone FR, Karamalis F, Flavell RA, Miller JFA, Heath WR. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 1998;393:478-80.
40. Schoenberger SP, Toes REM, van der Voort EIH, Offringa R, Melief CJM. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998;393:480-3; comment in Nature 1998;393:-4.