Arsenic trioxide and interferon-α synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells

Blood

Volumn 93, Issue 1, 1999, Pages 278-283

  Bazarbachi, Ali ^a   El Sabban, Marwan E ^b   Nasr, Rihab ^b   Quignon, Frédérique ^b   Awaraji, Christian ^b   Kersual, Joelle ^b   Dianoux, Laurent ^b   Zermati, Yael ^b   Haidar, Joud H ^b   Hermine, Olivier ^b   De Thé, Hughes ^b  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; RECOMBINANT ALPHA INTERFERON; ZIDOVUDINE;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PRIORITY JOURNAL; T CELL LEUKEMIA; T CELL LYMPHOMA;

EID: 0032910345     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.1.278     Document Type: Article

References (19)

1. Hinuma Y, Komoda H, Chosa T, KondoT, Kohakura M, Takenaka T, Kikuchi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takiuchi Y, Uchino H, Hanaoka M: Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: A nation-wide sero-epidemiologic study. Int J Cancer 29:631, 1982
2. Takatsuki F, Yamaguchi K, Hattori T: Adult T-cell leukemia/ lymphoma, in Gallo RC, Wong-Staal F (eds): Retrovirus Biology and Human Disease. New York, NY, Dekker, 1990, p 147
3. Shimoyama M: Treatment of patients with adult T-cell leukemia-lymphoma: An overview, in Advances in Takatsuki K, Hinuma Y, YoshidaM(eds): Adult T-cell Leukemia and HTLV-I Research. Tokyo, Japan, Scientific Societies, 1992, p 43
4. Gill P, Harrington W, Kaplan M, Ribeiro R, Bennett J, Liebman H, Bernstein-Singer M, Espina B, Cabral L, Allen S, Kornblau S, Pike M, Levine A: Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alpha and zidovudine. N Engl J Med 332:1744, 1995
5. Hermine O, Bouscary D, Gessain A, Turlure P, LeBlond V, Franck N, Buzyn-Veil A, Rio B, Macintyre E, Dreyfus F, Bazarbachi A: Treatment of HTLV-I associated adult T-cell leukemia-lymphoma with a combination of zidovudine and alpha-interferon. N Engl J Med 332:1749, 1995
6. Bazarbachi A, Hermine O: Treatment by a combination of zidovudine and alpha interferon in naive and pretreated adult T-cell leukemia/lymphoma patients. J AIDS Hum Retrovirol 13:s186, 1996
7. Chen G-Q, Zhu J, Shi X-G, Ni J-H, Zhong H-J, Si G-Y, Jin X-L, Tang W, Li X-S, Xong S-M, Shen Z-X, Sun G-L, Ma J, Zhang P, Zhang T-D, Gazin C, Naoe T, Chen S-J, Wang Z-Y, Chen Z: In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As) in the treatment of acute promyelocytic leukemia: As induces NB4 cell apoptosis with downregulation of bcl-2 expression and modulation of PML-RAR/PML proteins. Blood 88:1052, 1996
8. Zhu J, Koken M, Guignon F, Chelbi-Alix MK, Degos L, Yi Wang Z, Chen Z, de Thé H: Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:3978, 1997
9. Tsoi P, Visani G, Ottaviani E, Gamberi B, Cennachi A, Tura S: Synergistic cytotoxicity of AZT plus alpha and gamma interferon in chronic myeloid leukemia cell line K562. Eur J Haematol 51:209, 1993
10. Poiesz BJ, Ruscetti FW, Reitz MS, Kaylanaraman VS, Gallo RC: Isolation of a new type C retrovirus ( HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia. Nature 294:268, 1981
11. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y: Type C virus particles in a cord T cell line derived by cocultivating normal human cord leukocytes and human leukemic T cells. Nature 294:770, 1981
12. Quignon F, De Bels F, Koken M, Feuteun J, Ameisen J-C. The HD: PML induces a novel caspase independent death process. Nat Genet (in press)
13. Yoshida M: Human leukemia virus associated with adult T cell leukemia (ATL). Jpn J Cancer Res 74:777, 1983
14. Daniel MT, Koken M, Romagne O, Barbey S, Bazarbachi A, Stadler M, Guillemin MC, Degos L, Chomienne C, De Thé H: PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood 82:1858, 1993
15. Koken MHM, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz G, Stuurman N, de Jong L, Szosteski C, Calvo F, Chomienne C, Degos L, Puvion E, de Thé H: Thé t(15;17) translocation alters a nuclear body in a retinoic acid reversible fashion. EMBO J 13:1073, 1994
16. Dyck J, Maul GG, Miller WH Jr, Chen JD, Kazizuka A, Evans RM: A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 78:333, 1994
17. Weis K, Rambaud S, Lavau C, Jansen J, Carvahlo T, Carmo-Fonseca M, Lamond A, Dejean A: Retinoic acid regulates aberrant nuclear localization of PML/RARα in acute promyelocytic leukemia cells. Cell 76:345, 1994
18. Brasch K, Ochs RL: Nuclear bodies (Nbs): A newly "rediscovered organelle". Exp Cell Res 202:211, 1992
19. Desbois C, Rousset R, Bautignies F, Jalinot P: Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein. Science 273:951, 1996