In vitro interaction of the glycine receptor with the leptin receptor

Physiology and Behavior

Volumn 77, Issue 4-5, 2002, Pages 565-569

  Leite, John F ^a,b   Gribble, Brian ^a   Randolph, Norman ^a   Cascio, Michael ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cross talk; Filter binding assays; Glycine receptor; Ion channels; Leptin receptor; Library screening; Mass spectrometry; Nicotinicoid receptors

Indexed keywords

GLYCINE RECEPTOR; ION CHANNEL; LEPTIN RECEPTOR; LIGAND;

ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; CYTOPLASM; HYPOTHALAMUS; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SATIETY; SEQUENCE HOMOLOGY; SPINAL CORD; TISSUE HOMOGENATE;

EID: 0036955566     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(02)00912-5     Document Type: Article

References (39)

1. Pawson T., Scott J.D. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278:1997;2075-2080.
2. Betz H. Ligand-gated ion channels in the brain: the amino acid receptor superfamily. Neuron. 5:1990;383-392.
3. Corringer P.-J., Le Novère N., Changeux J.-P. Nicotinic receptors at the amino acid level. Annu. Rev. Pharmacol. Toxicol. 40:2000;31-58.
4. Legendre P. The glycinergic inhibitory synapse. Cell. Mol. Life Sci. 58:2001;760-793.
5. Karlin A. Emerging structure of the nicotinic acetylcholine receptors. Nat. Rev. Neurosci. 3:2002;102-114.
6. Grenningloh G., Schmieden V., Schofield P.R., Seeburg P.H., Siddique T., Mohandas T.K.et al. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 9:1990;771-776.
7. Cascio M., Schoppa N.E., Grodzicki R.L., Sigworth F.J., Fox R.O. Functional expression and purification of a homomeric human α1 glycine receptor in baculovirus-infected insect cells. J. Biol. Chem. 268:1993;22135-22142.
8. Pfeiffer F., Graham D., Betz H. Purification by affinity chromatography of the glycine receptor of rat spinal cord. J. Biol. Chem. 257:1982;9389-9393.
9. Langosch D., Thomas L., Betz H. Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer. Proc. Natl. Acad. Sci. U.S.A. 85:1988;7394-7398.
10. Wyszynski M., Sheng M. Analysis of ion channel associated proteins. Methods Enzymol. 294:1999;371-385.
11. Satler R., Xiong Z., Lu W.-Y., Hafner M., MacDonald J.F., Tymianski M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science. 284:1999;1845-1848.
12. Westphal R.S., Tavalin S.J., Lin J.W., Alto N.M., Fraser I.D.C., Langeberg L.K.et al. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science. 285:1999;93-96.
13. Hall ZW, Sanes JR. Synaptic structure and development: the neuromuscular junction. Cell/Neuron 1993;72/10:99-121 [Supplement].
14. Ruegg M.A., Bixby J.L. Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction. Trends Neurosci. 21:1998;22-27.
15. Glass D.J., Yancopoulos G.D. Sequential roles of agrin, MuSK, and rapsyn during neuromuscular junction formation. Curr. Opin. Neurobiol. 7:1997;379-384.
16. Akaabourne M., Culican S.M., Turney S.G., Lichtman J.W. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science. 286:1999;503-507.
17. Kirsch J., Langosch D., Prior P., Littauer U.Z., Schmitt B., Betz H. The 93-kDa glycine receptor-associated protein binds to tubulin. J. Biol. Chem. 266:1991;22242-22245.
18. Meyer G., Kirsch J., Betz H., Langosch D. Identification of a gephyrin binding motif on the glycine receptor β subunit. Neuron. 15:1995;563-572.
19. Altschuler R.A., Betz H., Parakkal M.H., Reeks K.A., Wenthold R.J. Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor. Brain Res. 369:1986;316-320.
20. Kirsch J., Betz H. The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J. Neurosci. 15:1995;4148-4156.
21. Sabatini D.M., Barrow R.K., Blackshaw S., Burnett P.E., Lai M.M., Field M.E.et al. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science. 284:1999;1161-1164.
22. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
23. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R.et al. Identification and expression cloning of a leptin receptor OB-R. Cell. 83:1995;1263-1271.
24. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature. 395:1998;763-770.
25. Schwartz M.W., Woods S.C., Porte D. Jr., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature. 404:2000;661-671.
26. Ahima R.S., Flier J.S. Leptin. Annu. Rev. Physiol. 62:2000;413-437.
27. Couce M.E., Burguera B., Parisi J.E., Jensen M.D., Lloyd R.V. Localization of leptin receptor in the human brain. Neuroendocrinology. 66:1997;145-150.
28. Shioda S., Funahashi H., Nakajo S., Yada T., Maruta O., Nakai Y. Immunohistochemical localization of leptin receptor in the rat brain. Neurosci. Lett. 243:1998;41-44.
29. White D.W., Kuropatwinski K.K., Devos R., Baumann H., Tartaglia L.A. Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J. Biol. Chem. 272:1997;4065-4071.
30. Baumann H., Morella K.K., White D.W., Dembski M., Bailon P.S., Kim H.et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. U.S.A. 93:1996;8374-8378.
31. Bjorbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272:1997;32686-32695.
32. Banks A.S., Davis S.M., Bates S.H., Meyers M.G. Jr. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275:2000;14563-14572.
33. Elmquist J.K., Maratos-Flier E., Saper C.B., Flier J.S. Unraveling the central nervous system pathways underlying responses to leptin. Nat. Neurosci. 1:1998;445-450.
34. Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 22:1999;221-232.
35. Glaum S.R., Hara M., Bindokas V.P., Lee C.C., Polonsky K.S., Bell G.I.et al. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol. Pharmacol. 50:1996;230-235.
36. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., Ashford M.L.J. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature. 390:1997;521-525.
37. Leite J.F., Cascio M. Structure of ligand-gated ion channels: critical assessment of biochemical data supports novel topology. Mol. Cell. Neurosci. 17:2001;777-792.
38. Cascio M., Shenkel S., Grodzicki R.L., Sigworth F.J., Fox R.O. Functional reconstitution and characterization of recombinant human α1 glycine receptors. J. Biol. Chem. 276:2001;20981-20988.
39. Liu F., Wan Q., Pristupa Z.B., Yu X.M., Wang Y.T., Niznik H.B. Direct protein-protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors. Nature. 403:2000;274-280.