메뉴 건너뛰기




Volumn 15, Issue 4, 2002, Pages 771-790

New agents in the treatment of acute lymphocytic leukaemia

Author keywords

Acute lymphocytic leukaemia; Drug resistance; Novel agents

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; ARSENIC TRIOXIDE; ASPARAGINASE; BORTEZOMIB; BRYOSTATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DIHYDROFOLATE REDUCTASE INHIBITOR; DOXORUBICIN; EPIPODOPHYLLOTOXIN; FLAVOPIRIDOL; IMATINIB; METHOTREXATE; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN; NEW DRUG; PREDNISONE; PROTEIN TYROSINE KINASE INHIBITOR; SEMAXANIB; TEZACITABINE; TRIMETREXATE; TUMOR NECROSIS FACTOR RECEPTOR; UNINDEXED DRUG; VINCA ALKALOID; VINCRISTINE; ANNAMYCIN; CLOFARABINE; FC RECEPTOR; FLUDARABINE; GUANINE ARABINOSIDE; IDARUBICIN; MULTIDRUG RESISTANCE PROTEIN 1; NELARABINE;

EID: 0036955496     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1053/beha.2003.0234     Document Type: Review
Times cited : (8)

References (113)
  • 1
    • 0027516927 scopus 로고
    • Therapy of the newly diagnosed adult with acute lymphoblastic leukemia
    • Hoelzer DF. Therapy of the newly diagnosed adult with acute lymphoblastic leukemia. Hematology and Oncology Clinics of North America 7: 1993; 139-160.
    • (1993) Hematology and Oncology Clinics of North America , vol.7 , pp. 139-160
    • Hoelzer, D.F.1
  • 2
    • 0028938844 scopus 로고
    • A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and Leukemia Group B study 8811
    • Larson RA, Dodge RK, Burns CP et al. A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and Leukemia Group B study 8811. Blood 1995; 85: 2025-2037.
    • (1995) Blood , vol.85 , pp. 2025-2037
    • Larson, R.A.1    Dodge, R.K.2    Burns, C.P.3
  • 3
    • 0033964380 scopus 로고    scopus 로고
    • Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia
    • Kantarjian HM, O'Brien S, Smith TL et al. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. Journal of Clinical Oncology 2000; 18: 547-561.
    • (2000) Journal of Clinical Oncology , vol.18 , pp. 547-561
    • Kantarjian, H.M.1    O'Brien, S.2    Smith, T.L.3
  • 4
    • 13344285351 scopus 로고    scopus 로고
    • Improved outcome in adult B-cell acute lymphoblastic leukemia
    • Hoelzer D, Ludwig WD, Thiel E et al. Improved outcome in adult B-cell acute lymphoblastic leukemia. Blood 1996; 87: 495-508.
    • (1996) Blood , vol.87 , pp. 495-508
    • Hoelzer, D.1    Ludwig, W.D.2    Thiel, E.3
  • 5
    • 0032812621 scopus 로고    scopus 로고
    • Hyper-CVAD program in Burkitt's-type adult acute lymphoblastic leukemia
    • Thomas DA, Cortes J, O'Brien S et al. Hyper-CVAD program in Burkitt's-type adult acute lymphoblastic leukemia. Journal of Clinical Oncology 1999: 17: 2461-2470.
    • (1999) Journal of Clinical Oncology , vol.17 , pp. 2461-2470
    • Thomas, D.A.1    Cortes, J.2    O'Brien, S.3
  • 6
    • 0033954540 scopus 로고    scopus 로고
    • Outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia
    • Faderl S, Kantarjian HM, Thomas DA et al. Outcome of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Leukemia and Lymphoma 2000; 36: 263-273.
    • (2000) Leukemia and Lymphoma , vol.36 , pp. 263-273
    • Faderl, S.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 7
    • 0034765167 scopus 로고    scopus 로고
    • Drug resistance in hematologic malignancies
    • Marie JP. Drug resistance in hematologic malignancies. Current Opinion in Oncology 2001; 13: 463-469.
    • (2001) Current Opinion in Oncology , vol.13 , pp. 463-469
    • Marie, J.P.1
  • 8
    • 0036192430 scopus 로고    scopus 로고
    • In vitro drug resistance profiles of adult acute lymphoblastic leukemia: Possible explanation for difference in outcome to similar therapeutic regimens
    • Styczynski J & Wysocki M. In vitro drug resistance profiles of adult acute lymphoblastic leukemia: possible explanation for difference in outcome to similar therapeutic regimens. Leukemia and Lymphoma 2002; 43: 301-307.
    • (2002) Leukemia and Lymphoma , vol.43 , pp. 301-307
    • Styczynski, J.1    Wysocki, M.2
  • 9
    • 0031681258 scopus 로고    scopus 로고
    • Anti-asparaginase antibodies following E coli asparaginase therapy in pediatric acute lymphoblastic leukemia
    • Woo MH, Hak LJ, Storm MC et al. Anti-asparaginase antibodies following E coli asparaginase therapy in pediatric acute lymphoblastic leukemia. Leukemia 1998; 12: 1527-1533.
    • (1998) Leukemia , vol.12 , pp. 1527-1533
    • Woo, M.H.1    Hak, L.J.2    Storm, M.C.3
  • 10
    • 0036255941 scopus 로고    scopus 로고
    • Antibody formation during intravenous and intramuscular therapy with Erwinia asparaginase
    • Albertsen BK, Schroder H, Jakobsen P et al. Antibody formation during intravenous and intramuscular therapy with Erwinia asparaginase. Medical and Pediatric Oncology 2002; 38: 310-316.
    • (2002) Medical and Pediatric Oncology , vol.38 , pp. 310-316
    • Albertsen, B.K.1    Schroder, H.2    Jakobsen, P.3
  • 11
    • 0027536607 scopus 로고
    • L-asparaginase and PEG asparaginase - Past, present, and future
    • Keating MJ, Holmes R, Lerner S & Ho DH. L-asparaginase and PEG asparaginase - past, present, and future. Leukemia and Lymphoma 1993; 10: 153-157.
    • (1993) Leukemia and Lymphoma , vol.10 , pp. 153-157
    • Keating, M.J.1    Holmes, R.2    Lerner, S.3    Ho, D.H.4
  • 12
    • 0032613231 scopus 로고    scopus 로고
    • The three asparaginases Comparative pharmacology and optimal use in childhood leukemia
    • Asselin BL. The three asparaginases Comparative pharmacology and optimal use in childhood leukemia. Advances in Experimental Medicine and Biology 1999; 457: 621-629.
    • (1999) Advances in Experimental Medicine and Biology , vol.457 , pp. 621-629
    • Asselin, B.L.1
  • 13
    • 0034284267 scopus 로고    scopus 로고
    • Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: A Pediatric Oncology Group Study
    • Abshire TC, Pollock BH, Billett AL et al. Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study. Blood 2000; 96: 1709-1715.
    • (2000) Blood , vol.96 , pp. 1709-1715
    • Abshire, T.C.1    Pollock, B.H.2    Billett, A.L.3
  • 14
    • 0037089437 scopus 로고    scopus 로고
    • Comparison of Escherichia coli asparaginase with Erwinia asparaginase in the treatment of childhood lymphoid malignancies: Results of a randomized European Organisation for Research and Treatment of Cancer-Children's Leukemia Group phase 3 trial
    • Duval M, Suciu S, Ferster A et al. Comparison of Escherichia coli asparaginase with Erwinia asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European Organisation for Research and Treatment of Cancer-Children's Leukemia Group phase 3 trial. Blood 2002; 99: 2734-2739.
    • (2002) Blood , vol.99 , pp. 2734-2739
    • Duval, M.1    Suciu, S.2    Ferster, A.3
  • 15
    • 0028085149 scopus 로고
    • Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lymphoblastic leukemia
    • Nagura E, Kimura K, Yamada K et al. Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lymphoblastic leukemia. Cancer Chemotherapy and Pharmacology 1994; 33: 359-365.
    • (1994) Cancer Chemotherapy and Pharmacology , vol.33 , pp. 359-365
    • Nagura, E.1    Kimura, K.2    Yamada, K.3
  • 16
    • 0037085747 scopus 로고    scopus 로고
    • A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: A Children's Cancer Group study
    • Avramis VI, Sencer S, Periclou AP et al. A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study. Blood 2002; 99: 1986-1994.
    • (2002) Blood , vol.99 , pp. 1986-1994
    • Avramis, V.I.1    Sencer, S.2    Periclou, A.P.3
  • 17
    • 0033214796 scopus 로고    scopus 로고
    • Combination therapy with methotrexate, vincristine, polyethylene-glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia
    • Aguayo A, Cortes J, Thomas D et al. Combination therapy with methotrexate, vincristine, polyethylene-glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia. Cancer 1999; 86: 1203-1209.
    • (1999) Cancer , vol.86 , pp. 1203-1209
    • Aguayo, A.1    Cortes, J.2    Thomas, D.3
  • 18
    • 0036163591 scopus 로고    scopus 로고
    • PEG-asparaginase (Oncaspar) 2500 U/m(2) BSA in reinduction and relapse treatment in the ALL/NHL-BFM protocols
    • Muller HJ, Beier R, da Palma JC et al. PEG-asparaginase (Oncaspar) 2500 U/m(2) BSA in reinduction and relapse treatment in the ALL/NHL-BFM protocols. Cancer Chemotherapy and Pharmacology 2002; 49: 149-154.
    • (2002) Cancer Chemotherapy and Pharmacology , vol.49 , pp. 149-154
    • Muller, H.J.1    Beier, R.2    da Palma, J.C.3
  • 19
    • 0034893950 scopus 로고    scopus 로고
    • Liposomal and nonliposomal drug pharmacokinetics after administration of liposome-encapsulated vincristine and their contribution to drug tissue distribution properties
    • Krishna R, Webb MS, St Onge G & Mayer LD. Liposomal and nonliposomal drug pharmacokinetics after administration of liposome-encapsulated vincristine and their contribution to drug tissue distribution properties. Journal of Pharmacology and Experimental Therapeutics 2001; 298: 1206-1212.
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.298 , pp. 1206-1212
    • Krishna, R.1    Webb, M.S.2    St Onge, G.3    Mayer, L.D.4
  • 20
    • 0033973456 scopus 로고    scopus 로고
    • Liposomal vincristine in relapsed non-Hodgkin's lymphomas: Early results of an ongoing phase II trial
    • Sarris AH, Hagemeister F, Romaguera J et al. Liposomal vincristine in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial. Annals of Oncology 2000; 11: 69-72.
    • (2000) Annals of Oncology , vol.11 , pp. 69-72
    • Sarris, A.H.1    Hagemeister, F.2    Romaguera, J.3
  • 21
    • 0003325207 scopus 로고    scopus 로고
    • Phase II study of liposomal vincristine (LipoV) in relapsed or refractory adult acute lymphoblastic leukemia (ALL)
    • abstract 4269
    • Thomas DA, Sarris A, O'Brien S et al. Phase II study of liposomal vincristine (LipoV) in relapsed or refractory adult acute lymphoblastic leukemia (ALL). Blood 1999; 94: 238b. abstract 4269.
    • (1999) Blood , vol.94
    • Thomas, D.A.1    Sarris, A.2    O'Brien, S.3
  • 22
    • 0032845069 scopus 로고    scopus 로고
    • Phase I study of liposomal daunorubicin in patients with acute leukemia
    • Cortes J, O'Brien S, Estey E et al. Phase I study of liposomal daunorubicin in patients with acute leukemia. Investigational New Drugs 1999; 17: 81-87.
    • (1999) Investigational New Drugs , vol.17 , pp. 81-87
    • Cortes, J.1    O'Brien, S.2    Estey, E.3
  • 23
    • 0035396908 scopus 로고    scopus 로고
    • High-dose liposomal daunorubicin and high-dose cytarabine combination in patients with refractory or relapsed acute myelogenous leukemia
    • Cortes J, Estey E, O'Brien S et al. High-dose liposomal daunorubicin and high-dose cytarabine combination in patients with refractory or relapsed acute myelogenous leukemia. Cancer 2001; 92: 7-14.
    • (2001) Cancer , vol.92 , pp. 7-14
    • Cortes, J.1    Estey, E.2    O'Brien, S.3
  • 24
    • 0003338248 scopus 로고    scopus 로고
    • A pilot study of dose-intensive anthracyclines for acute lymphoblastic leukemia (ALL) using liposomal daunorubicin (LD) with hyperfractionated cyclophosphamide (CTX), vincristine (VCR), and prednisone (PDN) (Hyper-CVXD)
    • abstract 110
    • Koller C, Cortes J, O'Brien S et al. A pilot study of dose-intensive anthracyclines for acute lymphoblastic leukemia (ALL) using liposomal daunorubicin (LD) with hyperfractionated cyclophosphamide (CTX), vincristine (VCR), and prednisone (PDN) (Hyper-CVXD). Proceedings of the American Society of Clinical Oncology 1998; 17: 28a. abstract 110.
    • (1998) Proceedings of the American Society of Clinical Oncology , vol.17
    • Koller, C.1    Cortes, J.2    O'Brien, S.3
  • 25
    • 0028269761 scopus 로고
    • Relationship between daunorubicin dosage delivered during induction therapy and outcome in adult acute lymphoblastic leukemia
    • Todeschini G, Meneghini V, Pizzolo G et al. Relationship between daunorubicin dosage delivered during induction therapy and outcome in adult acute lymphoblastic leukemia. Leukemia 1994; 8: 376-381.
    • (1994) Leukemia , vol.8 , pp. 376-381
    • Todeschini, G.1    Meneghini, V.2    Pizzolo, G.3
  • 26
    • 0031951221 scopus 로고    scopus 로고
    • Estimated 6-year event-free survival of 55% in 60 consecutive adult acute lymphoblastic leukemia patients treated with an intensive phase II protocol based on high induction dose of daunorubicin
    • Todeschini G, Tecchio C, Meneghini V et al. Estimated 6-year event-free survival of 55% in 60 consecutive adult acute lymphoblastic leukemia patients treated with an intensive phase II protocol based on high induction dose of daunorubicin. Leukemia 1998: 12; 144-149.
    • (1998) Leukemia , vol.12 , pp. 144-149
    • Todeschini, G.1    Tecchio, C.2    Meneghini, V.3
  • 27
    • 0012483654 scopus 로고    scopus 로고
    • The modified hyper-CVAD regimen in newly diagnosed adult acute lymphoblastic leukemia (ALL)
    • abstract 2474
    • Thomas DA, Cortes J, Giles FJ et al. The modified hyper-CVAD regimen in newly diagnosed adult acute lymphoblastic leukemia (ALL). Blood 2001; 98: 590a. abstract 2474.
    • (2001) Blood , vol.98
    • Thomas, D.A.1    Cortes, J.2    Giles, F.J.3
  • 28
    • 0030013639 scopus 로고    scopus 로고
    • The novel anthracycline annamycin is not affected by P-glycoprotein-related multidrug resistance: Comparison with idarubicin and doxorubicin in HL-60 leukemia cell lines
    • Consoli U, Priebe W, Ling YH et al. The novel anthracycline annamycin is not affected by P-glycoprotein-related multidrug resistance: comparison with idarubicin and doxorubicin in HL-60 leukemia cell lines. Blood 1996; 88: 633-644.
    • (1996) Blood , vol.88 , pp. 633-644
    • Consoli, U.1    Priebe, W.2    Ling, Y.H.3
  • 29
    • 0028880010 scopus 로고
    • Preclinical toxicity of liposome-incorporated annamycin: Selective bone marrow toxicity with lack of cardiotoxicity
    • Zou Y, Priebe W, Stephens LC & Perez-Soler R. Preclinical toxicity of liposome-incorporated annamycin: selective bone marrow toxicity with lack of cardiotoxicity. Clinical Cancer Research 1: 1995; 1369-1374.
    • (1995) Clinical Cancer Research , vol.1 , pp. 1369-1374
    • Zou, Y.1    Priebe, W.2    Stephens, L.C.3    Perez-Soler, R.4
  • 30
    • 4243467075 scopus 로고    scopus 로고
    • Phase I study of annamycin: A novel MDR-I independent anthracycline in relapsed/refractory AML
    • abstract 4212
    • Andreeff M, Giles R, Sanchez-Williams G et al. Phase I study of annamycin: a novel MDR-I independent anthracycline in relapsed/refractory AML. Blood 1999; 94: 226b. abstract 4212.
    • (1999) Blood , vol.94
    • Andreeff, M.1    Giles, R.2    Sanchez-Williams, G.3
  • 31
    • 0032605142 scopus 로고    scopus 로고
    • Mechanisms of methotrexate resistance in acute leukemia Decreased transport and polyglutamylation
    • Gorlick R, Cole P, Banerjee D et al. Mechanisms of methotrexate resistance in acute leukemia Decreased transport and polyglutamylation. Advances in Experimental Medicine and Biology 1999; 457: 543-550.
    • (1999) Advances in Experimental Medicine and Biology , vol.457 , pp. 543-550
    • Gorlick, R.1    Cole, P.2    Banerjee, D.3
  • 32
    • 0027484339 scopus 로고
    • Multidrug resistance: Clinical relevance in acute leukemia
    • List AF. Multidrug resistance: clinical relevance in acute leukemia. Oncology (Huntington) 1993; 7: 23-28.
    • (1993) Oncology (Huntington) , vol.7 , pp. 23-28
    • List, A.F.1
  • 33
    • 0027314191 scopus 로고
    • Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: Prognostic implications
    • Goasguen JE, Dossot JM, Fardel O et al. Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications. Blood 1993; 81: 2394-2398.
    • (1993) Blood , vol.81 , pp. 2394-2398
    • Goasguen, J.E.1    Dossot, J.M.2    Fardel, O.3
  • 34
    • 0025302665 scopus 로고
    • Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis
    • Whitehead VM, Rosenblatt DS, Vuchich MJ et al. Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis. Blood 1990; 76: 44-49.
    • (1990) Blood , vol.76 , pp. 44-49
    • Whitehead, V.M.1    Rosenblatt, D.S.2    Vuchich, M.J.3
  • 35
    • 0030756226 scopus 로고    scopus 로고
    • Differences in folylpolyglutamate synthetase and dihydrofolate reductase Expression in human B-lineage versus T-lineage leukemic lymphoblasts: Mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity
    • Galpin AJ, Schuetz JD, Masson E et al. Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity. Molecular Pharmacology 1997; 52: 155-163.
    • (1997) Molecular Pharmacology , vol.52 , pp. 155-163
    • Galpin, A.J.1    Schuetz, J.D.2    Masson, E.3
  • 36
    • 0028063423 scopus 로고
    • Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia
    • Synold TW, Relling MV, Boyett JM et al. Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia. Journal of Clinical Investigation 1994; 94: 1996-2001.
    • (1994) Journal of Clinical Investigation , vol.94 , pp. 1996-2001
    • Synold, T.W.1    Relling, M.V.2    Boyett, J.M.3
  • 37
    • 0028800680 scopus 로고
    • A phase II study of continuous infusion of trimetrexate in patients with refractory acute leukemia
    • Kheradpour A, Berman E, Goker E et al. A phase II study of continuous infusion of trimetrexate in patients with refractory acute leukemia. Cancer Investigation 1995; 13: 36-40.
    • (1995) Cancer Investigation , vol.13 , pp. 36-40
    • Kheradpour, A.1    Berman, E.2    Goker, E.3
  • 39
    • 0037096749 scopus 로고    scopus 로고
    • Trimetrexate in relapsed T-cell lymphoma with skin involvement
    • Sarris AH, Phan A, Duvic M et al. Trimetrexate in relapsed T-cell lymphoma with skin involvement. Journal of Clinical Oncology 2002; 20: 2876-2880.
    • (2002) Journal of Clinical Oncology , vol.20 , pp. 2876-2880
    • Sarris, A.H.1    Phan, A.2    Duvic, M.3
  • 40
    • 0031792644 scopus 로고    scopus 로고
    • Compound GW506U78 in refractory hematologic malignancies: Relationship between cellular pharmacokinetics and clinical response
    • Gandhi V, Plunkett W, Rodriguez CO Jr. et al. Compound GW506U78 in refractory hematologic malignancies: relationship between cellular pharmacokinetics and clinical response. Journal of Clinical Oncology 1998; 16: 3607-3615.
    • (1998) Journal of Clinical Oncology , vol.16 , pp. 3607-3615
    • Gandhi, V.1    Plunkett, W.2    Rodriguez C.O., Jr.3
  • 41
    • 0001462165 scopus 로고    scopus 로고
    • Compound 506 has activity in mature lymphoid leukemia
    • abstract 2022
    • O'Brien S, Thomas D, Kantarjian H et al. Compound 506 has activity in mature lymphoid leukemia. Blood 1998; 92: 490a. abstract 2022.
    • (1998) Blood , vol.92
    • O'Brien, S.1    Thomas, D.2    Kantarjian, H.3
  • 42
    • 0033999960 scopus 로고    scopus 로고
    • Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies
    • Kisor DF, Plunkett W, Kurtzberg J et al. Pharmacokinetics of nelarabine and 9-beta-D-arabinofuranosyl guanine in pediatric and adult patients during a phase I study of nelarabine for the treatment of refractory hematologic malignancies. Journal of Clinical Oncology 2000; 18: 995-1003.
    • (2000) Journal of Clinical Oncology , vol.18 , pp. 995-1003
    • Kisor, D.F.1    Plunkett, W.2    Kurtzberg, J.3
  • 43
    • 4243696026 scopus 로고    scopus 로고
    • A phase I study of 2-amino-9-b-D-arabinosyl-6-methoxy-9H-puine (nelarabine) administered on a consecutive five day schedule in children and adults with refractory hematologic malignancies
    • abstract 2794
    • Kurtzberg J, Ernst TJ, Keating MJ et al. A phase I study of 2-amino-9-b-D-arabinosyl-6-methoxy-9H-puine (nelarabine) administered on a consecutive five day schedule in children and adults with refractory hematologic malignancies. Blood 1999; 94: 699a. abstract 2794.
    • (1999) Blood , vol.94
    • Kurtzberg, J.1    Ernst, T.J.2    Keating, M.J.3
  • 44
    • 0035871440 scopus 로고    scopus 로고
    • Evaluation of the combination of nelarabine and fludarabine in leukemias: Clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells
    • Gandhi V, Plunkett W, Weller S et al. Evaluation of the combination of nelarabine and fludarabine in leukemias: clinical response, pharmacokinetics, and pharmacodynamics in leukemia cells. Journal of Clinical Oncology 2001; 19: 2142-2152.
    • (2001) Journal of Clinical Oncology , vol.19 , pp. 2142-2152
    • Gandhi, V.1    Plunkett, W.2    Weller, S.3
  • 45
    • 0036317944 scopus 로고    scopus 로고
    • Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs-host disease: The role of dGTP in antiproliferative action of BCX-1777
    • Banti S, Miller PJ, Parker CD et al. Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs-host disease: the role of dGTP in antiproliferative action of BCX-1777. International Immunopharmacology 2002; 2: 913-923.
    • (2002) International Immunopharmacology , vol.2 , pp. 913-923
    • Banti, S.1    Miller, P.J.2    Parker, C.D.3
  • 46
    • 0035179950 scopus 로고    scopus 로고
    • DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine
    • Yamauchi T, Nowak BJ, Keating MJ & Plunkett W. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clinical Cancer Research 2001; 7: 3580-3589.
    • (2001) Clinical Cancer Research , vol.7 , pp. 3580-3589
    • Yamauchi, T.1    Nowak, B.J.2    Keating, M.J.3    Plunkett, W.4
  • 47
    • 0003296548 scopus 로고    scopus 로고
    • Phase I and pharmacology study of clofarabine (2-Cl-2′-F-deoxy-9-D-arabino-furanosyladenine) in solid and hematologic cancers
    • Kantarjian HM, Gandhi VV, O'Brien S et al. Phase I and pharmacology study of clofarabine (2-Cl-2′-F-deoxy-9-D-arabino-furanosyladenine) in solid and hematologic cancers. Blood 2001; 98: 214b.
    • (2001) Blood , vol.98
    • Kantarjian, H.M.1    Gandhi, V.V.2    O'Brien, S.3
  • 48
    • 0012541145 scopus 로고    scopus 로고
    • Phase I study of clofarabine (Clofarex™) in pediatric leukemia
    • abstract 315
    • Jeha S, Gandhi V, Chan KW et al. Phase I study of clofarabine (Clofarex™) in pediatric leukemia. Blood 2002; 100: 86a. abstract 315.
    • (2002) Blood , vol.100
    • Jeha, S.1    Gandhi, V.2    Chan, K.W.3
  • 49
    • 0012535474 scopus 로고    scopus 로고
    • Clofarabine [2-chloro-9-(2-deoxy-2-fluoro- b-D-arabinofuranosyl) adenine is active for patients with refractory or relapsed acute leukemias, myelodysplastic syndromes (MDS) and chronic myeloid leukemia in blast phase (CML-BP)
    • abstract 739
    • Cortes JE, Gandhi V, Plunkett W et al. Clofarabine [2-chloro-9-(2-deoxy-2-fluoro- b-D-arabinofuranosyl) adenine is active for patients with refractory or relapsed acute leukemias, myelodysplastic syndromes (MDS) and chronic myeloid leukemia in blast phase (CML-BP). Blood 2002; 100: 197a. abstract 739.
    • (2002) Blood , vol.100
    • Cortes, J.E.1    Gandhi, V.2    Plunkett, W.3
  • 50
    • 0030029803 scopus 로고    scopus 로고
    • In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL 101,731, a novel ribonucleoside diphosphate reductase inhibitor
    • Piepmeier JM, Rabidou N, Schold SC et al. In vitro and in vivo inhibition of glioblastoma and neuroblastoma with MDL 101,731, a novel ribonucleoside diphosphate reductase inhibitor. Cancer Research 1996; 56: 359-361.
    • (1996) Cancer Research , vol.56 , pp. 359-361
    • Piepmeier, J.M.1    Rabidou, N.2    Schold, S.C.3
  • 51
    • 0036140950 scopus 로고    scopus 로고
    • Action of (E)-2′-deoxy-2′-(fluoromethylene)cytidine on DNA metabolism: Incorporation, excision, and cellular response
    • Zhou Y, Achanta G, Pelicano H et al. Action of (E)-2′-deoxy-2′-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response. Molecular Pharmacology 2002; 61: 222-229.
    • (2002) Molecular Pharmacology , vol.61 , pp. 222-229
    • Zhou, Y.1    Achanta, G.2    Pelicano, H.3
  • 52
    • 18344398937 scopus 로고    scopus 로고
    • Decreased vascular endothelial growth factor expression associated with tumor regression induced by (E)-2′-deoxy-2′-(flouromethylene) cytidine (MDL 101,731)
    • Woessner RD, Loudy DE, Wallace CD et al. Decreased vascular endothelial growth factor expression associated with tumor regression induced by (E)-2′-deoxy-2′-(flouromethylene) cytidine (MDL 101,731). Oncologic Research 1997; 9: 543-552.
    • (1997) Oncologic Research , vol.9 , pp. 543-552
    • Woessner, R.D.1    Loudy, D.E.2    Wallace, C.D.3
  • 53
    • 79960970834 scopus 로고    scopus 로고
    • Phase I study of Tezacitabine (FMdC) in patients with relapsed and refractory hematologic malignancies
    • abstract 2493
    • Faderl S, Garcia-Manero G, Thomas DA et al. Phase I study of Tezacitabine (FMdC) in patients with relapsed and refractory hematologic malignancies. Blood 2001; 98: 595a. abstract 2493.
    • (2001) Blood , vol.98
    • Faderl, S.1    Garcia-Manero, G.2    Thomas, D.A.3
  • 54
    • 0030909701 scopus 로고    scopus 로고
    • DNA methylation changes in hematologic malignancies: Biologic and clinical implications
    • Issa JP, Baylin SB & Herman JG. DNA methylation changes in hematologic malignancies: Biologic and clinical implications. Leukemia 1997; 11: S7-S11.
    • (1997) Leukemia , vol.11
    • Issa, J.P.1    Baylin, S.B.2    Herman, J.G.3
  • 55
    • 0027243484 scopus 로고
    • 5-Aza-2′-deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: Past, present and future trends
    • Pinto A & Zagonel V. 5-Aza-2′-deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: past, present and future trends. Leukemia 1993; 7: 51-60.
    • (1993) Leukemia , vol.7 , pp. 51-60
    • Pinto, A.1    Zagonel, V.2
  • 56
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
    • Wijermans P, Lubbert M, Verhoef G et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. Journal of Clinical Oncology 2000; 18: 956-962.
    • (2000) Journal of Clinical Oncology , vol.18 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3
  • 57
    • 0027193132 scopus 로고
    • Preliminary results with 5-aza-2′-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia
    • The EORTC Leukemia Cooperative Group
    • Willemze R, Archimbaud E & Muus P. Preliminary results with 5-aza-2′-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group. Leukemia 1993; 7: 49-50
    • (1993) Leukemia , vol.7 , pp. 49-50
    • Willemze, R.1    Archimbaud, E.2    Muus, P.3
  • 58
    • 0030990163 scopus 로고    scopus 로고
    • Decitabine (5-Aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: Preliminary observations
    • Schwartsmann G, Fernandes MS, Schaan MD et al. Decitabine (5-Aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: preliminary observations. Leukemia 1997; 11: S28-S31.
    • (1997) Leukemia , vol.11
    • Schwartsmann, G.1    Fernandes, M.S.2    Schaan, M.D.3
  • 59
    • 0035992430 scopus 로고    scopus 로고
    • DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia
    • Garcia-Manero G, Daniel J, Smith TL et al. DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. Clinical Cancer Research 2002; 8: 2217-2224.
    • (2002) Clinical Cancer Research , vol.8 , pp. 2217-2224
    • Garcia-Manero, G.1    Daniel, J.2    Smith, T.L.3
  • 60
    • 0036278485 scopus 로고    scopus 로고
    • DNA methylation patterns at relapse in adult acute lymphocytic leukemia
    • Garcia-Manero G, Bueso-Ramos C, Daniel J et al. DNA methylation patterns at relapse in adult acute lymphocytic leukemia. Clinical Cancer Research 2002; 8: 1897-1903.
    • (2002) Clinical Cancer Research , vol.8 , pp. 1897-1903
    • Garcia-Manero, G.1    Bueso-Ramos, C.2    Daniel, J.3
  • 61
    • 0035884639 scopus 로고    scopus 로고
    • United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia
    • Soignet SL, Frankel SR, Douer D et al. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. Journal of Clinical Oncology 2001; 19: 3852-3860.
    • (2001) Journal of Clinical Oncology , vol.19 , pp. 3852-3860
    • Soignet, S.L.1    Frankel, S.R.2    Douer, D.3
  • 62
    • 0031691443 scopus 로고    scopus 로고
    • Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: Activation of caspases and down-regulation of Bcl-2 protein
    • Akao Y, Mizoguchi H, Kojima S et al. Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases; and down-regulation of Bcl-2 protein. British Journal of Haematology 1998; 102: 1055-1060.
    • (1998) British Journal of Haematology , vol.102 , pp. 1055-1060
    • Akao, Y.1    Mizoguchi, H.2    Kojima, S.3
  • 63
    • 0032910345 scopus 로고    scopus 로고
    • Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells
    • Bazarbachi A, El-Sabban ME, Nasr R et al. Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells. Blood 1999; 93: 278-283.
    • (1999) Blood , vol.93 , pp. 278-283
    • Bazarbachi, A.1    El-Sabban, M.E.2    Nasr, R.3
  • 64
    • 18844477979 scopus 로고    scopus 로고
    • BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity
    • Puccetti E, Guller S, Orleth A et al. BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity. Cancer Research 2000; 60: 3409-3413.
    • (2000) Cancer Research , vol.60 , pp. 3409-3413
    • Puccetti, E.1    Guller, S.2    Orleth, A.3
  • 65
    • 0034743735 scopus 로고    scopus 로고
    • 3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells
    • 3 enhances selective cytotoxic effects of STI-571 against Bcr-Abl-positive acute leukemia cells. Leukemia 2001; 15: 772-778.
    • (2001) Leukemia , vol.15 , pp. 772-778
    • Porosnicu, M.1    Nimmanapalli, R.2    Nguyen, D.3
  • 66
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • Adams J, Palombella VJ, Sausville EA et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Research 1999; 59: 2615-2622.
    • (1999) Cancer Research , vol.59 , pp. 2615-2622
    • Adams, J.1    Palombella, V.J.2    Sausville, E.A.3
  • 67
    • 0003216241 scopus 로고    scopus 로고
    • Phase II study of PS-341, a novel proteasome inhibitor, alone or in combination with dexamethasone in patients with multiple myeloma who have relapsed following front-line therapy and are refractory to their most recent therapy
    • abstract 3223
    • Richardson PG, Berenson J, Irwin D et al. Phase II study of PS-341, a novel proteasome inhibitor, alone or in combination with dexamethasone in patients with multiple myeloma who have relapsed following front-line therapy and are refractory to their most recent therapy. Blood 2001; 98: 774a. abstract 3223.
    • (2001) Blood , vol.98
    • Richardson, P.G.1    Berenson, J.2    Irwin, D.3
  • 68
    • 0034015672 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
    • Waters JS, Webb A, Cunningham D et al. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. Journal of Clinical Oncology 2000; 18: 1812-1823.
    • (2000) Journal of Clinical Oncology , vol.18 , pp. 1812-1823
    • Waters, J.S.1    Webb, A.2    Cunningham, D.3
  • 69
    • 0025264496 scopus 로고
    • Bryostatin I, a unique biological response modifier: Antileukemic activity in vitro
    • Jones RJ, Sharkis SJ, Miller CB et al. Bryostatin I, a unique biological response modifier: antileukemic activity in vitro. Blood 1990; 75: 1319-1323.
    • (1990) Blood , vol.75 , pp. 1319-1323
    • Jones, R.J.1    Sharkis, S.J.2    Miller, C.B.3
  • 70
    • 0031982782 scopus 로고    scopus 로고
    • Phase I study of bryostatin I in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia
    • Varterasian ML, Mohammad RM, Eilender DS et al. Phase I study of bryostatin I in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Journal of Clinical Oncology 1998; 16: 56-62.
    • (1998) Journal of Clinical Oncology , vol.16 , pp. 56-62
    • Varterasian, M.L.1    Mohammad, R.M.2    Eilender, D.S.3
  • 71
    • 0034851019 scopus 로고    scopus 로고
    • Phase II study of bryostatin I in patients with relapsed multiple myeloma
    • Varterasian ML, Pemberton PA, Hulburd K et al. Phase II study of bryostatin I in patients with relapsed multiple myeloma. Investigational New Drugs 2001; 19: 245-247.
    • (2001) Investigational New Drugs , vol.19 , pp. 245-247
    • Varterasian, M.L.1    Pemberton, P.A.2    Hulburd, K.3
  • 72
    • 12944249449 scopus 로고    scopus 로고
    • Phase II trial of bryostatin I in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia
    • Varterasian ML, Mohammad RM, Shurafa MS et al. Phase II trial of bryostatin I in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Clinical Cancer Research 2000; 6: 825-828.
    • (2000) Clinical Cancer Research , vol.6 , pp. 825-828
    • Varterasian, M.L.1    Mohammad, R.M.2    Shurafa, M.S.3
  • 73
    • 0033539938 scopus 로고    scopus 로고
    • Modulation of clAP-I by novel antitubulin agents when combined with bryostatin I results in increased apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh
    • Wall NR, Mohammad RM, Nabha SM et al. Modulation of clAP-I by novel antitubulin agents when combined with bryostatin I results in increased apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh. Biochemical and Biophysical Research Communications 1999; 266: 76-80.
    • (1999) Biochemical and Biophysical Research Communications , vol.266 , pp. 76-80
    • Wall, N.R.1    Mohammad, R.M.2    Nabha, S.M.3
  • 74
    • 0032877433 scopus 로고    scopus 로고
    • Bax:Bcl-2 ratio modulation by bryostatin I and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh
    • Wall NR, Mohammad RM & Al-Katib AM. Bax:Bcl-2 ratio modulation by bryostatin I and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh. Leukemia Research 1999; 23: 881-888.
    • (1999) Leukemia Research , vol.23 , pp. 881-888
    • Wall, N.R.1    Mohammad, R.M.2    Al-Katib, A.M.3
  • 75
    • 0034132418 scopus 로고    scopus 로고
    • Bryostatin I induces ubiquitination and proteasome degradation of Bcl-2 in the human acute lymphoblastic leukemia cell line, Reh
    • Wall NR, Mohammad RM, Reddy KB et al. Bryostatin I induces ubiquitination and proteasome degradation of Bcl-2 in the human acute lymphoblastic leukemia cell line, Reh. International Journal of Molecular Medicine 2000; 5: 165-171.
    • (2000) International Journal of Molecular Medicine , vol.5 , pp. 165-171
    • Wall, N.R.1    Mohammad, R.M.2    Reddy, K.B.3
  • 76
    • 0031059348 scopus 로고    scopus 로고
    • Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
    • Perez-Atayde AR, Sallan SE, Tedrow U et al. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. American Journal of Pathology 1997; 150: 815-821.
    • (1997) American Journal of Pathology , vol.150 , pp. 815-821
    • Perez-Atayde, A.R.1    Sallan, S.E.2    Tedrow, U.3
  • 77
    • 85112389844 scopus 로고    scopus 로고
    • Human acute lymphoblastic leukemia promotes angiogenesis in vivo: Pre-clinical models to develop targeted intervention
    • abstract 484
    • Veiga JP, Sallan SE, Nadler LM & Cardoso AA. Human acute lymphoblastic leukemia promotes angiogenesis in vivo: pre-clinical models to develop targeted intervention. Blood 2000; 96. 113a. abstract 484.
    • (2000) Blood , vol.96
    • Veiga, J.P.1    Sallan, S.E.2    Nadler, L.M.3    Cardoso, A.A.4
  • 78
    • 0033107767 scopus 로고    scopus 로고
    • Inhibition of tumor growth, angiogenesis, and microcirculation by the novel flk-I inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy
    • Vajkoczy P, Menger MD, Vollmar B et al. Inhibition of tumor growth, angiogenesis, and microcirculation by the novel flk-I inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. Neoplasia 1999; 1: 31-41.
    • (1999) Neoplasia , vol.1 , pp. 31-41
    • Vajkoczy, P.1    Menger, M.D.2    Vollmar, B.3
  • 79
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-I/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-I/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Research 1999; 59: 99-106.
    • (1999) Cancer Research , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3
  • 81
    • 0031454003 scopus 로고    scopus 로고
    • CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
    • Carroll M, Ohno-Jones S, Tamura S et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 1997; 90: 4947-4952.
    • (1997) Blood , vol.90 , pp. 4947-4952
    • Carroll, M.1    Ohno-Jones, S.2    Tamura, S.3
  • 82
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of BCR-ABL positive cells
    • Druker BJ, Tamura S, Buchdunger E et al. Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of BCR-ABL positive cells. Nature Medicine 1996; 2: 561-566.
    • (1996) Nature Medicine , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 83
    • 15444350807 scopus 로고    scopus 로고
    • Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148)
    • Beran M, Cao, X, Estrov Z et al. Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148). Clinical Cancer Research 1998; 4: 1661-1672.
    • (1998) Clinical Cancer Research , vol.4 , pp. 1661-1672
    • Beran, M.1    Cao, X.2    Estrov, Z.3
  • 84
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. New England Journal of Medicine 2001; 344. 1038-1042.
    • (2001) New England Journal of Medicine , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 85
    • 0037105560 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate (Glivec) in patients with relapsed or refractory Philadelphia chromosome positive acute lymphoid leukemias
    • Ottmann OG, Druker BJ, Sawyers CL et al. A phase II study of imatinib mesylate (Glivec) in patients with relapsed or refractory Philadelphia chromosome positive acute lymphoid leukemias. Blood 2002; 100: 1965-1971.
    • (2002) Blood , vol.100 , pp. 1965-1971
    • Ottmann, O.G.1    Druker, B.J.2    Sawyers, C.L.3
  • 86
    • 0003285566 scopus 로고    scopus 로고
    • Combination of hyper-CVAD with imatinib mesylate (STI571) for Philadelphia (Ph)-positive adult acute lymphoblastic leukemia (ALL) or chronic myelogenous leukemia in lymphoid blast phase (CML-LBP)
    • abstract 3340
    • Thomas DA, Cortes J, Giles FJ et al. Combination of hyper-CVAD with imatinib mesylate (STI571) for Philadelphia (Ph)-positive adult acute lymphoblastic leukemia (ALL) or chronic myelogenous leukemia in lymphoid blast phase (CML-LBP). Blood 2001; 98: 803a. abstract 3340.
    • (2001) Blood , vol.98
    • Thomas, D.A.1    Cortes, J.2    Giles, F.J.3
  • 87
    • 0037045589 scopus 로고    scopus 로고
    • Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: A gene-expression study
    • Hofmann WK, de Vos S, Elashoff D et al. Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study. Lancet 2002; 359: 481-486.
    • (2002) Lancet , vol.359 , pp. 481-486
    • Hofmann, W.K.1    de Vos, S.2    Elashoff, D.3
  • 88
    • 0036493544 scopus 로고    scopus 로고
    • Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    • Hofmann WK, Jones LC, Lemp NA et al. Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood 2002; 99: 1860-1862.
    • (2002) Blood , vol.99 , pp. 1860-1862
    • Hofmann, W.K.1    Jones, L.C.2    Lemp, N.A.3
  • 89
    • 0033387144 scopus 로고    scopus 로고
    • Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor
    • Uckun FM, Messinger Y, Chen CL et al. Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor. Clinical Cancer Research 1999; 5: 3906-3913.
    • (1999) Clinical Cancer Research , vol.5 , pp. 3906-3913
    • Uckun, F.M.1    Messinger, Y.2    Chen, C.L.3
  • 90
    • 0021813140 scopus 로고
    • Reactivity of rat monoclonal antibody CAMPATH-I with human leukemia cells and its possible application for autologous bone marrow transplantation
    • Hale G, Swirsky D, Waldmann H et al. Reactivity of rat monoclonal antibody CAMPATH-I with human leukemia cells and its possible application for autologous bone marrow transplantation. British Journal of Haematology 1985; 60: 41-48.
    • (1985) British Journal of Haematology , vol.60 , pp. 41-48
    • Hale, G.1    Swirsky, D.2    Waldmann, H.3
  • 91
    • 0024566393 scopus 로고
    • Effects of Campath-IH antibodies in vivo in patients with lymphoid malignancies: Influence of antibody isotype
    • Dyer MJ, Hale G, Hayhoe FGJ et al. Effects of Campath-IH antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype. Blood 1989; 73: 1431-1439.
    • (1989) Blood , vol.73 , pp. 1431-1439
    • Dyer, M.J.1    Hale, G.2    Hayhoe, F.G.J.3
  • 92
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-IH) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V et al. Therapeutic role of alemtuzumab (Campath-IH) in patients who have failed fludarabine: results of a large international study. Blood 2000; 99: 3554-3561.
    • (2000) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 93
    • 0032719863 scopus 로고    scopus 로고
    • Preclinical and phase I and II trials of rituximab
    • Maloney DG. Preclinical and phase I and II trials of rituximab. Seminars in Oncology 1999; 26: 74-78.
    • (1999) Seminars in Oncology , vol.26 , pp. 74-78
    • Maloney, D.G.1
  • 94
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • McLaughlin P, Grillo-Lopez AJ, Link BK et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. Journal of Clinical Oncology 1998; 16: 2825-2833.
    • (1998) Journal of Clinical Oncology , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-Lopez, A.J.2    Link, B.K.3
  • 95
    • 0003259284 scopus 로고    scopus 로고
    • Chemokine upregulation in response to rituximab in B-cell non-Hodgkin's lymphoma
    • abstract 377
    • Ansell SM, Tschumper RC, Witzig TE et al. Chemokine upregulation in response to rituximab in B-cell non-Hodgkin's lymphoma. Blood 1999; 94: 86a. abstract 377.
    • (1999) Blood , vol.94
    • Ansell, S.M.1    Tschumper, R.C.2    Witzig, T.E.3
  • 96
    • 0344766075 scopus 로고    scopus 로고
    • Treatment of low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy
    • Czuczman MS, Grillo-Lopez AJ, White CA et al. Treatment of low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. Journal of Clinical Oncology 1999; 17: 268-276.
    • (1999) Journal of Clinical Oncology , vol.17 , pp. 268-276
    • Czuczman, M.S.1    Grillo-Lopez, A.J.2    White, C.A.3
  • 97
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier B, Lepage E, Briere J et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. New England Journal of Medicine 2002; 346: 235-242.
    • (2002) New England Journal of Medicine , vol.346 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3
  • 98
    • 85112374294 scopus 로고    scopus 로고
    • Significance of CD20 positivity in de novo acute lymphocytic leukemia (ALL)
    • abstract 468
    • Thomas DA, Cortes J, O'Brien SM et al. Significance of CD20 positivity in de novo acute lymphocytic leukemia (ALL). Blood 2000; 96: 109a. abstract 468.
    • (2000) Blood , vol.96
    • Thomas, D.A.1    Cortes, J.2    O'Brien, S.M.3
  • 99
    • 79960971206 scopus 로고    scopus 로고
    • Rituximab and hyper-CVAD for adult Burkitt's (BL) or Burkitt's-like (BLL) leukemia or lymphoma
    • abstract 3342
    • Thomas DA, Cortes J, Giles FJ et al. Rituximab and hyper-CVAD for adult Burkitt's (BL) or Burkitt's-like (BLL) leukemia or lymphoma. Blood 2001; 98: 804a. abstract 3342.
    • (2001) Blood , vol.98
    • Thomas, D.A.1    Cortes, J.2    Giles, F.J.3
  • 100
    • 0020606415 scopus 로고
    • B4, a human B lymphocyte associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes
    • Nadler LM, Anderson KC, Marti G et al. B4, a human B lymphocyte associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. Journal of Immunology 1983; 131: 244-250.
    • (1983) Journal of Immunology , vol.131 , pp. 244-250
    • Nadler, L.M.1    Anderson, K.C.2    Marti, G.3
  • 101
    • 0027502253 scopus 로고
    • Anti-B4-blocked ricin: A phase I trial of 7-day continuous infusion in patients with B-cell neoplasms
    • Grossbard ML, Lambert JM, Goldmacher VS et al. Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms. Journal of Clinical Oncology 1993; 11: 726-737.
    • (1993) Journal of Clinical Oncology , vol.11 , pp. 726-737
    • Grossbard, M.L.1    Lambert, J.M.2    Goldmacher, V.S.3
  • 102
    • 0031685787 scopus 로고    scopus 로고
    • Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and I-asparaginase
    • Ek O, Gaynon P, Zeren T et al. Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and I-asparaginase. Leukemia and Lymphoma 1998; 31: 143-149.
    • (1998) Leukemia and Lymphoma , vol.31 , pp. 143-149
    • Ek, O.1    Gaynon, P.2    Zeren, T.3
  • 103
    • 0034090987 scopus 로고    scopus 로고
    • Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro
    • Herrera L, Farah RA, Pellegrini VA et al. Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro. Leukemia 2000; 14: 853-858.
    • (2000) Leukemia , vol.14 , pp. 853-858
    • Herrera, L.1    Farah, R.A.2    Pellegrini, V.A.3
  • 104
    • 0027394952 scopus 로고
    • In vivo anti-leukemic efficacy of anti-CD7-pokeweed antiviral protein immunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency
    • Gunther R, Chelstrom LM, Finnegan D et al. In vivo anti-leukemic efficacy of anti-CD7-pokeweed antiviral protein immunotoxin against human T-lineage acute lymphoblastic leukemia/lymphoma in mice with severe combined immunodeficiency. Leukemia 1993; 7: 298-309.
    • (1993) Leukemia , vol.7 , pp. 298-309
    • Gunther, R.1    Chelstrom, L.M.2    Finnegan, D.3
  • 105
    • 0012534761 scopus 로고    scopus 로고
    • BL22, an anti-CD22 recombinant immunotoxin, is active in vitro and in vivo against B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells from pediatric patients
    • abstract 3024
    • Lew G, Gu L, Zhou M et al. BL22, an anti-CD22 recombinant immunotoxin, is active in vitro and in vivo against B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells from pediatric patients. Blood 2002; 100: 764a. abstract 3024.
    • (2002) Blood , vol.100
    • Lew, G.1    Gu, L.2    Zhou, M.3
  • 106
    • 0033151526 scopus 로고    scopus 로고
    • Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: A phase I study of an anti-CD33 calicheamicin immunoconjugate
    • Sievers EL, Appelbaum FA, Spielberger RT et al. Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood 1999; 93: 3678-3684.
    • (1999) Blood , vol.93 , pp. 3678-3684
    • Sievers, E.L.1    Appelbaum, F.A.2    Spielberger, R.T.3
  • 107
    • 0036733277 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin)
    • Larson RA, Boogaerts M, Estey E et al. Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin). Leukemia 2002; 16: 1627-1636.
    • (2002) Leukemia , vol.16 , pp. 1627-1636
    • Larson, R.A.1    Boogaerts, M.2    Estey, E.3
  • 108
    • 0035878068 scopus 로고    scopus 로고
    • Mylotarg (gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation
    • Giles FJ, Kantarjian HM, Kornblau SM et al. Mylotarg (gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation. Cancer 2001; 92: 406-413.
    • (2001) Cancer , vol.92 , pp. 406-413
    • Giles, F.J.1    Kantarjian, H.M.2    Kornblau, S.M.3
  • 109
    • 0036182540 scopus 로고    scopus 로고
    • Immunotherapy of non-Hodgkin's lymphoma with hLL2 (epratuzumab, an anti-CD22 monoclonal antibody) and HuID10 (apolizumab)
    • Leonard JP & Link BK. Immunotherapy of non-Hodgkin's lymphoma with hLL2 (epratuzumab, an anti-CD22 monoclonal antibody) and HuID10 (apolizumab). Seminars in Oncology 2002; 29: 81-86.
    • (2002) Seminars in Oncology , vol.29 , pp. 81-86
    • Leonard, J.P.1    Link, B.K.2
  • 110
    • 0035992309 scopus 로고    scopus 로고
    • In vivo pharmacodynamic effects of HuID10 (remitogen), a humanized antibody reactive against a polymorphic determinant of HLA-DR expressed on B cells
    • Shi JD, Bullock C, Hall WC et al. In vivo pharmacodynamic effects of HuID10 (remitogen), a humanized antibody reactive against a polymorphic determinant of HLA-DR expressed on B cells. Leukemia and Lymphoma 2002; 43: 1303-1312.
    • (2002) Leukemia and Lymphoma , vol.43 , pp. 1303-1312
    • Shi, J.D.1    Bullock, C.2    Hall, W.C.3
  • 111
    • 0003351083 scopus 로고    scopus 로고
    • Phase I trial of humanized ID10 (HUID10) monoclonal antibody targeting class II molecules in patients with relapsed lymphoma
    • abstract 86
    • Link BK, Wang H, Byrd JC et al. Phase I trial of humanized ID10 (HUID10) monoclonal antibody targeting class II molecules in patients with relapsed lymphoma. Proceedings of the American Society of Clinical Oncology 2000; 19: 24a. abstract 86
    • (2000) Proceedings of the American Society of Clinical Oncology , vol.19
    • Link, B.K.1    Wang, H.2    Byrd, J.C.3
  • 112
    • 19044399684 scopus 로고    scopus 로고
    • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    • Yeoh EJ, Ross ME, Shurtleff SA et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002; 1: 133-143.
    • (2002) Cancer Cell , vol.1 , pp. 133-143
    • Yeoh, E.J.1    Ross, M.E.2    Shurtleff, S.A.3
  • 113
    • 17144474314 scopus 로고    scopus 로고
    • Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    • Ferrando AA, Neuberg DS, Staunton J et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002; 1: 75-87.
    • (2002) Cancer Cell , vol.1 , pp. 75-87
    • Ferrando, A.A.1    Neuberg, D.S.2    Staunton, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.